PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27169587-7 2016 To find out the upstream activator of Pyk2, we examined the intracellular calcium source that was released by sound wave stimulation. Calcium 74-81 protein tyrosine kinase 2 beta Homo sapiens 38-42 28228260-6 2017 Increased cytosolic calcium levels activate PYK2 SRC STAT3 signaling, leading to increased expression of pluripotency factors and BCSC enrichment. Calcium 20-27 protein tyrosine kinase 2 beta Homo sapiens 44-48 20348095-11 2010 These results suggest CXCL12 regulates restitution through calcium-activated Pyk2 localized to active focal adhesions. Calcium 59-66 protein tyrosine kinase 2 beta Homo sapiens 77-81 22581436-9 2012 The results suggest that PAC1 regulates PYK-2 tyrosine phosphorylation in a calcium-dependent manner. Calcium 76-83 protein tyrosine kinase 2 beta Homo sapiens 40-45 21238585-0 2011 CD44-mediated elongated T cell spreading requires Pyk2 activation by Src family kinases, extracellular calcium, phospholipase C and phosphatidylinositol-3 kinase. Calcium 103-110 protein tyrosine kinase 2 beta Homo sapiens 50-54 21238585-5 2011 In these cells, Pyk2 phosphorylation was dependent on Src family kinase activity and required actin polymerisation, phosphatidylinositol-3 kinase and phospholipase C activity as well as extracellular calcium. Calcium 200-207 protein tyrosine kinase 2 beta Homo sapiens 16-20 21429240-12 2010 pUS28 stimulation with CCL5 results in ligand-dependent and calcium-dependent phosphorylation of Pyk2 Tyr-402 and induced the formation of an active Pyk2 kinase complex containing several novel Pyk2 binding proteins. Calcium 60-67 protein tyrosine kinase 2 beta Homo sapiens 97-101 21429240-12 2010 pUS28 stimulation with CCL5 results in ligand-dependent and calcium-dependent phosphorylation of Pyk2 Tyr-402 and induced the formation of an active Pyk2 kinase complex containing several novel Pyk2 binding proteins. Calcium 60-67 protein tyrosine kinase 2 beta Homo sapiens 149-153 20688918-0 2010 Regulation of the tyrosine kinase Pyk2 by calcium is through production of reactive oxygen species in cytotoxic T lymphocytes. Calcium 42-49 protein tyrosine kinase 2 beta Homo sapiens 34-38 20826662-1 2010 Proline-rich tyrosine kinase 2 (PYK2), also known as cell adhesion kinase beta or protein tyrosine kinase 2b, is a calcium-dependent signaling protein involved in cell migration. Calcium 115-122 protein tyrosine kinase 2 beta Homo sapiens 0-30 20826662-1 2010 Proline-rich tyrosine kinase 2 (PYK2), also known as cell adhesion kinase beta or protein tyrosine kinase 2b, is a calcium-dependent signaling protein involved in cell migration. Calcium 115-122 protein tyrosine kinase 2 beta Homo sapiens 32-36 20826662-1 2010 Proline-rich tyrosine kinase 2 (PYK2), also known as cell adhesion kinase beta or protein tyrosine kinase 2b, is a calcium-dependent signaling protein involved in cell migration. Calcium 115-122 protein tyrosine kinase 2 beta Homo sapiens 53-78 27616980-5 2016 GSK1016790A increased the phosphorylated AMP-activated protein kinase (p-AMPK) and decreased the phosphorylated protein kinase B (p-Akt) protein levels, which was attenuated by removing extracellular calcium or by a calcium/calmodulin-dependent protein kinase kinase-beta antagonist. Calcium 200-207 protein tyrosine kinase 2 beta Homo sapiens 112-128 23584706-4 2013 Our immunohistochemistry approach has shown that the insulin receptor, insulin receptor substrate 1 (IRS1), protein kinase B (PKB) and insulin-sensitive glucose transporter (GLUT4) are expressed in the sensory epithelium of the human saccule, which also exhibits expression of a calcium-sensitive cAMP/cGMP phosphodiesterase 1C (PDE1C) and the vasopressin type 2 receptor. Calcium 279-286 protein tyrosine kinase 2 beta Homo sapiens 108-124 23584706-4 2013 Our immunohistochemistry approach has shown that the insulin receptor, insulin receptor substrate 1 (IRS1), protein kinase B (PKB) and insulin-sensitive glucose transporter (GLUT4) are expressed in the sensory epithelium of the human saccule, which also exhibits expression of a calcium-sensitive cAMP/cGMP phosphodiesterase 1C (PDE1C) and the vasopressin type 2 receptor. Calcium 279-286 protein tyrosine kinase 2 beta Homo sapiens 126-129 19563802-6 2009 It was also found that OT phosphorylates proline-rich tyrosine kinase-2 (Pyk-2) and Src kinase in a PLC- and calcium-dependent manner. Calcium 109-116 protein tyrosine kinase 2 beta Homo sapiens 41-71 20400701-4 2010 In human macrophages, zymosan rapidly activated a calcium-dependent pathway downstream of Dectin-1 and Syk that led to activation of calmodulin-dependent kinase II and Pyk2. Calcium 50-57 protein tyrosine kinase 2 beta Homo sapiens 168-172 20400701-5 2010 Calmodulin-dependent kinase and Pyk2 transduced calcium signals into activation of the ERK-MAPK pathway, CREB, and generation of an oxidative burst, leading to downstream production of IL-10. Calcium 48-55 protein tyrosine kinase 2 beta Homo sapiens 32-36 19563802-6 2009 It was also found that OT phosphorylates proline-rich tyrosine kinase-2 (Pyk-2) and Src kinase in a PLC- and calcium-dependent manner. Calcium 109-116 protein tyrosine kinase 2 beta Homo sapiens 73-78 16574377-1 2006 The calcium-dependent proline-rich tyrosine kinase Pyk2 is activated by tyrosine phosphorylation, associates with focal adhesion proteins, and has been linked to proliferative and migratory responses in a variety of mesenchymal and epithelial cell types. Calcium 4-11 protein tyrosine kinase 2 beta Homo sapiens 51-55 17205062-6 2007 Pyk2 is activated by treatment with keratinocyte-differentiating agents, 12-O-tetradecanoylphorbol-13-acetate and calcium via a mechanism that requires intracellular calcium release and functional protein kinase C (PKC) and Src activities. Calcium 114-121 protein tyrosine kinase 2 beta Homo sapiens 0-4 17205062-6 2007 Pyk2 is activated by treatment with keratinocyte-differentiating agents, 12-O-tetradecanoylphorbol-13-acetate and calcium via a mechanism that requires intracellular calcium release and functional protein kinase C (PKC) and Src activities. Calcium 166-173 protein tyrosine kinase 2 beta Homo sapiens 0-4 17327421-5 2007 Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. Calcium 84-91 protein tyrosine kinase 2 beta Homo sapiens 102-132 18290763-3 2008 In the latest issue of the Biochemical Journal, Sasaki and co-workers have provided insight into the calcium-dependent regulation of Pyk2. Calcium 101-108 protein tyrosine kinase 2 beta Homo sapiens 133-137 18290763-4 2008 The findings suggest that calmodulin may bind the FERM (4.1/ezrin/radixin/moesin) domain to promote Pyk2 activation in response to calcium signals triggered by vasopressin. Calcium 131-138 protein tyrosine kinase 2 beta Homo sapiens 100-104 18290763-5 2008 While the molecular details of the protein-protein interaction and mechanism of activation remain to be firmly established, this study is the first to provide mechanistic insight into the regulation of Pyk2 by calcium. Calcium 210-217 protein tyrosine kinase 2 beta Homo sapiens 202-206 17686966-6 2007 Intracellular calcium chelation blocks TZD-induced Pyk2 activation; here, Src activation by both TZDs and ciglitazone-induced EGFR transactivation were prevented by calcium chelation. Calcium 14-21 protein tyrosine kinase 2 beta Homo sapiens 51-55 17686966-6 2007 Intracellular calcium chelation blocks TZD-induced Pyk2 activation; here, Src activation by both TZDs and ciglitazone-induced EGFR transactivation were prevented by calcium chelation. Calcium 165-172 protein tyrosine kinase 2 beta Homo sapiens 51-55 15601262-4 2005 Calcium-dependent phosphorylation of MEKK4 is mediated by Pyk2. Calcium 0-7 protein tyrosine kinase 2 beta Homo sapiens 58-62 16870295-1 2006 The mitochondrial calcium and downstream proline-rich tyrosine kinase-2 (PyK2) signaling pathway are critical to hepatitis B virus (HBV) replication, and the endoplasmic reticulum (ER) plays an important role in intracellular calcium regulation. Calcium 18-25 protein tyrosine kinase 2 beta Homo sapiens 73-77 15919658-8 2005 VEGF also stimulated phosphorylation of Pyk-2; VEGF-induced phosphorylation of Pyk2, c-Src and Raf-1 could be abolished by BAPTA/AM, demonstrating requirement for induction of intracellular calcium currents. Calcium 190-197 protein tyrosine kinase 2 beta Homo sapiens 40-45 15919658-8 2005 VEGF also stimulated phosphorylation of Pyk-2; VEGF-induced phosphorylation of Pyk2, c-Src and Raf-1 could be abolished by BAPTA/AM, demonstrating requirement for induction of intracellular calcium currents. Calcium 190-197 protein tyrosine kinase 2 beta Homo sapiens 79-83 16611900-2 2006 Much of the cytoplasmic signal transduction activity associated with HBx expression and its stimulation of viral replication is attributable to HBx-induced activation of calcium signaling pathways involving Pyk2 and Src tyrosine kinases. Calcium 170-177 protein tyrosine kinase 2 beta Homo sapiens 207-211 15601262-7 2005 Immunofluorescence imaging of HaCaT cells shows an IFNgamma-dependent co-localization of annexin II with Pyk2 in the perinuclear region, suggesting that annexin II mediates the calcium-dependent regulation of Pyk2. Calcium 177-184 protein tyrosine kinase 2 beta Homo sapiens 105-109 15601262-7 2005 Immunofluorescence imaging of HaCaT cells shows an IFNgamma-dependent co-localization of annexin II with Pyk2 in the perinuclear region, suggesting that annexin II mediates the calcium-dependent regulation of Pyk2. Calcium 177-184 protein tyrosine kinase 2 beta Homo sapiens 209-213 15226266-6 2004 These signals cause the selective, sequential activation of the calcium-dependent, proline-rich kinase Pyk2 and the small GTP binding factors Rac-1 and Cdc42. Calcium 64-71 protein tyrosine kinase 2 beta Homo sapiens 103-107 14676843-4 2004 Since calcium regulates RAFTK/Pyk2, we investigated its role in p38 activity. Calcium 6-13 protein tyrosine kinase 2 beta Homo sapiens 24-29 14676843-4 2004 Since calcium regulates RAFTK/Pyk2, we investigated its role in p38 activity. Calcium 6-13 protein tyrosine kinase 2 beta Homo sapiens 30-34 12231407-12 2002 Increasing intracellular calcium with ionomycin caused a decrease in the tyrosine phosphorylation of Pyk2 and the loss of the actin ring in a manner similar to the effect of calcitonin. Calcium 25-32 protein tyrosine kinase 2 beta Homo sapiens 101-105 14729602-0 2004 Phosphatidylinositol triphosphate kinase-dependent and c-jun NH2-terminal kinase-dependent induction of telomerase by calcium requires Pyk2. Calcium 118-125 protein tyrosine kinase 2 beta Homo sapiens 135-139 14729602-1 2004 Calcium signaling has been linked to activation of Pyk2, a calcium-dependent, focal adhesion kinase-related, non-receptor tyrosine kinase. Calcium 0-7 protein tyrosine kinase 2 beta Homo sapiens 51-55 14729602-1 2004 Calcium signaling has been linked to activation of Pyk2, a calcium-dependent, focal adhesion kinase-related, non-receptor tyrosine kinase. Calcium 59-66 protein tyrosine kinase 2 beta Homo sapiens 51-55 14729602-4 2004 Here, we show that calcium signaling in ovarian surface epithelial cells not only induces telomerase activity via JNK but also activates Pyk2. Calcium 19-26 protein tyrosine kinase 2 beta Homo sapiens 137-141 12193071-3 2002 We have observed that Pyk2, a calcium-dependent cytoplasmic tyrosine kinase, was expressed in human renal mesangial cells and was tyrosine phosphorylated after ET-1 treatment. Calcium 30-37 protein tyrosine kinase 2 beta Homo sapiens 22-26 12358757-3 2002 A 1-h incubation of neuronal cultures with tetrodotoxin (TTX), the PI3K inhibitor wortmannin, the NMDA receptor antagonist MK-801 or removal of extracellular calcium significantly reduced basal levels of phospho(Ser473)-PKB, indicating that activity-dependent glutamate release maintains PKB activation through an NMDA receptor-PI3K pathway. Calcium 158-165 protein tyrosine kinase 2 beta Homo sapiens 220-223 12358757-3 2002 A 1-h incubation of neuronal cultures with tetrodotoxin (TTX), the PI3K inhibitor wortmannin, the NMDA receptor antagonist MK-801 or removal of extracellular calcium significantly reduced basal levels of phospho(Ser473)-PKB, indicating that activity-dependent glutamate release maintains PKB activation through an NMDA receptor-PI3K pathway. Calcium 158-165 protein tyrosine kinase 2 beta Homo sapiens 288-291 12358757-5 2002 NMDA stimulation of phospho-PKB was blocked by wortmannin, the CaMKII inhibitor KN-93, MK-801, and removal of extracellular calcium. Calcium 124-131 protein tyrosine kinase 2 beta Homo sapiens 28-31 12074576-0 2002 Thrombin-stimulated Pyk2 phosphorylation in human endothelium is dependent on intracellular calcium and independent of protein kinase C and Src kinases. Calcium 92-99 protein tyrosine kinase 2 beta Homo sapiens 20-24 12074576-3 2002 The cytosolic tyrosine kinase Pyk2 is postulated to link GPCA-induced changes in intracellular calcium to activation of the MAP kinase cascade. Calcium 95-102 protein tyrosine kinase 2 beta Homo sapiens 30-34 11916084-6 2002 By contrast, tyrosine phosphorylation of Pyk2 was only partially reduced by aspirin and RGDS, and was not affected by either calcium chelation or PKC inhibition, suggesting that activation of this kinase does not require phospholipase-mediated signalling. Calcium 125-132 protein tyrosine kinase 2 beta Homo sapiens 41-45 11743208-3 2001 In our study, HBx activated cytosolic calcium-dependent proline-rich tyrosine kinase-2 (Pyk2), a Src kinase activator. Calcium 38-45 protein tyrosine kinase 2 beta Homo sapiens 56-86 11698270-0 2001 HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. Calcium 118-125 protein tyrosine kinase 2 beta Homo sapiens 40-44 11743208-3 2001 In our study, HBx activated cytosolic calcium-dependent proline-rich tyrosine kinase-2 (Pyk2), a Src kinase activator. Calcium 38-45 protein tyrosine kinase 2 beta Homo sapiens 88-92 10766859-8 2000 N-Acetylcysteine did inhibit the phosphorylation of the calcium sensitive tyrosine kinases PYK2 and Src, effects that also occurred using nitric oxide. Calcium 56-63 protein tyrosine kinase 2 beta Homo sapiens 91-95 11278472-2 2001 We recently reported the calcium-dependent activation of tyrosine kinase Pyk2 by angiotensin II (Ang II) in pulmonary vein endothelial cells (PVEC). Calcium 25-32 protein tyrosine kinase 2 beta Homo sapiens 73-77 11278472-4 2001 In the present study, we investigated the mechanism of the calcium-dependent activation of Pyk2 in response to Ang II by using 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors and isoprenoid intermediates in PVEC. Calcium 59-66 protein tyrosine kinase 2 beta Homo sapiens 91-95 11278472-5 2001 We have obtained substantial evidence indicating that Ang II activates Pyk2 through calcium-mediated activation of the geranylgeranylated small G protein Rap1 and the Rap1 association with Pyk2. Calcium 84-91 protein tyrosine kinase 2 beta Homo sapiens 71-75 11278472-5 2001 We have obtained substantial evidence indicating that Ang II activates Pyk2 through calcium-mediated activation of the geranylgeranylated small G protein Rap1 and the Rap1 association with Pyk2. Calcium 84-91 protein tyrosine kinase 2 beta Homo sapiens 189-193 11278472-6 2001 Thus, the small G protein Rap1 is an intermediary signaling molecule linking Ang II-induced calcium signal to Pyk2 activation in PVEC. Calcium 92-99 protein tyrosine kinase 2 beta Homo sapiens 110-114 10704819-4 2000 RAFTK/Pyk2 can be activated by a variety of extracellular signals that elevate intracellular calcium concentration, and by stress signals. Calcium 93-100 protein tyrosine kinase 2 beta Homo sapiens 0-5 10704819-4 2000 RAFTK/Pyk2 can be activated by a variety of extracellular signals that elevate intracellular calcium concentration, and by stress signals. Calcium 93-100 protein tyrosine kinase 2 beta Homo sapiens 6-10 7589581-3 1995 Kinase activity of Src-PTK was essential for tyrosine phosphorylation of Syk and calcium mobilization upon receptor ligation, whereas these events were not affected by the mutation of SH2 domain. Calcium 81-88 protein tyrosine kinase 2 beta Homo sapiens 23-26 10597281-1 1999 Related Adhesion Focal Tyrosine Kinase (RAFTK; also known as Pyk2), is a member of the Focal Adhesion Kinase (FAK) subfamily and is activated by TNF alpha, UV light and increases in intracellular calcium levels. Calcium 196-203 protein tyrosine kinase 2 beta Homo sapiens 0-38 10597281-1 1999 Related Adhesion Focal Tyrosine Kinase (RAFTK; also known as Pyk2), is a member of the Focal Adhesion Kinase (FAK) subfamily and is activated by TNF alpha, UV light and increases in intracellular calcium levels. Calcium 196-203 protein tyrosine kinase 2 beta Homo sapiens 40-45 10597281-1 1999 Related Adhesion Focal Tyrosine Kinase (RAFTK; also known as Pyk2), is a member of the Focal Adhesion Kinase (FAK) subfamily and is activated by TNF alpha, UV light and increases in intracellular calcium levels. Calcium 196-203 protein tyrosine kinase 2 beta Homo sapiens 61-65 10022914-1 1999 The protein tyrosine kinase PYK2 has been implicated in signaling pathways activated by G-protein-coupled receptors, intracellular calcium, and stress signals. Calcium 131-138 protein tyrosine kinase 2 beta Homo sapiens 28-32 10022914-7 1999 Activation of PYK2 by agents that elevate intracellular calcium or by phorbol ester induce tyrosine phosphorylation of Nirs. Calcium 56-63 protein tyrosine kinase 2 beta Homo sapiens 14-18 10022914-11 1999 We propose that the Nir and rdgB proteins represent a new family of evolutionarily conserved PYK2-binding proteins that play a role in the control of calcium and phosphoinositide metabolism downstream of G-protein-coupled receptors. Calcium 150-157 protein tyrosine kinase 2 beta Homo sapiens 93-97 9603937-1 1998 Pyk2 is a protein tyrosine kinase that links G-protein-coupled receptors, inflammatory cytokines, and extracellular stimuli that elevate intracellular calcium concentration with activation of the mitogen-activated protein kinase pathways and regulation of ion channel functions. Calcium 151-158 protein tyrosine kinase 2 beta Homo sapiens 0-4 9310476-3 1997 RAFTK, the second member of the focal adhesion kinase (FAK) family, is known to be activated in response to calcium flux in neuronal cells and integrin stimulation in megakaryocytes and B cells. Calcium 108-115 protein tyrosine kinase 2 beta Homo sapiens 0-5 9099753-9 1997 Stimulation of platelets by several agonists such as collagen, ADP, epinephrine, and calcium ionophore A23187 induced RAFTK phosphorylation. Calcium 85-92 protein tyrosine kinase 2 beta Homo sapiens 118-123 9099753-10 1997 Tyrosine phosphorylation of RAFTK in platelets is regulated by calcium and is mediated through the protein kinase C pathway. Calcium 63-70 protein tyrosine kinase 2 beta Homo sapiens 28-33 8999881-8 1997 These results show that in GN4 cells, Ang II selectively activates p70(S6K) through effects on calcium, p90(RSK) through effects on protein kinase C. The activation of p70(S6K) by calcium stimuli or Ang II was independent of calmodulin but correlated well with the activation of the recently identified, nonreceptor calcium-dependent tyrosine kinase (CADTK)/PYK-2. Calcium 180-187 protein tyrosine kinase 2 beta Homo sapiens 316-349 8999881-8 1997 These results show that in GN4 cells, Ang II selectively activates p70(S6K) through effects on calcium, p90(RSK) through effects on protein kinase C. The activation of p70(S6K) by calcium stimuli or Ang II was independent of calmodulin but correlated well with the activation of the recently identified, nonreceptor calcium-dependent tyrosine kinase (CADTK)/PYK-2. Calcium 180-187 protein tyrosine kinase 2 beta Homo sapiens 351-356 8999881-8 1997 These results show that in GN4 cells, Ang II selectively activates p70(S6K) through effects on calcium, p90(RSK) through effects on protein kinase C. The activation of p70(S6K) by calcium stimuli or Ang II was independent of calmodulin but correlated well with the activation of the recently identified, nonreceptor calcium-dependent tyrosine kinase (CADTK)/PYK-2. Calcium 180-187 protein tyrosine kinase 2 beta Homo sapiens 358-363 8999881-9 1997 Both calcium- and Ang II-dependent activation of p70(S6K) were attenuated by the tyrosine kinase inhibitor genistein, and activation of p70(S6K) was higher in GN4 than WB cells, correlating with the increased expression and activation of CADTK/PYK-2 in GN4 cells. Calcium 5-12 protein tyrosine kinase 2 beta Homo sapiens 238-243 8999881-9 1997 Both calcium- and Ang II-dependent activation of p70(S6K) were attenuated by the tyrosine kinase inhibitor genistein, and activation of p70(S6K) was higher in GN4 than WB cells, correlating with the increased expression and activation of CADTK/PYK-2 in GN4 cells. Calcium 5-12 protein tyrosine kinase 2 beta Homo sapiens 244-249 8999881-10 1997 In summary, these results demonstrate that intracellular calcium selectively activates p70(S6K) in GN4 cells, consistent with increased CADTK/PYK-2 signaling in these cells. Calcium 57-64 protein tyrosine kinase 2 beta Homo sapiens 136-141 8999881-10 1997 In summary, these results demonstrate that intracellular calcium selectively activates p70(S6K) in GN4 cells, consistent with increased CADTK/PYK-2 signaling in these cells. Calcium 57-64 protein tyrosine kinase 2 beta Homo sapiens 142-147 8939945-11 1996 In summary, cells expressing CADTK/PYK2 appear to have two alternative JNK activation pathways: one stress-activated and the other calcium-dependent. Calcium 131-138 protein tyrosine kinase 2 beta Homo sapiens 29-34 8939945-11 1996 In summary, cells expressing CADTK/PYK2 appear to have two alternative JNK activation pathways: one stress-activated and the other calcium-dependent. Calcium 131-138 protein tyrosine kinase 2 beta Homo sapiens 35-39 9366396-6 1997 Stimulation of PYK-2 tyrosine phosphorylation was inhibited by the tyrosine kinase inhibitor herbimycin A, but not by EGTA, indicating that PYK-2 tyrosine phosphorylation is PTK, but not calcium, dependent. Calcium 187-194 protein tyrosine kinase 2 beta Homo sapiens 15-20 9366396-6 1997 Stimulation of PYK-2 tyrosine phosphorylation was inhibited by the tyrosine kinase inhibitor herbimycin A, but not by EGTA, indicating that PYK-2 tyrosine phosphorylation is PTK, but not calcium, dependent. Calcium 187-194 protein tyrosine kinase 2 beta Homo sapiens 140-145 8939945-6 1996 Agonists for other G protein-coupled receptors (e.g. LPA), or those increasing intracellular calcium (thapsigargin), also stimulated CADTK. Calcium 93-100 protein tyrosine kinase 2 beta Homo sapiens 133-138 8939945-8 1996 Although maximal JNK activation by stress-dependent pathways (e.g. UV and anisomycin) was equivalent in the two cell lines, calcium-dependent JNK activation was 5-fold greater in GN4, correlating with CADTK activation. Calcium 124-131 protein tyrosine kinase 2 beta Homo sapiens 201-206 33832505-1 2021 BACKGROUND: Phosphotyrosine kinase (PTK)-mediated phospholipase C-gamma1 (PLC-gamma1) signaling plays a crucial role in the release of the universal second messenger calcium from intracellular stores, which is mandatory for several cellular processes, including cell migration. Calcium 166-173 protein tyrosine kinase 2 beta Homo sapiens 12-34 7544443-1 1995 The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Calcium 200-207 protein tyrosine kinase 2 beta Homo sapiens 28-32 7544443-3 1995 PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system. Calcium 78-85 protein tyrosine kinase 2 beta Homo sapiens 0-4 34543986-4 2021 This study is to investigate whether HUK can protect endothelial cells after balloon injury or H2O2-induced endothelial cell damage through the proline-rich tyrosine kinase 2 (Pyk2)/mitochondrial calcium uniporter (MCU) pathway. Calcium 196-203 protein tyrosine kinase 2 beta Homo sapiens 144-174 34543986-4 2021 This study is to investigate whether HUK can protect endothelial cells after balloon injury or H2O2-induced endothelial cell damage through the proline-rich tyrosine kinase 2 (Pyk2)/mitochondrial calcium uniporter (MCU) pathway. Calcium 196-203 protein tyrosine kinase 2 beta Homo sapiens 176-180 34543986-6 2021 HUK could prevent these injuries partially via the bradykinin B2 receptor by inhibiting Pyk2/MCU pathway, which prevented the mitochondrial damage, maintained calcium balance, and eventually inhibited cell apoptosis. Calcium 159-166 protein tyrosine kinase 2 beta Homo sapiens 88-92 7589123-3 1995 This response was abolished by prior treatment with protein tyrosine kinase (PTK) inhibitors, suggesting that SEA-triggered calcium mobilization in B cells is probably dependent on the activation of PTK. Calcium 124-131 protein tyrosine kinase 2 beta Homo sapiens 77-80 7589123-3 1995 This response was abolished by prior treatment with protein tyrosine kinase (PTK) inhibitors, suggesting that SEA-triggered calcium mobilization in B cells is probably dependent on the activation of PTK. Calcium 124-131 protein tyrosine kinase 2 beta Homo sapiens 199-202 8181516-3 1994 We have assayed the ability of a panel of protein tyrosine kinase (PTK) inhibitors to interfere with activation of the NF-AT transcription factor by TcR ligation or treatment with phorbol ester and calcium ionophore which bypass many of the early events of TcR signal transduction. Calcium 198-205 protein tyrosine kinase 2 beta Homo sapiens 67-70 8181516-5 1994 Moreover, one inhibitor (genistein) revealed the existence of a PTK which down-regulates specifically calcium-mediated signaling at a point downstream of the PTK p56lck but upstream of calcium mobilization. Calcium 102-109 protein tyrosine kinase 2 beta Homo sapiens 64-67 8181516-5 1994 Moreover, one inhibitor (genistein) revealed the existence of a PTK which down-regulates specifically calcium-mediated signaling at a point downstream of the PTK p56lck but upstream of calcium mobilization. Calcium 102-109 protein tyrosine kinase 2 beta Homo sapiens 158-161 8181516-5 1994 Moreover, one inhibitor (genistein) revealed the existence of a PTK which down-regulates specifically calcium-mediated signaling at a point downstream of the PTK p56lck but upstream of calcium mobilization. Calcium 185-192 protein tyrosine kinase 2 beta Homo sapiens 64-67 34909713-4 2021 Furthermore, our results show that afatinib may interfere with vitamin D3 metabolism, acting via CYP27A1 and CYP24A1 to regulate calcium concentration through the phosphatidylinositol 3-kinase/protein kinase B pathway. Calcium 129-136 protein tyrosine kinase 2 beta Homo sapiens 193-209 33832505-1 2021 BACKGROUND: Phosphotyrosine kinase (PTK)-mediated phospholipase C-gamma1 (PLC-gamma1) signaling plays a crucial role in the release of the universal second messenger calcium from intracellular stores, which is mandatory for several cellular processes, including cell migration. Calcium 166-173 protein tyrosine kinase 2 beta Homo sapiens 36-39 32234888-5 2020 RESULTS: Calcium-mediated degradation of Src decreased survival signaling via phosphoinositide 3-kinase and protein kinase B and resulted in significant inhibition of the clonogenic ability of hormone-dependent breast cancer cells. Calcium 9-16 protein tyrosine kinase 2 beta Homo sapiens 108-124 30478830-6 2019 A functional enrichment analysis showed that the upregulated genes were mostly enriched in pathways as inflammatory response, calcium-mediated signaling, cytokine-cytokine receptor interaction, and extracellular matrix (ECM)-receptor interaction, whereas the downregulated genes were mostly enriched in pathways as phospholipid metabolic processes, positive regulation of protein kinase B signaling, and metabolism of xenobiotics by cytochrome P450. Calcium 126-133 protein tyrosine kinase 2 beta Homo sapiens 372-388 31634727-0 2020 Calcium promotes differentiation in ameloblast-like LS8 cells by downregulation of phosphatidylinositol 3 kinase /protein kinase B pathway. Calcium 0-7 protein tyrosine kinase 2 beta Homo sapiens 114-130 30894012-8 2019 The direct activation of Pyk2 by calcium ions provides a connection between GPCRs (G-protein coupled receptors) and Src family kinases. Calcium 33-40 protein tyrosine kinase 2 beta Homo sapiens 25-29