PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31836657-10	2020	Inhibition of SHIP1/SHIP2 reduced cellular survival and S6 phosphorylation and enhanced basal calcium levels in human CLL cells.	Calcium	94-101	inositol polyphosphate-5-phosphatase D	Homo sapiens	14-19	
11805146-4	2002	In addition, we show that defects of calcium mobilization and c-Jun NH2-terminal kinase (JNK) activation in Vav3-deficient cells are relieved by deletion of a PIP3 hydrolyzing enzyme, SH2 domain-containing inositol polyphosphate 5"-phosphatase (SHIP).	Calcium	37-44	inositol polyphosphate-5-phosphatase D	Homo sapiens	184-243	
16601135-5	2006	Cas and c-Cbl, known to function in podosomes of osteoclasts, were identified as novel proteins binding to the SHIP SH2 domain by mass spectrometric analysis, and this interaction appeared to be dependent on the Src kinase activity.	Calcium	0-3	inositol polyphosphate-5-phosphatase D	Homo sapiens	111-115	
16236046-0	2005	Calcium antagonists and deep gingival pockets in the population-based SHIP study.	Calcium	0-7	inositol polyphosphate-5-phosphatase D	Homo sapiens	70-74	
10779347-8	2000	However, studies with an Shc-deficient B-cell line indicated that Shc-SHIP complex formation is not required and that other proteins that bind these tyrosines may be important in FcgammaRIIB1/SHIP-mediated calcium inhibition.	Calcium	206-213	inositol polyphosphate-5-phosphatase D	Homo sapiens	192-196	
11709085-0	2001	FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization.	Calcium	226-233	inositol polyphosphate-5-phosphatase D	Homo sapiens	142-146	
11418650-4	2001	SHIP-deficient B cell blasts display efficient FcgammaRIIB-dependent inhibition of calcium mobilization as well as Akt and extracellular signal-related protein kinase phosphorylation.	Calcium	83-90	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-4	
10779347-3	2000	While point mutations of the signature motifs in the inositol phosphatase domain abolish SHIP"s ability to inhibit calcium flux in B cells, little is known about the function of the evolutionarily conserved, putative noncatalytic regions of SHIP in vivo.	Calcium	115-122	inositol polyphosphate-5-phosphatase D	Homo sapiens	89-93	
9597145-6	1998	The regulation of calcium responses involves a network of tyrosine kinases (e.g. lyn, syk), tyrosine or lipid phosphatases (CD45, SHP-1, SHIP), and accessory molecules (CD21/CD19, CD22, FcR gamma 2b).	Calcium	18-25	inositol polyphosphate-5-phosphatase D	Homo sapiens	137-141	
9857188-7	1998	These results suggest that SHIP prevents SF from triggering degranulation of normal BMMCs, and does so by hydrolyzing PIP3, which in turn limits extracellular calcium entry at a step after the release of intracellular calcium.	Calcium	159-166	inositol polyphosphate-5-phosphatase D	Homo sapiens	27-31	
9857188-7	1998	These results suggest that SHIP prevents SF from triggering degranulation of normal BMMCs, and does so by hydrolyzing PIP3, which in turn limits extracellular calcium entry at a step after the release of intracellular calcium.	Calcium	218-225	inositol polyphosphate-5-phosphatase D	Homo sapiens	27-31	
8805703-4	1996	SHIP, by hydrolysing the 5-phosphate of phosphatidylinositol(3,4,5)P3 and inositol(1,3,4,5)P4, suggests a mechanism by which Fc(gamma)RIIB can inhibit calcium influx and downstream responses triggered by immune receptors.	Calcium	151-158	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-4