PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24746261-1 2014 INTRODUCTION: In this work we compared the level, localization and binding partners of a calcium binding protein, S100A6, in extracellular matrix of Wharton"s jelly of healthy and preeclamptic patients. Calcium 89-96 S100 calcium binding protein A6 Homo sapiens 114-120 26646427-2 2015 We previously found the calcium-binding protein S100A6 was expressed in ~80% of the analyzed OS primary and/or metastatic tumor samples. Calcium 24-31 S100 calcium binding protein A6 Homo sapiens 48-54 25450463-1 2014 S100A6 is a calcium binding protein expressed in many types of epithelia including epidermis. Calcium 12-19 S100 calcium binding protein A6 Homo sapiens 0-6 25256682-1 2014 S100A6 is a calcium binding protein belonging to the S100 family. Calcium 12-19 S100 calcium binding protein A6 Homo sapiens 0-6 25256682-4 2014 The search for a potential target/receptor of S100A6 in the membrane fraction of WJMS cells allowed us to identify some proteins, among them integrin beta1, which interacts with S100A6 in a calcium dependent manner. Calcium 190-197 S100 calcium binding protein A6 Homo sapiens 46-52 25256682-4 2014 The search for a potential target/receptor of S100A6 in the membrane fraction of WJMS cells allowed us to identify some proteins, among them integrin beta1, which interacts with S100A6 in a calcium dependent manner. Calcium 190-197 S100 calcium binding protein A6 Homo sapiens 178-184 25488653-2 2015 Our data reveal a rich diversity of proteins that are dynamically modulated, and we selectively highlight a family of calcium binding proteins (S-100 molecules) including calcyclin (S100-A6), calgranulins A (S100-A8) and B (S100-A9), and calgizzarin (S100-A11). Calcium 118-125 S100 calcium binding protein A6 Homo sapiens 171-180 25488653-2 2015 Our data reveal a rich diversity of proteins that are dynamically modulated, and we selectively highlight a family of calcium binding proteins (S-100 molecules) including calcyclin (S100-A6), calgranulins A (S100-A8) and B (S100-A9), and calgizzarin (S100-A11). Calcium 118-125 S100 calcium binding protein A6 Homo sapiens 182-189 23796514-1 2013 S100A6 is a calcium binding protein that, like some other members of the S100 protein family, is able to bind p53. Calcium 12-19 S100 calcium binding protein A6 Homo sapiens 0-6 23095053-4 2012 Analysis of total endothelial mRNAs using a human gene chip array revealed significant gene expression of the S100 calcium-binding protein family members S100A6, S100A10, S100A11 and S100A13. Calcium 115-122 S100 calcium binding protein A6 Homo sapiens 154-160 23537648-1 2013 S100A6 is involved in several vital biological functions, such as calcium sensing and cell proliferation. Calcium 66-73 S100 calcium binding protein A6 Homo sapiens 0-6 23076148-0 2012 S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation. Calcium 35-42 S100 calcium binding protein A6 Homo sapiens 0-6 23076148-1 2012 S100A6 is a small EF-hand calcium- and zinc-binding protein involved in the regulation of cell proliferation and cytoskeletal dynamics. Calcium 26-33 S100 calcium binding protein A6 Homo sapiens 0-6 21923636-1 2012 S100A6, a calcium-binding protein also known as calcyclin, was detected in human umbilical cord by immunoblotting. Calcium 10-17 S100 calcium binding protein A6 Homo sapiens 0-6 22560296-1 2012 In this paper we document an increased expression of S100A6, a calcium binding protein of the S100 family, and its co-localization with beta-catenin in colorectal cancer tissues and in metastatic, SW620, versus non-metastatic, SW480, human colorectal cancer cell lines. Calcium 63-70 S100 calcium binding protein A6 Homo sapiens 53-59 21923636-1 2012 S100A6, a calcium-binding protein also known as calcyclin, was detected in human umbilical cord by immunoblotting. Calcium 10-17 S100 calcium binding protein A6 Homo sapiens 48-57 19712129-1 2009 S100A6 is a calcium-binding protein implicated in many cellular processes and frequently upregulated in cancer. Calcium 12-19 S100 calcium binding protein A6 Homo sapiens 0-6 20213445-2 2011 Later, it was found that Sgt1 is present in plant and mammalian organisms and that it binds other ligands such as S100A6, a calcium-binding protein. Calcium 124-131 S100 calcium binding protein A6 Homo sapiens 114-120 21132840-6 2011 These systems, the folding of Protein A and of Protein G, the conformational changes in the calcium sensor S100A6, the glucose-galactose-binding protein, maltodextrin, and lactoferrin, are also compared against other approaches that have been suggested in the literature. Calcium 92-99 S100 calcium binding protein A6 Homo sapiens 107-113 19536568-8 2009 The structural differences resulting upon calcium binding change the global shape and the distribution of hydrophobic and charged residues of the S100A5 homodimer in a modest but significantly different manner with respect to the closest homologues S100A4 and S100A6. Calcium 42-49 S100 calcium binding protein A6 Homo sapiens 260-266 18765292-4 2009 Here, we report, based on affinity chromatography and co-immunoprecipitation results that S100A6 interacts with p53 in the presence of calcium ions. Calcium 135-142 S100 calcium binding protein A6 Homo sapiens 90-96 18620780-1 2009 BACKGROUND: In a previously published in vitro study based on top-down proteomics we found that the calcium-binding proteins S100A6 and S100A4 were affected by exposure to ionizing radiation in a p53-dependent fashion. Calcium 100-107 S100 calcium binding protein A6 Homo sapiens 125-131 17495951-1 2007 S100A6 (calcyclin) is a calcium-binding protein of cell-specific expression whose gene is clustered with other S100 genes within the epidermal differentiation complex, on human chromosome 1q21. Calcium 24-31 S100 calcium binding protein A6 Homo sapiens 0-6 20093725-1 2009 Three-dimensional structures of S100B, S100A1, S100A6 and S100A11 have shown that calcium binding to these proteins results in a conformational change allowing them to interact with many biological targets. Calcium 82-89 S100 calcium binding protein A6 Homo sapiens 47-53 17970874-1 2007 OBJECTIVE: The expression of S100A6 (calcyclin), a member of the S100 calcium binding protein family, is elevated in a number of malignant tumors, but there have been few reports about its expression in gastric cancer. Calcium 70-77 S100 calcium binding protein A6 Homo sapiens 29-35 17970874-1 2007 OBJECTIVE: The expression of S100A6 (calcyclin), a member of the S100 calcium binding protein family, is elevated in a number of malignant tumors, but there have been few reports about its expression in gastric cancer. Calcium 70-77 S100 calcium binding protein A6 Homo sapiens 37-46 18201235-1 2008 BACKGROUND: S100A6, a calcium-binding protein in the S100 family, has been observed in melanocytic nevi, neural tumors, fibrohistiocytic tumors and is overexpressed in melanoma. Calcium 22-29 S100 calcium binding protein A6 Homo sapiens 12-18 17721932-5 2008 In exogenously S100A6 induced Hep3B cells, cell viability was significantly decreased compared with mock and S100A6-knockdown cells under calcium ionophore A23187 treatment. Calcium 138-145 S100 calcium binding protein A6 Homo sapiens 15-21 17721932-5 2008 In exogenously S100A6 induced Hep3B cells, cell viability was significantly decreased compared with mock and S100A6-knockdown cells under calcium ionophore A23187 treatment. Calcium 138-145 S100 calcium binding protein A6 Homo sapiens 109-115 17495951-1 2007 S100A6 (calcyclin) is a calcium-binding protein of cell-specific expression whose gene is clustered with other S100 genes within the epidermal differentiation complex, on human chromosome 1q21. Calcium 24-31 S100 calcium binding protein A6 Homo sapiens 8-17 17466273-4 2007 Overexpression of S100A6, a calcium binding protein that interacts with the C-terminal part of Sgt1, decreased the amount of chaperone bound to Sgt1. Calcium 28-35 S100 calcium binding protein A6 Homo sapiens 18-24 12859951-1 2003 S100A6 (calcyclin) is an acidic calcium binding protein with two EF-hand motifs and overexpressed in several tumors including intrahepatic carcinoma. Calcium 32-39 S100 calcium binding protein A6 Homo sapiens 0-6 16288473-1 2006 S100A6 (calcyclin) is a small calcium-binding protein of the S100 family often associated with cancer and metastasis. Calcium 30-37 S100 calcium binding protein A6 Homo sapiens 0-6 16288473-1 2006 S100A6 (calcyclin) is a small calcium-binding protein of the S100 family often associated with cancer and metastasis. Calcium 30-37 S100 calcium binding protein A6 Homo sapiens 8-17 16015609-0 2005 Promoter hyper-methylation of calcium binding proteins S100A6 and S100A2 in human prostate cancer. Calcium 30-37 S100 calcium binding protein A6 Homo sapiens 55-72 16015609-1 2005 BACKGROUND: S100A6 and S100A2 are members of the S100 family of calcium binding proteins, which are down regulated in prostate cancer, however the molecular mechanism(s) underlying their loss of expression is unknown. Calcium 64-71 S100 calcium binding protein A6 Homo sapiens 12-29 16912968-4 2006 With this combined approach we were able to detect nine calcium-dependent interactions between Arg-Gly-Ser-(RGS)-His6 tagged proteins derived from the library and GST-tagged S100B and S100A6, respectively. Calcium 56-63 S100 calcium binding protein A6 Homo sapiens 184-190 16733908-8 2006 Sequencing results and homology analysis demonstrated that the two positive clones were significantly homologous with the genes of autotaxin-t and calcium binding protein calcyclin (S100A6), respectively. Calcium 147-154 S100 calcium binding protein A6 Homo sapiens 171-180 16733908-8 2006 Sequencing results and homology analysis demonstrated that the two positive clones were significantly homologous with the genes of autotaxin-t and calcium binding protein calcyclin (S100A6), respectively. Calcium 147-154 S100 calcium binding protein A6 Homo sapiens 182-188 12859951-1 2003 S100A6 (calcyclin) is an acidic calcium binding protein with two EF-hand motifs and overexpressed in several tumors including intrahepatic carcinoma. Calcium 32-39 S100 calcium binding protein A6 Homo sapiens 8-17 12577318-1 2003 Calcyclin (S100A6) is a member of the S100A family of calcium binding proteins. Calcium 54-61 S100 calcium binding protein A6 Homo sapiens 11-17 12577318-1 2003 Calcyclin (S100A6) is a member of the S100A family of calcium binding proteins. Calcium 54-61 S100 calcium binding protein A6 Homo sapiens 0-9 12577318-7 2003 These observations suggest a role for calcyclin in modulating calcium dependent signaling events that regulate progression through the cell cycle. Calcium 62-69 S100 calcium binding protein A6 Homo sapiens 38-47 11937060-0 2002 Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. Calcium 77-84 S100 calcium binding protein A6 Homo sapiens 22-28 12379109-6 2002 In the typical EF-hand, the position of helix 3 is similar to that of another member of the S100 protein family, calcyclin (S100A6), and less like that of other S100 family members for which three-dimensional structures are available in the calcium-free state (e.g., S100B and S100A1). Calcium 241-248 S100 calcium binding protein A6 Homo sapiens 113-122 12379109-6 2002 In the typical EF-hand, the position of helix 3 is similar to that of another member of the S100 protein family, calcyclin (S100A6), and less like that of other S100 family members for which three-dimensional structures are available in the calcium-free state (e.g., S100B and S100A1). Calcium 241-248 S100 calcium binding protein A6 Homo sapiens 124-130 11401666-1 2001 BACKGROUND: S100A6, an S100 calcium-binding protein, has been found in a variety of cutaneous and extracutaneous lesions including: melanocytic nevi, melanoma, some salivary gland and epithelial tumors, and malignant fibrous histiocytoma (MFH). Calcium 28-35 S100 calcium binding protein A6 Homo sapiens 12-18 10913138-0 2000 S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. Calcium 47-54 S100 calcium binding protein A6 Homo sapiens 0-6 11118618-1 2000 Calcyclin (S100A6) is a calcium-binding protein overexpressed in several tumor cell lines including melanoma with high metastatic activity. Calcium 24-31 S100 calcium binding protein A6 Homo sapiens 0-9 11118618-1 2000 Calcyclin (S100A6) is a calcium-binding protein overexpressed in several tumor cell lines including melanoma with high metastatic activity. Calcium 24-31 S100 calcium binding protein A6 Homo sapiens 11-17 10885611-1 2000 The expression of calcium-binding protein S100A6 was investigated in normal colon tissue, in colon adenomas and in colorectal carcinomas. Calcium 18-25 S100 calcium binding protein A6 Homo sapiens 42-48 9578461-1 1998 Calcyclin (CaCY) is a member of the S100 subfamily of helix-loop-helix (EF-hand) calcium-binding proteins. Calcium 81-88 S100 calcium binding protein A6 Homo sapiens 0-9 10612291-4 1999 Conversely, the expression of a novel variant of heat shock protein70 and several members of the S100 protein family of calcium-binding proteins (two isoforms of S100A9, S100A8, S100A11 and S100A6) were upregulated in transformed colon mucosa. Calcium 120-127 S100 calcium binding protein A6 Homo sapiens 190-196 9578461-1 1998 Calcyclin (CaCY) is a member of the S100 subfamily of helix-loop-helix (EF-hand) calcium-binding proteins. Calcium 81-88 S100 calcium binding protein A6 Homo sapiens 11-15 7552735-1 1995 The structure of the apo form of calcyclin, a member of the S100 family of calcium-binding proteins, reveals a novel dimer fold that may reflect the presence of a new interface for target protein recognition. Calcium 75-82 S100 calcium binding protein A6 Homo sapiens 33-42 7552751-4 1995 Dimerization is mediated by hydrophobic contacts from several highly conserved residues, which suggests that the dimer fold identified for calcyclin will serve as a structural paradigm for the S100 subfamily of calcium-binding proteins. Calcium 211-218 S100 calcium binding protein A6 Homo sapiens 139-148 8204608-0 1994 Purification and characterization of the recombinant human calcium-binding S100 proteins CAPL and CACY. Calcium 59-66 S100 calcium binding protein A6 Homo sapiens 98-102 1467312-1 1992 Calcyclin is a member of the S-100 family of calcium-binding proteins, whose expression is enhanced when quiescent cells are exposed to mitogenic signals. Calcium 45-52 S100 calcium binding protein A6 Homo sapiens 0-9 8499593-2 1993 Calcyclin was identified in brain soluble proteins that were bound to phenyl-sepharose in a calcium dependent fashion. Calcium 92-99 S100 calcium binding protein A6 Homo sapiens 0-9 1467312-2 1992 The function of calcyclin is unknown, but it is thought to be involved in modulating the intracellular calcium concentration following mitogenic stimuli. Calcium 103-110 S100 calcium binding protein A6 Homo sapiens 16-25 3405210-7 1988 They belong to a novel subfamily of highly homologous calcium-binding proteins which includes S100 alpha, S100 beta, intestinal calcium-binding protein, P11, and calcyclin (2A9). Calcium 54-61 S100 calcium binding protein A6 Homo sapiens 162-171 1384693-0 1992 S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. Calcium 79-86 S100 calcium binding protein A6 Homo sapiens 22-26 1737392-7 1992 These findings show that expression of calcyclin is related to metastasis of human melanoma cell lines in nude mice and emphasize the role of this family of calcium-binding proteins in neoplastic progression as was reported for the mouse homologue of calcyclin and other members of the same family. Calcium 157-164 S100 calcium binding protein A6 Homo sapiens 39-48 34008212-1 2021 S100 calcium binding protein A6 (S100A6) has been reported to involve in many kinds of cancers through regulating intracellular calcium homeostasis. Calcium 5-12 S100 calcium binding protein A6 Homo sapiens 33-39 34012513-7 2021 We identified linear and circular transcripts of the S100 Calcium Binding Protein 6 (S100A6) and translocation associated membrane protein 1 (TRAM1) as highly promising potential tumor markers. Calcium 58-65 S100 calcium binding protein A6 Homo sapiens 85-91 32555370-7 2020 We showed that S100A6 regulates intracellular and mitochondria calcium buffering of HSC upon cytokine stimulation and have demonstrated that Akt activator SC79 reverts the levels of intracellular and mitochondrial calcium in HSC. Calcium 63-70 S100 calcium binding protein A6 Homo sapiens 15-21 32555370-7 2020 We showed that S100A6 regulates intracellular and mitochondria calcium buffering of HSC upon cytokine stimulation and have demonstrated that Akt activator SC79 reverts the levels of intracellular and mitochondrial calcium in HSC. Calcium 214-221 S100 calcium binding protein A6 Homo sapiens 15-21 31916625-0 2020 S100A6 is a positive regulator of PPP5C-FKBP51-dependent regulation of endothelial calcium signaling. Calcium 83-90 S100 calcium binding protein A6 Homo sapiens 0-6 33335992-1 2020 Purpose: S100A6 protein (calcyclin), a small calcium-binding protein of the S100 family, is often upregulated in various types of cancers, including hepatocellular carcinoma (HCC). Calcium 45-52 S100 calcium binding protein A6 Homo sapiens 9-15 33335992-1 2020 Purpose: S100A6 protein (calcyclin), a small calcium-binding protein of the S100 family, is often upregulated in various types of cancers, including hepatocellular carcinoma (HCC). Calcium 45-52 S100 calcium binding protein A6 Homo sapiens 25-34 31916625-6 2020 One of these family members, S100A6, exhibits a calcium-dependent translocation to the plasma membrane. Calcium 48-55 S100 calcium binding protein A6 Homo sapiens 29-35 31916625-10 2020 Global calcium entry and ISOC are decreased by S100A6 in a PPP5C-dependent manner and by FKBP51 in a S100A6-dependent manner. Calcium 7-14 S100 calcium binding protein A6 Homo sapiens 47-53 31916625-10 2020 Global calcium entry and ISOC are decreased by S100A6 in a PPP5C-dependent manner and by FKBP51 in a S100A6-dependent manner. Calcium 7-14 S100 calcium binding protein A6 Homo sapiens 101-107 31916625-11 2020 Further, calcium entry-induced endothelial barrier disruption is decreased by S100A6 dependent upon PPP5C, and by FKBP51 dependent upon S100A6. Calcium 9-16 S100 calcium binding protein A6 Homo sapiens 78-84 31916625-11 2020 Further, calcium entry-induced endothelial barrier disruption is decreased by S100A6 dependent upon PPP5C, and by FKBP51 dependent upon S100A6. Calcium 9-16 S100 calcium binding protein A6 Homo sapiens 136-142 31916625-12 2020 Overall, these data reveal that S100A6 plays a key role in the PPP5C-FKBP51 axis to inhibit ISOC and protect the endothelial barrier against calcium entry-induced disruption. Calcium 141-148 S100 calcium binding protein A6 Homo sapiens 32-38 27709523-1 2016 BACKGROUND: Elevated expression levels of S100A6, a calcium-binding low-molecular-weight protein, were demonstrated in various malignancies. Calcium 52-59 S100 calcium binding protein A6 Homo sapiens 42-48 30656909-1 2018 S100A6, a calcium binding protein, whose gene was first identified as growth inducible one, has been linked to the process of cell proliferation and growth related phenomena ever since. Calcium 10-17 S100 calcium binding protein A6 Homo sapiens 0-6 29020611-1 2018 S100A6 is a calcium binding protein expressed mainly in fibroblasts and epithelial cells. Calcium 12-19 S100 calcium binding protein A6 Homo sapiens 0-6 30805941-2 2019 S100A6 is a small calcium-binding protein, characteristic mainly of epithelial cells and fibroblasts, strongly implicated in cell proliferation and upregulated in tumors. Calcium 18-25 S100 calcium binding protein A6 Homo sapiens 0-6 26361956-2 2016 Recent studies have demonstrated a link involving S100 Calcium Binding Proteins (S100A2, S100A6) and non-small cell lung cancer (NSCLC), but the expediency of their serum levels in NSCLC has not been established. Calcium 55-62 S100 calcium binding protein A6 Homo sapiens 89-95