PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18095570-7	2007	CONCLUSION: Lycopene can induce apoptosis of PC-3, change the cell cycle distribution and downregulate the expression of cyclin D1 and bcl-2 and upregulate the expression of bax and then restrain cell proliferation.	Lycopene	12-20	BCL2 apoptosis regulator	Homo sapiens	135-140	
24053141-6	2013	Using real time PCR assay, lycopene also induced apoptosis in prostate cancer cells with altered gene expression of Bax and Bcl-2.	Lycopene	27-35	BCL2 apoptosis regulator	Homo sapiens	124-129	
20067883-15	2009	beta-carotene, lycopene and all-trans retinoic acid alone and in combination with docetaxel were found to influence the expression of bcl-2 and p53 antigen in the cells examined.	Lycopene	15-23	BCL2 apoptosis regulator	Homo sapiens	134-139	
32718121-11	2021	Lycopene treatment significantly increased Bax expression (P < 0.0001) and decreased Bcl-2 expression (P < 0.0001) in HeLa cells.	Lycopene	0-8	BCL2 apoptosis regulator	Homo sapiens	85-90	
32718121-13	2021	CONCLUSION: Lycopene increases the sensitization of cervical cancer cells to cisplatin via inhibition of cell viability, up-regulation of Bax expression, and down-regulation of Bcl-2 expression.	Lycopene	12-20	BCL2 apoptosis regulator	Homo sapiens	177-182	
32885410-5	2020	Lycopene also ameliorated H2 O2 -induced damage and reduced the expression of apoptotic markers, such as Bcl-2, Bax, and cleaved caspase 3.	Lycopene	0-8	BCL2 apoptosis regulator	Homo sapiens	105-110	
31741457-4	2019	In the present study, we showed that lycopene reduces the viability of AGS cells by inducing DNA fragmentation and increasing the Bax/Bcl-2 ratio.	Lycopene	37-45	BCL2 apoptosis regulator	Homo sapiens	134-139	
31491956-6	2019	Lycopene decreased cell viability and increased apoptotic indices (DNA fragmentation, apoptosis inducing factor, cleavage of caspase-3 and caspase-9, Bax/Bcl-2 ratio).	Lycopene	0-8	BCL2 apoptosis regulator	Homo sapiens	154-159	
27035331-5	2016	Additionally, lycopene counteracted H2O2-induced mitochondrial dysfunction, which was evidenced by suppression of mitochondrial permeability transition pore opening, attenuation of the decline of the mitochondrial membrane potential, and inhibition of the increase of Bax and decrease of Bcl-2 levels within the mitochondria.	Lycopene	14-22	BCL2 apoptosis regulator	Homo sapiens	288-293	
30939781-6	2019	Lycopene reduced cell viability with increases in active caspase-3 and the Bax to Bcl-2 ratio in PANC-1 cells.	Lycopene	0-8	BCL2 apoptosis regulator	Homo sapiens	82-87	
31279748-6	2019	After lycopene treatment, the protein expression of Bax (an apoptotic protein) in SKOV3 cells increased significantly, and the protein expression of Bcl-2 (an anti-apoptotic protein) decreased significantly.	Lycopene	6-14	BCL2 apoptosis regulator	Homo sapiens	149-154	
28345329-0	2017	Lycopene Extracts from Different Tomato-Based Food Products Induce Apoptosis in Cultured Human Primary Prostate Cancer Cells and Regulate TP53, Bax and Bcl-2 Transcript Expression Carotenoids are the main tomato components, especially lycopene.	Lycopene	0-8	BCL2 apoptosis regulator	Homo sapiens	152-157	
28345329-5	2017	Using real time PCR assay, we found that lycopene promotedan upregulation of TP53 and Bax transcript expression and also downregulation of Bcl-2 expression in PCa cells.	Lycopene	41-49	BCL2 apoptosis regulator	Homo sapiens	139-144	
26535076-6	2015	Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment.	Lycopene	13-21	BCL2 apoptosis regulator	Homo sapiens	157-174	
26535076-6	2015	Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment.	Lycopene	13-21	BCL2 apoptosis regulator	Homo sapiens	176-181