PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30786954-3	2019	Carotenoids and their metabolites have also been related to reduced inflammation and oxidative stress via interacting with transcription factors, such as NF-kappaB and Nrf-2, as well as with the nuclear receptors retinoic acid receptor/retinoid X receptor, implicated in immune functions and cellular differentiation.	Carotenoids	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	168-173	
33238590-2	2020	We previously reported that carotenoid oxidation products are the active mediators in the activation of the transcription factor Nrf2 and the inhibition of the NF-kB transcription system by carotenoids.	Carotenoids	28-38	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133	
25134454-7	2014	Carotenoids can also block oxidative stress by interacting with the nuclear factor erythroid 2-related factor 2 pathway, enhancing its translocation into the nucleus, and activating phase II enzymes and antioxidants, such as glutathione-S-transferases.	Carotenoids	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	68-111	
31213029-5	2019	Though carotenoids can act as direct antioxidants, quenching, for example, singlet oxygen and peroxide radicals, an important biological function appears to rest also in the activation of the body"s own antioxidant defence system, related to superoxide-dismutase, catalase, and glutathione-peroxidase expression, likely due to the interaction with transcription factors, such as nuclear-factor erythroid 2-related factor 2 (Nrf-2).	Carotenoids	7-18	NFE2 like bZIP transcription factor 2	Homo sapiens	379-422	
31213029-5	2019	Though carotenoids can act as direct antioxidants, quenching, for example, singlet oxygen and peroxide radicals, an important biological function appears to rest also in the activation of the body"s own antioxidant defence system, related to superoxide-dismutase, catalase, and glutathione-peroxidase expression, likely due to the interaction with transcription factors, such as nuclear-factor erythroid 2-related factor 2 (Nrf-2).	Carotenoids	7-18	NFE2 like bZIP transcription factor 2	Homo sapiens	424-429	
25672622-3	2015	Health-promoting nutrients and other factors act, at least in part by raising Nrf2 including: many phenolic antioxidants; gamma- and delta-tocopherols and tocotrienols; long chain omega-3 fatty acids DHA and EPA; many carotenoids of which lycopene may be the most active; isothiocyanates from cruciferous vegetables; sulfur compounds from allium vegetables; terpenoids.	Carotenoids	218-229	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82	
33808148-10	2021	This study demonstrates that carotenoids and polyphenols cooperate in balancing UV-induced skin cell damage, and suggests that NFkappaB and ARE/Nrf2 are involved in these effects.	Carotenoids	29-40	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148	
25078119-4	2014	Carotenoids, hydrophobic plant pigments, are devoid of electrophilic groups, and we have previously demonstrated that carotenoid derivatives, but not the native compounds activate the Nrf2 transcription system.	Carotenoids	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	184-188	
25078119-4	2014	Carotenoids, hydrophobic plant pigments, are devoid of electrophilic groups, and we have previously demonstrated that carotenoid derivatives, but not the native compounds activate the Nrf2 transcription system.	Carotenoids	118-128	NFE2 like bZIP transcription factor 2	Homo sapiens	184-188	
21620794-9	2011	It appears to us that PPARgamma signaling pathways and Keap1-Nrf2/EpRE/ARE signaling pathway were involved in the inhibition of K562 cell proliferation by carotenoids and the up-regulation of PPARgamma expression at least partly contributed to the antiproliferative effects of beta-carotene, astaxanthin, capsanthin, and bixin on K562 cells.	Carotenoids	155-166	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65	
34856476-6	2022	RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA.	Carotenoids	52-63	NFE2 like bZIP transcription factor 2	Homo sapiens	279-283	
34943127-4	2021	Previous studies have shown that dietary carotenoids and polyphenols activate the cell"s antioxidant defense system by increasing antioxidant response element/Nrf2 (ARE/Nrf2) transcriptional activity and reducing the inflammatory response.	Carotenoids	41-52	NFE2 like bZIP transcription factor 2	Homo sapiens	159-163	
34943127-4	2021	Previous studies have shown that dietary carotenoids and polyphenols activate the cell"s antioxidant defense system by increasing antioxidant response element/Nrf2 (ARE/Nrf2) transcriptional activity and reducing the inflammatory response.	Carotenoids	41-52	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173