PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33345665-4	2021	In children, two double-blind randomised placebo-controlled studies describing the effects of diet vs. mixed carotenoid supplementation on insulin resistance, adipokines and the rate of accrual of subcutaneous abdominal fat, implicate supplementation of these compounds to achieve targetable levels may be useful in the management of obesity accrual in this population.	Carotenoids	109-119	insulin	Homo sapiens	139-146	
10966898-0	2000	Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols.	Carotenoids	87-98	insulin	Homo sapiens	17-24	
9921962-4	1999	All serum carotenoids were inversely related to fasting serum insulin after adjustment for confounders (p < 0.05 for each carotenoid).	Carotenoids	10-21	insulin	Homo sapiens	62-69	
9921962-4	1999	All serum carotenoids were inversely related to fasting serum insulin after adjustment for confounders (p < 0.05 for each carotenoid).	Carotenoids	10-20	insulin	Homo sapiens	62-69	
9921962-5	1999	If confirmed, these data suggest new opportunities for research that include exploring a possible role for carotenoids in the pathogenesis of insulin resistance and diabetes.	Carotenoids	107-118	insulin	Homo sapiens	142-149	
16597706-0	2006	Associations of serum carotenoid concentrations with the development of diabetes and with insulin concentration: interaction with smoking: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.	Carotenoids	22-32	insulin	Homo sapiens	90-97	
16597706-7	2006	Similarly, year 15 insulin and insulin resistance values, adjusted for baseline levels, were inversely related to sum of carotenoids only in nonsmokers (per SD increase in insulin level, slope = -0.46 (p = 0.03); per SD increase in insulin resistance, slope = -0.14 (p = 0.01)).	Carotenoids	121-132	insulin	Homo sapiens	19-26	
16597706-7	2006	Similarly, year 15 insulin and insulin resistance values, adjusted for baseline levels, were inversely related to sum of carotenoids only in nonsmokers (per SD increase in insulin level, slope = -0.46 (p = 0.03); per SD increase in insulin resistance, slope = -0.14 (p = 0.01)).	Carotenoids	121-132	insulin	Homo sapiens	31-38	
16597706-7	2006	Similarly, year 15 insulin and insulin resistance values, adjusted for baseline levels, were inversely related to sum of carotenoids only in nonsmokers (per SD increase in insulin level, slope = -0.46 (p = 0.03); per SD increase in insulin resistance, slope = -0.14 (p = 0.01)).	Carotenoids	121-132	insulin	Homo sapiens	31-38	
16597706-8	2006	In CARDIA, higher serum carotenoid concentrations are associated with lower risk of diabetes and insulin resistance in nonsmokers but not in smokers.	Carotenoids	24-34	insulin	Homo sapiens	97-104	
16155284-6	2005	RESULTS: Mean 2-h postload plasma glucose and fasting insulin concentrations decreased significantly with increasing quintiles of the 5 serum carotenoids--alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin, and lycopene.	Carotenoids	142-153	insulin	Homo sapiens	54-61	
33345665-5	2021	We will discuss the role of carotenoids and their conversion products (retinoids) in adipogenesis, lipolysis, insulin resistance and the pathophysiology of the metabolic syndrome and review the animal studies, which help support these findings.	Carotenoids	28-39	insulin	Homo sapiens	110-117	
30908741-8	2019	Total carotenoids positively correlated with per cent-predicted FEV1 and inversely correlated with insulin resistance among obese asthmatics only.	Carotenoids	6-17	insulin	Homo sapiens	99-106	
31504714-0	2020	Obesity and Insulin Resistance Are Inversely Associated with Serum and Adipose Tissue Carotenoid Concentrations in Adults.	Carotenoids	86-96	insulin	Homo sapiens	12-19	
31504714-1	2020	BACKGROUND: Low tissue concentrations of carotenoids have been suggested to contribute to insulin resistance in obesity.	Carotenoids	41-52	insulin	Homo sapiens	90-97	
31504714-11	2020	CONCLUSIONS: Multiple serum and adipose tissue carotenoids are associated with favorable metabolic traits, including insulin sensitivity in liver and adipose tissue in humans.	Carotenoids	47-58	insulin	Homo sapiens	117-124	
24906472-1	2015	PURPOSE: Many epidemiological studies find an inverse correlation between carotenoids intake or carotenoids plasma concentrations and body mass index (BMI), insulin resistance or metabolic syndrome in the general population.	Carotenoids	74-85	insulin	Homo sapiens	157-164	
24906472-1	2015	PURPOSE: Many epidemiological studies find an inverse correlation between carotenoids intake or carotenoids plasma concentrations and body mass index (BMI), insulin resistance or metabolic syndrome in the general population.	Carotenoids	96-107	insulin	Homo sapiens	157-164	
25660385-6	2015	Further properties of carotenoids leading to a potential reduction of cardiovascular risk are represented by lowering of blood pressure, reduction of pro-inflammatory cytokines and markers of inflammation (such as C-reactive protein), and improvement of insulin sensitivity in muscle, liver, and adipose tissues.	Carotenoids	22-33	insulin	Homo sapiens	254-261	
23936766-0	2013	Serum Retinol and Carotenoids in Association with Biomarkers of Insulin Resistance among Premenopausal Women.	Carotenoids	18-29	insulin	Homo sapiens	64-71