PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7782923-2 1995 Assorted monoterpenes, sesquiterpenes, carotenoids and tocotrienols posttranscriptionally down regulate 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, a key activity in the sterologenic pathway. Carotenoids 39-50 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 104-151 7784459-2 1995 Assorted monoterpenes, sesquiterpenes, carotenoids and tocotrienols down regulate, post-transcriptionally, 3-hydroxy-3-methylglutaryl coenzyme A reductase activity thereby modestly decreasing cholesterol synthesis and concomitantly decreasing LDL cholesterol. Carotenoids 39-50 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 107-154 34343336-11 2021 CONCLUSION: Carotenoids from S. mombin demonstrate HMG-CoA reductase (HMGCR) inhibition, anti-lipidaemic, and anticancer effects. Carotenoids 12-23 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 70-75 34343336-12 2021 The inhibition of HMGCR by the carotenoids extract further poses it as a potential anti-hypercholesterolaemia compounds. Carotenoids 31-42 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 18-23