PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15796208-0	2005	Effects of selected flavonoids and carotenoids on drug accumulation and apoptosis induction in multidrug-resistant colon cancer cells expressing MDR1/LRP.	Carotenoids	35-46	ATP binding cassette subfamily B member 1	Homo sapiens	145-149	
22770743-2	2012	A selection of carotenoids (beta-carotene, crocin, retinoic acid, canthaxanthin, and fucoxanthin) was investigated whether they are substrates of P-gp, and if they can reverse MDR in resistant Caco-2 and CEM/ADR5000 cells as compared to the sensitive parent cell line CCRF-CEM.	Carotenoids	15-26	ATP binding cassette subfamily B member 1	Homo sapiens	146-150	
20645919-4	2010	In our previous work we studied modulation of MDR in cancer cells expressing P-gp or MRP1 by selected carotenoids, flavonoids and extracts from medically important Chinese plants.	Carotenoids	102-113	ATP binding cassette subfamily B member 1	Homo sapiens	77-81	
22770743-4	2012	The carotenoids increased accumulation of these P-gp substrates in a dose-dependent manner indicating that they themselves also function as substrates.	Carotenoids	4-15	ATP binding cassette subfamily B member 1	Homo sapiens	48-52	
22770743-9	2012	RT-PCR was applied to evaluate the mRNA levels of P-gp in Caco-2 cells after treatment with carotenoids.	Carotenoids	92-103	ATP binding cassette subfamily B member 1	Homo sapiens	50-54	
15113052-3	2004	The effects of carotenoids were studied on the activity of the MDR-1 gene-encoded efflux pump system.	Carotenoids	15-26	ATP binding cassette subfamily B member 1	Homo sapiens	63-68	
15113052-4	2004	The carotenoids, isolated from paprika and other vegetables, were tested on the rhodamine 123 accumulation of human MDR-1 gene-transfected L1210 mouse lymphoma cells and human breast cancer cells MDA-MB-231 (HTB-26).	Carotenoids	4-15	ATP binding cassette subfamily B member 1	Homo sapiens	116-121	
15309450-6	2004	In addition, carotenoid- or retinol-mediated gene expression of PXR-responsive genes like CYP3A4/CYP3A7, CYP3A5, MDR-1 and MRP-2 has been determined in HepG2 cells by RT-PCR with up-regulative properties of beta-carotene or retinol being comparable to or even higher than that of rifampicin.	Carotenoids	13-23	ATP binding cassette subfamily B member 1	Homo sapiens	113-118	
15309450-7	2004	In conclusion, PXR-mediated up-regulation of CYP3A4/CYP3A7 and CYP3A5 as well as MDR1 and MRP2 by carotenoids points to a potential interference on the metabolism of xenobiotic and endogenous relevant compounds.	Carotenoids	98-109	ATP binding cassette subfamily B member 1	Homo sapiens	81-85