PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29055397-3 2017 Elastin can be degraded by elastases and has a high calcium affinity. Calcium 52-59 elastin Homo sapiens 0-7 31991212-5 2020 At physiological pH, the degree of elastin mineralization is influenced by hydrolysis and complexity of medium composition, since ionic species, as sodium, potassium, magnesium, in addition to calcium and phosphorus, interfere with the calcification process. Calcium 193-200 elastin Homo sapiens 35-42 9501199-0 1998 Nuclear and cytoplasmic free calcium level changes induced by elastin peptides in human endothelial cells. Calcium 29-36 elastin Homo sapiens 62-69 24748954-7 2014 Efforts to understand these associations through studying the effects of processes such as calcium and lipid binding and glycation on the mechanical properties of elastin preparations in vitro have produced a confusing picture, and further efforts are required to determine the molecular basis of such effects. Calcium 91-98 elastin Homo sapiens 163-170 11428170-7 2001 A progressive age dependent uncoupling of the elastin-laminin receptor occurs impairing its transduction pathway and which results in alteration of the calcium signaling and loss in calcium homeostasis of the cells. Calcium 152-159 elastin Homo sapiens 46-53 11428170-7 2001 A progressive age dependent uncoupling of the elastin-laminin receptor occurs impairing its transduction pathway and which results in alteration of the calcium signaling and loss in calcium homeostasis of the cells. Calcium 182-189 elastin Homo sapiens 46-53 9854552-5 1998 In this study, the ability of amlodipine--a calcium antagonist--to influence elastin degradation, was assessed in a previously described model of aneurysmal disease. Calcium 44-51 elastin Homo sapiens 77-84 17274635-1 2007 In this work, we report a new method to reversibly immobilize proteins to a surface in a functionally active orientation directly from cell lysate by employing a fusion protein consisting of a thermal-responsive elastin (ELP) domain as the surface anchor and a calcium-responsive calmodulin (CalM) domain for protein capturing. Calcium 261-268 elastin Homo sapiens 212-219 15039439-3 2004 Binding assays revealed high affinity calcium-independent binding of two overlapping fibrillin-1 fragments (encoded by central exons 18-25 and 24-30) to tropoelastin, which, in microfibrils, map to an exposed "arms" feature adjacent to the beads. Calcium 38-45 elastin Homo sapiens 153-165 15662945-1 2004 Action on calcium fluxes and vasomotricity induced by elastin peptides]. Calcium 10-17 elastin Homo sapiens 54-61 15662945-11 2004 For example, the age-dependant vasodilation and endothelial calcium influx induced by elastin peptide are modulated by extracellular glucose levels. Calcium 60-67 elastin Homo sapiens 86-93 12888257-4 2003 Our results show that low (0 mM) or high (33 mM) extracellular glucose concentrations abolish the extracellular calcium influx induced, under normal glucose level (11 mM), by the elastin peptides in cultured human endothelial cells. Calcium 112-119 elastin Homo sapiens 179-186 11805834-5 2002 Here we show that fibulin-5 is a calcium-dependent, elastin-binding protein that localizes to the surface of elastic fibres in vivo. Calcium 33-40 elastin Homo sapiens 52-59 11704704-3 2001 Calcium antagonists may affect many calcium-dependent events in the formation of atherosclerosis such as the localized accumulation of collagen, elastin, and calcium together with monocyte infiltration and smooth muscle proliferation and migration. Calcium 0-7 elastin Homo sapiens 145-152 11704704-3 2001 Calcium antagonists may affect many calcium-dependent events in the formation of atherosclerosis such as the localized accumulation of collagen, elastin, and calcium together with monocyte infiltration and smooth muscle proliferation and migration. Calcium 36-43 elastin Homo sapiens 145-152 11881065-12 2001 2) higher doses of captopril and enalapril prevent the hypercholesterolaemia-induced increase in aortic elastin-bound calcium. Calcium 118-125 elastin Homo sapiens 104-111 11064275-2 2000 The matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent enzymes produced by inflammatory cells that are capable of degrading collagen, elastin, and proteoglycans. Calcium 63-70 elastin Homo sapiens 160-167 10761632-6 1999 The calcium transients triggered by elastin peptides acting on the receptor decrease with age, the receptor appears to be uncoupled from the G-proteins, but superoxide release is increased. Calcium 4-11 elastin Homo sapiens 36-43 9180345-0 1997 Effect of lithium on superoxide production and intracellular free calcium mobilization in elastin peptide (kappa-elastin) and FMLP stimulated human PMNS. Calcium 66-73 elastin Homo sapiens 90-97 9180345-0 1997 Effect of lithium on superoxide production and intracellular free calcium mobilization in elastin peptide (kappa-elastin) and FMLP stimulated human PMNS. Calcium 66-73 elastin Homo sapiens 113-120 7669085-7 1995 Biochemical studies of aortic wall and purified elastin showed significantly increased content of lipids (atherosclerotic 67.7 mmol/g elastin, control 54.7 mmol/g elastin) and calcium (atherosclerotic 38.3 mmol/g elastin, control 19.6 mmol/g elastin). Calcium 176-183 elastin Homo sapiens 48-55 8896999-13 1996 Calcium binding to elastin was increased at acid pH, but decreased at higher pH. Calcium 0-7 elastin Homo sapiens 19-26 15374255-9 1995 Indeed it has been demonstrated that calcium antagonists have a protective effect against vascular lesions because they inhibit smooth muscle cell proliferation, lipid uptake by macrophages and the production of collagen and elastin. Calcium 37-44 elastin Homo sapiens 225-232 8062142-9 1994 Calcium accumulation was most marked in the middle, elastin-rich layer of the media, increasing from 1.4 micrograms Ca/mg tissue at 20 years of age to 49.50 micrograms Ca/mg tissue by 90 years of age. Calcium 0-7 elastin Homo sapiens 52-59 8279451-7 1994 Energy dispersive x-ray analysis and TEM demonstrated iron and calcium on the microfibrillar portion of elastin. Calcium 63-70 elastin Homo sapiens 104-111 2166694-6 1990 One of them at least, the elastin receptor was shown to be linked through a G-protein-phospholipase C-IP3 mediated relay to the regulation of intracellular calcium. Calcium 156-163 elastin Homo sapiens 26-33 8149747-1 1993 Binding of proteins, lipoproteins and calcium salts to arterial elastin occurs with age and in disease. Calcium 38-45 elastin Homo sapiens 64-71 1416069-4 1992 Its antagonism to calcium is speculated to play a protective role in maintaining the extensibility of elastin. Calcium 18-25 elastin Homo sapiens 102-109 1867300-3 1991 We postulate that the abnormal aggregation of macromolecules with a high affinity for calcium (resulting in abnormalities in elastin in cases of pseudoxanthoma elasticum) also develops at the cribriform plate, disrupting axonal flow and leading to disk drusen formation. Calcium 86-93 elastin Homo sapiens 125-132 3103130-2 1987 In small amounts (between 0.1 and 1 microgram/ml), elastin peptides strongly increased calcium influx and inhibited calcium efflux by an apparently calmodulin-dependent mechanism. Calcium 87-94 elastin Homo sapiens 51-58 3201397-0 1988 Inhibitory effects of soluble elastin on intraplatelet free calcium concentration. Calcium 60-67 elastin Homo sapiens 30-37 3390898-0 1988 Effect of elastin peptides and N-formyl-methionyl-leucyl phenylalanine on cytosolic free calcium in polymorphonuclear leukocytes of healthy middle-aged and elderly subjects. Calcium 89-96 elastin Homo sapiens 10-17 35364318-7 2022 Additionally, we find that elevated levels of calcium ions and glucose hinder the extensibility of tropoelastin by rearranging structural domains and altering hydrogen bonding patterns, respectively. Calcium 46-53 elastin Homo sapiens 99-111 35364318-12 2022 Here, we present the first study on how these changes in elastin structure and extensibility are induced by hypercalcemia and hyperglycemia at a molecular scale, revealing the essential roles that calcium and glucose play in triggering structural alterations and mechanical stiffness. Calcium 197-204 elastin Homo sapiens 57-64 3103130-2 1987 In small amounts (between 0.1 and 1 microgram/ml), elastin peptides strongly increased calcium influx and inhibited calcium efflux by an apparently calmodulin-dependent mechanism. Calcium 116-123 elastin Homo sapiens 51-58 4421595-0 1974 Calcium ion binding to carbonyls of elastin hexapeptide. Calcium 0-7 elastin Homo sapiens 36-43 3643024-5 1986 The action of elastin peptides on intracellular calcium level and cGMP levels may well be related to its previously demonstrated chemotactic activity. Calcium 48-55 elastin Homo sapiens 14-21 4843779-0 1974 Additional evidence for the binding of calcium ions to elastin at neutral sites. Calcium 39-46 elastin Homo sapiens 55-62 4372871-0 1974 Calcium binding to elastin. Calcium 0-7 elastin Homo sapiens 19-26 4279804-0 1974 Investigations of free and elastin-bound fluorescent substances present in the atherosclerotic lipid and calcium-plaques. Calcium 105-112 elastin Homo sapiens 27-34 4823434-0 1974 Neutral site binding of calcium ion to elastin coacervate IR spectroscopy. Calcium 24-31 elastin Homo sapiens 39-46 4411779-0 1974 A synthetic polypeptide related to elastin and its interaction with calcium ions. Calcium 68-75 elastin Homo sapiens 35-42 4474887-0 1974 Specificity and sites of calcium ion interactions with elastin. Calcium 25-32 elastin Homo sapiens 55-62 5110569-0 1971 Altered lipid and calcium binding by calcified aortic elastin. Calcium 18-25 elastin Homo sapiens 54-61 4251554-0 1971 Neutral sites for calcium ion binding to elastin and collagen: a charge neutralization theory for calcification and its relationship to atherosclerosis. Calcium 18-25 elastin Homo sapiens 41-48 5103930-0 1971 Calcium ion effects a notable change in elastin conformation by interacting at neutral sites. Calcium 0-7 elastin Homo sapiens 40-47 4251554-1 1971 Neutral, uncharged binding sites for calcium ions are proposed for elastin and collagen. Calcium 37-44 elastin Homo sapiens 67-74 4995409-0 1970 Coordinately bound calcium as a cross linking agent in elastin and as an activator of elastolysis. Calcium 19-26 elastin Homo sapiens 55-62 5553332-0 1971 Some features of the binding of calcium ions to elastin. Calcium 32-39 elastin Homo sapiens 48-55 5721103-0 1968 Some features of the binding of calcium ions to elastin. Calcium 32-39 elastin Homo sapiens 48-55