PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29793020-0 2018 EphA2 stimulates VCAM-1 expression through calcium-dependent NFAT1 activity. Calcium 43-50 vascular cell adhesion molecule 1 Homo sapiens 17-23 29857167-3 2018 Vascular cell adhesion molecule-1 is a calcium independent transmembrane glycoprotein. Calcium 39-46 vascular cell adhesion molecule 1 Homo sapiens 0-33 29793020-8 2018 Consistent with robust NFAT activation, ephrin-A1-induced an EphA2-dependent calcium influx in endothelial cells that was required for ephrin-A1-induced NFAT activation and VCAM-1 expression. Calcium 77-84 vascular cell adhesion molecule 1 Homo sapiens 173-179 28583863-5 2017 Knocking-down VCAM-1 by siRNA abolished calcium-induced monocytes adhesion on HUVECs. Calcium 40-47 vascular cell adhesion molecule 1 Homo sapiens 14-20 28583863-6 2017 Follow up mechanistic investigations identified that extracellular Ca2+-increased calcium influx contributed to the activation of VCAM-1. Calcium 82-89 vascular cell adhesion molecule 1 Homo sapiens 130-136 22970700-0 2012 Distinct sites within the vascular cell adhesion molecule-1 (VCAM-1) cytoplasmic domain regulate VCAM-1 activation of calcium fluxes versus Rac1 during leukocyte transendothelial migration. Calcium 118-125 vascular cell adhesion molecule 1 Homo sapiens 26-59 22970700-0 2012 Distinct sites within the vascular cell adhesion molecule-1 (VCAM-1) cytoplasmic domain regulate VCAM-1 activation of calcium fluxes versus Rac1 during leukocyte transendothelial migration. Calcium 118-125 vascular cell adhesion molecule 1 Homo sapiens 61-67 22970700-0 2012 Distinct sites within the vascular cell adhesion molecule-1 (VCAM-1) cytoplasmic domain regulate VCAM-1 activation of calcium fluxes versus Rac1 during leukocyte transendothelial migration. Calcium 118-125 vascular cell adhesion molecule 1 Homo sapiens 97-103 22970700-2 2012 Binding of leukocytes to vascular cell adhesion molecule-1 (VCAM-1) activates signals in endothelial cells, including Rac1 and calcium fluxes. Calcium 127-134 vascular cell adhesion molecule 1 Homo sapiens 25-58 22970700-2 2012 Binding of leukocytes to vascular cell adhesion molecule-1 (VCAM-1) activates signals in endothelial cells, including Rac1 and calcium fluxes. Calcium 127-134 vascular cell adhesion molecule 1 Homo sapiens 60-66 22970700-8 2012 S728 and Y729, but not S730 or S737, were necessary for VCAM-1 activation of calcium fluxes. Calcium 77-84 vascular cell adhesion molecule 1 Homo sapiens 56-62 22970700-11 2012 Together, these data indicate that S728 and Y729, and S730 and S737, are distinct functional sites that coordinate VCAM-1 activation of calcium fluxes and Rac1 during leukocyte transendothelial migration. Calcium 136-143 vascular cell adhesion molecule 1 Homo sapiens 115-121 19542230-4 2009 Specifically, we show that CpG/SR-B1 triggers calcium entry into primary B lymphocytes via phospholipase C gamma-1-mediated activation of TRPC3 channels and also B cell adhesion to vascular cell adhesion molecule-1. Calcium 46-53 vascular cell adhesion molecule 1 Homo sapiens 181-214 19005408-10 2008 CONCLUSION: An extracellular calcium-dependent H2O2 pathway is the critical mediator of VCAM-1 expression by pancreatic islets and beta-cells. Calcium 29-36 vascular cell adhesion molecule 1 Homo sapiens 88-94 16960156-3 2007 The up-regulation of soluble LDV peptide or vascular cell adhesion molecule-1 (VCAM-1) binding by these stimuli was critically dependent on activation of phospholipase C (PLC), inositol 1,4,5-triphosphate receptors, increased intracellular calcium, influx of extracellular calcium, and calmodulin, suggesting that this signaling pathway is required for alpha4 integrins to assume a high-affinity conformation. Calcium 240-247 vascular cell adhesion molecule 1 Homo sapiens 44-77 16960156-3 2007 The up-regulation of soluble LDV peptide or vascular cell adhesion molecule-1 (VCAM-1) binding by these stimuli was critically dependent on activation of phospholipase C (PLC), inositol 1,4,5-triphosphate receptors, increased intracellular calcium, influx of extracellular calcium, and calmodulin, suggesting that this signaling pathway is required for alpha4 integrins to assume a high-affinity conformation. Calcium 240-247 vascular cell adhesion molecule 1 Homo sapiens 79-85 16960156-3 2007 The up-regulation of soluble LDV peptide or vascular cell adhesion molecule-1 (VCAM-1) binding by these stimuli was critically dependent on activation of phospholipase C (PLC), inositol 1,4,5-triphosphate receptors, increased intracellular calcium, influx of extracellular calcium, and calmodulin, suggesting that this signaling pathway is required for alpha4 integrins to assume a high-affinity conformation. Calcium 273-280 vascular cell adhesion molecule 1 Homo sapiens 44-77 16960156-3 2007 The up-regulation of soluble LDV peptide or vascular cell adhesion molecule-1 (VCAM-1) binding by these stimuli was critically dependent on activation of phospholipase C (PLC), inositol 1,4,5-triphosphate receptors, increased intracellular calcium, influx of extracellular calcium, and calmodulin, suggesting that this signaling pathway is required for alpha4 integrins to assume a high-affinity conformation. Calcium 273-280 vascular cell adhesion molecule 1 Homo sapiens 79-85 12714597-6 2003 The effect of UTP on VCAM-1 expression in HCAEC was prevented by depletion of intracellular calcium stores with thapsigargin or by inhibition of p38 mitogen-activated protein kinase or Rho kinase, but was not affected by inhibitors of the mitogen-activated protein/extracellular signal-regulated kinase pathway (i.e. MEK1/2). Calcium 92-99 vascular cell adhesion molecule 1 Homo sapiens 21-27 16088429-7 2005 The effect of L-VCAM-1 binding to HEC on intracellular calcium ([Ca(2+)](i)) and distribution of actin was determined by fluorimetry and fluorescence microscopy. Calcium 55-62 vascular cell adhesion molecule 1 Homo sapiens 14-22 15643983-5 2005 Monocyte contact with porcine but not human endothelium leads to an endothelial calcium transient mediated via a G-protein-coupled receptor (GPCR) that results in up-regulation of porcine VCAM-1 and E-selectin. Calcium 80-87 vascular cell adhesion molecule 1 Homo sapiens 188-194 9837867-9 1998 In summary, we have identified a calcium-dependent interaction of Lp(a) with HCAEC capable of inducing potent surface expression of VCAM-1 and E-selectin that does not appear to involve any of the known potential Lp(a) binding sites. Calcium 33-40 vascular cell adhesion molecule 1 Homo sapiens 132-138 10913015-2 2000 We determined whether the VCAM-1-induced hyperpolarization is sufficient to augment the increase in intracellular free calcium ([Ca(2+)](i)) produced by Ca(2+) store depletion with thapsigargin (TG) and readdition of external CaCl(2) in fura 2-loaded THP-1 monocytes. Calcium 119-126 vascular cell adhesion molecule 1 Homo sapiens 26-32 9486977-3 1998 In this study we report for the first time that native LDL (n-LDL) binding to the LDL receptor (100-700 mug/ml) triggers a rise in intracellular calcium which acts as a second messenger to induce vascular cell adhesion molecule-1 (VCAM-1) expression in human coronary artery (HCAEC) and pig aortic endothelial cells (PAEC) and VCAM-1 and E-selectin expression in human aortic (HAEC) endothelial cells. Calcium 145-152 vascular cell adhesion molecule 1 Homo sapiens 196-229 9486977-0 1998 Native low density lipoprotein-induced calcium transients trigger VCAM-1 and E-selectin expression in cultured human vascular endothelial cells. Calcium 39-46 vascular cell adhesion molecule 1 Homo sapiens 66-72 9486977-3 1998 In this study we report for the first time that native LDL (n-LDL) binding to the LDL receptor (100-700 mug/ml) triggers a rise in intracellular calcium which acts as a second messenger to induce vascular cell adhesion molecule-1 (VCAM-1) expression in human coronary artery (HCAEC) and pig aortic endothelial cells (PAEC) and VCAM-1 and E-selectin expression in human aortic (HAEC) endothelial cells. Calcium 145-152 vascular cell adhesion molecule 1 Homo sapiens 231-237 9486977-6 1998 The increase in VCAM-1 by n-LDL results in increased monocyte binding to HCAEC which can be attenuated by inhibiting the intracellular calcium rise or by blocking the VCAM-1 binding sites. Calcium 135-142 vascular cell adhesion molecule 1 Homo sapiens 16-22 9212737-2 1997 A rapid and calcium-dependent activation of native (unstimulated) xenogenic endothelial cells by human neutrophils leads to 1) translocation of P-selectin from the Wiebel-Palade bodies to the surface of xenogeneic endothelial cells, 2) increased synthesis and expression of vascular cell adhesion molecule-1 on the xenogeneic endothelial cells, and 3) enhanced killing of the xenogeneic endothelium by natural killer cells. Calcium 12-19 vascular cell adhesion molecule 1 Homo sapiens 274-307