PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28018391-3	2016	Carotenoid cleavage dioxygenase 4 (CCD4) is involved in carotenoid breakdown in senescing leaf and desiccating seed, and is part of the proteome of plastoglobules (PG), which are thylakoid-associated lipid droplets.	Carotenoids	56-66	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	0-33	
35137037-10	2022	The study suggests that carotenoid catabolism is regulated by the CCD4 in tissue and cultivar specific manners, and also demonstrated the use of the genome editing tool in developing transgene-free biofortified banana.	Carotenoids	24-34	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	66-70	
28018391-3	2016	Carotenoid cleavage dioxygenase 4 (CCD4) is involved in carotenoid breakdown in senescing leaf and desiccating seed, and is part of the proteome of plastoglobules (PG), which are thylakoid-associated lipid droplets.	Carotenoids	56-66	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	35-39	
28018391-5	2016	Leaves of Arabidopsis thaliana ccd4 mutants constitutively expressing CCD4 fused to yellow fluorescent protein showed strong fluorescence in PG and reduced carotenoid levels upon dark-induced senescence.	Carotenoids	156-166	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	31-35	
28018391-5	2016	Leaves of Arabidopsis thaliana ccd4 mutants constitutively expressing CCD4 fused to yellow fluorescent protein showed strong fluorescence in PG and reduced carotenoid levels upon dark-induced senescence.	Carotenoids	156-166	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	70-74	
28018391-7	2016	Moreover, carotenoids were shown to accumulate in PG of ccd4 mutant plants during senescence, indicating translocation of carotenoids to PG prior to degradation.	Carotenoids	10-21	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	56-60	
28018391-7	2016	Moreover, carotenoids were shown to accumulate in PG of ccd4 mutant plants during senescence, indicating translocation of carotenoids to PG prior to degradation.	Carotenoids	122-133	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	56-60	
24368792-4	2013	Linkage mapping and genome-wide association studies of Arabidopsis seed carotenoids identified CAROTENOID cleavage dioxygenase4 (CCD4) as a major negative regulator of seed carotenoid content, especially beta-carotene.	Carotenoids	72-83	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	95-127	
27811075-1	2016	The Arabidopsis carotenoid cleavage dioxygenase 4 (AtCCD4) is a negative regulator of the carotenoid content of seeds and has recently been suggested as a candidate for the generation of retrograde signals that are thought to derive from the cleavage of poly-cis-configured carotene desaturation intermediates.	Carotenoids	16-26	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	51-57	
27208224-5	2016	We previously showed that two CAROTENOID CLEAVAGE DIOXYGENASE enzymes, CCD1 and CCD4, are the primary mediators of seed carotenoid degradation, and here we demonstrate that ZEP acts as an upstream control point of carotenoid homeostasis, with ZEP-mediated epoxidation targeting carotenoids for degradation by CCD enzymes.	Carotenoids	120-130	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	80-84	
27208224-5	2016	We previously showed that two CAROTENOID CLEAVAGE DIOXYGENASE enzymes, CCD1 and CCD4, are the primary mediators of seed carotenoid degradation, and here we demonstrate that ZEP acts as an upstream control point of carotenoid homeostasis, with ZEP-mediated epoxidation targeting carotenoids for degradation by CCD enzymes.	Carotenoids	278-289	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	80-84	
24368792-4	2013	Linkage mapping and genome-wide association studies of Arabidopsis seed carotenoids identified CAROTENOID cleavage dioxygenase4 (CCD4) as a major negative regulator of seed carotenoid content, especially beta-carotene.	Carotenoids	72-83	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	129-133	
24368792-4	2013	Linkage mapping and genome-wide association studies of Arabidopsis seed carotenoids identified CAROTENOID cleavage dioxygenase4 (CCD4) as a major negative regulator of seed carotenoid content, especially beta-carotene.	Carotenoids	72-82	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	95-127	
24368792-4	2013	Linkage mapping and genome-wide association studies of Arabidopsis seed carotenoids identified CAROTENOID cleavage dioxygenase4 (CCD4) as a major negative regulator of seed carotenoid content, especially beta-carotene.	Carotenoids	72-82	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	129-133	
24368792-5	2013	Loss of CCD4 function did not affect carotenoid homeostasis during seed development but greatly reduced carotenoid degradation during seed desiccation, increasing beta-carotene content 8.4-fold relative to the wild type.	Carotenoids	104-114	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	8-12	
24368792-6	2013	Allelic complementation of a ccd4 null mutant demonstrated that single-nucleotide polymorphisms and insertions and deletions at the locus affect dry seed carotenoid content, due at least partly to differences in CCD4 expression.	Carotenoids	154-164	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	29-33	
24368792-7	2013	CCD4 also plays a major role in carotenoid turnover during dark-induced leaf senescence, with beta-carotene accumulation again most strongly affected in the ccd4 mutant.	Carotenoids	32-42	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	0-4	
24368792-8	2013	These results demonstrate that CCD4 plays a major role in beta-carotene degradation in drying seeds and senescing leaves and suggest that CCD4 orthologs would be promising targets for stabilizing and increasing the level of provitamin A carotenoids in seeds of major food crops.	Carotenoids	237-248	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	31-35	
24368792-8	2013	These results demonstrate that CCD4 plays a major role in beta-carotene degradation in drying seeds and senescing leaves and suggest that CCD4 orthologs would be promising targets for stabilizing and increasing the level of provitamin A carotenoids in seeds of major food crops.	Carotenoids	237-248	nine-cis-epoxycarotenoid dioxygenase 4	Arabidopsis thaliana	138-142