PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17160145-5 2006 Moreover, an apoptotic pathway, via an intracellular calcium increase following calpain activation and cdk5/p25 formation, has been postulated. Calcium 53-60 cyclin dependent kinase 5 Homo sapiens 103-107 18289510-3 2008 The cleavage of p35 to p25, mediated by calpain and calcium, caused CDK5 dislocation and subsequently p25/CDK5-induced tau hyperphosphorylation, which disrupted the cytoskeleton and resulted in neuronal death. Calcium 52-59 cyclin dependent kinase 5 Homo sapiens 68-72 18289510-3 2008 The cleavage of p35 to p25, mediated by calpain and calcium, caused CDK5 dislocation and subsequently p25/CDK5-induced tau hyperphosphorylation, which disrupted the cytoskeleton and resulted in neuronal death. Calcium 52-59 cyclin dependent kinase 5 Homo sapiens 106-110 12572681-10 2003 This effects on tau phosphorylation patterns seems to be a consequence of a decrease in the Cdk5/p25 complex activity that appears to result from a depletion of the activator p25, a mechanism in which calcium transients could be implicated. Calcium 201-208 cyclin dependent kinase 5 Homo sapiens 92-96 34790098-0 2021 Targeting CDK5 in Astrocytes Promotes Calcium Homeostasis Under Excitotoxic Conditions. Calcium 38-45 cyclin dependent kinase 5 Homo sapiens 10-14 12223541-0 2002 The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. Calcium 157-164 cyclin dependent kinase 5 Homo sapiens 4-29 12223541-7 2002 The association of CaMKIIalpha and alpha-actinin-1 to the Cdk5 activators, as well as to each other, is stimulated by calcium. Calcium 118-125 cyclin dependent kinase 5 Homo sapiens 58-62 34790098-1 2021 Glutamate excitotoxicity triggers overactivation of CDK5 and increases calcium influx in neural cells, which promotes dendritic retraction, spine loss, increased mitochondrial calcium from the endoplasmic reticulum, and neuronal death. Calcium 176-183 cyclin dependent kinase 5 Homo sapiens 52-56 34790098-3 2021 However, how CDK5-targeted astrocytes affect calcium regulation and whether this phenomenon is associated with changes in neuronal plasticity have not yet been analyzed. Calcium 45-52 cyclin dependent kinase 5 Homo sapiens 13-17 34790098-4 2021 In this study, CDK5 KD astrocytes transplanted in CA3 remained at the injection site without proliferation, regulated calcium in the CA1 hippocampal region after excitotoxicity by glutamate in ex vivo hippocampal slices, improving synapsin and PSD95 clustering. Calcium 118-125 cyclin dependent kinase 5 Homo sapiens 15-19 34790098-6 2021 Also, these effects were supported by CDK5 inhibition (CDK5i) in vitro through intracellular stabilization of calcium levels in astrocytes. Calcium 110-117 cyclin dependent kinase 5 Homo sapiens 38-42 34790098-8 2021 In summary, induction of calcium homeostasis at the CA1 hippocampal area by CDK5 KD astrocytes transplanted in the CA3 area highlights the role of astrocytes as a cell therapy target due to CDK5-KD astrocyte-mediated synaptic clustering, calcium spreading regulation between both areas, and recovery of the intracellular astrocyte-neuron calcium imbalance and plasticity impairment generated by glutamate excitotoxicity. Calcium 25-32 cyclin dependent kinase 5 Homo sapiens 76-80 35318705-6 2022 We find that this mechanism involves Calpain 2-mediated hyperactivation of Cdk5 downstream of receptor- and activity-dependent calcium influx. Calcium 127-134 cyclin dependent kinase 5 Homo sapiens 75-79 27651795-0 2016 Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells. Calcium 80-87 cyclin dependent kinase 5 Homo sapiens 52-56 32773603-10 2020 We focus on Cdk5-substrates that have been linked to nociceptive pathways, including channels (e.g., transient receptor potential cation channel, voltage-gated calcium channel), proteins involved in neurotransmitter release (e.g., synaptophysin, collapsin response mediator protein 2), and receptors (e.g., glutamate, purinergic, and opioid). Calcium 160-167 cyclin dependent kinase 5 Homo sapiens 12-16 27651795-0 2016 Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells. Calcium 80-87 cyclin dependent kinase 5 Homo sapiens 96-100 25760044-6 2015 For this manuscript we review evidence showing that Tat, via calcium dysregulation, promotes calpain-1 cleavage of p35 to p25, which in turn hyper-activates CDK5 resulting in abnormal phosphorylation of downstream targets such as Tau, collapsin response mediator protein-2 [CRMP2], doublecortin [DCX] and MEF2. Calcium 61-68 cyclin dependent kinase 5 Homo sapiens 157-161 24822036-2 2014 p25 is a calcium-dependent degradation product of p35, the principal activator of cyclin-dependent kinase 5 (Cdk5). Calcium 9-16 cyclin dependent kinase 5 Homo sapiens 82-107 24822036-2 2014 p25 is a calcium-dependent degradation product of p35, the principal activator of cyclin-dependent kinase 5 (Cdk5). Calcium 9-16 cyclin dependent kinase 5 Homo sapiens 109-113 23401660-12 2013 Inhibiting Cdk5 activity in HCLE or suppressing Cdk5 expression in a stable HCLE-derived cell line (ShHCLE) decreased calcium-dependent cell adhesion, promoted the cytoplasmic localization of E-cadherin, and accelerated the loss of surface-biotinylated E-cadherin. Calcium 118-125 cyclin dependent kinase 5 Homo sapiens 11-15 23401660-12 2013 Inhibiting Cdk5 activity in HCLE or suppressing Cdk5 expression in a stable HCLE-derived cell line (ShHCLE) decreased calcium-dependent cell adhesion, promoted the cytoplasmic localization of E-cadherin, and accelerated the loss of surface-biotinylated E-cadherin. Calcium 118-125 cyclin dependent kinase 5 Homo sapiens 48-52 21740229-6 2011 Hyperactivation of Cdk5 due to the conversion of p35 to p25 by the calcium-dependent protease calpain during neurotoxicity also contributes to the pathological state. Calcium 67-74 cyclin dependent kinase 5 Homo sapiens 19-23 20506302-6 2011 Using selective pharmacological tools, we showed that enhanced intracellular calcium lead to cyclin-dependent kinase 5 (cdk5) activation, by calpain proteolysis of p35 to p25, as well as glycogen synthase kinase 3beta (GSK3beta) activation, by its phosphorylation at tyrosine 216. Calcium 77-84 cyclin dependent kinase 5 Homo sapiens 93-118 20506302-6 2011 Using selective pharmacological tools, we showed that enhanced intracellular calcium lead to cyclin-dependent kinase 5 (cdk5) activation, by calpain proteolysis of p35 to p25, as well as glycogen synthase kinase 3beta (GSK3beta) activation, by its phosphorylation at tyrosine 216. Calcium 77-84 cyclin dependent kinase 5 Homo sapiens 120-124 19741129-6 2009 We further demonstrate that statins block calcium-dependent calpain activation, resulting in complete suppression of protein truncation events on multiple calpain substrates that are involved in neuronal death including CDK5 coactivator p35 cleavage to p25, GSK3 and beta-catenin. Calcium 42-49 cyclin dependent kinase 5 Homo sapiens 220-224 19591849-5 2009 We demonstrate, using pharmacological tools, that PKA activation causes increase of calcium levels, leading to cyclin-dependent kinase 5 activation by calpain proteolysis of p35 to p25 and glycogen synthase kinase 3beta activation by its phosphorylation at tyrosine 216. Calcium 84-91 cyclin dependent kinase 5 Homo sapiens 111-136 23968646-4 2013 This study demonstrates that this condition medium from astrocytes elevates calcium level in the neurons, which subsequently increases calpain activity, a calcium-dependent protease, leading to enhance p25/Cdk5 activity and phosphorylation and activation of the STAT3 (signal transducer and activator of transcription) transcription factor. Calcium 76-83 cyclin dependent kinase 5 Homo sapiens 206-210 23968646-4 2013 This study demonstrates that this condition medium from astrocytes elevates calcium level in the neurons, which subsequently increases calpain activity, a calcium-dependent protease, leading to enhance p25/Cdk5 activity and phosphorylation and activation of the STAT3 (signal transducer and activator of transcription) transcription factor. Calcium 155-162 cyclin dependent kinase 5 Homo sapiens 206-210