PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24036327-9	2014	CONCLUSIONS: PPARgamma signaling pathway, via stimulating p21 and inhibiting cyclin D1, may play an important role in the anti-proliferative effects of carotenoid and rosiglitazone combination on K562 cells.	Carotenoids	152-162	peroxisome proliferator activated receptor gamma	Homo sapiens	13-22	
24036327-0	2014	PPARgamma-dependent pathway in the growth-inhibitory effects of K562 cells by carotenoids in combination with rosiglitazone.	Carotenoids	78-89	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9	
24036327-1	2014	BACKGROUND: Carotenoids have been found to play roles in the prevention and therapy of some cancers which PPARgamma was also discovered to be involved in.	Carotenoids	12-23	peroxisome proliferator activated receptor gamma	Homo sapiens	106-115	
24036327-4	2014	When PPARgamma has been inhibited by GW9662 and siRNA, cycle-related regulator expression in K562 cells treated with carotenoid and rosiglitazone combination was analyzed by Western blotting.	Carotenoids	117-127	peroxisome proliferator activated receptor gamma	Homo sapiens	5-14	
24036327-6	2014	Specific PPARgamma inhibition attenuated the cell growth suppression induced by carotenoid and rosiglitazone combination.	Carotenoids	80-90	peroxisome proliferator activated receptor gamma	Homo sapiens	9-18	
24036327-8	2014	Moreover, GW9662 and PPARgamma siRNA also significantly attenuated the up-regulation of p21 and down-regulation of cyclin D1 caused by carotenoids and rosiglitazone.	Carotenoids	135-146	peroxisome proliferator activated receptor gamma	Homo sapiens	21-30	
22707263-0	2012	The natural carotenoid astaxanthin, a PPAR-alpha agonist and PPAR-gamma antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes.	Carotenoids	12-22	peroxisome proliferator activated receptor gamma	Homo sapiens	61-71	
20573495-11	2011	Moreover, the carotenoid increased peroxisome proliferator-activated receptor gamma levels in THP-1 macrophages.	Carotenoids	14-24	peroxisome proliferator activated receptor gamma	Homo sapiens	35-83	
21208793-6	2011	Concomitant addition of lycopene and the PPARgamma inhibitor GW9662 or lycopene and mevalonate blocked the carotenoid-induced increase in ABCA1 and cav-1 expressions.	Carotenoids	107-117	peroxisome proliferator activated receptor gamma	Homo sapiens	41-50	
21620794-9	2011	It appears to us that PPARgamma signaling pathways and Keap1-Nrf2/EpRE/ARE signaling pathway were involved in the inhibition of K562 cell proliferation by carotenoids and the up-regulation of PPARgamma expression at least partly contributed to the antiproliferative effects of beta-carotene, astaxanthin, capsanthin, and bixin on K562 cells.	Carotenoids	155-166	peroxisome proliferator activated receptor gamma	Homo sapiens	22-31	
21620794-0	2011	Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARgamma) in K562 cancer cells.	Carotenoids	0-11	peroxisome proliferator activated receptor gamma	Homo sapiens	112-121	
21620794-4	2011	Involvement of PPARgamma in the growth inhibition of leukemia K562 cells by carotenoids was investigated in the present study.	Carotenoids	76-87	peroxisome proliferator activated receptor gamma	Homo sapiens	15-24	
21620794-6	2011	Pretreatment with GW9662, a potent antagonist of PPARgamma, partly attenuated the inhibition of K562 cell proliferation by the four carotenoids at 8muM.	Carotenoids	132-143	peroxisome proliferator activated receptor gamma	Homo sapiens	49-58	
21620794-7	2011	These carotenoids up-regulated the expression of PPARgamma and p21 and down-regulated the expression of cyclin D1 in a dose-dependent manner.	Carotenoids	6-17	peroxisome proliferator activated receptor gamma	Homo sapiens	49-58	
15949696-1	2005	The effects of fatty acids and retinoic acid (carotene) on brown adipose tissue differentiation are mediated by activation of the transcription factors PPARgamma and PPARalpha in combination with RXR.	Carotenoids	46-54	peroxisome proliferator activated receptor gamma	Homo sapiens	152-161	
21625550-11	2011	Moreover, the carotenoid increased PPARgamma levels which, in turn, enhanced PTEN expression and decreased pAKT levels in CSE-exposed cells.	Carotenoids	14-24	peroxisome proliferator activated receptor gamma	Homo sapiens	35-44	
29731858-6	2018	GW9662, an irreversible PPARgamma antagonist, partly attenuated the decrease in EC109 cell viability induced by these carotenoids.	Carotenoids	118-129	peroxisome proliferator activated receptor gamma	Homo sapiens	24-33	
29731858-8	2018	These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression.	Carotenoids	32-42	peroxisome proliferator activated receptor gamma	Homo sapiens	175-184