PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7584011-9 1994 RET, a transmembrane receptor protein, has a large glycosylated extracellular domain containing clustered cysteine residues and calcium-binding motifs, a single hydrophobic transmembrane domain, and a cytoplasmic domain with tyrosine kinase catalytic activity. Calcium 128-135 ret proto-oncogene Homo sapiens 0-3 31392261-5 2019 Two key interaction points required for RET extracellular domain binding were observed: (i) the calcium-binding site in RET that contacts GFRalpha2 domain 3 and (ii) the RET cysteine-rich domain interaction with NRTN. Calcium 96-103 ret proto-oncogene Homo sapiens 40-43 2575183-3 1989 In the individual at risk for developing MEN IIa, annual screening should include measurement of the basal and stimulated plasma CT levels, and determination of plasma levels of calcium, PTH, and CEA. Calcium 178-185 ret proto-oncogene Homo sapiens 41-48 950371-10 1976 Calcium infusion combined with the measurement of serum iPTH levels may detect occult parathyroid hyperplasia in patients with MEN 2a, normocalcemia, and normal basal iPTH values. Calcium 0-7 ret proto-oncogene Homo sapiens 127-133 31392261-5 2019 Two key interaction points required for RET extracellular domain binding were observed: (i) the calcium-binding site in RET that contacts GFRalpha2 domain 3 and (ii) the RET cysteine-rich domain interaction with NRTN. Calcium 96-103 ret proto-oncogene Homo sapiens 120-123 31392261-5 2019 Two key interaction points required for RET extracellular domain binding were observed: (i) the calcium-binding site in RET that contacts GFRalpha2 domain 3 and (ii) the RET cysteine-rich domain interaction with NRTN. Calcium 96-103 ret proto-oncogene Homo sapiens 120-123 26950000-0 2016 Defects in the calcium-binding region drastically affect the cadherin-like domains of RET tyrosine kinase. Calcium 15-22 ret proto-oncogene Homo sapiens 86-89 26950000-3 2016 In this article, the functionally significant mutations in the RET CLD1-4 calcium-binding site which lead to HSCR, and depletion of calcium ions in the RET CLD1-4 calcium binding site, were investigated by molecular dynamics simulations--to understand the mechanistic action of the mutations or loss of calcium ions in altering the protein kinase structure, dynamics, and stability. Calcium 74-81 ret proto-oncogene Homo sapiens 63-66 26950000-3 2016 In this article, the functionally significant mutations in the RET CLD1-4 calcium-binding site which lead to HSCR, and depletion of calcium ions in the RET CLD1-4 calcium binding site, were investigated by molecular dynamics simulations--to understand the mechanistic action of the mutations or loss of calcium ions in altering the protein kinase structure, dynamics, and stability. Calcium 132-139 ret proto-oncogene Homo sapiens 152-155 26950000-3 2016 In this article, the functionally significant mutations in the RET CLD1-4 calcium-binding site which lead to HSCR, and depletion of calcium ions in the RET CLD1-4 calcium binding site, were investigated by molecular dynamics simulations--to understand the mechanistic action of the mutations or loss of calcium ions in altering the protein kinase structure, dynamics, and stability. Calcium 132-139 ret proto-oncogene Homo sapiens 152-155 26950000-3 2016 In this article, the functionally significant mutations in the RET CLD1-4 calcium-binding site which lead to HSCR, and depletion of calcium ions in the RET CLD1-4 calcium binding site, were investigated by molecular dynamics simulations--to understand the mechanistic action of the mutations or loss of calcium ions in altering the protein kinase structure, dynamics, and stability. Calcium 132-139 ret proto-oncogene Homo sapiens 152-155 22355350-3 2012 Here we report that the RET receptor induces calcium (Ca(2+)) signaling and regulates neocortical neuronal progenitor migration through the Phospholipase-C gamma (PLCgamma) binding domain Tyr1015. Calcium 45-52 ret proto-oncogene Homo sapiens 24-27 26950000-7 2016 Overall, the findings may provide useful structural insights into the molecular mechanism underlying RET calcium-binding site mutations and assist in development of novel drugs targeting the extracellular ligand contact site of wildtype RET. Calcium 105-112 ret proto-oncogene Homo sapiens 101-104 26950000-7 2016 Overall, the findings may provide useful structural insights into the molecular mechanism underlying RET calcium-binding site mutations and assist in development of novel drugs targeting the extracellular ligand contact site of wildtype RET. Calcium 105-112 ret proto-oncogene Homo sapiens 237-240 23547958-16 2013 CONCLUSIONS: Sporadic PHPT, MEN1- and MEN2A-related PHPT are three distinct entities as is reflected preoperatively by differences in gender, age at diagnosis and calcium and PTH levels. Calcium 163-170 ret proto-oncogene Homo sapiens 38-43 15157557-17 2004 Pentagastrin- or calcium-stimulated plasma CT testing is useful in identifying CCH or early MTC in carriers of RET mutations that are associated with late onset MTC. Calcium 17-24 ret proto-oncogene Homo sapiens 111-114 19169490-8 2008 In the present case, prompt sequential dosage of calcium, diagnosis of PHT, and genetic analysis would have resulted in pancreatitis prevention and early MEN2A management. Calcium 49-56 ret proto-oncogene Homo sapiens 154-159 17217081-2 2007 All seven TRPCs (TRPC1 through TRPC7) can be activated through Gq/11 receptors or receptor tyrosine kinase (RTK) by mechanisms downstream of phospholipase C. The last decade saw a rapidly growing interest in understanding the role of TRPC channels in calcium entry pathways as well as in understanding the signal(s) responsible for TRPC activation. Calcium 251-258 ret proto-oncogene Homo sapiens 82-106 17217081-2 2007 All seven TRPCs (TRPC1 through TRPC7) can be activated through Gq/11 receptors or receptor tyrosine kinase (RTK) by mechanisms downstream of phospholipase C. The last decade saw a rapidly growing interest in understanding the role of TRPC channels in calcium entry pathways as well as in understanding the signal(s) responsible for TRPC activation. Calcium 251-258 ret proto-oncogene Homo sapiens 108-111 16356097-1 2005 Primary hyperparathyroidism (PHP; serum calcium 2.75 mmol/L, PTH 226 pg/ml) had been the first clinical manifestation of MEN-2A in a female patient (aged 55 years) with a mutation (Y791F, TAT-->TTT) in exon 13 of the RET proto-oncogene. Calcium 40-47 ret proto-oncogene Homo sapiens 121-127 9467954-0 1998 Calcium-dependent Ret activation by GDNF and neurturin. Calcium 0-7 ret proto-oncogene Homo sapiens 18-21 11445581-0 2001 Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site. Calcium 128-135 ret proto-oncogene Homo sapiens 54-57 11445581-0 2001 Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site. Calcium 128-135 ret proto-oncogene Homo sapiens 58-82 9575150-0 1998 Expression of the receptor tyrosine kinase Ret on the plasma membrane is dependent on calcium. Calcium 86-93 ret proto-oncogene Homo sapiens 43-46 9575150-3 1998 Here we show that expression of p170(ret) is dependent on calcium. Calcium 58-65 ret proto-oncogene Homo sapiens 37-40 9575150-4 1998 Depletion of extracellular calcium completely blocks p170(ret) expression, which is not caused by a decrease in half-life of p170(ret) at the plasma membrane but by a defect in processing of p150(ret) into p170(ret). Calcium 27-34 ret proto-oncogene Homo sapiens 58-61 9575150-6 1998 We propose that a relatively high concentration of luminal calcium is necessary for the proper folding of Ret in the endoplasmic reticulum. Calcium 59-66 ret proto-oncogene Homo sapiens 106-109 9024637-4 1997 Besides activation by a specific ligand, a newly defined RTK function involves signal integration of a variety of stimuli, including calcium-dependent responses in neuronal cells, activation of G-protein-coupled receptors or cellular stress such as UV irradiation. Calcium 133-140 ret proto-oncogene Homo sapiens 57-60