PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24743742-5 2014 Treatment with TNF-alpha/IL-1beta inhibited BMP-2-induced alkaline phosphatase activity, calcium deposition, osteogenic transcriptional factor Runx2, and the expression of osteogenic markers in C2C12 and MC3T3-E1 cells. Calcium 89-96 interleukin 1 beta Mus musculus 25-33 30233585-15 2018 Calcium content-matched primary CPP caused twice more IL-1beta secretion than did secondary CPP, which was associated with increased calcium-dependent inflammasome activation, suggesting that intracellular CPP dissolution and calcium overload may cause this inflammation. Calcium 0-7 interleukin 1 beta Mus musculus 54-62 30233585-15 2018 Calcium content-matched primary CPP caused twice more IL-1beta secretion than did secondary CPP, which was associated with increased calcium-dependent inflammasome activation, suggesting that intracellular CPP dissolution and calcium overload may cause this inflammation. Calcium 133-140 interleukin 1 beta Mus musculus 54-62 27882934-4 2016 IL-1beta causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in cardiomyocytes, which are changes that underlie arrhythmia propensity. Calcium 122-129 interleukin 1 beta Mus musculus 0-8 25091392-5 2014 IL-1beta promoted hyperpolarization of the resting membrane potential (Vrest), decrease of input resistance (Rin), decrease of Ih rectification, decrease in action potential (AP) threshold and decrease in the number of APs in low threshold calcium spike (LTS) bursts, while IL-6 promoted decrease of Rin and decrease in the number of APs in LTS bursts. Calcium 240-247 interleukin 1 beta Mus musculus 0-8 30003120-8 2016 The nodose neurons express receptors for TNF and IL-1beta, and we show that exposing them to TNF and IL-1beta significantly stimulates their calcium uptake. Calcium 141-148 interleukin 1 beta Mus musculus 49-57 30003120-8 2016 The nodose neurons express receptors for TNF and IL-1beta, and we show that exposing them to TNF and IL-1beta significantly stimulates their calcium uptake. Calcium 141-148 interleukin 1 beta Mus musculus 101-109 23550835-5 2013 Cofilin phosphorylation induced by UTP in IL-1beta-treated mPCNs is also decreased by inhibitors of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), suggesting a role for P2Y2R-mediated and Gq-dependent calcium mobilization in neurite outgrowth. Calcium 210-217 interleukin 1 beta Mus musculus 42-50 23836031-3 2013 Overnight exposure to IL-1B+IL-6 in islets isolated from normal mice and humans disrupted glucose-stimulated intracellular calcium responses; cytokine-induced effects were more severe among islets from prediabetic db/db mice that otherwise showed no signs of dysfunction. Calcium 123-130 interleukin 1 beta Mus musculus 22-27 23836031-4 2013 IL-1B+IL-6 exposure reduced endoplasmic reticulum (ER) calcium storage, activated ER stress responses (Nos2, Bip, Atf4, and Ddit3 [CHOP]), impaired glucose-stimulated insulin secretion, and increased cell death only in islets from prediabetic db/db mice. Calcium 55-62 interleukin 1 beta Mus musculus 0-5 12126975-7 2002 In addition, rhein (10, 30 microM) inhibited calcium release from mouse calvaria induced by interleukin-1 beta, prostaglandin E(2) and parathyroid hormone 1-34 human fragment. Calcium 45-52 interleukin 1 beta Mus musculus 92-110 18490713-8 2008 We delineated two distinct release pathways: the well-known caspase-1 cascade mediating release of processed IL-1beta that was selectively blocked by inhibition of caspase-1 or panx1, and a calcium-independent, caspase-1/panx1-independent release of pro-IL-1beta that was selectively blocked by glycine. Calcium 190-197 interleukin 1 beta Mus musculus 109-117 19675207-5 2009 IL-1beta release at a low TLO dose requires potassium efflux, calcium influx, and the activities of calcium-independent PLA(2), caspase-1, and cathepsin B. Calcium 62-69 interleukin 1 beta Mus musculus 0-8 19675207-5 2009 IL-1beta release at a low TLO dose requires potassium efflux, calcium influx, and the activities of calcium-independent PLA(2), caspase-1, and cathepsin B. Calcium 100-107 interleukin 1 beta Mus musculus 0-8 17668318-4 2007 Pharmacological inhibitor of tyrosine kinase, PI3 kinase, protein kinase C, p42/44, p38, JNK and intracellular calcium immobilizing agent down regulated the WGA induced expression of cytokines TNF-alpha, IL-1beta, IL-12 and IFN-gamma. Calcium 111-118 interleukin 1 beta Mus musculus 204-212 17668318-9 2007 The pharmacological inhibitors were also used to check the cascade of activation of tyrosine kinase, PKC, PI3 kinase, p42/44, p38, JNK and release of calcium from intracellular storage to sort out the signal pathways involved in the release of TNF-alpha, IL-1beta, IL-12, and IFN-gamma by macrophages on treatment with WGA in vitro. Calcium 150-157 interleukin 1 beta Mus musculus 255-263 7499244-1 1995 In view of the observations that the calcium ionophores, A23187 and ionomycin, enhance the processing and secretion of interleukin-1 (IL-1 alpha) and IL-1 beta from macrophages, and IL-1 alpha processing is mediated by calpain, a calcium-dependent protease, we evaluated the possibility that calpain might also play a role in the processing of IL-1 beta. Calcium 37-44 interleukin 1 beta Mus musculus 150-159 11853703-4 2002 Celecoxib (0.1 microM) completely inhibited the calcium release induced by IL-1beta, TNF-alpha, and LPS. Calcium 48-55 interleukin 1 beta Mus musculus 75-83 10362533-4 1999 Des-Arg10-kallidin (10 microM), a BDKRB1 agonist, increased intracellular calcium ion ([Ca2+]i) in IL-1beta (5 ng/ml, 24 h)-exposed cells, an increase not observed in the cells not exposed to IL-1beta. Calcium 74-81 interleukin 1 beta Mus musculus 99-107 9914554-2 1999 We investigated the effects of the cytochrome P450 pathway in IL-1beta-induced calcium release from cultured mouse calvaria in vitro in the presence of clotrimazole, a cytochrome P450 inhibitor, or L-N(G)-arginine methyl ester, a nitric oxide synthase inhibitor. Calcium 79-86 interleukin 1 beta Mus musculus 62-70 11125308-4 2000 However, following stimulation with lipopolysaccharide or phorbol myristate acetate/calcium ionophore, peritoneal cells from H2(b) mice synthesised significantly more IL-1 beta, TNF-alpha, TNFR and IFN-gamma protein and IFN-gamma mRNA than cells from congenic H2(k) or H2(d) mice. Calcium 84-91 interleukin 1 beta Mus musculus 167-176 7499244-1 1995 In view of the observations that the calcium ionophores, A23187 and ionomycin, enhance the processing and secretion of interleukin-1 (IL-1 alpha) and IL-1 beta from macrophages, and IL-1 alpha processing is mediated by calpain, a calcium-dependent protease, we evaluated the possibility that calpain might also play a role in the processing of IL-1 beta. Calcium 37-44 interleukin 1 beta Mus musculus 344-353 7723245-6 1995 In contrast, pre-incubating calvariae with either anti-IL-1 beta or IL-1 beta RA did not alter basal calcium efflux but completely blocked the beta 2m induced calcium efflux. Calcium 159-166 interleukin 1 beta Mus musculus 55-64 8569283-0 1995 Age-dependent stimulation or inhibition of calcium release from bone cultures by interleukin-1 beta. Calcium 43-50 interleukin 1 beta Mus musculus 81-99 7648334-0 1995 Calcium antagonists decrease plasma and tissue concentrations of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-1 alpha in a mouse model of endotoxin. Calcium 0-7 interleukin 1 beta Mus musculus 94-112 7723245-6 1995 In contrast, pre-incubating calvariae with either anti-IL-1 beta or IL-1 beta RA did not alter basal calcium efflux but completely blocked the beta 2m induced calcium efflux. Calcium 159-166 interleukin 1 beta Mus musculus 68-77 7723245-8 1995 Thus, the beta 2m-induced calcium efflux observed in neonatal mouse calvariae is dependent on interleukin-1 beta but not prostaglandins. Calcium 26-33 interleukin 1 beta Mus musculus 94-112 2104887-10 1990 Our results suggest that activated macrophages possess a novel processing independent, possibly calcium-dependent, mechanism that allows for the release of the precursor forms of IL-1 alpha and IL-1 beta. Calcium 96-103 interleukin 1 beta Mus musculus 194-203 1500719-4 1992 The calcium ionophore A23187 and the detergent saponin caused complete release of nonprocessed 35-kDa pro-IL-1 beta and liberation into the extracellular medium of the cytoplasmic marker enzyme LDH and the lysosomal enzyme beta-N-acetylglucosaminidase. Calcium 4-11 interleukin 1 beta Mus musculus 106-115