PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23726937-4 2013 Direct application of MCP-1 consistently induced intracellular calcium increases in dorsal root ganglia large and medium-sized neurons but not in small neurons mainly dissociated from paclitaxel-treated but not vehicle-treated animals. Calcium 63-70 C-C motif chemokine ligand 2 Homo sapiens 22-27 23996571-4 2014 MCP-1 induction preceded peak induction of calcium signaling activator calmodulin 1 (CALM1) and transcription factors JUN and FOS, which were at 3 days. Calcium 43-50 C-C motif chemokine ligand 2 Homo sapiens 0-5 21610146-5 2011 RESULTS: CCR2b transduction led to CCL2-induced calcium flux and increased transmigration, as well as augmentation of in vitro T-cell killing ability. Calcium 48-55 C-C motif chemokine ligand 2 Homo sapiens 35-39 22487721-2 2012 Binding of CCL2 to its receptor CCR2 triggers calcium mobilization and chemotaxis. Calcium 46-53 C-C motif chemokine ligand 2 Homo sapiens 11-15 23095175-0 2012 Intracoronary monocyte chemoattractant protein 1 and vascular endothelial growth factor levels are associated with necrotic core, calcium and fibrous tissue atherosclerotic plaque components: an intracoronary ultrasound radiofrequency study. Calcium 130-137 C-C motif chemokine ligand 2 Homo sapiens 14-48 21215246-5 2010 These effects are produced through N-type high voltage-activated calcium currents for SDF-1 and potassium channels for MCP-1. Calcium 65-72 C-C motif chemokine ligand 2 Homo sapiens 119-124 19864434-6 2010 Whole-cell T-type calcium currents in acutely dissociated dorsal root ganglia neurons are effectively inhibited by MCP-1, consistent with the notion that these cells express Ca(v)3.2. Calcium 18-25 C-C motif chemokine ligand 2 Homo sapiens 115-120 19524871-7 2009 We used calcium ionophore as a positive control for stimulating transcription and translation of CCL2/MCP-1. Calcium 8-15 C-C motif chemokine ligand 2 Homo sapiens 97-101 19524871-7 2009 We used calcium ionophore as a positive control for stimulating transcription and translation of CCL2/MCP-1. Calcium 8-15 C-C motif chemokine ligand 2 Homo sapiens 102-107 16698264-3 2006 Functionally, it blocked MCP-1 (CCL2)-induced calcium mobilization (IC50=50 nM) and chemotaxis mediated through the CCR2 receptor (9.6 nM). Calcium 46-53 C-C motif chemokine ligand 2 Homo sapiens 25-30 18286574-5 2008 Constitutive signaling was shown using inositol phosphate assays and inducible calcium signaling by response to CCL2, CCL5 and CCL11. Calcium 79-86 C-C motif chemokine ligand 2 Homo sapiens 112-116 17148667-9 2006 The intracellular calcium chelator BAPTA-AM blocked resistin-induced NF-kappaB activation and monocyte chemoattractant protein-1 expression. Calcium 18-25 C-C motif chemokine ligand 2 Homo sapiens 94-128 18790652-6 2008 Accordingly, MCP-1 significantly promoted the release of RANTES from endogenous pre-made vesicles, in an active process that depended on calcium from intracellular and extracellular sources, and on intracellular transport of RANTES towards exocytosis. Calcium 137-144 C-C motif chemokine ligand 2 Homo sapiens 13-18 18469140-7 2008 It is noteworthy that CCL2 mediated extracellular signal-regulated kinase 1/2 phosphorylation and calcium mobilization was significantly enhanced by CXCL8 in monocytes, indicating cooperative downstream signaling pathways during enhanced chemotaxis. Calcium 98-105 C-C motif chemokine ligand 2 Homo sapiens 22-26 19116667-7 2008 Similarly, chelating intracellular calcium ([Ca(2+)](i)) blocked Tat+/-morphine-evoked MCP-1 and IL-6 release, while artificially increasing the concentration of extracellular Ca(2+) reversed this effect. Calcium 35-42 C-C motif chemokine ligand 2 Homo sapiens 87-92 16698264-3 2006 Functionally, it blocked MCP-1 (CCL2)-induced calcium mobilization (IC50=50 nM) and chemotaxis mediated through the CCR2 receptor (9.6 nM). Calcium 46-53 C-C motif chemokine ligand 2 Homo sapiens 32-36 16131811-9 2005 CONCLUSION: CRP exerted a proinflammatory effect in human mesangial cells by inducing MCP-1 gene expression via NF-kappaB activation, which was mediated, at least in part, through intracellular calcium and ROS. Calcium 194-201 C-C motif chemokine ligand 2 Homo sapiens 86-91 15553662-1 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists (DHPs), blocked tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 expression in endothelial cells (ECs), thus suggesting that nifedipine may inhibit monocyte recruitment, an initiating step in atherosclerosis. Calcium 88-95 C-C motif chemokine ligand 2 Homo sapiens 222-256 15553663-3 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists, blocked tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression in endothelial cells (ECs) through its antioxidative properties. Calcium 88-95 C-C motif chemokine ligand 2 Homo sapiens 153-187 14570645-5 2003 Furthermore, we demonstrated that lidocaine suppressed MCP-1-induced chemotaxis and peak cytosolic-free calcium in THP-1 cells. Calcium 104-111 C-C motif chemokine ligand 2 Homo sapiens 55-60 14570645-8 2003 Lidocaine may modulate MCP-1-induced monocyte response, as reflected by chemotaxis, cytosolic-free calcium, and lipopolysaccharide-induced MCP-1 production by human monocytic THP-1 cells. Calcium 99-106 C-C motif chemokine ligand 2 Homo sapiens 23-28 12724308-9 2003 Further studies evaluating the calcium response that is triggered upon MCP-1 interaction with its receptor, CCR2, indicate that this response is not altered by antisense or sense ODN treatment, thus supporting our hypothesis that PKCbeta is critical for post-receptor signal transduction downstream of the immediate calcium signal. Calcium 31-38 C-C motif chemokine ligand 2 Homo sapiens 71-76 12885941-4 2003 Cells expressing this receptor show pertussis toxin-sensitive chemotaxis and small intracellular calcium transients in response to the chemokines CCL2, CCL7, CCL8, and CCL5. Calcium 97-104 C-C motif chemokine ligand 2 Homo sapiens 146-150 12271471-2 2002 Here we show that cultured human fetal astrocytes express CCR2 at the mRNA and protein levels, and display chemotaxis and calcium flux in response to MCP-1. Calcium 122-129 C-C motif chemokine ligand 2 Homo sapiens 150-155 15018304-2 2003 We have very recently found that nifedipine, one of the most popularly used dihydropyridine-based calcium antagonists, prevented EC monocyte chemoattractant protein-1 production elicited by tumor necrosis factor-alpha (TNF-alpha through its antioxidative properties. Calcium 98-105 C-C motif chemokine ligand 2 Homo sapiens 132-166 11350939-3 2001 This has functional consequences, as the CCR2 and CCR5 ligands monocyte chemotactic protein-1 (MCP-1) and RANTES (regulated upon activation, normal T cell-expressed and secreted) cooperate to trigger calcium responses at concentrations 10- to 100-fold lower than the threshold for either chemokine alone. Calcium 200-207 C-C motif chemokine ligand 2 Homo sapiens 63-93 11590385-8 2001 MCP-1 induces chemotaxis and calcium mobilization in eosinophils. Calcium 29-36 C-C motif chemokine ligand 2 Homo sapiens 0-5 11559700-5 2001 In addition, whereas 1 microm concentrations of eotaxin were able to recruit CCR2b transfectants, substimulatory concentrations of eotaxin inhibited MCP-1-induced chemotaxis of CCR2b transfectants and also inhibited MCP-1-induced intracellular calcium flux of THP-1 cells. Calcium 244-251 C-C motif chemokine ligand 2 Homo sapiens 149-154 11544333-0 2001 Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1. Calcium 0-7 C-C motif chemokine ligand 2 Homo sapiens 84-118 11350939-3 2001 This has functional consequences, as the CCR2 and CCR5 ligands monocyte chemotactic protein-1 (MCP-1) and RANTES (regulated upon activation, normal T cell-expressed and secreted) cooperate to trigger calcium responses at concentrations 10- to 100-fold lower than the threshold for either chemokine alone. Calcium 200-207 C-C motif chemokine ligand 2 Homo sapiens 95-100 10984371-9 2000 RESULTS: Calcium influx was induced by monocyte chemotactic protein (MCP) 1, MCP-3, MCP-4, RANTES, eotaxin, IL-8, and stromal cell-derived factor 1alpha, which are chemokines that bind several chemokine receptors. Calcium 9-16 C-C motif chemokine ligand 2 Homo sapiens 39-75 9862860-13 1999 Exposure of HSC to MCP-1 was associated with an increase in cytosolic calcium concentration, PI 3-K activity, protein tyrosine phosphorylation. Calcium 70-77 C-C motif chemokine ligand 2 Homo sapiens 19-24 10419877-5 1999 Furthermore, the biologic response to MCP-1, as measured by intracellular calcium ions increase and chemotactic response, was lost in 7-day-cultured macrophages. Calcium 74-81 C-C motif chemokine ligand 2 Homo sapiens 38-43 10770925-5 2000 The compounds are effective blockers of MCP-1-driven inhibition of adenylate cyclase and MCP-1- and MCP-3-driven cytosolic calcium influx; the compounds are not agonists for these pathways. Calcium 123-130 C-C motif chemokine ligand 2 Homo sapiens 40-45 10770925-5 2000 The compounds are effective blockers of MCP-1-driven inhibition of adenylate cyclase and MCP-1- and MCP-3-driven cytosolic calcium influx; the compounds are not agonists for these pathways. Calcium 123-130 C-C motif chemokine ligand 2 Homo sapiens 89-94 9501202-4 1998 In this report, we show that MCP-1 binding to the CCR2 receptor in Mono Mac 1 cells promotes the rapid desensitization of MCP-1-induced calcium flux responses. Calcium 136-143 C-C motif chemokine ligand 2 Homo sapiens 29-34 9696841-8 1998 The MCP-1-induced calcium mobilization mediated by CCR2b signaling was unaffected by the polymorphism, but MCP-1 signaling mediated by either CCR2b- or CCR2-V64I-encoded receptors resulted in heterologous desensitization (i.e., limiting the signal response of other receptors) of both CCR5 and CXCR4. Calcium 18-25 C-C motif chemokine ligand 2 Homo sapiens 4-9 9501202-4 1998 In this report, we show that MCP-1 binding to the CCR2 receptor in Mono Mac 1 cells promotes the rapid desensitization of MCP-1-induced calcium flux responses. Calcium 136-143 C-C motif chemokine ligand 2 Homo sapiens 122-127 9353321-7 1997 Chelation of intracellular calcium and inhibition of protein kinase C block the induction of TF by MCP-1, suggesting that in SMC it is mediated by activation of phospholipase C. SMC bind MCP-1 with a Kd similar to that previously reported for macrophages. Calcium 27-34 C-C motif chemokine ligand 2 Homo sapiens 99-104 9353321-7 1997 Chelation of intracellular calcium and inhibition of protein kinase C block the induction of TF by MCP-1, suggesting that in SMC it is mediated by activation of phospholipase C. SMC bind MCP-1 with a Kd similar to that previously reported for macrophages. Calcium 27-34 C-C motif chemokine ligand 2 Homo sapiens 187-192 9336350-11 1997 Addition of either MCP-1 or MCP-3 produced a concentration-dependent elevation of intracellular calcium with a maximun response 2-fold higher than that seen with RANTES or MIP-1alpha. Calcium 96-103 C-C motif chemokine ligand 2 Homo sapiens 19-24 7759884-8 1995 MCP-1 desensitized transfected HEK-293 cells expressing the MCP-1 receptor to activation by MCP-3 in the calcium mobilization assay, but MCP-3 did not effectively desensitize these cells to MCP-1. Calcium 105-112 C-C motif chemokine ligand 2 Homo sapiens 60-65 7679707-5 1993 Although MCAF and MIP-1 alpha competed for RANTES binding to monocytes with apparent lower affinity (with estimated Kd of 6 and 1.6, nM respectively) both of these cytokines effectively desensitized the calcium mobilization induced by RANTES. Calcium 203-210 C-C motif chemokine ligand 2 Homo sapiens 9-13 7515094-2 1994 All three chemokines tested, MCP-1, MIP-1 alpha, and RANTES, elicited mobilization of intracellular free calcium in monocytes and THP-1 cells. Calcium 105-112 C-C motif chemokine ligand 2 Homo sapiens 29-34 7890708-2 1995 In human 293 cells stably transfected with the MCP-1 receptor, MCP-1 bound specifically with high affinity (Kd = 260 pM) and induced a rapid mobilization of calcium from intracellular stores. Calcium 157-164 C-C motif chemokine ligand 2 Homo sapiens 47-52 7680615-2 1993 We have studied the effects of four CC-chemokines and show that MCP-1, RANTES (regulated on activation, normal T expressed and secreted) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are potent basophil agonists inducing a rapid change of cytosolic free calcium ([Ca2+]i), the release of histamine and sulfido-leukotrienes, and chemotaxis. Calcium 266-273 C-C motif chemokine ligand 2 Homo sapiens 64-69 1569397-4 1992 MCP-1 causes a rise in the cytosolic free calcium level in basophils and monocytes, but not in other blood leukocyte types, and triggers basophil degranulation at low concentrations (ED50 = 3-10 nM). Calcium 42-49 C-C motif chemokine ligand 2 Homo sapiens 0-5 7679430-0 1993 Receptor-activated calcium influx in human monocytes exposed to monocyte chemotactic protein-1 and related cytokines. Calcium 19-26 C-C motif chemokine ligand 2 Homo sapiens 64-94 32000013-7 2020 At the same time, the induction of TNFalpha and IL-1beta was diminished by the Ca2+/calmodulin-dependent protein kinase inhibitor, whereas the induction of IL-6 and CCL-2 was reduced by the inhibitor of phosphoinositide 3-kinase. Calcium 79-83 C-C motif chemokine ligand 2 Homo sapiens 165-170 1868242-0 1991 Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. Calcium 47-54 C-C motif chemokine ligand 2 Homo sapiens 18-26 1868242-4 1991 In addition, pure recombinant hMCP-1/JE stimulates monocytes, inducing an increase in cytosolic free calcium and the respiratory burst, but is completely inactive on human neutrophils. Calcium 101-108 C-C motif chemokine ligand 2 Homo sapiens 30-39 34893345-3 2022 We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. Calcium 31-38 C-C motif chemokine ligand 2 Homo sapiens 58-62 35062054-6 2022 The cumulative evidence synthesized in the current review suggests that, traditional therapies which include thiazolidinediones, statins and some calcium channel blockers can be useful in the primary prevention of atherosclerosis by inhibiting the formation of monocyte-derived microparticles, and pro-inflammatory cytokines such as IL-6, TNF-alpha, MCP-1, and NF-kappaB in patients with T2D. Calcium 146-153 C-C motif chemokine ligand 2 Homo sapiens 350-355 33656516-0 2021 Serum Monocyte-Chemoattractant Protein-1 Could Be an Indicator of Coronary Artery Calcium Score. Calcium 82-89 C-C motif chemokine ligand 2 Homo sapiens 6-40 33656517-0 2021 Serum Monocyte-Chemoattractant Protein-1 Could be an Indicator of Coronary Artery Calcium Score-Reply. Calcium 82-89 C-C motif chemokine ligand 2 Homo sapiens 6-40 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Calcium 14-21 C-C motif chemokine ligand 2 Homo sapiens 122-156 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Calcium 14-21 C-C motif chemokine ligand 2 Homo sapiens 158-163 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Calcium 14-21 C-C motif chemokine ligand 2 Homo sapiens 164-168 33075233-6 2020 Moreover, when cells were pretreated with Ro 32-0432 (an inhibitor of calcium-dependent PKC) and LY294002 (a PI3K inhibitor), this also resulted in a down-regulation of any Cd-induced CCL2 expression. Calcium 70-77 C-C motif chemokine ligand 2 Homo sapiens 184-188 33228784-6 2020 CCL2 can enhance presynaptic calcium signal. Calcium 29-36 C-C motif chemokine ligand 2 Homo sapiens 0-4 1371775-10 1992 MCAF-induced degranulation was a calcium-dependent process. Calcium 33-40 C-C motif chemokine ligand 2 Homo sapiens 0-4 33782965-2 2021 CCL2 is a member of the CC chemokine superfamily, which binds to its receptor, C-C motif chemokine receptor-2 (CCR2), for the induction of chemotactic activity and an increase of calcium influx. Calcium 179-186 C-C motif chemokine ligand 2 Homo sapiens 0-4 28424406-9 2017 We demonstrated that CCL2 treatment promoted A549 cell viability, motility and invasion by upregulating MMP-9 expression and that this induction was significantly suppressed by CAS 445479-97-0. Calcium 177-180 C-C motif chemokine ligand 2 Homo sapiens 21-25 29141644-11 2017 CONCLUSIONS: Our findings provide the first evidence that the bacterial endotoxin LPS potentiates calcium mobilization and ERK/p38 MAPK pathway activation and leads to the secretion of the pro-inflammatory chemokine MCP-1 by inducing PAR-2 expression and its associated activity in vascular ECs. Calcium 98-105 C-C motif chemokine ligand 2 Homo sapiens 216-221 26554595-9 2016 The membrane-permeant calcium chelator BAPTA-AM reduced ES-induced CCL2 secretion. Calcium 22-29 C-C motif chemokine ligand 2 Homo sapiens 67-71 27393275-0 2017 Urinary MCP-1 HMGB1 increased in calcium nephrolithiasis patients and the influence of hypercalciuria on the production of the two cytokines. Calcium 33-40 C-C motif chemokine ligand 2 Homo sapiens 8-13 27393275-9 2017 Results showed that urinary MCP-1 and HMGB1 increased in calcium nephrolithiasis patients and hypercalciuria might affect the identical pathways (through the reactive oxygen species) with other factors in stimulating the production of MCP-1 and HMGB1 in vivo. Calcium 57-64 C-C motif chemokine ligand 2 Homo sapiens 28-33 26867220-0 2016 Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy. Calcium 102-109 C-C motif chemokine ligand 2 Homo sapiens 64-69 25767113-5 2015 SCH-C inhibited RANTES (regulated on activation, normal T cell expressed and secreted) (CCL5)-mediated calcium flux on CCR5 with an IC50 of 22.8 nM but was inactive against monocyte chemoattractant protein-1 (CCL2)-mediated calcium flux on CCR2b. Calcium 103-110 C-C motif chemokine ligand 2 Homo sapiens 209-213 26714421-4 2015 METHODS: We measured the serum levels of MCP-1 in SAH patients who had CAs and compared it with that of MCP-1 in two control groups: including patients with SAH without CAs, and the normal population of blood donors. Calcium 71-74 C-C motif chemokine ligand 2 Homo sapiens 41-46 26714421-7 2015 RESULTS: Mean serum MCP-1 level in patients with SAH and CAs was 188.2168 Pg/ml and 331.3982 Pg/ml in the normal population. Calcium 57-60 C-C motif chemokine ligand 2 Homo sapiens 20-25 26714421-11 2015 There was a relationship between poor clinical grade and MCP-1 levels in patients with CAs. Calcium 87-90 C-C motif chemokine ligand 2 Homo sapiens 57-62 25767113-6 2015 However, SCH-C inhibited CCL2-induced calcium flux against a CCR5/CCR2b chimera consisting of transmembrane domains IV-VI of CCR5 with an IC50 of 55 nM. Calcium 38-45 C-C motif chemokine ligand 2 Homo sapiens 25-29 26093886-8 2015 Only in diabetic plaques, calcium content was inversely correlated with MCP1 and IL1b, whereas the direct correlation with TNF-alpha expression seen in non-diabetic plaques was lost in diabetes. Calcium 26-33 C-C motif chemokine ligand 2 Homo sapiens 72-76 25272052-7 2015 P2X7R antagonists, such as the oxidized ATP, A438079, brilliant blue G, and broad spectrum P2 receptor antagonist suramin, attenuated Tat-induced CCL2 release in a calcium- and extracellular signal-regulated kinase (ERK)1/2-dependent manner. Calcium 164-171 C-C motif chemokine ligand 2 Homo sapiens 146-150 25272052-13 2015 We proposed the following cascade for Tat-mediated CCL2 release from astrocytes: Tat mediates increase in P2X7R expression, which on activation evokes increase in intracellular calcium, which further leads to phosphorylation of ERK1/2 followed by the release of CCL2 from astrocytes. Calcium 177-184 C-C motif chemokine ligand 2 Homo sapiens 51-55 25272052-13 2015 We proposed the following cascade for Tat-mediated CCL2 release from astrocytes: Tat mediates increase in P2X7R expression, which on activation evokes increase in intracellular calcium, which further leads to phosphorylation of ERK1/2 followed by the release of CCL2 from astrocytes. Calcium 177-184 C-C motif chemokine ligand 2 Homo sapiens 262-266 25053617-5 2014 Moreover, MCP-1 promoted the engagement of Galphai1, Galpha13, Galphaz, and betaarrestin2 to the heterooligomer, resulting in calcium signaling that was synergistically potentiated on coactivation of CCR2 and CXCR4, demonstrating that complexes larger than dimers reach the cell surface as functional units. Calcium 126-133 C-C motif chemokine ligand 2 Homo sapiens 10-15