PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18180380-5 2008 Furthermore, using several established megakaryocyte-like cells lines, we performed promoter analysis of the CD154 gene and found that NFAT, a calcium-dependent transcriptional regulator associated with activated T cells, mediated both differentiation-dependent and inducible megakaryocyte-specific CD154 expression. Calcium 143-150 CD40 ligand Homo sapiens 109-114 20039299-2 2010 This study demonstrates that engagement of CD154 in Jurkat D1.1 cells with soluble CD40 leads to PKC alpha and delta activation, calcium mobilization, and phosphorylation of the Map kinases ERK1/2 and p38. Calcium 129-136 CD40 ligand Homo sapiens 43-48 19397878-3 2009 Blocking the interaction between CD40 and CD40L with CD40Ig, a fusion protein of CD40 and IgG, impaired proliferation of EBV-infected AGS cells and enhanced their calcium ionophore-induced apoptosis. Calcium 163-170 CD40 ligand Homo sapiens 42-47 16963006-5 2006 The dissection of TCR generated signals into calcium and PKC-dependent pathways demonstrates that calcium is sufficient to induce membrane CD40L yet insufficient for sCD40L. Calcium 98-105 CD40 ligand Homo sapiens 139-144 14645155-1 2003 Neonatal CD4(+) T cells express less CD154 protein and mRNA than adult CD4(+) T cells after activation by calcium ionophore and phorbol ester, but the mechanism for this reduced expression and its relevance to the primary immune response remain unclear. Calcium 106-113 CD40 ligand Homo sapiens 37-42 13680192-4 2004 Activated T cells (ATs) consisted of autologous peripheral blood lymphocytes that had been activated with phytohemagglutinin (PHA) and then stimulated with calcium ionophore to up-regulate expression of CD40L. Calcium 156-163 CD40 ligand Homo sapiens 203-208 14645155-5 2003 Decreased CD154 expression by neonatal cells after alphabeta TCR-CD3 engagement was paralleled by a lower free intracellular calcium concentration, a key event for CD154 gene transcription. Calcium 125-132 CD40 ligand Homo sapiens 10-15 14645155-5 2003 Decreased CD154 expression by neonatal cells after alphabeta TCR-CD3 engagement was paralleled by a lower free intracellular calcium concentration, a key event for CD154 gene transcription. Calcium 125-132 CD40 ligand Homo sapiens 164-169 12852836-1 2003 AIM: To investigate whether CD40-CD40 ligand interaction can activate diacylglycerol (DAG)-protein kinase C (PKC) signaling pathway and intracellular free calcium ([Ca2+]i) in cultured human peripheral blood monocytes (PBMC). Calcium 155-162 CD40 ligand Homo sapiens 33-44 12852836-0 2003 Effect of CD40-CD40 ligand interaction on diacylglycerol-protein kinase C signal transduction pathway and intracellular calcium in cultured human monocytes. Calcium 120-127 CD40 ligand Homo sapiens 15-26 12852836-12 2003 CONCLUSION: CD40-CD40 ligand interaction induced a robust stimulation of the DAG-PKC pathway and calcium mobilization from intracellular pool in PBMC. Calcium 97-104 CD40 ligand Homo sapiens 17-28 12234621-6 2002 Differential cAMP effects appear interrelated to calcium signaling since the level of CD40L induced by calcium ionophore was increased by cAMP in both cell subsets, although nai;ve cells were more calcium responsive. Calcium 49-56 CD40 ligand Homo sapiens 86-91 12234621-6 2002 Differential cAMP effects appear interrelated to calcium signaling since the level of CD40L induced by calcium ionophore was increased by cAMP in both cell subsets, although nai;ve cells were more calcium responsive. Calcium 103-110 CD40 ligand Homo sapiens 86-91 12234621-6 2002 Differential cAMP effects appear interrelated to calcium signaling since the level of CD40L induced by calcium ionophore was increased by cAMP in both cell subsets, although nai;ve cells were more calcium responsive. Calcium 103-110 CD40 ligand Homo sapiens 86-91 12234621-7 2002 Calcium-dependent calcineurin activity appeared necessary for CD40L expression, although no interaction of calcineurin and cAMP regulation was demonstrable. Calcium 0-7 CD40 ligand Homo sapiens 62-67 11588047-6 2001 Calcium signaling selectively antagonized IL-12 production by mature DCs activated with IFN-gamma, TNF-alpha, and soluble CD40L. Calcium 0-7 CD40 ligand Homo sapiens 122-127 11985663-10 2002 These data indicate that endothelial cell costimulation can interact with cAMP through calcium signalling pathways to synergistically enhance CD40L expression. Calcium 87-94 CD40 ligand Homo sapiens 142-147 8625977-2 1996 In contrast to the activation markers CD25 and CD71, a strong CD40L expression could be induced by calcium ionophore alone but not by phorbol 12-myristate 13-acetate (PMA). Calcium 99-106 CD40 ligand Homo sapiens 62-67 10510356-4 1999 Moreover, we demonstrate that CD154 mRNA is unstable, but can be stabilized by treatment with either phorbol esters or calcium ionophores. Calcium 119-126 CD40 ligand Homo sapiens 30-35 10087189-5 1999 In contrast, cAMP enhanced CD40L induced by CD2-mediated T cell activation or by calcium-dependent mechanisms. Calcium 81-88 CD40 ligand Homo sapiens 27-32 10087189-6 1999 While neither CD28 costimulation nor exogenous IL-2 or IL-4 prevented cAMP inhibition in TCR activated cells, addition of calcium ionophore to TCR activation prevented any inhibitory effects and caused cAMP to increase CD40L expression. Calcium 122-129 CD40 ligand Homo sapiens 219-224 7699321-4 1995 This surface expression does not require de novo protein synthesis and lasts for only 1-2 h. Preformed CD40 ligand (CD40L) was not detected in any CD4+ CD45RA+ T cells, but > 90% of all CD4+ T cells from the tonsil can be induced to express large amounts of CD40L on culture with phorbol myristate acetate and the calcium ionophore ionomycin. Calcium 317-324 CD40 ligand Homo sapiens 103-114 7542098-2 1995 CD40L expression in T cells is transient, requires activation of protein kinase C and a rise in intracellular calcium concentration ([Ca2+]i), and is inhibited by cyclosporin A (CsA). Calcium 110-117 CD40 ligand Homo sapiens 0-5 7699321-4 1995 This surface expression does not require de novo protein synthesis and lasts for only 1-2 h. Preformed CD40 ligand (CD40L) was not detected in any CD4+ CD45RA+ T cells, but > 90% of all CD4+ T cells from the tonsil can be induced to express large amounts of CD40L on culture with phorbol myristate acetate and the calcium ionophore ionomycin. Calcium 317-324 CD40 ligand Homo sapiens 116-121 32999825-7 2020 Mechanistically, protein mass spectrum analysis is performed and it is revealed that Chaperonin containing TCP1 subunit 2 (CCT2) enriches in UC-MSC-EVs, which regulates the calcium channels to affect Ca2+ influx and suppress CD154 synthesis in CD4+ T cells. Calcium 173-180 CD40 ligand Homo sapiens 225-230