PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9633924-2 1998 The underlying mechanism includes HDL3-mediated inhibition of phosphatidylinositol 4,5-bis-phosphate turnover, 1,2-diacylglycerol and inositol 1,4,5-tris-phosphate formation, and intracellular calcium mobilization. Calcium 193-200 HDL3 Homo sapiens 34-38 11137079-5 2001 Secondly, the HDL(3) binding characteristics (K(d) and B(max) values), the activation of protein kinase C (PKC) and the inhibition of thrombin-induced inositoltriphosphate (IP(3)) formation and calcium (Ca(2+)) mobilization mediated by HDL(3) particles were similar in platelets from control subjects and patients with type I and type II Glanzmann"s thrombasthenia, which are characterized by total and partial lack of GPIIb-IIIa and fibrinogen, respectively. Calcium 194-201 HDL3 Homo sapiens 14-20 9633924-3 1998 The inhibitory effects of HDL3 on inositol 1,4,5-tris-phosphate formation and intracellular calcium mobilization were abolished after covalent modification of HDL3 with dimethylsuberimidate. Calcium 92-99 HDL3 Homo sapiens 26-30 9633924-3 1998 The inhibitory effects of HDL3 on inositol 1,4,5-tris-phosphate formation and intracellular calcium mobilization were abolished after covalent modification of HDL3 with dimethylsuberimidate. Calcium 92-99 HDL3 Homo sapiens 159-163 9633924-7 1998 We observed a close temporal relationship between the HDL3-mediated inhibition of thrombin-induced inositol 1,4,5-tris-phosphate formation, intracellular calcium mobilization, and fibrinogen binding and the phosphorylation of the protein kinase C 40- to 47-kD major protein substrate. Calcium 154-161 HDL3 Homo sapiens 54-58 1332716-9 1992 Fluorescence recordings from single cells exposed to LDL and HDL3 revealed a prolonged series of transient oscillations of [Ca2+]i, a phenomenon typical for calcium-mobilizing hormones. Calcium 157-164 HDL3 Homo sapiens 61-65 8801866-6 1995 Not only were the calcium-binding phospholipids phosphatidylinositol (PI) + phosphatidylserine (PS), and the membrane fluidizer phosphatidylethanolamine (PE) were significantly reduced in their VLDL + LDL, but all phospholipids (L, sphingomyelin (SPH), PI + PS, and PE) were significantly reduced in their neutral lipid content in both the HDL2 and HDL3 subfractions. Calcium 18-25 HDL3 Homo sapiens 349-353 2159347-6 1990 Other calcium antagonists such as diltiazem, nifedipine, nitrendipine or amphiphilic drugs such as phenothiazines and propranolol also enhanced HDL3 uptake by Hep G2 cells. Calcium 6-13 HDL3 Homo sapiens 144-148 1329984-4 1992 The low-affinity binding sites are calcium-independent and interact with IDL, LDL, high density lipoproteins-3 (HDL3), apolipoprotein (apo) E-liposomes, apoCs-liposomes, apoA-I-liposomes but not with liposomes containing albumin or erythrocyte membrane proteins. Calcium 35-42 HDL3 Homo sapiens 112-116 2159347-7 1990 These effects of verapamil on HDL3 metabolism could be related to its amphiphilic characteristics, and to its calcium antagonist properties. Calcium 110-117 HDL3 Homo sapiens 30-34