PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35533600-0	2022	Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway.	Lycopene	0-8	androgen receptor	Homo sapiens	112-129	
35533600-6	2022	In addition, the expression of p-AKT, p-EZH2 and androgen receptor (AR) were significantly down-regulated in 22RV1 and C4-2B cells and the proliferation and invasion of CRPC cells were inhibited after treatment with lycopene, while SC79 (an AKT agonist) markedly rescue this effect.	Lycopene	216-224	androgen receptor	Homo sapiens	49-66	
35533600-6	2022	In addition, the expression of p-AKT, p-EZH2 and androgen receptor (AR) were significantly down-regulated in 22RV1 and C4-2B cells and the proliferation and invasion of CRPC cells were inhibited after treatment with lycopene, while SC79 (an AKT agonist) markedly rescue this effect.	Lycopene	216-224	androgen receptor	Homo sapiens	68-70	
35533600-8	2022	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.	Lycopene	77-85	androgen receptor	Homo sapiens	121-123	
35533600-8	2022	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.	Lycopene	147-155	androgen receptor	Homo sapiens	121-123	
20819671-16	2010	CONCLUSIONS: Lycopene as an antioxidant dietary factor could significantly inhibit DNA synthesis in a dose-dependent pattern; the result revealed lycopene might inhibit androgen receptor gene element activity and expression.	Lycopene	13-21	androgen receptor	Homo sapiens	169-186	
20819671-0	2010	Effect of lycopene on androgen receptor and prostate-specific antigen velocity.	Lycopene	10-18	androgen receptor	Homo sapiens	22-39	
20819671-2	2010	This study was carried out to evaluate the impact of the dietary factor lycopene on DNA synthesis, activity and expression of the androgen receptor gene element in prostate LnCaP cells and to report our pilot phase II study investigating its effect on prostate-specific antigen velocity over one year.	Lycopene	72-80	androgen receptor	Homo sapiens	130-147	
20819671-5	2010	A transient transfection of a plasmid DNA recombinant containing an androgen receptor element-luciferase (ARE-Luc) report gene into LnCaP cells was developed and the impact of different concentrations of lycopene on the androgen receptor element was reflected by quantitative analysis of the luciferase enzyme function.	Lycopene	204-212	androgen receptor	Homo sapiens	220-237	
20819671-10	2010	We showed for the first time that lycopene inhibited the activity of the androgen receptor gene element in a dose-related manner.	Lycopene	34-42	androgen receptor	Homo sapiens	73-90	
20819671-16	2010	CONCLUSIONS: Lycopene as an antioxidant dietary factor could significantly inhibit DNA synthesis in a dose-dependent pattern; the result revealed lycopene might inhibit androgen receptor gene element activity and expression.	Lycopene	146-154	androgen receptor	Homo sapiens	169-186	
17121935-6	2006	The binding of lycopene to the ligand-binding domain of the human androgen receptor was carried out, but lycopene was not found to be a ligand for this receptor.	Lycopene	15-23	androgen receptor	Homo sapiens	66-83	
18283040-11	2008	In this study, lycopene, in dietary concentrations, reversed DHT effects of 6S cells on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I"s effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3.	Lycopene	15-23	androgen receptor	Homo sapiens	151-153