PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17011717-4	2007	Indeed, the data from dihydropyridine-based calcium antagonist (DHP) trails are consistent in that they could not protect against new-onset heart failure or progression of renal disease in patients with left-ventricular systolic dysfunction or overt proteinuria, respectively.	Calcium	44-51	dihydropyrimidinase	Homo sapiens	64-67	
15661163-4	2005	This calcium signal is totally blocked when cells are stimulated in the presence of DHP receptor inhibitors such as nimodipine or calcicludine, thus suggesting the implication of this L-type calcium channel.	Calcium	5-12	dihydropyrimidinase	Homo sapiens	84-87	
15661163-6	2005	Interestingly, we demonstrate that Tat-induced calcium mobilization is tightly linked to TNF-alpha production, thus indicating that Tat-induced mobilization and TNF-alpha production are entirely mediated by DHP receptors, as shown by their total inhibition by nimodipine, calcicludine, or anti-alpha1D antisense oligonucleotides.	Calcium	47-54	dihydropyrimidinase	Homo sapiens	207-210	
15661163-0	2005	Human immunodeficiency virus type 1 Tat protein induces an intracellular calcium increase in human monocytes that requires DHP receptors: involvement in TNF-alpha production.	Calcium	73-80	dihydropyrimidinase	Homo sapiens	123-126	
16425978-1	2005	We have previously shown that azelnidipine, a long-acting dihydropyridine-based calcium antagonist (DHP), inhibited tumor necrosis factor-alpha-induced endothelial cell (EC) activation through its antioxidative properties.	Calcium	80-87	dihydropyrimidinase	Homo sapiens	100-103	
32308799-8	2020	Compound 4 had 9 times higher calcium agonist activity than the classic DHP calcium agonist Bay K8644.	Calcium	76-83	dihydropyrimidinase	Homo sapiens	72-75	
1658191-7	1991	Our results indicate that the DHP binding site of the L-type calcium channel is close to the extracellular surface of the cell membrane and that ionized DHP molecules may interact with the receptor in a manner that is uniquely affected by calcium.	Calcium	61-68	dihydropyrimidinase	Homo sapiens	30-33	
1658191-7	1991	Our results indicate that the DHP binding site of the L-type calcium channel is close to the extracellular surface of the cell membrane and that ionized DHP molecules may interact with the receptor in a manner that is uniquely affected by calcium.	Calcium	61-68	dihydropyrimidinase	Homo sapiens	153-156	
33219601-8	2021	RESULTS: Multivariate results revealed inverse associations for time to PD diagnosis with exposure to the combination of the combination of angiotensin receptor II blockers (ARBs) and dihydropyridine calcium channel blockers (DHP-CCB) (HR=0.55, p< 0.01) and angiotensin converting enzyme inhibitors (ACEi) and diuretics (HR=0.60, p-value <0.01).	Calcium	200-207	dihydropyrimidinase	Homo sapiens	226-229	
33137694-8	2021	These studies reveal that nicardipine, a DHP derivative, shows a strong Cav1.2 blocking activity, requiring more 2500 pN force to pull calcium ion towards the channel"s pore in the presence of the compound.	Calcium	135-142	dihydropyrimidinase	Homo sapiens	41-44	
1695946-3	1990	We find that DHP agonists and antagonists act at low concentration on calcium currents in frog sympathetic neurons but that the effects are small even at optimal concentrations.	Calcium	70-77	dihydropyrimidinase	Homo sapiens	13-16	
1695946-6	1990	These results suggest the presence of an L-type calcium current, with DHP sensitivity similar to L-currents in cardiac muscle.	Calcium	48-55	dihydropyrimidinase	Homo sapiens	70-73	
1695946-7	1990	The predominant (greater than 90%) calcium current in frog sympathetic neurons is a DHP-resistant N-type current.	Calcium	35-42	dihydropyrimidinase	Homo sapiens	84-87	
31735158-5	2019	1,4-DHP is a potent Voltage-Gated Calcium Channel (VGCC) antagonist derivative which acts as an anti-hypertensive, anti- anginal, anti-tumor, anti-inflammatory, anti-tubercular, anti-cancer, anti-hyperplasia, anti-mutagenic, anti-dyslipidemic, and anti-ulcer agent.	Calcium	34-41	dihydropyrimidinase	Homo sapiens	4-7	
31735158-6	2019	From the inferences of the study, it can be concluded that the basic nucleus, 1,4-DHP which is a voltage-gated calcium ion channel blocker, acts as a base for its derivatives that possess different important therapeutic effects.	Calcium	111-118	dihydropyrimidinase	Homo sapiens	82-85