PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14994387-4 2004 IFN-gamma and IL-4 production by CD4+ T cells stimulated with phorbol myristate acetate (PMA) and calcium ionophore A23187 was measured by intracellular cytokine staining and flow cytometry. Calcium 98-105 interferon gamma Homo sapiens 0-9 17585980-8 2007 We demonstrated that propanil interfering with PHA-induced intracellular calcium increase modulated IL-10 and IFN-gamma transcription and translation, which indicates that propanil acts on early events triggered by PHA. Calcium 73-80 interferon gamma Homo sapiens 110-119 16116176-7 2005 However, pretreatment with intracellular calcium chelator BAPTA-AM or disruption of lipid rafts using methyl beta-cyclodextrin completely abrogated IFN-gamma-induced Hsp72 release. Calcium 41-48 interferon gamma Homo sapiens 148-157 15601262-3 2005 MEKK4 is tyrosine-phosphorylated and the IFNgamma-dependent phosphorylation requires intracellular calcium. Calcium 99-106 interferon gamma Homo sapiens 41-49 15601262-7 2005 Immunofluorescence imaging of HaCaT cells shows an IFNgamma-dependent co-localization of annexin II with Pyk2 in the perinuclear region, suggesting that annexin II mediates the calcium-dependent regulation of Pyk2. Calcium 177-184 interferon gamma Homo sapiens 51-59 15735741-7 2005 These results establish that DIM-induced IFNgamma expression in human breast tumor cells is mediated by activation of both JNK and p38 pathways, which is ultimately dependent on intracellular calcium signaling. Calcium 192-199 interferon gamma Homo sapiens 41-49 17404310-3 2007 IFN-gamma increased cysLT receptor 2 (CysLTR2) mRNA expression and CysLTR2-specific calcium signaling in endothelial cells. Calcium 84-91 interferon gamma Homo sapiens 0-9 15695932-0 2005 B cell antigen receptor signaling enhances IFN-gamma-induced Stat1 target gene expression through calcium mobilization and activation of multiple serine kinase pathways. Calcium 98-105 interferon gamma Homo sapiens 43-52 11751951-1 2002 In this study, we show that binding to autologous dendritic cells (DC) induces a calcium influx in NK cells, followed by activation of the calcium-calmodulin kinase II (CAMKII), release of perforin and granzymes, and IFN-gamma secretion. Calcium 81-88 interferon gamma Homo sapiens 217-226 12767900-7 2003 IFN-gamma increased intracellular calcium ion concentration ([Ca(2+)](i)) consisting of a spike and a sustained phase, and the latter was completely abrogated by CsA. Calcium 34-41 interferon gamma Homo sapiens 0-9 12210826-0 2002 Interferon-gamma acutely induces calcium influx in human microglia. Calcium 33-40 interferon gamma Homo sapiens 0-16 12210826-1 2002 The acute actions of the cytokine, interferon-gamma (IFN-gamma), on intracellular calcium [Ca(2+)](i) levels in human microglia were investigated. Calcium 82-89 interferon gamma Homo sapiens 35-51 12210826-1 2002 The acute actions of the cytokine, interferon-gamma (IFN-gamma), on intracellular calcium [Ca(2+)](i) levels in human microglia were investigated. Calcium 82-89 interferon gamma Homo sapiens 53-62 12210826-2 2002 In the presence of a calcium-containing physiological solution (Ca(2+)-PSS), IFN-gamma caused a progressive increase in [Ca(2+)](i) to a plateau level with a mean rate of increase of 0.81 +/- 0.17 nM/s and mean amplitude of 102 +/- 12 nM (n = 67 cells). Calcium 21-28 interferon gamma Homo sapiens 77-86 14578204-3 2003 During CaM antagonist-mediated apoptosis in IFN-gamma-pretreated Fas-low cells, cleavage of caspases-8, -9, and -3 and Bid, release of cytochrome c from the mitochondria and an increase in the free cytosolic calcium concentration were observed. Calcium 208-215 interferon gamma Homo sapiens 44-53 12645529-10 2003 Inhibition of p11 expression by inhibitory antisense RNAs (iRNA) treatment resulted in enhanced IFN-gamma and calcium ionophore-stimulated arachidonic acid release suggesting that at least in part IFN-gamma-stimulated p11 expression may serve a counterregulatory role. Calcium 110-117 interferon gamma Homo sapiens 197-206 11958824-0 2002 Interferon-gamma-induced calcium influx in T lymphocytes of multiple sclerosis and rheumatoid arthritis patients: a complementary mechanism for T cell activation? Calcium 25-32 interferon gamma Homo sapiens 0-16 11751951-4 2002 NK cell-mediated lysis of DC and IFN-gamma release by NK cells upon NK/DC contact are inhibited by exogenous HIV-1 Tat: the protein blocks calcium influx and impairs CAMKII activation elicited via LFA-1 in NK cells, eventually inhibiting degranulation. Calcium 139-146 interferon gamma Homo sapiens 33-42 11500833-6 2001 We show that: (1) the calcium response is identical following weak and strong TCR stimulation; (2) mitogen-activated protein kinase(MAPK) activation is a gradual phenomenon depending upon the strength of TCR activation; (3) a calcium response, even weak, triggers IL-4 expression; (4) IFN-gamma synthesis requires not only a calcium response but also MAPK activation. Calcium 22-29 interferon gamma Homo sapiens 285-294 11703361-6 2001 As expected, CD8+ T lymphocytes from peripheral blood of healthy volunteers produced significantly more IFN-gamma in the presence of PMA and calcium-ionophore than after stimulation with anti-CD3 antibodies. Calcium 141-148 interferon gamma Homo sapiens 104-113 11703361-7 2001 However, in subjects with allergic asthma, IFN-gamma secretion of CD8+ T cells was significantly higher when incubated with anti-CD3 antibodies than after activation with PMA and calcium-ionophore. Calcium 179-186 interferon gamma Homo sapiens 43-52 11588047-6 2001 Calcium signaling selectively antagonized IL-12 production by mature DCs activated with IFN-gamma, TNF-alpha, and soluble CD40L. Calcium 0-7 interferon gamma Homo sapiens 88-97 15080501-0 2002 Cocaine increases intracellular calcium in the interferon-gamma-primed macrophages but not in the LPS-primed-macrophages. Calcium 32-39 interferon gamma Homo sapiens 47-63 11703361-8 2001 While IFN-gamma secretion of CD8+ T lymphocytes of patients with allergic asthma was lower than that of healthy controls in the presence of PMA/calcium-ionophore, it was significantly elevated when compared with normal controls after stimulation with anti-CD3 antibodies. Calcium 144-151 interferon gamma Homo sapiens 6-15 11500833-6 2001 We show that: (1) the calcium response is identical following weak and strong TCR stimulation; (2) mitogen-activated protein kinase(MAPK) activation is a gradual phenomenon depending upon the strength of TCR activation; (3) a calcium response, even weak, triggers IL-4 expression; (4) IFN-gamma synthesis requires not only a calcium response but also MAPK activation. Calcium 226-233 interferon gamma Homo sapiens 285-294 11500833-6 2001 We show that: (1) the calcium response is identical following weak and strong TCR stimulation; (2) mitogen-activated protein kinase(MAPK) activation is a gradual phenomenon depending upon the strength of TCR activation; (3) a calcium response, even weak, triggers IL-4 expression; (4) IFN-gamma synthesis requires not only a calcium response but also MAPK activation. Calcium 226-233 interferon gamma Homo sapiens 285-294 11342663-0 2001 ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gamma. Calcium 13-20 interferon gamma Homo sapiens 86-95 9809619-0 1998 The effect of calcium-related factors on the predominance of IFN-gamma or interleukin-4 in cultured mononuclear cells. Calcium 14-21 interferon gamma Homo sapiens 61-70 11936187-0 2001 Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms. Calcium 21-28 interferon gamma Homo sapiens 42-58 11936187-2 2001 Previously, we have shown that interferon-gamma (IFN-gamma) induces transient calcium signals in PMN, but only after intracellular calcium store depletion. Calcium 78-85 interferon gamma Homo sapiens 31-47 11936187-2 2001 Previously, we have shown that interferon-gamma (IFN-gamma) induces transient calcium signals in PMN, but only after intracellular calcium store depletion. Calcium 78-85 interferon gamma Homo sapiens 49-58 11936187-2 2001 Previously, we have shown that interferon-gamma (IFN-gamma) induces transient calcium signals in PMN, but only after intracellular calcium store depletion. Calcium 131-138 interferon gamma Homo sapiens 31-47 11936187-2 2001 Previously, we have shown that interferon-gamma (IFN-gamma) induces transient calcium signals in PMN, but only after intracellular calcium store depletion. Calcium 131-138 interferon gamma Homo sapiens 49-58 11936187-3 2001 Using a digital imaging system, we show that adhesion of PMN is critical for IFN-gamma-induced calcium signals, and with PMN attached to the optimal coating, the calcium signals are evoked even in presence of extracellular calcium, that is, non-depleted calcium stores. Calcium 95-102 interferon gamma Homo sapiens 77-86 11936187-3 2001 Using a digital imaging system, we show that adhesion of PMN is critical for IFN-gamma-induced calcium signals, and with PMN attached to the optimal coating, the calcium signals are evoked even in presence of extracellular calcium, that is, non-depleted calcium stores. Calcium 162-169 interferon gamma Homo sapiens 77-86 11936187-3 2001 Using a digital imaging system, we show that adhesion of PMN is critical for IFN-gamma-induced calcium signals, and with PMN attached to the optimal coating, the calcium signals are evoked even in presence of extracellular calcium, that is, non-depleted calcium stores. Calcium 162-169 interferon gamma Homo sapiens 77-86 11936187-3 2001 Using a digital imaging system, we show that adhesion of PMN is critical for IFN-gamma-induced calcium signals, and with PMN attached to the optimal coating, the calcium signals are evoked even in presence of extracellular calcium, that is, non-depleted calcium stores. Calcium 162-169 interferon gamma Homo sapiens 77-86 11936187-5 2001 In accordance with previous observations, IFN-gamma-induced calcium signals in fibronectin adherent cells were totally abolished by the G-protein inhibitor pertussis toxin and were also inhibited by the sphingosine kinase inhibitors dimethylsphingosine (DMS) and N-acetylsphingosine (N-Ac-Sp). Calcium 60-67 interferon gamma Homo sapiens 42-51 11936187-11 2001 In conclusion, fibronectin contact evokes by itself a calcium signal in PMN and further promotes calcium signaling by IFN-gamma. Calcium 97-104 interferon gamma Homo sapiens 118-127 11936187-13 2001 Apparently, sphingosine kinase activity is also involved in IFN-gamma induced calcium signals. Calcium 78-85 interferon gamma Homo sapiens 60-69 10353535-8 1999 Both calcium ionophore, A23187, and the protein kinase C (PKC) activator phorbol-myristate-acetate (PMA) had a synergistic effect on IFN-gamma-induced EC apoptosis (p < .05). Calcium 5-12 interferon gamma Homo sapiens 133-142 10353535-12 1999 These findings suggest that the signal transduction pathway required for induction of EC apoptosis by IFN-gamma is TPK dependent and is independent of calcium and PKC. Calcium 151-158 interferon gamma Homo sapiens 102-111 11833469-6 2001 Differing from that of IL-4, IFN gamma gene expression always requires MAP-kinase activation in addition to a calcium signal. Calcium 110-117 interferon gamma Homo sapiens 29-38 10233728-3 1999 Thus, in IFN-gamma-primed U937 cells, FcgammaRI aggregation results in an increase of PKC activity which is essentially calcium independent resulting from the translocation to the membrane of the novel PKCs, delta and epsilon, together with the atypical PKC zeta. Calcium 120-127 interferon gamma Homo sapiens 9-18 10048787-1 1999 Interferon-gamma (IFN-gamma) has multiple effects on Ca2+ signalling in polymorphonuclear neutrophils (PMNs), including evoked cytosolic Ca2+ transients, increased capacitative calcium influx and increased sequestration of Ca2+ in intracellular stores. Calcium 177-184 interferon gamma Homo sapiens 0-16 10048787-1 1999 Interferon-gamma (IFN-gamma) has multiple effects on Ca2+ signalling in polymorphonuclear neutrophils (PMNs), including evoked cytosolic Ca2+ transients, increased capacitative calcium influx and increased sequestration of Ca2+ in intracellular stores. Calcium 177-184 interferon gamma Homo sapiens 18-27 9809619-5 1998 Calcium-independent cytokine induction using anti-CD28 and PMA resulted in production of both cytokines, whereas depletion of extracellular calcium and magnesium adversely influenced the yield of both IL-4 and IFN-gamma. Calcium 0-7 interferon gamma Homo sapiens 210-219 9809619-5 1998 Calcium-independent cytokine induction using anti-CD28 and PMA resulted in production of both cytokines, whereas depletion of extracellular calcium and magnesium adversely influenced the yield of both IL-4 and IFN-gamma. Calcium 140-147 interferon gamma Homo sapiens 210-219 9616137-2 1998 We demonstrate here that interferon-gamma (IFN-gamma) increases the expression of chemokine receptors CCR1, CCR3, and CCR5 in monocytoid U937 cells as detected by cell surface molecule labeling and mRNA expression, as well as by intracellular calcium mobilization and cell migration in response to specific ligands. Calcium 243-250 interferon gamma Homo sapiens 25-41 9616137-2 1998 We demonstrate here that interferon-gamma (IFN-gamma) increases the expression of chemokine receptors CCR1, CCR3, and CCR5 in monocytoid U937 cells as detected by cell surface molecule labeling and mRNA expression, as well as by intracellular calcium mobilization and cell migration in response to specific ligands. Calcium 243-250 interferon gamma Homo sapiens 43-52 9687151-2 1998 We have shown previously that IFNgamma inhibited thyroglobulin (Tg) gene transcription, and that its action was mediated by an increase in intracellular calcium and inositol phosphates. Calcium 153-160 interferon gamma Homo sapiens 30-38 9754910-6 1998 B2 bradykinin receptor mRNA expression was increased as early as 1 h following IFNgamma stimulation, and continued to accumulate for 24 h. Bradykinin-stimulated intracellular calcium mobilization was also increased in IFNgamma-treated T24 cells compared to controls. Calcium 175-182 interferon gamma Homo sapiens 218-226 9506551-2 1998 Here, we report that in patients with MS the combined action of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-2, and IL-6 leads to the activation of most peripheral T cells (mainly CD4 memory) by promoting a persistent intracellular calcium increase via two independent signaling pathways. Calcium 274-281 interferon gamma Homo sapiens 64-80 9545263-3 1998 We show here that, in a human monocytic cell line primed with interferon-gamma, FcgammaRI mobilizes intracellular calcium stores using a novel pathway that involves tyrosine kinase coupling to phospholipase D and resultant downstream activation of sphingosine kinase. Calcium 114-121 interferon gamma Homo sapiens 62-78 9506551-2 1998 Here, we report that in patients with MS the combined action of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-2, and IL-6 leads to the activation of most peripheral T cells (mainly CD4 memory) by promoting a persistent intracellular calcium increase via two independent signaling pathways. Calcium 274-281 interferon gamma Homo sapiens 82-91 8937348-0 1996 Interferon-gamma activated calcium influx in peripheral blood lymphocytes from patients with primary and secondary progressive multiple sclerosis. Calcium 27-34 interferon gamma Homo sapiens 0-16 9328251-0 1997 Interferon-gamma induced increases in intracellular calcium in T lymphocytes from patients with multiple sclerosis precede clinical exacerbations and detection of active lesions on MRI. Calcium 52-59 interferon gamma Homo sapiens 0-16 9328251-1 1997 BACKGROUND: Interferon (IFN)-gamma exerts a multiplicity of actions potentially relevant for the pathogenesis of multiple sclerosis, including the expression of a transplasmalemma calcium (Ca2+) influx leading to an intracellular Ca2+ ([Ca2+]i) increase able to lower T lymphocyte threshold of excitability. Calcium 180-187 interferon gamma Homo sapiens 12-34 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. Calcium 238-245 interferon gamma Homo sapiens 69-85 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. Calcium 238-245 interferon gamma Homo sapiens 87-96 9555982-0 1998 IFN-gamma induces calcium transients and increases the capacitative calcium entry in human neutrophils. Calcium 18-25 interferon gamma Homo sapiens 0-9 9555982-0 1998 IFN-gamma induces calcium transients and increases the capacitative calcium entry in human neutrophils. Calcium 68-75 interferon gamma Homo sapiens 0-9 9555982-1 1998 We have previously reported that long-term priming of human polymorphonuclear neutrophilic granulocytes (PMN) with interferon-gamma (IFN-gamma) increased the fMLP-stimulated calcium influx. Calcium 174-181 interferon gamma Homo sapiens 115-131 9555982-1 1998 We have previously reported that long-term priming of human polymorphonuclear neutrophilic granulocytes (PMN) with interferon-gamma (IFN-gamma) increased the fMLP-stimulated calcium influx. Calcium 174-181 interferon gamma Homo sapiens 133-142 9555982-2 1998 We now show that also after short-term incubation with IFN-gamma, PMN calcium metabolism is modulated. Calcium 70-77 interferon gamma Homo sapiens 55-64 9555982-4 1998 The results of this protocol indicated that IFN-gamma increases both calcium influx and calcium sequestration. Calcium 69-76 interferon gamma Homo sapiens 44-53 9555982-4 1998 The results of this protocol indicated that IFN-gamma increases both calcium influx and calcium sequestration. Calcium 88-95 interferon gamma Homo sapiens 44-53 9555982-5 1998 Store dependent Ca2+ influx, directly measured on readdition of calcium to Tg-treated cells incubated in EGTA buffer, was significantly enhanced in IFN-gamma-treated cells. Calcium 64-71 interferon gamma Homo sapiens 148-157 9555982-7 1998 Strikingly, in low extracellular calcium concentrations, IFN-gamma induced calcium transients in 20%-60% of the cells. Calcium 33-40 interferon gamma Homo sapiens 57-66 9555982-7 1998 Strikingly, in low extracellular calcium concentrations, IFN-gamma induced calcium transients in 20%-60% of the cells. Calcium 75-82 interferon gamma Homo sapiens 57-66 9555982-11 1998 Thus, IFN-gamma can increase capacitative calcium influx, induce calcium transients, and possibly affect calcium sequestration in human PMN. Calcium 42-49 interferon gamma Homo sapiens 6-15 9555982-11 1998 Thus, IFN-gamma can increase capacitative calcium influx, induce calcium transients, and possibly affect calcium sequestration in human PMN. Calcium 65-72 interferon gamma Homo sapiens 6-15 9555982-11 1998 Thus, IFN-gamma can increase capacitative calcium influx, induce calcium transients, and possibly affect calcium sequestration in human PMN. Calcium 65-72 interferon gamma Homo sapiens 6-15 8937348-1 1996 Interferon-gamma (IFN-gamma) contributes to the early events leading to T cell activation in relapsing-remitting (RR) multiple sclerosis (MS) by activating a transplasmalemma calcium influx, the detection of which is closely associated with clinical and MRI evidence of disease activity. Calcium 175-182 interferon gamma Homo sapiens 0-16 8937348-1 1996 Interferon-gamma (IFN-gamma) contributes to the early events leading to T cell activation in relapsing-remitting (RR) multiple sclerosis (MS) by activating a transplasmalemma calcium influx, the detection of which is closely associated with clinical and MRI evidence of disease activity. Calcium 175-182 interferon gamma Homo sapiens 18-27 8937348-3 1996 It is still questioned whether the same immune mediated mechanisms also operate in primary progressive (PP)MS. Fluorimetric evidence of the IFN-gamma activated calcium influx was sought in 16 patients with PPMS and 39 patients with secondary progressive (SP)MS. To compare peripheral versus CNS evidence of immune activation 11 of the patients with PPMS and 27 of the patients with SPMS underwent gadolinium enhanced brain MRI. Calcium 160-167 interferon gamma Homo sapiens 140-149 8623163-0 1996 Identification of a calcium-inducible, cyclosporine sensitive element in the IFN-gamma promoter that is a potential NFAT binding site. Calcium 20-27 interferon gamma Homo sapiens 77-86 8645468-0 1996 Interferon-gamma increases inositol phosphate formation and cellular calcium ion concentration independent of ICAM-1 antigen enhancement in renal tubular cells. Calcium 69-76 interferon gamma Homo sapiens 0-16 8623163-10 1996 These results suggest that the P2 sequence, and probably the P1 sequence, in the IFN-gamma promoter are NFAT binding sites and contribute to the calcium inducibility and CsA sensitivity of IFN-gamma production. Calcium 145-152 interferon gamma Homo sapiens 81-90 8623163-10 1996 These results suggest that the P2 sequence, and probably the P1 sequence, in the IFN-gamma promoter are NFAT binding sites and contribute to the calcium inducibility and CsA sensitivity of IFN-gamma production. Calcium 145-152 interferon gamma Homo sapiens 189-198 8762005-10 1996 Likewise, the induction of IFN-gamma and IL-2 mRNA by calcium ionophore A23187 was inhibited with IC50 of 14 ng/ml (95% CI = 8-27 ng/ml) and 32 ng/ml (95% CI = 5-178 ng/ml), respectively, while the IC50 for inhibition of IFN-gamma protein secretion was 8 ng/ml (95% CI = 9-18 ng/ml). Calcium 54-61 interferon gamma Homo sapiens 27-36 8762005-10 1996 Likewise, the induction of IFN-gamma and IL-2 mRNA by calcium ionophore A23187 was inhibited with IC50 of 14 ng/ml (95% CI = 8-27 ng/ml) and 32 ng/ml (95% CI = 5-178 ng/ml), respectively, while the IC50 for inhibition of IFN-gamma protein secretion was 8 ng/ml (95% CI = 9-18 ng/ml). Calcium 54-61 interferon gamma Homo sapiens 221-230 8752503-2 1995 All epithelial cells exhibited constitutive NOS activity that was calcium-dependent, and inducible, lesser calcium-dependent activity in the presence of interferon-gamma, interleukin-1 beta, tumor necrosis factor-alpha, and lipopolysaccharide. Calcium 107-114 interferon gamma Homo sapiens 153-169 8543752-4 1995 The release of IL-4 and IFN-gamma from peripheral blood mononuclear cells stimulated by polyclonal agents (calcium ionophore A23187 and phorbol myristate acetate) was measured by ELISA. Calcium 107-114 interferon gamma Homo sapiens 24-33 7588238-0 1995 Interferon-gamma increases intracellular calcium and inositol phosphates in primary human thyroid cell culture. Calcium 41-48 interferon gamma Homo sapiens 0-16 7913411-3 1994 In the present study, we investigated the role of calcium (Ca2+) and calmodulin (CaM) in the retinoic acid and gamma-interferon (IFN-gamma) signaling in the human neuroblastoma cell line SK-N-SH for up-regulating ICAM-1 expression. Calcium 50-57 interferon gamma Homo sapiens 129-138 7561155-5 1995 Digital image processing analysis demonstrated that SEB induced a transient increase of intracellular calcium concentration only in the IFN-gamma-treated DJM-1 cells. Calcium 102-109 interferon gamma Homo sapiens 136-145 7536905-3 1995 Treatment of neuron cultures for 24 h with the combined stimulation of IFN-gamma plus IL-1 beta, TNF-alpha and LPS induced NOS activity by 87-fold which was calcium-independent. Calcium 157-164 interferon gamma Homo sapiens 71-80 7954708-3 1994 Initial release of calcium from stores following Fc gamma R cross-linking is enhanced by prior treatment of U937 cells with both interferon-gamma, and, to a lesser extent, with dibutyryl cAMP. Calcium 19-26 interferon gamma Homo sapiens 129-145 8088386-0 1994 Interferon-gamma modulates cytosolic free calcium in human neutrophilic granulocytes. Calcium 42-49 interferon gamma Homo sapiens 0-16 8088386-1 1994 To investigate the role of cytosolic free calcium ([Ca2+]i in interferon-gamma (IFN-gamma) pre-activation (priming) of human neutrophilic granulocytes (PMN) we used three different fluorescence methods, i.e. digital imaging of single, adherent, Fura-2 loaded cells, flow cytometric measurements of single, non-adherent, Fluo-3 loaded cells, and spectrofluorometry of Indo-1 loaded PMN in suspension. Calcium 42-49 interferon gamma Homo sapiens 62-78 8088386-7 1994 We suggest that IFN-gamma increases the plasma membrane permeability for calcium in PMN, and substantiate this by demonstrating compliance with a capacitative model for intracellular calcium regulation. Calcium 73-80 interferon gamma Homo sapiens 16-25 8088386-7 1994 We suggest that IFN-gamma increases the plasma membrane permeability for calcium in PMN, and substantiate this by demonstrating compliance with a capacitative model for intracellular calcium regulation. Calcium 183-190 interferon gamma Homo sapiens 16-25 7954708-4 1994 A large and prolonged entry of external calcium is observed in dibutyryl cAMP treated cells; this may be due to direct regulation of calcium channels by the low affinity receptor, Fc gamma RII (whose expression is up-regulated in these cells), since the smaller and more transient entry observed in interferon-gamma treated cells, (where the high affinity receptor, Fc gamma RI, is up-regulated) argues against a common pathway of store-mediated calcium entry. Calcium 40-47 interferon gamma Homo sapiens 299-315 7954708-4 1994 A large and prolonged entry of external calcium is observed in dibutyryl cAMP treated cells; this may be due to direct regulation of calcium channels by the low affinity receptor, Fc gamma RII (whose expression is up-regulated in these cells), since the smaller and more transient entry observed in interferon-gamma treated cells, (where the high affinity receptor, Fc gamma RI, is up-regulated) argues against a common pathway of store-mediated calcium entry. Calcium 133-140 interferon gamma Homo sapiens 299-315 7905278-0 1994 Interferon-gamma increases cellular calcium ion concentration and inositol 1,4,5-trisphosphate formation in human renal carcinoma cells: relation to ICAM-1 antigen expression. Calcium 36-43 interferon gamma Homo sapiens 0-16 8176225-6 1994 The increase in hPAF-R expression was associated with an augmented response of IFN-gamma-treated cells to PAF in terms of cytosolic calcium ([Ca2+]i) variations. Calcium 132-139 interferon gamma Homo sapiens 79-88 7905278-1 1994 In the present study, we investigated the effect of interferon-gamma (IFN-gamma) on cellular calcium ion concentration [Ca2+]i and inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) formation in the human renal carcinoma cell line CaKi-1. Calcium 93-100 interferon gamma Homo sapiens 52-68 7905278-9 1994 IFN-gamma signal transduction in our model may not be limited to an increase in [Ca2+]i and Ins 1,4,5-P3, since IFN-gamma-induced ICAM-1 antigen expression was abrogated to a minor degree by calcium antagonists and not coupled to Ins 1,4,5-P3 formation. Calcium 191-198 interferon gamma Homo sapiens 0-9 7905278-9 1994 IFN-gamma signal transduction in our model may not be limited to an increase in [Ca2+]i and Ins 1,4,5-P3, since IFN-gamma-induced ICAM-1 antigen expression was abrogated to a minor degree by calcium antagonists and not coupled to Ins 1,4,5-P3 formation. Calcium 191-198 interferon gamma Homo sapiens 112-121 7905278-1 1994 In the present study, we investigated the effect of interferon-gamma (IFN-gamma) on cellular calcium ion concentration [Ca2+]i and inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) formation in the human renal carcinoma cell line CaKi-1. Calcium 93-100 interferon gamma Homo sapiens 70-79 7905278-3 1994 IFN-gamma caused a rapid concentration-dependent rise in [Ca2+]i, which was partly inhibited by diltiazem, a calcium channel blocker, TMB-8, an inhibitor of intracellular calcium redistribution, and in calcium-free medium. Calcium 109-116 interferon gamma Homo sapiens 0-9 7905278-3 1994 IFN-gamma caused a rapid concentration-dependent rise in [Ca2+]i, which was partly inhibited by diltiazem, a calcium channel blocker, TMB-8, an inhibitor of intracellular calcium redistribution, and in calcium-free medium. Calcium 171-178 interferon gamma Homo sapiens 0-9 8113394-5 1994 Calcium ionophore A23187 (10(-5) M) further increased the [3H]AA release from the IFN-gamma-treated cells. Calcium 0-7 interferon gamma Homo sapiens 82-91 8292227-4 1993 However, when given exogenously, IFN-gamma delayed the onset and reduced the incidence of Cas-induced neurologic disease. Calcium 90-93 interferon gamma Homo sapiens 33-42 7974918-4 1994 The calcium ionophore, 4-bromo-calcium ionophore A23187 (Bromo-A23187) significantly enhanced the IFN-gamma and PMA effect. Calcium 4-11 interferon gamma Homo sapiens 98-107 8103344-3 1993 Calcium ionophore A23187 significantly enhanced IFN-gamma- and PMA-induced ICAM-1 staining. Calcium 0-7 interferon gamma Homo sapiens 48-57 8384238-3 1993 Following pretreatment of human PMNs with recombinant IFN-gamma, superoxide anion release was selectively primed toward the receptor-initiated stimulants f-Met-Leu-Phe (fMLP) and C5a but not toward the transduction-mediated stimulants phorbol myristate acetate and A23187, a calcium ionophore. Calcium 275-282 interferon gamma Homo sapiens 54-63 7684703-5 1993 In addition, it was shown that the effects of IFN-gamma on LPS-induced G-CSF protein secretion could be mimicked by the calcium ionophore A23187, suggesting that the Ca(2+)-dependent pathway might be triggered after binding of the ligand to the receptor. Calcium 120-127 interferon gamma Homo sapiens 46-55 7679423-6 1993 Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium. Calcium 208-215 interferon gamma Homo sapiens 33-42 7679423-6 1993 Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium. Calcium 208-215 interferon gamma Homo sapiens 115-124 7679423-1 1993 We have previously demonstrated that HLA-DR molecule expression induced by IFN-gamma is associated with phosphatidylinositide turnover, activation of protein kinase C, and elevation of intracellular calcium. Calcium 199-206 interferon gamma Homo sapiens 75-84 7679423-8 1993 These findings suggest that the tyrosine phosphorylation is an early and critical event that precedes phosphatidylinositide turnover leading to activation of protein kinase C and elevation of intracellular calcium concentration during IFN-gamma-inducible DR molecule expression. Calcium 206-213 interferon gamma Homo sapiens 235-244 1310709-1 1992 Calcium ionophore A23187 can mimic IFN-gamma-induced macrophage activation for intracellular Leishmania killing and secretion of L-arginine-derived nitrite. Calcium 0-7 interferon gamma Homo sapiens 35-44 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Calcium 65-72 interferon gamma Homo sapiens 243-259 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Calcium 65-72 interferon gamma Homo sapiens 261-270 1621011-7 1992 In addition, IFN-gamma showed the synergistic action with calcium ionophores on the reduction of EGF binding to the cells, suggesting that Ca2+ may be one of the second mediators which was induced by TPA and which cooperated with IFN-gamma. Calcium 58-65 interferon gamma Homo sapiens 230-239 1386860-5 1992 The CD44+ population includes very immature precursor T cells and produced high titers of IL-2, TNF-alpha, and IFN-gamma upon activation with calcium ionophore and phorbol ester. Calcium 142-149 interferon gamma Homo sapiens 111-120 1511424-8 1992 These results indicate that verapamil synergistically interacts with rIFN-gamma on the class I antigen induction in K562 cells irrespective of c-myc gene expression and that class I antigen induction in this cell line may not be relevant to calcium influx triggered by IFN-gamma. Calcium 241-248 interferon gamma Homo sapiens 70-79 1431547-4 1992 In response to 10 microM calcium ionophore A23187 incubation (30 min), undifferentiated and IFN-gamma-differentiated HL60 cells formed both cyclooxygenase products (thromboxane and prostaglandins) and lipoxygenase products (leukotrienes and hydroxyeicosatetraenoic acids). Calcium 25-32 interferon gamma Homo sapiens 92-101 1370514-8 1992 Stimulation with Con A also induced very low or no measurable levels of IL-2 and IFN-gamma, whereas activation with TPA and the calcium ionophore A23187 resulted in the production of high levels of IL-4, IL-5, IL-2, and IFN-gamma. Calcium 128-135 interferon gamma Homo sapiens 220-229 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Calcium 92-99 interferon gamma Homo sapiens 212-221 1880416-2 1991 It was specifically down-modulated after stimulation of monocytes by physiologic activating/differentiating agents such as bacterial LPS and IFN-gamma, by the pharmacologic agents PMA and calcium ionophore A23187, and by anti-CD14 antibodies. Calcium 188-195 interferon gamma Homo sapiens 141-150 1705283-0 1991 Human recombinant interferon gamma enhances neonatal polymorphonuclear leukocyte activation and movement, and increases free intracellular calcium. Calcium 139-146 interferon gamma Homo sapiens 18-34 1901945-1 1991 Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages. Calcium 176-183 interferon gamma Homo sapiens 30-46 1901945-1 1991 Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages. Calcium 176-183 interferon gamma Homo sapiens 48-57 1899359-0 1991 Induction of interferon-gamma by cord blood mononuclear cells is calcium dependent. Calcium 65-72 interferon gamma Homo sapiens 13-29 1899359-8 1991 These data suggested that the soluble factor produced by PHA-stimulated adult macrophage supernatant and PHA-stimulated U937 supernatant induced IFN-gamma production in PHA-stimulated cord blood MNC by inducing calcium-dependent signals at more than one site. Calcium 211-218 interferon gamma Homo sapiens 145-154 1901779-2 1991 We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. Calcium 133-140 interferon gamma Homo sapiens 39-55 1901779-2 1991 We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. Calcium 133-140 interferon gamma Homo sapiens 57-66 2212676-8 1990 Taken together, these results suggest that IFN-gamma activates PKC and stimulates calcium influx, resulting in the induction of transcription of DRA and B and DPA and B genes without de novo protein synthesis. Calcium 82-89 interferon gamma Homo sapiens 43-52 2106525-6 1990 The results of this study provide presumptive evidence for an important role of agonist (IFN gamma)-calcium-modulated eicosanoid metabolism in the regulated synthesis of 1,25-(OH)2D by PAM in sarcoidosis. Calcium 100-107 interferon gamma Homo sapiens 89-98 2140394-0 1990 Role of intracellular calcium concentration and protein kinase C activation in IFN-gamma stimulation of U937 cells. Calcium 22-29 interferon gamma Homo sapiens 79-88 2140394-5 1990 IFN-gamma caused a rapid and concentration-dependent increase in [Ca2+]i, which was partly inhibited by calcium-free medium, diltiazem, and TMB-8. Calcium 104-111 interferon gamma Homo sapiens 0-9 2140394-9 1990 We conclude that IFN-gamma induces antigenic expression on human U937 cells by a mechanism dependent on, but not limited to, an increase in intracellular calcium, which is likely due to inositol 1,4,5-trisphosphate generation. Calcium 154-161 interferon gamma Homo sapiens 17-26 2156322-3 1990 We hypothesized that U937 and THP-1 cells would release LTB4, LTC4, and LTD4 in response to stimulation with the non-physiologic agonist, calcium ionophore A23187 and that preincubation with IFN-gamma or PMA might alter leukotriene release by these cells. Calcium 138-145 interferon gamma Homo sapiens 191-200 2966398-0 1988 Calcium influx and the Ca2+-calmodulin complex are involved in interferon-gamma-induced expression of HLA class II molecules on HL-60 cells. Calcium 0-7 interferon gamma Homo sapiens 63-79 34767749-5 2021 Functionally, IFN-gamma-treated CMs exhibited a more matured electrophysiological profile, such as increased calcium dynamics and action potential upstroke velocity, demonstrated through calcium imaging and MEA. Calcium 109-116 interferon gamma Homo sapiens 14-23 34767749-5 2021 Functionally, IFN-gamma-treated CMs exhibited a more matured electrophysiological profile, such as increased calcium dynamics and action potential upstroke velocity, demonstrated through calcium imaging and MEA. Calcium 187-194 interferon gamma Homo sapiens 14-23 35510301-12 2022 EGTA and PKCi reduced eATP-induced IDO and IFNgamma expressions by hPDLCs, confirming the role of calcium signaling. Calcium 98-105 interferon gamma Homo sapiens 43-51 2481524-14 1989 Preliminary studies demonstrated that production of human interferon gamma by peripheral blood mononuclear cells was calcium dependent, but production of human interferon alpha was not. Calcium 117-124 interferon gamma Homo sapiens 58-74 2481524-15 1989 Thus, almost all agents studied that influenced calcium dependent intracellular processes influenced the titer of human interferon gamma produced, but not that of human interferon alpha. Calcium 48-55 interferon gamma Homo sapiens 120-136 2504627-0 1989 Differences in intracellular calcium mobilization by interferon-beta and interferon-gamma in RPMI-4788 cells. Calcium 29-36 interferon gamma Homo sapiens 73-89 1982067-9 1990 An inhibitor of calcium calmodulin, W7, decreased the IFN-gamma induced ICAM-1 expression, and addition of calcium ionophore to endothelial cells could replace IFN-gamma in the up-regulation of ICAM-1. Calcium 16-23 interferon gamma Homo sapiens 54-63 1982067-10 1990 Finally, IFN-gamma caused a significant increase in the calcium flux of endothelial cells. Calcium 56-63 interferon gamma Homo sapiens 9-18 2507204-0 1989 Interleukin 2, interleukin 2 receptor, and interferon-gamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans. Calcium 123-130 interferon gamma Homo sapiens 43-59 2463903-7 1989 Keratinocytes grown in 0.1 mM calcium serum-free medium (which prevents differentiation) were more sensitive to both the stimulatory and inhibitory effects of IFN gamma than keratinocytes grown in 1.2 mM calcium serum-free medium (which permits differentiation). Calcium 30-37 interferon gamma Homo sapiens 159-168 2463903-7 1989 Keratinocytes grown in 0.1 mM calcium serum-free medium (which prevents differentiation) were more sensitive to both the stimulatory and inhibitory effects of IFN gamma than keratinocytes grown in 1.2 mM calcium serum-free medium (which permits differentiation). Calcium 204-211 interferon gamma Homo sapiens 159-168 2466090-2 1988 We have found that the production of human (Hu) IFN-gamma is affected significantly by alterations in calcium flux; however, this influence is dependent upon the nature of the compound used to induce IFN. Calcium 102-109 interferon gamma Homo sapiens 48-57 2466090-5 1988 The production of IFN-gamma by PBMC was reduced by diminished concentrations in extracellular calcium but not extracellular magnesium. Calcium 94-101 interferon gamma Homo sapiens 18-27 2966398-9 1988 These results suggest that IFN-gamma stimulates calcium influx by a so-called receptor-mediated calcium channel and activates the calmodulin branch of the calcium messenger system, resulting in the induction of DR molecules on the surface of HL-60 cells. Calcium 48-55 interferon gamma Homo sapiens 27-36 2966398-9 1988 These results suggest that IFN-gamma stimulates calcium influx by a so-called receptor-mediated calcium channel and activates the calmodulin branch of the calcium messenger system, resulting in the induction of DR molecules on the surface of HL-60 cells. Calcium 96-103 interferon gamma Homo sapiens 27-36 2966398-7 1988 In fact, IFN-gamma evoked a calcium influx into HL-60 cells, whereas depletion of Ca2+ from culture medium resulted in a failure of IFN-gamma to induce DR expression. Calcium 28-35 interferon gamma Homo sapiens 9-18 3115598-4 1987 However, activation by the phorbol ester PMA in conjunction with either PHA or the calcium ionophore A23187 induces large amounts of IFN-gamma and IL-2. Calcium 83-90 interferon gamma Homo sapiens 133-142 3124262-7 1988 In addition, the combination of the calcium ionophore A 23187 and PMA induced a strong IFN-gamma secretion in all patient groups and in the controls. Calcium 36-43 interferon gamma Homo sapiens 87-96 3040858-10 1987 In fact, the measurement of calcium influx into HL-60 cells showed that a remarkable and time-dependent calcium accumulation was caused by IFN-gamma, and that depletion of Ca2+ from culture medium resulted in failure of IFN-gamma to induce class II antigen expression. Calcium 104-111 interferon gamma Homo sapiens 139-148 3040858-12 1987 These results suggest that IFN-gamma stimulates calcium influx and activates the calmodulin branch of the calcium messenger system, resulting in the induction of class II antigen expression on HL-60 cells. Calcium 48-55 interferon gamma Homo sapiens 27-36 3040858-12 1987 These results suggest that IFN-gamma stimulates calcium influx and activates the calmodulin branch of the calcium messenger system, resulting in the induction of class II antigen expression on HL-60 cells. Calcium 106-113 interferon gamma Homo sapiens 27-36 3040858-13 1987 On the other hand, cross-linking of FcR elicited the accumulation of intracellular cAMP, which appeared to suppress the IFN-gamma-induced calcium influx, resulting in annulling HLA class II antigen-inducing activity of IFN-gamma. Calcium 138-145 interferon gamma Homo sapiens 120-129 3040858-13 1987 On the other hand, cross-linking of FcR elicited the accumulation of intracellular cAMP, which appeared to suppress the IFN-gamma-induced calcium influx, resulting in annulling HLA class II antigen-inducing activity of IFN-gamma. Calcium 138-145 interferon gamma Homo sapiens 219-228 3086215-0 1986 Calcium ionophore A 23 187 in the presence of phorbol ester PMA: a potent inducer of interleukin 2 and interferon-gamma synthesis by human blood cells. Calcium 0-7 interferon gamma Homo sapiens 103-119 2955785-0 1987 Potential mechanisms of cytosolic calcium modulation in interferon-gamma treated U937 cells. Calcium 34-41 interferon gamma Homo sapiens 56-72 3113436-0 1987 The induction of IFN-gamma production and m-RNAs of interleukin 2 and IFN-gamma by phorbol esters and a calcium ionophore. Calcium 104-111 interferon gamma Homo sapiens 17-26 3113436-0 1987 The induction of IFN-gamma production and m-RNAs of interleukin 2 and IFN-gamma by phorbol esters and a calcium ionophore. Calcium 104-111 interferon gamma Homo sapiens 70-79 3113436-1 1987 Human peripheral blood mononuclear leukocytes were found to produce large amounts of interferon-gamma in response to the calcium ionophore A23187 combined with the phorbol ester mezerein. Calcium 121-128 interferon gamma Homo sapiens 85-101 3021873-5 1986 Addition of the calcium ionophore A23187 partially restored IFN-gamma production. Calcium 16-23 interferon gamma Homo sapiens 60-69 3021873-8 1986 Enhancement of the flux of calcium into the cell may restore some of the ability to produce IFN-gamma. Calcium 27-34 interferon gamma Homo sapiens 92-101 3086215-1 1986 Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA. Calcium 61-68 interferon gamma Homo sapiens 233-249 3086215-1 1986 Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA. Calcium 61-68 interferon gamma Homo sapiens 251-260 31132974-10 2019 We found that calcium supplementation improved the PWM-induced production of IFN-gamma. Calcium 14-21 interferon gamma Homo sapiens 77-86 3099131-3 1986 Using this improved method we demonstrated that reagents such as 12-O-tetradecanoylphorbol-13-acetate (TPA), concanavalin A (Con A) and a calcium ionophore (A23187) could induce the expression of IFN-gamma gene of a human T-lymphoblastoid cell line, TCL-Fuj 2M, where TPA functioned synergistically with Con A and A23187. Calcium 138-145 interferon gamma Homo sapiens 196-205 3923610-5 1985 On the contrary, the calcium ionophore A23187 (considered to act as a second specific step, following oxidation of galactose residues, toward genetic derepression of IFN-gamma) induced considerable IFN-gamma production in all the three tested patients. Calcium 21-28 interferon gamma Homo sapiens 166-175 3923610-5 1985 On the contrary, the calcium ionophore A23187 (considered to act as a second specific step, following oxidation of galactose residues, toward genetic derepression of IFN-gamma) induced considerable IFN-gamma production in all the three tested patients. Calcium 21-28 interferon gamma Homo sapiens 198-207 6162895-5 1981 Galactose oxidase- and calcium ionophore-induced interferons were neutralized to undetectable levels by the antiserum to IFN gamma. Calcium 23-30 interferon gamma Homo sapiens 121-130 33891607-0 2021 Mesencephalic astrocyte-derived neurotrophic factor is secreted from interferon-gamma-activated tumor cells through ER calcium depletion. Calcium 119-126 interferon gamma Homo sapiens 69-85 33891607-10 2021 However, IFN-gamma induced ER calcium depletion, which was necessary for MANF secretion, as Dantrolene, an inhibitor of ER calcium release, prevented its secretion. Calcium 30-37 interferon gamma Homo sapiens 9-18 31150805-6 2019 in vitro assay, we found that trichloroethylene metabolites trichloroacetaldehyde (TCAH), not trichloroacetic acid (TCA) or Trichloroethanol (TCOH) could activate the naive CD4+ T cells characterized by a rise in intracellular calcium, down-regulated CD62 L and subsequently trigger the secretion of IL-2, IFN-gamma and TNF-alpha. Calcium 227-234 interferon gamma Homo sapiens 306-315 3155566-1 1985 Mitogenic induction of interferon-gamma in human peripheral blood mononuclear cells (PBMC) is prevented by enzymatic cleavage of galactose residues on the cell membrane, and by calcium depletion, suggesting that oxidation of galactose on the membrane glycoproteins and activation of a calcium flux across the membrane are critical events for interferon-gamma induction in nonspecifically stimulated human PBMC. Calcium 177-184 interferon gamma Homo sapiens 23-39 3155566-1 1985 Mitogenic induction of interferon-gamma in human peripheral blood mononuclear cells (PBMC) is prevented by enzymatic cleavage of galactose residues on the cell membrane, and by calcium depletion, suggesting that oxidation of galactose on the membrane glycoproteins and activation of a calcium flux across the membrane are critical events for interferon-gamma induction in nonspecifically stimulated human PBMC. Calcium 285-292 interferon gamma Homo sapiens 23-39 3155566-3 1985 The results of these experiments show that also antigenic induction of interferon-gamma by purified protein derivative, tetanus toxoid, and MLR requires integrity of galactose residues and calcium intake suggesting that alteration of membrane-bound galactose and activation of a calcium flow are critical triggering events for both specific and nonspecific lymphocyte activation. Calcium 189-196 interferon gamma Homo sapiens 71-87 3155566-3 1985 The results of these experiments show that also antigenic induction of interferon-gamma by purified protein derivative, tetanus toxoid, and MLR requires integrity of galactose residues and calcium intake suggesting that alteration of membrane-bound galactose and activation of a calcium flow are critical triggering events for both specific and nonspecific lymphocyte activation. Calcium 279-286 interferon gamma Homo sapiens 71-87 33854984-5 2021 Either blocking calcium or specifically inhibiting phosphorylation of ERK1/2 decreased the production of IFN-gamma induced by Hlb. Calcium 16-23 interferon gamma Homo sapiens 105-114 26315505-8 2016 Furthermore, an immunofluorescence staining assay showed that more MG63 cells were OPN-positive, while an Alizarin red staining indicated the increased formation of calcium nodules in the IFN-gamma and TNF-alpha combined pretreatment group. Calcium 165-172 interferon gamma Homo sapiens 188-197 28431214-0 2017 Interferon-gamma Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves. Calcium 70-77 interferon gamma Homo sapiens 0-16 27303033-5 2016 We demonstrate the utility of this microfluidic assay with natural killer cells interacting with tumor cells, and our findings suggest a possible role for the strength of early calcium signaling in selective coordination of subsequent cytotoxicity and IFN-gamma production. Calcium 177-184 interferon gamma Homo sapiens 252-261 24067141-2 2014 Though Ca(2+) signaling is of particular significance in sperm, the effect of IFN-gamma intracellular calcium on these cells is still unknown. Calcium 102-109 interferon gamma Homo sapiens 78-87 26142328-7 2015 Both a nuclear factor-kappaB inhibitor (PDTC) and an intracellular calcium antagonist (TMB-8) prevented upregulation of IFN-gamma production. Calcium 67-74 interferon gamma Homo sapiens 120-129 27137130-4 2016 The influence of IFN-gamma incorporated nanoemulsions on functional activity of mononuclear cell for Escherichia coli enteropathogenic was analyzed through superoxide release, phagocytosis, microbicidal activity and intracellular calcium release. Calcium 230-237 interferon gamma Homo sapiens 17-26 24190972-3 2014 In those T cells, calcium signaling triggers the expression of Tle4, a member of the Groucho family of corepressors, which is then recruited to a distal regulatory element in the Ifng locus and causes the establishment of repressive epigenetic marks at the Ifng gene regulatory elements. Calcium 18-25 interferon gamma Homo sapiens 257-261 23551080-8 2013 However, after the heterozygote PMNs had been incubated with IFN-gamma (100 U/ml) for 2 h, both the proportion of cells responding and the size of the CRP-induced calcium signals increased. Calcium 163-170 interferon gamma Homo sapiens 61-70 24190972-3 2014 In those T cells, calcium signaling triggers the expression of Tle4, a member of the Groucho family of corepressors, which is then recruited to a distal regulatory element in the Ifng locus and causes the establishment of repressive epigenetic marks at the Ifng gene regulatory elements. Calcium 18-25 interferon gamma Homo sapiens 179-183 22413885-5 2012 RESULTS: Calcium-dependent activation of T cells using CD3/CD28 and PMA/CD3 stimulation induced a Th1 expression profile reflected by increased expression of T-bet, RUNX3, IL-2, and IFNgamma, whereas calcium-independent activation via PMA/CD28 induced a Th2 expression profile which included GATA3, RXRA, CCL1 and Itk. Calcium 9-16 interferon gamma Homo sapiens 182-190 23551080-13 2013 However, increased expression of FcgammaRIa (CD64), stimulated by IFN-gamma, can augment calcium signalling by CRP in low-responders. Calcium 89-96 interferon gamma Homo sapiens 66-75 19919129-0 2009 FIP-fve stimulates interferon-gamma production via modulation of calcium release and PKC-alpha activation. Calcium 65-72 interferon gamma Homo sapiens 19-35 20654672-0 2010 Inhibitory effects of SSRIs on IFN-gamma induced microglial activation through the regulation of intracellular calcium. Calcium 111-118 interferon gamma Homo sapiens 31-40 18048764-8 2008 Thus, the cytokines IL-1beta and interferon-gamma, putative mediators of beta-cell loss in type 1 diabetes, induce severe ER stress through, respectively, NO-mediated depletion of ER calcium and inhibition of ER chaperones, thus hampering beta-cell defenses and amplifying the proapoptotic pathways. Calcium 183-190 interferon gamma Homo sapiens 33-49 19306841-6 2009 Stimulation of HeLa cells with IFNgamma upregulates expression of P2X(7) mRNA and full-length protein, modifies ATP-dependent calcium fluxes, and renders the cells sensitive to ATP-induced apoptosis, which can be blocked by a P2X(7) antagonist. Calcium 126-133 interferon gamma Homo sapiens 31-39 18320029-7 2008 Importantly, sustained transmembranous calcium flux, activation of Src-kinases as well as activation of PI3K were found to be absolutely required for CD28SA-mediated production of IFN-gamma and IL-2. Calcium 39-46 interferon gamma Homo sapiens 180-189 18779390-6 2008 IL-12 and IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was mediated by Janus kinase-signal transducers and activators of transcription (JAK-STAT)-dependent signaling without induction of calcium flux. Calcium 225-232 interferon gamma Homo sapiens 73-82 18541274-0 2008 Attenuation of interferon-gamma mRNA expression in activated Jurkat T cells by exogenous zinc via down-regulation of the calcium-independent PKC-AP-1 signaling pathway. Calcium 121-128 interferon gamma Homo sapiens 15-31 18541274-6 2008 These results suggest a novel target of zinc in the calcium-independent protein kinase C-AP-1 pathway to regulate endogenous IFN-gamma gene expression in activated T cells. Calcium 52-59 interferon gamma Homo sapiens 125-134