PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24891766-1	2014	We revisited the action of a carotenoid, the lycopene, on the expression of proinflammatory genes, reactive oxygen species (ROS) production, and metalloprotease (MMP9) activity.	Lycopene	45-53	matrix metallopeptidase 9	Homo sapiens	162-166	
28723216-10	2017	Using transient transfection of siRNA against NOX4, we found that the downregulation of NOX4 could mimic lycopene by inhibiting cell migration and the activities of MMP-9 and MMP-2 during the incubation with or without TGF-beta on SK-Hep-1 cells.	Lycopene	105-113	matrix metallopeptidase 9	Homo sapiens	165-170	
24891766-6	2014	Lycopene enhanced MMP9 secretion via a c-AMP-dependent process, and reduced ROS production at higher concentrations than 2 muM.	Lycopene	0-8	matrix metallopeptidase 9	Homo sapiens	18-22	
22309082-0	2012	Modulation of MMP-9 pathway by lycopene in macrophages and fibroblasts exposed to cigarette smoke.	Lycopene	31-39	matrix metallopeptidase 9	Homo sapiens	14-19	
22309082-3	2012	However, at the moment, it is unknown if lycopene may inhibit cigarette smoke-induced MMP-9 expression.	Lycopene	41-49	matrix metallopeptidase 9	Homo sapiens	86-91	
22309082-4	2012	Presently, we examined the inhibitory mechanism of lycopene on MMP-9 induction in cultured human macrophages (THP-1 cells), in isolated rat alveolar macrophages (AMs) and in cultured RAT-1 fibroblasts, all cellular sources of MMP-9, exposed to cigarette smoke extract (CSE).	Lycopene	51-59	matrix metallopeptidase 9	Homo sapiens	63-68	
22309082-6	2012	A 8 h-lycopene pre-treatment (0.5-2 muM) reduced CSE-mediated MMP-9 induction in a dose- and time-dependent manner.	Lycopene	6-14	matrix metallopeptidase 9	Homo sapiens	62-67	
22309082-9	2012	Lycopene-mediated inhibition of MMP-9 was reversed by mevalonate and associated with a reduced expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.	Lycopene	0-8	matrix metallopeptidase 9	Homo sapiens	32-37	
22309082-10	2012	Taken together, these results suggest that lycopene may inhibit CSE-mediated MMP-9 induction, primarily by blocking prenylation of Ras in a signaling pathway, in which MEK1/2-ERK1/2 and NF-kappaB are involved.	Lycopene	43-51	matrix metallopeptidase 9	Homo sapiens	77-82	
18287363-7	2008	High-lycopene supplementation also decreased the positive rate of proliferating cellular nuclear antigen (PCNA), the level of VEGF, and protein expressions of PCNA, MMP-9, and VEGF in lung tissues.	Lycopene	5-13	matrix metallopeptidase 9	Homo sapiens	165-170	
16514180-5	2006	Lycopene decreased the gelatinolytic activities of both matrix metalloproteinase (MMP)-2 and MMP-9, which were secreted from the SK-Hep1 cells.	Lycopene	0-8	matrix metallopeptidase 9	Homo sapiens	93-98	
17049831-0	2007	Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1.	Lycopene	0-8	matrix metallopeptidase 9	Homo sapiens	18-44	
17049831-3	2007	Here, we used SK-Hep-1 cells (from a human hepatoma) to test whether lycopene exerts its anti-invasion activity via down-regulation of the expression of matrix metalloproteinase (MMP)-9, an important enzyme in the degradation of basement membrane in cancer invasion.	Lycopene	69-77	matrix metallopeptidase 9	Homo sapiens	153-185	
17049831-6	2007	We showed that lycopene (1-10 microM) significantly inhibited SK-Hep-1 invasion (P<.05) and that this effect correlated with the inhibition of MMP-9 at the levels of enzyme activity (r(2)=.94, P<.001), protein expression (r(2)=.80, P=.007) and mRNA expression (r(2)=.94, P<.001).	Lycopene	15-23	matrix metallopeptidase 9	Homo sapiens	146-151	
17049831-8	2007	The antioxidant effect of lycopene appeared to play a minor role in its inhibition of MMP-9 and invasion activity of SK-Hep-1 cells because coincubation of cells with lycopene plus hydrogen peroxide abolished the antioxidant effect but did not significantly affect the anti-invasion ability of lycopene.	Lycopene	26-34	matrix metallopeptidase 9	Homo sapiens	86-91	
17049831-9	2007	Thus, lycopene decreases the invasive ability of SK-Hep-1 cells by inhibiting MMP-9 expression and suppressing the binding activity of NF-kappaB and Sp1.	Lycopene	6-14	matrix metallopeptidase 9	Homo sapiens	78-83