PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35120355-10	2022	In addition, lycopene upregulated endothelial nitric oxide synthase (eNOS), protein kinase B (Akt) and phosphatidylinositol 3-kinases (PI3K), and downregulated vascular endothelial growth factor receptor 2 (VEGFR-2) protein expressions (p<0.05) in the livers of the BDL rats.	Lycopene	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	94-97	
35120355-11	2022	CONCLUSION: Lycopene ameliorated liver fibrosis, hyperdynamic circulation and pathological angiogenesis in biliary cirrhotic rats, possibly through the modulation of intrahepatic Akt/PI3K/eNOS and VEGFR-2 pathways.	Lycopene	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	179-182	
31017253-9	2019	Furthermore, the combination of LP and IPoC inhibited the expression of glucose-regulated protein 78 and C/EBP homologous protein, increased the phosphorylation levels of AKT, ERK1/2 and glycogen synthase kinase-3beta, repressed mitochondrial permeability transition pore opening, and reduced the expression of cytochrome c, cleaved caspase-9 and cleaved caspase-3.	Lycopene	32-34	AKT serine/threonine kinase 1	Rattus norvegicus	171-174	
34055003-0	2021	Lycopene Attenuates Hypoxia-Induced Testicular Injury by Inhibiting PROK2 Expression and Activating PI3K/AKT/mTOR Pathway in a Varicocele Adult Rat.	Lycopene	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	105-108	
24660901-0	2014	Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways.	Lycopene	20-28	AKT serine/threonine kinase 1	Rattus norvegicus	125-128	
25197372-9	2014	Administration of lycopene decreased the levels of MDA content and expression of CTGF, increased Akt/PKB phosphorylation and SOD activity in diabetic renal tissues.	Lycopene	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	97-100	
25197372-9	2014	Administration of lycopene decreased the levels of MDA content and expression of CTGF, increased Akt/PKB phosphorylation and SOD activity in diabetic renal tissues.	Lycopene	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	101-104	
25197372-10	2014	CONCLUSIONS: Lycopene protects against development of diabetic nephropathy and ameliorates renal function via improving oxidative status and regulating p-Akt and CTGF.	Lycopene	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	154-157	
24971153-5	2014	Moreover, lycopene treatment prevented the increase in the phosphorylation of serine-threonine kinase Akt and glycogen synthase kinase-3beta (GSK-3 beta ) caused by U-II without affecting the protein levels of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN).	Lycopene	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	102-105	
24971153-7	2014	These findings imply that lycopene yields antihypertrophic effects that can prevent the activation of the Akt/GSK-3 beta hypertrophic pathway by modulating PTEN inactivation through U-II treatment.	Lycopene	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	106-109