PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10779415-10 2000 Hrk was induced in FDCP-Mix cells treated with ionomicin in the presence of IL-3, suggesting that cytosolic calcium may regulate the expression of this proapoptotic protein. Calcium 108-115 interleukin 3 Mus musculus 76-80 22875843-6 2012 Because IL-3-induced IL-4 production was sensitive to calcineurin inhibitors and an intracellular calcium chelator, in addition to PI3K inhibitors, SLP-76 appears to regulate FcepsilonRI- and IL-3 receptor-induced IL-4 production via mediating PLCgamma2 activation in basophils. Calcium 98-105 interleukin 3 Mus musculus 8-12 15355467-8 2004 Nonspecific stimulus with calcium ionophore and phorbol-myristate-acetate of BM CD34(+) cells caused release of IL-5, IL-3 and GM-CSF. Calcium 26-33 interleukin 3 Mus musculus 118-122 15182734-7 2004 Taken together, our present results demonstrate that extracellular ATP triggers autocrine production of IL-4 through calcium-dependent activation of calcineurin and secreted IL-4 substitutes IL-3 in protecting FDC.P2 cells from apoptosis even in the absence of IL-3. Calcium 117-124 interleukin 3 Mus musculus 261-265 17027084-1 2007 Crosslinking of Fcvarepsilon receptor on mast cells induces IL-3 gene expression with the concentration dependent of intracellular calcium, but its regulatory mechanism remains unclear. Calcium 131-138 interleukin 3 Mus musculus 60-64 11019782-7 2000 Our data suggest that IL-3 mRNA stabilization by either calcium-dependent or oncogenic pathways involves different intracellular mechanisms. Calcium 56-63 interleukin 3 Mus musculus 22-26 11019782-1 2000 In interleukin-3 (IL-3)-dependent PB-3c mast cells, the normally short-lived IL-3 mRNA is stabilized upon calcium-ionophore treatment or following v-H-ras induced oncogenesis. Calcium 106-113 interleukin 3 Mus musculus 3-22 11019782-1 2000 In interleukin-3 (IL-3)-dependent PB-3c mast cells, the normally short-lived IL-3 mRNA is stabilized upon calcium-ionophore treatment or following v-H-ras induced oncogenesis. Calcium 106-113 interleukin 3 Mus musculus 18-22 9557611-9 1998 Treatment of IL-3 dependent cells with calcium ionophores eliminated the proteins binding to the ARE in wild-type IL-3-dependent FL5.12 cells and also resulted in the accumulation of IL-3 mRNA transcripts with a long half-life. Calcium 39-46 interleukin 3 Mus musculus 13-17 14634284-10 1999 Calcium uptake however, was stimulated by IL-3 in both parental and oncogene-transformed cells. Calcium 0-7 interleukin 3 Mus musculus 42-46 9557611-9 1998 Treatment of IL-3 dependent cells with calcium ionophores eliminated the proteins binding to the ARE in wild-type IL-3-dependent FL5.12 cells and also resulted in the accumulation of IL-3 mRNA transcripts with a long half-life. Calcium 39-46 interleukin 3 Mus musculus 114-118 9557611-9 1998 Treatment of IL-3 dependent cells with calcium ionophores eliminated the proteins binding to the ARE in wild-type IL-3-dependent FL5.12 cells and also resulted in the accumulation of IL-3 mRNA transcripts with a long half-life. Calcium 39-46 interleukin 3 Mus musculus 114-118 9292524-6 1997 The results showed that IL-3 was induced by calcium ionophore and that the IL-3 induced by Fc gammaRIII stimulation was blocked by EGTA or FK506, but not by staurosporine (protein kinase C [PKC] inhibitor), indicating the important role of calcium-calcineurin in this system. Calcium 44-51 interleukin 3 Mus musculus 24-28 8886988-1 1996 DNA fragmentation in isolated nuclei from the murine IL3-dependent bone marrow cell line BAF3 could be stimulated either by decreasing pH below 6.5 or by adding microM calcium at neutral pH. Calcium 168-175 interleukin 3 Mus musculus 53-56 1538126-0 1992 Inhibition of apoptosis by calcium ionophores in IL-3-dependent bone marrow cells is dependent upon production of IL-4+. Calcium 27-34 interleukin 3 Mus musculus 49-53 8804994-0 1996 Impaired interleukin-3 mRNA decay in autocrine mast cell tumors after transient calcium ionophore stimulation. Calcium 80-87 interleukin 3 Mus musculus 9-22 8804994-6 1996 The data indicate that a recessive defect of IL-3 mRNA degradation can be revealed in class-I tumor cells by transient calcium ionophore stimulation. Calcium 119-126 interleukin 3 Mus musculus 45-49 7961806-1 1994 In mast cells, expression of interleukin-3 (IL-3) is induced following IgE-receptor activation via calcium-dependent mRNA stabilization. Calcium 99-106 interleukin 3 Mus musculus 29-42 7961806-1 1994 In mast cells, expression of interleukin-3 (IL-3) is induced following IgE-receptor activation via calcium-dependent mRNA stabilization. Calcium 99-106 interleukin 3 Mus musculus 44-48 7961806-3 1994 Similar to endogenous IL-3 mRNA, exogenous IL-3 transcripts had a short half-life and were stabilized following stimulation of calcium influx by ionomycin. Calcium 127-134 interleukin 3 Mus musculus 43-47 8454620-0 1993 Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. Calcium 154-161 interleukin 3 Mus musculus 35-48 8454620-0 1993 Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. Calcium 154-161 interleukin 3 Mus musculus 50-54 8454620-0 1993 Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. Calcium 154-161 interleukin 3 Mus musculus 64-68 1430702-5 1992 Both antigen and ATP had significant effects on intracellular calcium in cells cultured for as little as 1 week with interleukin-3, when few cells exhibited morphologic or functional characteristics of mast cells. Calcium 62-69 interleukin 3 Mus musculus 117-130 1408138-9 1992 Treatment with ionomycin, a calcium ionophore, induced high levels of IL-3 expression only in ras-expressing rT clones. Calcium 28-35 interleukin 3 Mus musculus 70-74 8605330-0 1996 Hematopoietic progenitors and interleukin-3-dependent cell lines synthesize histamine in response to calcium ionophore. Calcium 101-108 interleukin 3 Mus musculus 30-43 8605330-6 1996 The finding that all IL-3-dependent cell lines tested so far exhibit increased histamine production and HDC mRNA expression in response to calcium influx lends further support to this notion. Calcium 139-146 interleukin 3 Mus musculus 21-25 8352798-0 1993 Apoptosis induction in 32D cells by IL-3 withdrawal is preceded by a drop in the intracellular calcium level. Calcium 95-102 interleukin 3 Mus musculus 36-40 8352798-2 1993 We show here that IL-3 induces a slow increase in endocellular calcium, which is sizeable two hours after the addition. Calcium 63-70 interleukin 3 Mus musculus 18-22 8352798-3 1993 Withdrawal of the cytokine induces apoptosis, whose classic late events are evident after 16/18 hours, and are preceded by a calcium drop during the first 2/3 hours after IL-3 subtraction. Calcium 125-132 interleukin 3 Mus musculus 171-175 1538126-1 1992 Calcium ionophores inhibit apoptosis in the IL-3-dependent cell line BAF3 and maintain the cells in a viable noncycling state. Calcium 0-7 interleukin 3 Mus musculus 44-48 2307840-3 1990 In high serum-supplemented cells, but not in cells that were preincubated in serum-deficient media for 6 h, subsequent treatment for 15 min with synthetic IL-3 (10 micrograms/ml) caused up to a sixfold increase in the calcium- and lipid-stimulated histone H1 phosphorylating activity of particulate-associated PKC after fractionation on MonoQ. Calcium 218-225 interleukin 3 Mus musculus 155-159 2169925-0 1990 Calcium ionophore but not phorbol ester promotes eicosanoids release by proliferating interleukin-3-dependent bone marrow cells. Calcium 0-7 interleukin 3 Mus musculus 86-99 2118109-0 1990 Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores. Calcium 90-97 interleukin 3 Mus musculus 27-40 1932749-1 1991 Short-term stimulation (up to 16 hours) of interleukin-3 (IL-3)-dependent mouse bone marrow-derived mast cells, Abelson transformed mouse liver-derived mast cells, or rat basophilic leukemia cells by either IgE-Ag or calcium ionophore A23187 resulted in inhibition of their proliferation as measured by 3H-thymidine incorporation and MTT (tetrazolium) assays, and in accumulation of the mRNAs of c-fos, c-jun, junB and slightly of junD proto-oncogenes. Calcium 217-224 interleukin 3 Mus musculus 43-56 1649225-8 1991 In addition to culture density, removal of extracellular calcium or sodium during irradiation, treatment with amiloride, or inhibition of new mRNA synthesis with cordycepin was shown to influence the UVR-induced alteration in release of IL-3 or GM-CSF bioactivity from both confluent and subconfluent PAM 212 cells. Calcium 57-64 interleukin 3 Mus musculus 237-241 1834578-1 1991 Interleukin-3 (IL-3)-dependent mast cell lines, upon stimulation by calcium ionophores or by Fc epsilon RI cross-linking, express mRNA for, and secrete, a distinct pattern of cytokines, similar to those secreted by cloned mouse T cells of the TH2 type. Calcium 68-75 interleukin 3 Mus musculus 0-19 3493490-2 1987 These cells also require IL-3 to display antigen-mediated serotonin release, which is coupled to a transient increase of cytosolic free calcium ([Ca2+]i). Calcium 136-143 interleukin 3 Mus musculus 25-29 2105489-0 1990 Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions. Calcium 117-124 interleukin 3 Mus musculus 14-27 2105489-3 1990 Large amounts of IL-3 mRNA accumulated after exposure of cells to calcium ionophore A23187, a reagent that increases intracellular Ca2+. Calcium 66-73 interleukin 3 Mus musculus 17-21 3142956-8 1988 The calcium ionophore A23187 enhanced the proliferation of BDM-1 cells costimulated with TPA and IL-3. Calcium 4-11 interleukin 3 Mus musculus 97-101