PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25765155-10 2015 Moreover, Epo reduced the basal intracellular calcium (Ca(2+)) levels, suggesting an effect in the Ca(2+)-signaling pathway. Calcium 46-53 erythropoietin Mus musculus 10-13 23456860-19 2013 Epo has been shown to regulate a variety of cell functions such as calcium flux (Korbel et al. Calcium 67-74 erythropoietin Mus musculus 0-3 24756702-6 2014 The major demonstrated functions of TRPC2 are regulation of pheromone-evoked signaling in the rodent VNO, regulation of erythropoietin-stimulated calcium influx in murine erythroid cells, and ZP3-evoked calcium influx into sperm. Calcium 146-153 erythropoietin Mus musculus 120-134 15329338-0 2004 Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R. Calcium 25-32 erythropoietin Mus musculus 0-14 21924222-1 2012 Transient receptor potential (TRP) channels Trpc2 and Trpc3 are expressed on normal murine erythroid precursors, and erythropoietin stimulates an increase in intracellular calcium ([Ca(2+)](i)) through TRPC2 and TRPC3. Calcium 172-179 erythropoietin Mus musculus 117-131 21924222-9 2012 Although erythropoietin-induced calcium influx through TRPC2 or TRPC3 is not critical for erythroid production, these data demonstrate that TRPC2 plays an important role in oxidative stress-induced hemolysis, which may be related to reduced calcium entry in red cells in the presence of Trpc2 depletion. Calcium 32-39 erythropoietin Mus musculus 9-23 21924222-9 2012 Although erythropoietin-induced calcium influx through TRPC2 or TRPC3 is not critical for erythroid production, these data demonstrate that TRPC2 plays an important role in oxidative stress-induced hemolysis, which may be related to reduced calcium entry in red cells in the presence of Trpc2 depletion. Calcium 241-248 erythropoietin Mus musculus 9-23 19164545-5 2009 Activation of group I mGluRs triggers fast and highly regular intracellular calcium oscillations and we show that EPO interferes with this signaling event by altering the frequency of the oscillations. Calcium 76-83 erythropoietin Mus musculus 114-117 18276585-1 2008 Erythropoietin (Epo) stimulates a significant increase in the intracellular calcium concentration ([Ca(2+)](i)) through activation of the murine transient receptor potential channel TRPC2, but TRPC2 is a pseudogene in humans. Calcium 76-83 erythropoietin Mus musculus 0-14 18276585-1 2008 Erythropoietin (Epo) stimulates a significant increase in the intracellular calcium concentration ([Ca(2+)](i)) through activation of the murine transient receptor potential channel TRPC2, but TRPC2 is a pseudogene in humans. Calcium 76-83 erythropoietin Mus musculus 16-19 15329338-2 2004 Erythroblasts were isolated from the spleens of phenylhydrazine-treated mice, and Epo stimulation resulted in a significant and dose-dependent increase in intracellular calcium concentration ([Ca(2+)](i)). Calcium 169-176 erythropoietin Mus musculus 82-85 1367500-4 1990 When calcium-free suspension culture media (Joklik, DME-S, McCoy 5A-S) were used, single cell suspension cultures were obtained and high Epo production observed. Calcium 5-12 erythropoietin Mus musculus 137-140 12167663-0 2002 Erythropoietin modulates calcium influx through TRPC2. Calcium 25-32 erythropoietin Mus musculus 0-14 12167663-2 2002 Erythropoietin (Epo) stimulates a rise in intracellular calcium ([Ca](i)) via activation of voltage-independent calcium channel(s) in erythroid cells. Calcium 56-63 erythropoietin Mus musculus 0-14 12167663-2 2002 Erythropoietin (Epo) stimulates a rise in intracellular calcium ([Ca](i)) via activation of voltage-independent calcium channel(s) in erythroid cells. Calcium 56-63 erythropoietin Mus musculus 16-19 12167663-11 2002 These results identify a calcium-permeable channel, TRPC2, in erythroid cells and demonstrate modulation of calcium influx through this channel by erythropoietin. Calcium 25-32 erythropoietin Mus musculus 147-161 10995753-5 2000 We also observed that Epo stimulation activates Jak2/Stat5 signal transduction and increases cytoplasmic calcium, which is dependent on tyrosine phosphorylation. Calcium 105-112 erythropoietin Mus musculus 22-25 1284250-0 1992 Regulation of programmed death in erythroid progenitor cells by erythropoietin: effects of calcium and of protein and RNA syntheses. Calcium 91-98 erythropoietin Mus musculus 64-78 2792225-0 1989 Calcium response to erythropoietin in erythroleukemia cells. Calcium 0-7 erythropoietin Mus musculus 20-34 2792225-2 1989 The antigen-positive subpopulation of cells responded to EPO by transiently changing indo 1 fluorescence emissions, indicating a change in cytoplasmic calcium concentration. Calcium 151-158 erythropoietin Mus musculus 57-60 2496770-0 1989 The effect of recombinant erythropoietin on intracellular free calcium in erythropoietin-responsive cells. Calcium 63-70 erythropoietin Mus musculus 26-40 2496770-0 1989 The effect of recombinant erythropoietin on intracellular free calcium in erythropoietin-responsive cells. Calcium 63-70 erythropoietin Mus musculus 74-88 30048878-5 2018 The current work aimed to explore the dynamics of calcium transport across Spalax nonhematopoietic cells" membrane compared to above ground rat and mouse, and the role of the erythropoietin receptor of Spalax in the regulation of calcium influx under hypoxia. Calcium 230-237 erythropoietin Mus musculus 175-189 35563527-0 2022 DOT1L Methyltransferase Regulates Calcium Influx in Erythroid Progenitor Cells in Response to Erythropoietin. Calcium 34-41 erythropoietin Mus musculus 94-108 35563527-2 2022 An important downstream response of EPO signaling is calcium (Ca2+) influx, which is regulated by transient receptor potential channel (TRPC) proteins, particularly TRPC2 and TRPC6. Calcium 53-60 erythropoietin Mus musculus 36-39 2496770-1 1989 We have investigated whether recombinant erythropoietin (r-Epo) elicits a change in intracellular free calcium (IFC) in purified Epo-responsive cells in spleens of mice treated with phenylhydrazine. Calcium 103-110 erythropoietin Mus musculus 41-55 2496770-1 1989 We have investigated whether recombinant erythropoietin (r-Epo) elicits a change in intracellular free calcium (IFC) in purified Epo-responsive cells in spleens of mice treated with phenylhydrazine. Calcium 103-110 erythropoietin Mus musculus 59-62 115902-2 1979 The in vitro plasma clot technique was employed to examine the role of calcium during the interaction of erythropoietin and mouse erythroid progenitor cells. Calcium 71-78 erythropoietin Mus musculus 105-119 115902-8 1979 Marrow cells incubated first in calcium-free medium with erythropoietin and then cultured in the presence of calcium but not erythropoietin, failed to form erythroid colonies although colony formation occurred when erythropoietin was provided. Calcium 32-39 erythropoietin Mus musculus 57-71 115902-9 1979 Taken together, the data indicate that calcium is required for both extracellular and intracellular events during the interaction of erythropoietin with its target cells. Calcium 39-46 erythropoietin Mus musculus 133-147