PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26727270-1 2016 The drug pentamidine inhibits calcium-dependent complex formation with p53 ((Ca)S100B p53) in malignant melanoma (MM) and restores p53 tumor suppressor activity in vivo. Calcium 30-37 S100 calcium binding protein B Homo sapiens 80-85 26797416-4 2016 S100P is a small calcium-binding protein in the S100 protein family that regulates cellular, physiological and pathological processes in various cancers. Calcium 17-24 S100 calcium binding protein B Homo sapiens 0-4 25963887-9 2015 In addition, a new class of calcium binding family S100 proteins has been getting attention as they play significant roles in tumor progression and metastasis by modulating TME. Calcium 28-35 S100 calcium binding protein B Homo sapiens 51-55 26880885-1 2016 The family of S100 proteins represents 25 relatively small (9-13 kD) calcium binding proteins. Calcium 69-76 S100 calcium binding protein B Homo sapiens 14-18 26409143-1 2015 BACKGROUND: S100 proteins are small calcium binding proteins encoded by genes located in the epidermal differentiation complex (EDC). Calcium 36-43 S100 calcium binding protein B Homo sapiens 12-16 26527685-0 2016 Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY. Calcium 163-170 S100 calcium binding protein B Homo sapiens 63-68 27847933-2 2016 S100B protein is a calcium-binding molecule, mainly secreted by glial cells, which, depending on its concentration, has a trophic or toxic effect on neuronal cells. Calcium 19-26 S100 calcium binding protein B Homo sapiens 0-5 24947426-2 2014 CaM has been proposed to be functionally distinct from the S100 proteins, a related family of eukaryotic calcium-binding proteins. Calcium 105-112 S100 calcium binding protein B Homo sapiens 59-63 25694263-5 2015 The reported affinity of distamycin A for the calcium(II)-loaded S100beta reinforces the idea that some biological activities of the DNA-minor-groove-binding ligands arise from the binding to cellular proteins. Calcium 46-57 S100 calcium binding protein B Homo sapiens 65-73 25488653-2 2015 Our data reveal a rich diversity of proteins that are dynamically modulated, and we selectively highlight a family of calcium binding proteins (S-100 molecules) including calcyclin (S100-A6), calgranulins A (S100-A8) and B (S100-A9), and calgizzarin (S100-A11). Calcium 118-125 S100 calcium binding protein B Homo sapiens 144-149 25202915-1 2014 S100B is a calcium-binding protein secreted in central nervous system from astrocytes and other glia cells. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 26055713-1 2015 The S100 family of EF-hand calcium (Ca(2+))-binding proteins is essential for a wide range of cellular functions. Calcium 27-34 S100 calcium binding protein B Homo sapiens 4-8 25760235-1 2015 The fused-type S100 protein profilaggrin and its proteolytic products including filaggrin are important in the formation of a normal epidermal barrier; however, the specific function of the S100 calcium-binding domain in profilaggrin biology is poorly understood. Calcium 195-202 S100 calcium binding protein B Homo sapiens 15-19 25760235-1 2015 The fused-type S100 protein profilaggrin and its proteolytic products including filaggrin are important in the formation of a normal epidermal barrier; however, the specific function of the S100 calcium-binding domain in profilaggrin biology is poorly understood. Calcium 195-202 S100 calcium binding protein B Homo sapiens 190-194 25760235-2 2015 To explore its molecular function, we determined a 2.2 A-resolution crystal structure of the N-terminal fused-type S100 domain of human profilaggrin with bound calcium ions. Calcium 160-167 S100 calcium binding protein B Homo sapiens 115-119 25999659-5 2015 S100A2, a calcium-binding protein in S100 protein family, is upregulated in KKU-M213. Calcium 10-17 S100 calcium binding protein B Homo sapiens 0-4 24627490-0 2014 Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK. Calcium 103-110 S100 calcium binding protein B Homo sapiens 26-31 25818737-1 2014 S100 protein is the largest subtribe in calcium binding protein family. Calcium 40-47 S100 calcium binding protein B Homo sapiens 0-4 24063890-1 2013 S100B is a calcium sensing protein belonging to the S100 protein family with intracellular and extracellular roles. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 24235330-2 2013 S100B participates physiologically in the regulation of intracellular free calcium levels, and exerts a neurotrophic activity on cerebral cells. Calcium 75-82 S100 calcium binding protein B Homo sapiens 0-5 24076007-3 2013 The S100 calcium-binding beta (S100B), which is expressed and secreted by astrocytes, has been found to be associated with PD. Calcium 9-16 S100 calcium binding protein B Homo sapiens 31-36 24262594-1 2013 BACKGROUND/AIMS: Calprotectin is a 36.5 kD calcium and zinc binding protein in the S100 protein family. Calcium 43-50 S100 calcium binding protein B Homo sapiens 83-87 24137128-0 2013 The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults. Calcium 31-38 S100 calcium binding protein B Homo sapiens 55-60 24137128-1 2013 S100B is a calcium binding peptide produced predominantly by astroglial cells in the central nervous system. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 24396798-1 2013 BACKGROUND: S100B is a calcium-binding protein, belonging to the S100 family proteins which are characterized by their high solubility and, currently, comprises 21 members which are expressed in a cell-specific manner. Calcium 23-30 S100 calcium binding protein B Homo sapiens 12-17 23889347-4 2013 S100B, a calcium-binding protein in glial cells, and neuron specific enolase (NSE) in neuron cytoplasma are protein markers of astrocyte and neuron damage, respectively. Calcium 9-16 S100 calcium binding protein B Homo sapiens 0-5 23899389-1 2013 The S100 protein family consists of small, dimeric proteins that exert their biological functions in response to changing calcium concentrations. Calcium 122-129 S100 calcium binding protein B Homo sapiens 4-8 23899389-2 2013 S100B is the best-studied member and has been shown to interact with more than 20 binding partners in a calcium-dependent manner. Calcium 104-111 S100 calcium binding protein B Homo sapiens 0-5 23755753-1 2013 S100B, a 21kDa cytosolic calcium-binding protein of the EF-hand type, present in high abundance in the brain, stimulates inflammatory responses in different cellular types inside and outside the central nervous system. Calcium 25-32 S100 calcium binding protein B Homo sapiens 0-5 23523337-1 2013 BACKGROUND: S100B is a calcium binding protein that can be measured in cerebral and extra cerebral biological tissues and fluids. Calcium 23-30 S100 calcium binding protein B Homo sapiens 12-17 23313430-3 2013 Calcium-dependent binding of dimeric S100B(betabeta) to p53-NRD blocks access to these PTM sites and disrupts the p53 tetramer to inhibit p53 activation. Calcium 0-7 S100 calcium binding protein B Homo sapiens 37-52 23438158-3 2013 S100B is a calcium-binding protein that has been proposed as a marker of astrocyte activation and brain dysfunction. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 23296614-6 2013 The library was screened against the calcium-binding protein S100B. Calcium 37-44 S100 calcium binding protein B Homo sapiens 61-66 23296623-0 2013 Clinical use of the calcium-binding S100B protein. Calcium 20-27 S100 calcium binding protein B Homo sapiens 36-41 22913742-3 2012 Previously, peptides derived from CapZ, p53, NDR, HDM2, and HDM4 have been shown to interact with S100B in a calcium-dependent manner. Calcium 109-116 S100 calcium binding protein B Homo sapiens 98-103 23296623-1 2013 S100B is a calcium-binding protein most abundant in neuronal tissue. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 23053020-8 2012 Special emphasis is put on the S100 family of calcium binding proteins that is more and more emerging as a potentially important group of both molecular key players and biomarkers in the etiology, progression, manifestation, and therapy of neoplastic disorders, including malignant melanoma. Calcium 46-53 S100 calcium binding protein B Homo sapiens 31-35 23031665-1 2012 S100B is a calcium-binding protein released into the blood from astroglial cells due to brain injury. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 23095053-2 2012 The S100 family of calcium-binding proteins regulates many aspects of cell function but their roles in vascular physiology are less well understood. Calcium 19-26 S100 calcium binding protein B Homo sapiens 4-8 23095053-4 2012 Analysis of total endothelial mRNAs using a human gene chip array revealed significant gene expression of the S100 calcium-binding protein family members S100A6, S100A10, S100A11 and S100A13. Calcium 115-122 S100 calcium binding protein B Homo sapiens 110-114 23169921-2 2012 S100B is a calcium-binding protein expressed in, and secreted by, astrocytes. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 22420334-1 2012 BACKGROUND: S100B is a calcium-binding protein that is produced primarily by astrocytes. Calcium 23-30 S100 calcium binding protein B Homo sapiens 12-17 22978053-0 2012 The value of the calcium binding protein S100 in the management of patients with traumatic brain injury. Calcium 17-24 S100 calcium binding protein B Homo sapiens 41-45 22266138-1 2012 S100 proteins are low molecular weight calcium binding proteins expressed in vertebrates. Calcium 39-46 S100 calcium binding protein B Homo sapiens 0-4 22145907-1 2012 S100B is a calcium-binding protein concentrated in glial cells, although it has also been detected in definite extra-neural cell types. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 21932834-8 2011 NMR titration data indicated that although an interaction between apo-S100B and IC3-C58 occurs without calcium, the binding was enhanced more than 100-fold upon calcium binding. Calcium 103-110 S100 calcium binding protein B Homo sapiens 70-75 22528103-1 2012 The S100 proteins are a large family of 10-12 kDa EF-hand signaling proteins that bind calcium, and in some cases zinc and copper, functioning as central regulators in a diversity of cellular processes. Calcium 87-94 S100 calcium binding protein B Homo sapiens 4-8 22295074-1 2012 Calcyclin-binding protein (CacyBP/SIP), identified on the basis of its ability to interact with S100 proteins in a calcium-dependent manner, was previously found to inhibit the proliferation and tumorigenesis of gastric cancer cells in our laboratory. Calcium 115-122 S100 calcium binding protein B Homo sapiens 96-100 21185668-1 2012 OBJECTIVE: S100B is a calcium-binding protein produced by astroglia in the brain and has been used as a marker of neuronal damage after brain trauma. Calcium 22-29 S100 calcium binding protein B Homo sapiens 11-16 23028280-3 2012 Here, we study the molecular details of this signaling mechanism by applying both Molecular Dynamics and Monte Carlo methods to S100B, a calcium-modulated homodimeric protein, and two of its IDP targets, p53 and TRTK-12. Calcium 137-144 S100 calcium binding protein B Homo sapiens 128-133 21932834-0 2011 Identification of calcium-independent and calcium-enhanced binding between S100B and the dopamine D2 receptor. Calcium 18-25 S100 calcium binding protein B Homo sapiens 75-80 21932834-0 2011 Identification of calcium-independent and calcium-enhanced binding between S100B and the dopamine D2 receptor. Calcium 42-49 S100 calcium binding protein B Homo sapiens 75-80 21932834-1 2011 S100B is a dimeric EF-hand protein that undergoes a calcium-induced conformational change and exposes a hydrophobic protein-binding surface. Calcium 52-59 S100 calcium binding protein B Homo sapiens 0-5 21932834-8 2011 NMR titration data indicated that although an interaction between apo-S100B and IC3-C58 occurs without calcium, the binding was enhanced more than 100-fold upon calcium binding. Calcium 161-168 S100 calcium binding protein B Homo sapiens 70-75 21932834-4 2011 In this work the calcium-sensitive ability for S100B to recruit the IC3 of the dopamine D2 receptor was examined, and regions in both proteins required for complex formation were identified. Calcium 17-24 S100 calcium binding protein B Homo sapiens 47-52 21932834-11 2011 This work represents the first example of an S100B target that interacts with both the apo- and calcium-saturated forms of S100B. Calcium 96-103 S100 calcium binding protein B Homo sapiens 45-50 21932834-11 2011 This work represents the first example of an S100B target that interacts with both the apo- and calcium-saturated forms of S100B. Calcium 96-103 S100 calcium binding protein B Homo sapiens 123-128 20306096-2 2011 While the importance of modulation of the function of the S100 family of EF-hand proteins by calcium is well established, a substantial proportion is also regulated by zinc or copper. Calcium 93-100 S100 calcium binding protein B Homo sapiens 58-62 20306096-3 2011 Indeed regulation by zinc in addition to calcium was suggested almost as soon as the first S100 protein was discovered and has been confirmed for many family members by numerous experiments. Calcium 41-48 S100 calcium binding protein B Homo sapiens 91-95 20306096-8 2011 Some S100 protein-mediated events, such as signalling in the extracellular space, where the levels of calcium are already high, are most unlikely to be calcium regulated. Calcium 102-109 S100 calcium binding protein B Homo sapiens 5-9 20306096-8 2011 Some S100 protein-mediated events, such as signalling in the extracellular space, where the levels of calcium are already high, are most unlikely to be calcium regulated. Calcium 152-159 S100 calcium binding protein B Homo sapiens 5-9 21756915-0 2011 The crystal structure of zebrafish S100Z: implications for calcium-promoted S100 protein oligomerisation. Calcium 59-66 S100 calcium binding protein B Homo sapiens 35-39 21756915-1 2011 The S100 family, with about 20 members in humans, is composed of EF-hand calcium-regulated proteins and is linked to a range of serious human diseases, including cancer and autoimmune and neurological disorders. Calcium 73-80 S100 calcium binding protein B Homo sapiens 4-8 21756915-4 2011 Here, we report the first crystal structure of an S100 protein from this organism, the calcium-bound state of S100Z to 2.03 A resolution. Calcium 87-94 S100 calcium binding protein B Homo sapiens 50-54 21756915-7 2011 Structural comparisons between known S100 multimeric assemblies together with analysis of calcium-driven changes to the dimerisation cores suggest a mechanism for calcium-promoted oligomerisation of S100 proteins. Calcium 90-97 S100 calcium binding protein B Homo sapiens 199-203 21756915-7 2011 Structural comparisons between known S100 multimeric assemblies together with analysis of calcium-driven changes to the dimerisation cores suggest a mechanism for calcium-promoted oligomerisation of S100 proteins. Calcium 163-170 S100 calcium binding protein B Homo sapiens 37-41 21756915-7 2011 Structural comparisons between known S100 multimeric assemblies together with analysis of calcium-driven changes to the dimerisation cores suggest a mechanism for calcium-promoted oligomerisation of S100 proteins. Calcium 163-170 S100 calcium binding protein B Homo sapiens 199-203 20950652-0 2011 The crystal structures of human S100B in the zinc- and calcium-loaded state at three pH values reveal zinc ligand swapping. Calcium 55-62 S100 calcium binding protein B Homo sapiens 32-37 21949546-1 2011 S100 proteins are small, calcium-binding proteins whose genes are localized in a cluster on human chromosome 1. Calcium 25-32 S100 calcium binding protein B Homo sapiens 0-4 21949546-2 2011 Through their ability to interact with various protein partners in a calcium-dependent manner, the S100 proteins exert their influence on many vital cellular processes such as cell cycle, cytoskeleton activity and cell motility, differentiation, etc. Calcium 69-76 S100 calcium binding protein B Homo sapiens 99-103 20950652-1 2011 S100B is a homodimeric zinc-, copper-, and calcium-binding protein of the family of EF-hand S100 proteins. Calcium 43-50 S100 calcium binding protein B Homo sapiens 0-5 20708613-3 2010 Here we show that application of the acidic calcium-binding protein S100B to inside-out patches of Xenopus oocytes causes Ca(2+)-dependent inhibition of expressed hEAG1 channels. Calcium 44-51 S100 calcium binding protein B Homo sapiens 68-73 21428964-8 2011 IQ1 (the first IQ motif) interacts with the myosin essential light chain Mlc1sa and the first two undergo a calcium-dependent interaction with S100B. Calcium 108-115 S100 calcium binding protein B Homo sapiens 143-148 21465945-2 2011 The S100B is a calcium-binding peptide and is used as a parameter of glial activation and/or death in many disorders of the central nervous system (CNS). Calcium 15-22 S100 calcium binding protein B Homo sapiens 4-9 20510426-1 2010 S100B is a calcium-binding protein, which is produced primarily by glial cells. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 20621410-0 2010 Modulation of quaternary structure of S100 proteins by calcium ions. Calcium 55-62 S100 calcium binding protein B Homo sapiens 38-42 20621410-1 2010 It is well established that calcium binding leads to conformational changes in S100 proteins. Calcium 28-35 S100 calcium binding protein B Homo sapiens 79-83 20708613-5 2010 Thus, S100B is a potential alternative calcium sensor for hEAG1 potassium channels. Calcium 39-46 S100 calcium binding protein B Homo sapiens 6-11 20140014-3 2010 We found that S100A1, S100A2, S100A4, S100A6 and S100B proteins bound different p63 and p73 tetramerization domain variants and naturally occurring isoforms with varying affinities in a calcium-dependent manner. Calcium 186-193 S100 calcium binding protein B Homo sapiens 49-54 21132089-2 2010 In such cancers, S100B binds wild-type p53 in a calcium-dependent manner, sequestering it, and promoting its degradation, resulting in the loss of p53-dependent tumor suppression activities. Calcium 48-55 S100 calcium binding protein B Homo sapiens 17-22 20928981-4 2010 In addition to advanced glycation end products (AGE), RAGE has other important ligands such as: high mobility group box 1 protein (HMGB1, also termed amphoterin), the group of calcium binding cellular factors S100 (also termed calgranulin), amiloid beta peptides and Mac-1, a beta-2 integrin (CD1lb/CD18). Calcium 176-183 S100 calcium binding protein B Homo sapiens 209-213 20351179-3 2010 In this example, we report that the mitochondrial ATAD3A protein is a major, high-affinity, and calcium-dependent S100B target protein in OPC. Calcium 96-103 S100 calcium binding protein B Homo sapiens 114-119 20351179-5 2010 Molecular characterization of the S100B binding domain on ATAD3A by nuclear magnetic resonance (NMR) spectroscopy techniques defined a consensus calcium-dependent S100B binding motif. Calcium 145-152 S100 calcium binding protein B Homo sapiens 34-39 20351179-5 2010 Molecular characterization of the S100B binding domain on ATAD3A by nuclear magnetic resonance (NMR) spectroscopy techniques defined a consensus calcium-dependent S100B binding motif. Calcium 145-152 S100 calcium binding protein B Homo sapiens 163-168 20351179-0 2010 The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A. Calcium 4-11 S100 calcium binding protein B Homo sapiens 42-47 21090084-8 2010 The present article is aimed at investigating the role of dosage biochemical markers in non-invasive biological fluids such as S100B, a calcium binding protein, activin A, a protein expressed in Central nervous System (CNS). Calcium 136-143 S100 calcium binding protein B Homo sapiens 127-132 19932492-1 2010 Several studies show that calcium-binding protein S100B is increased in schizophrenia and may be involved in the pathogenesis of tardive dyskinesia (TD). Calcium 26-33 S100 calcium binding protein B Homo sapiens 50-55 20140014-7 2010 The regulation of the p53 family by S100 is complicated and depends on the target preference of each individual S100 protein, the concentration of the proteins and calcium, as well as the splicing variation of p63 or p73. Calcium 164-171 S100 calcium binding protein B Homo sapiens 36-40 20053360-10 2010 Lastly, it follows that any small-molecule inhibitor bound to Ca(2+)-S100B would also have to cause an increase in calcium-ion-binding affinity to be effective therapeutically inside a cell, so these data need to be considered in future drug design studies involving S100B. Calcium 115-122 S100 calcium binding protein B Homo sapiens 69-74 20053360-10 2010 Lastly, it follows that any small-molecule inhibitor bound to Ca(2+)-S100B would also have to cause an increase in calcium-ion-binding affinity to be effective therapeutically inside a cell, so these data need to be considered in future drug design studies involving S100B. Calcium 115-122 S100 calcium binding protein B Homo sapiens 267-272 20827422-0 2010 The Calcium-Dependent Interaction of S100B with Its Protein Targets. Calcium 4-11 S100 calcium binding protein B Homo sapiens 37-42 20827422-1 2010 S100B is a calcium signaling protein that is a member of the S100 protein family. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 19360884-5 2009 S100B is a calcium-binding protein of 21 kDa that is predominantly expressed and secreted by astrocytes, which has trophic paracrine activity on neurite growth, glial proliferation, and neuronal survival. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 19539717-1 2009 S100B is a calcium-binding protein, mainly produced and secreted by astrocytes, and it mediates the interaction among glial cells and between glial cells and neurons. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 19536568-1 2009 S100A5 is a calcium binding protein of the S100 family, with one canonical and one S100-specific EF-hand motif per subunit. Calcium 12-19 S100 calcium binding protein B Homo sapiens 0-4 19536568-1 2009 S100A5 is a calcium binding protein of the S100 family, with one canonical and one S100-specific EF-hand motif per subunit. Calcium 12-19 S100 calcium binding protein B Homo sapiens 43-47 19536568-6 2009 For the first time for a full-length S100 protein, relaxation measurements were performed on both the apo and the calcium-bound forms. Calcium 114-121 S100 calcium binding protein B Homo sapiens 37-41 19827097-2 2009 S100B undergoes a calcium-dependent conformational change allowing it to interact with a short contiguous sequence from the actin-capping protein CapZ (TRTK12). Calcium 18-25 S100 calcium binding protein B Homo sapiens 0-5 19469484-0 2009 Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography. Calcium 77-84 S100 calcium binding protein B Homo sapiens 91-96 19446668-5 2009 S100B protein is a constitutive protein of glial cells, whose physiological functions are both intracellular, i.e. intracytosolic calcium binding, and extracellular, e.g. by promoting neuritic proliferation and/or neuronal apoptosis. Calcium 130-137 S100 calcium binding protein B Homo sapiens 0-5 19132530-2 2009 S100B, a calcium binding protein, originates in the central nervous system but it can be also produced by extra-cerebral sources; it is passively released from damaged glial cells and neurons; it has limited passage through the BBB. Calcium 9-16 S100 calcium binding protein B Homo sapiens 0-5 19121341-5 2009 S100 proteins are small calcium binding proteins with high structural homology. Calcium 24-31 S100 calcium binding protein B Homo sapiens 0-4 19275165-1 2009 The S100 proteins make up a family of dimeric calcium binding proteins that function in response to changing calcium levels. Calcium 46-53 S100 calcium binding protein B Homo sapiens 4-8 19275165-1 2009 The S100 proteins make up a family of dimeric calcium binding proteins that function in response to changing calcium levels. Calcium 109-116 S100 calcium binding protein B Homo sapiens 4-8 18443896-1 2009 S100A12 is a member of the S100 family of EF-hand calcium-binding proteins. Calcium 50-57 S100 calcium binding protein B Homo sapiens 0-4 18384084-0 2008 Analysis of the structure of human apo-S100B at low temperature indicates a unimodal conformational distribution is adopted by calcium-free S100 proteins. Calcium 127-134 S100 calcium binding protein B Homo sapiens 39-44 19940340-0 2009 The calcium-modulated structures of calmodulin and S100b proteins are useful to monitor hydrogen/deuterium exchange efficiency using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Calcium 4-11 S100 calcium binding protein B Homo sapiens 51-56 20093725-1 2009 Three-dimensional structures of S100B, S100A1, S100A6 and S100A11 have shown that calcium binding to these proteins results in a conformational change allowing them to interact with many biological targets. Calcium 82-89 S100 calcium binding protein B Homo sapiens 32-37 20093730-6 2009 S100B, a calcium binding astrocyte-specific cytokine, presents a marker of astrocytic activation. Calcium 9-16 S100 calcium binding protein B Homo sapiens 0-5 19468240-3 2009 S100B is a glial calcium-binding protein with neuroplastic properties; S100B serum levels have been shown to be increased in depressive patients. Calcium 17-24 S100 calcium binding protein B Homo sapiens 0-5 19468240-3 2009 S100B is a glial calcium-binding protein with neuroplastic properties; S100B serum levels have been shown to be increased in depressive patients. Calcium 17-24 S100 calcium binding protein B Homo sapiens 71-76 18706914-0 2008 Identification of a dimeric intermediate in the unfolding pathway for the calcium-binding protein S100B. Calcium 74-81 S100 calcium binding protein B Homo sapiens 98-103 18706914-3 2008 One member of this family, S100B, is a homodimeric protein shown to control the assembly of several cytoskeletal proteins and regulate phosphorylation events in a calcium-sensitive manner. Calcium 163-170 S100 calcium binding protein B Homo sapiens 27-32 18706914-4 2008 Calcium binding to S100B causes a conformational change involving movement of helix III in the second calcium-binding site (EF2) that exposes a hydrophobic surface enabling interactions with other proteins such as tubulin and Ndr kinase. Calcium 0-7 S100 calcium binding protein B Homo sapiens 19-24 18706914-4 2008 Calcium binding to S100B causes a conformational change involving movement of helix III in the second calcium-binding site (EF2) that exposes a hydrophobic surface enabling interactions with other proteins such as tubulin and Ndr kinase. Calcium 102-109 S100 calcium binding protein B Homo sapiens 19-24 18706914-6 2008 In this work, we have examined the guanidine hydrochloride (GuHCl)-induced unfolding of dimeric calcium-free S100B. Calcium 96-103 S100 calcium binding protein B Homo sapiens 109-114 18706914-10 2008 Together these observations show that calcium-free S100B unfolds via a dimeric intermediate. Calcium 38-45 S100 calcium binding protein B Homo sapiens 51-56 19201880-1 2009 The S100 calcium-binding proteins S100A8 and S100A9 are elevated systemically in patients with viral infections. Calcium 9-16 S100 calcium binding protein B Homo sapiens 4-8 18982242-1 2008 S100B protein is a calcium-binding protein mostly derived from glial cells, which exerts trophic or toxic effects on neural cell depending on its concentration. Calcium 19-26 S100 calcium binding protein B Homo sapiens 0-5 18587628-3 2008 The same region has been implicated in binding to two calmodulin-like proteins, the myosin essential light chain Mlc1sa and the calcium and zinc ion binding protein S100B. Calcium 128-135 S100 calcium binding protein B Homo sapiens 165-170 18587628-6 2008 The first and second IQ motifs interact with S100B in the presence of calcium ions. Calcium 70-77 S100 calcium binding protein B Homo sapiens 45-50 18384084-1 2008 S100B is one of the best-characterized members of the calcium-signaling S100 protein family. Calcium 54-61 S100 calcium binding protein B Homo sapiens 0-5 18384084-3 2008 S100B and other S100 proteins respond to calcium increases in the cell by coordinating calcium and undergoing a conformational change that allows them to interact with a variety of cellular targets. Calcium 41-48 S100 calcium binding protein B Homo sapiens 0-5 18384084-3 2008 S100B and other S100 proteins respond to calcium increases in the cell by coordinating calcium and undergoing a conformational change that allows them to interact with a variety of cellular targets. Calcium 87-94 S100 calcium binding protein B Homo sapiens 0-5 17348038-3 2007 S100B is part of a superfamily of proteins, some of which (including S100B) have been implicated as calcium-dependent regulatory proteins that modulate the activity of effector proteins or cells. Calcium 100-107 S100 calcium binding protein B Homo sapiens 0-5 18445708-1 2008 S100B is a calcium-binding protein with both extracellular and intracellular regulatory activities in the mammalian brain. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 18558557-1 2008 BACKGROUND: S-100B is a calcium binding acute phase protein and a potential biomarker for brain injury. Calcium 24-31 S100 calcium binding protein B Homo sapiens 12-18 18275604-0 2008 Structural and functional diversification in the teleost S100 family of calcium-binding proteins. Calcium 72-79 S100 calcium binding protein B Homo sapiens 57-61 18275604-1 2008 BACKGROUND: Among the EF-Hand calcium-binding proteins the subgroup of S100 proteins constitute a large family with numerous and diverse functions in calcium-mediated signaling. Calcium 30-37 S100 calcium binding protein B Homo sapiens 71-75 18275604-1 2008 BACKGROUND: Among the EF-Hand calcium-binding proteins the subgroup of S100 proteins constitute a large family with numerous and diverse functions in calcium-mediated signaling. Calcium 150-157 S100 calcium binding protein B Homo sapiens 71-75 17705023-1 2007 S100B, a small acidic protein, is a member of a multigenic family of calcium-modulated proteins. Calcium 69-76 S100 calcium binding protein B Homo sapiens 0-5 17584159-0 2007 A search for inhibitors of S100B, a member of the S100 family of calcium-binding proteins. Calcium 65-72 S100 calcium binding protein B Homo sapiens 27-32 18582527-1 2008 S100B is a calcium-binding protein, produced and secreted by astrocytes, which has a putative paracrine neurotrophic activity. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 18328712-1 2008 S-100B is a calcium-binding protein that is expressed in astrocytes. Calcium 12-19 S100 calcium binding protein B Homo sapiens 0-6 18019087-1 2007 BACKGROUND: S100beta, a calcium binding protein associated with astroglial cells and other tissues has been shown to be raised in the serum of patients with a number of neurological pathologies. Calcium 24-31 S100 calcium binding protein B Homo sapiens 12-20 17536784-0 2007 Amide exchange shows calcium-induced conformational changes are transmitted to the dimer interface of S100B. Calcium 21-28 S100 calcium binding protein B Homo sapiens 102-107 17536784-3 2007 S100B binds calcium and undergoes a conformation change leading to the exposure of hydrophobic surface residues that enable the protein to interact with biological target molecules. Calcium 12-19 S100 calcium binding protein B Homo sapiens 0-5 17536784-5 2007 In this work, the calcium-sensitive conformational change has been studied by utilizing fast 1H-15N HSQC experiments and water-transfer methods to follow the amide exchange in apo-S100B and Ca-S100B at 35 degrees C. In apo-S100B, the protection factors are 2-3 orders of magnitude lower for helix III than for helix I, II, or IV. Calcium 18-25 S100 calcium binding protein B Homo sapiens 180-185 17536784-5 2007 In this work, the calcium-sensitive conformational change has been studied by utilizing fast 1H-15N HSQC experiments and water-transfer methods to follow the amide exchange in apo-S100B and Ca-S100B at 35 degrees C. In apo-S100B, the protection factors are 2-3 orders of magnitude lower for helix III than for helix I, II, or IV. Calcium 18-25 S100 calcium binding protein B Homo sapiens 193-198 17536784-5 2007 In this work, the calcium-sensitive conformational change has been studied by utilizing fast 1H-15N HSQC experiments and water-transfer methods to follow the amide exchange in apo-S100B and Ca-S100B at 35 degrees C. In apo-S100B, the protection factors are 2-3 orders of magnitude lower for helix III than for helix I, II, or IV. Calcium 18-25 S100 calcium binding protein B Homo sapiens 193-198 17536784-9 2007 These data have been compared with those of the monomeric S100 protein, calbindin D9k, to illustrate that upon calcium binding there is a balance maintained between the amide exchange rates in helices II and III, although largely the rates are dissimilar for each of these proteins. Calcium 111-118 S100 calcium binding protein B Homo sapiens 58-62 17536784-10 2007 This distinguishing feature may be important for the calcium-induced conformational change in S100B, where calcium binding is transmitted to the dimer-forming helices. Calcium 53-60 S100 calcium binding protein B Homo sapiens 94-99 17536784-10 2007 This distinguishing feature may be important for the calcium-induced conformational change in S100B, where calcium binding is transmitted to the dimer-forming helices. Calcium 107-114 S100 calcium binding protein B Homo sapiens 94-99 17348038-3 2007 S100B is part of a superfamily of proteins, some of which (including S100B) have been implicated as calcium-dependent regulatory proteins that modulate the activity of effector proteins or cells. Calcium 100-107 S100 calcium binding protein B Homo sapiens 69-74 17624933-0 2007 The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes. Calcium 4-11 S100 calcium binding protein B Homo sapiens 29-34 16403530-1 2007 PURPOSE: To examine the possibility that structural damage to the brain may play a role in the pathogenesis of schizophrenia by measuring the level of plasma S-100B, a calcium-binding protein found predominantly in the cytosol of glial cells. Calcium 168-175 S100 calcium binding protein B Homo sapiens 158-164 17239974-1 2007 Human S100A2 is an EF-hand calcium-binding S100 protein that is localized mainly in the nucleus and functions as tumor suppressor. Calcium 27-34 S100 calcium binding protein B Homo sapiens 6-10 16400473-4 2006 S100B is a calcium-binding protein produced and released predominantly by astrocytes that has been used as a marker of reactive gliosis and astrocytic death in many pathological conditions. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 16957538-2 2006 The S100-beta is a calcium-binding protein that is expressed by astrocytes in the central nervous system during depression and has been suggested to modulate the impact of ECT on cognition. Calcium 19-26 S100 calcium binding protein B Homo sapiens 4-13 16928177-2 2006 S100B is a calcium-binding protein, primarily produced by glial cells, and exerts auto- and paracrine functions. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 16491116-3 2006 OPN is a cytokine and cell attachment protein which has been implicated in human tumor progression and metastasis, the calcium binding 126MRP protein is related to the human S100 protein family involved in invasive cell growth, and the Rac2 protein belongs to the Rho family of small GTPases regulating actin reorganization and cell migration. Calcium 119-126 S100 calcium binding protein B Homo sapiens 174-178 17010455-1 2006 S100B is an EF-hand containing calcium-binding protein of the S100 protein family that exerts its biological effect by binding and affecting various target proteins. Calcium 31-38 S100 calcium binding protein B Homo sapiens 0-5 17010455-10 2006 Examining the binding sites of such targets and new protein sequence searches provided additional potential target proteins for S100B including Hdm2 and Hdm4, which were both found to bind S100B in a calcium-dependent manner. Calcium 200-207 S100 calcium binding protein B Homo sapiens 128-133 17010455-10 2006 Examining the binding sites of such targets and new protein sequence searches provided additional potential target proteins for S100B including Hdm2 and Hdm4, which were both found to bind S100B in a calcium-dependent manner. Calcium 200-207 S100 calcium binding protein B Homo sapiens 189-194 16912968-4 2006 With this combined approach we were able to detect nine calcium-dependent interactions between Arg-Gly-Ser-(RGS)-His6 tagged proteins derived from the library and GST-tagged S100B and S100A6, respectively. Calcium 56-63 S100 calcium binding protein B Homo sapiens 174-179 16237100-4 2005 This Nef-induced priming of TCR signaling pathways occurred independently of calcium signaling and involved a very proximal step before protein kinase C activation. Calcium 77-84 S100 calcium binding protein B Homo sapiens 5-8 17168733-1 2006 S-100 protein, described initially by Moore, constitutes a large family of at least 20 proteins with calcium binding ability. Calcium 101-108 S100 calcium binding protein B Homo sapiens 0-5 16797859-1 2006 Arundic acid (ONO-2506) is believed to be neuroprotective because of its actions on glia cells; i.e., its inhibitory effects on the synthesis of a calcium-binding protein S100B. Calcium 147-154 S100 calcium binding protein B Homo sapiens 171-176 15966402-1 2005 PURPOSE: S100B is a calcium-binding protein which exists in abundance in glial cells of the central nervous system (CNS). Calcium 20-27 S100 calcium binding protein B Homo sapiens 9-14 15882069-0 2005 Calcium-binding properties of wild-type and EF-hand mutants of S100B in the presence and absence of a peptide derived from the C-terminal negative regulatory domain of p53. Calcium 0-7 S100 calcium binding protein B Homo sapiens 63-68 15882069-1 2005 S100B is a dimeric Ca(2+)-binding protein that undergoes a 90 +/- 3 degrees rotation of helix 3 in the typical EF-hand domain (EF2) upon the addition of calcium. Calcium 153-160 S100 calcium binding protein B Homo sapiens 0-5 15882069-5 2005 These data are consistent with a previously reported result, which showed that that target peptide binding to S100B enhances its calcium-binding affinity [Rustandi et al. Calcium 129-136 S100 calcium binding protein B Homo sapiens 110-115 15882069-9 2005 EF-hand calcium-binding mutants of S100B were engineered at the -Z position (EF-hand 1, E31A; EF-hand 2, E72A; both EF-hands, E31A + E72A) and examined to further understand how specific residues contribute to calcium binding in S100B in the absence and presence of the p53 peptide. Calcium 8-15 S100 calcium binding protein B Homo sapiens 35-40 15882069-9 2005 EF-hand calcium-binding mutants of S100B were engineered at the -Z position (EF-hand 1, E31A; EF-hand 2, E72A; both EF-hands, E31A + E72A) and examined to further understand how specific residues contribute to calcium binding in S100B in the absence and presence of the p53 peptide. Calcium 210-217 S100 calcium binding protein B Homo sapiens 35-40 15824882-4 2005 The calcium binding astrocyte protein, S100B, may be a candidate for this role. Calcium 4-11 S100 calcium binding protein B Homo sapiens 39-44 16012747-4 2005 Screening of the subtracted libraries resulted in isolation of several known as well as novel genes including the gene encoding S100P calcium-binding protein that belongs to S100 family, whose members can bind and modulate effector proteins in a calcium-dependent manner. Calcium 134-141 S100 calcium binding protein B Homo sapiens 128-132 16012747-4 2005 Screening of the subtracted libraries resulted in isolation of several known as well as novel genes including the gene encoding S100P calcium-binding protein that belongs to S100 family, whose members can bind and modulate effector proteins in a calcium-dependent manner. Calcium 134-141 S100 calcium binding protein B Homo sapiens 174-178 15838637-1 2005 UNLABELLED: S100 family proteins are calcium-binding proteins, some of which have been shown to have intracellular and extracellular functions associated with inflammation. Calcium 37-44 S100 calcium binding protein B Homo sapiens 12-16 15857298-4 2005 Specifically, the calcium binding protein S100B exerts detrimental effects on cell survival through activation of various intracellular signaling pathways, resulting in altered protein expression. Calcium 18-25 S100 calcium binding protein B Homo sapiens 42-47 15819419-1 2005 The calcium-binding proteins of the S100 and the annexin protein families have been implicated in a variety of important physiological functions including membrane remodeling, calcium-related intracellular signaling, cytoskeleton dynamics, tissue homeostasis, and formation of the cornified envelope in differentiating keratinocytes. Calcium 4-11 S100 calcium binding protein B Homo sapiens 36-40 15708543-1 2005 OBJECTIVES: S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. Calcium 31-38 S100 calcium binding protein B Homo sapiens 12-17 14997170-1 2004 S100B, a calcium-binding protein produced by astroglial cells, mediates paracrine and autocrine effects on neurons and glial cells. Calcium 9-16 S100 calcium binding protein B Homo sapiens 0-5 15456252-0 2004 Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction. Calcium 72-79 S100 calcium binding protein B Homo sapiens 90-95 15203200-1 2004 The EF-hand superfamily of calcium binding proteins includes the S100, calcium binding protein, and troponin subfamilies. Calcium 27-34 S100 calcium binding protein B Homo sapiens 65-69 15720411-1 2005 AIMS: To survey the expression of members of the S100 family of calcium-binding proteins in normal human tissues and common cancers using tissue microarrays. Calcium 64-71 S100 calcium binding protein B Homo sapiens 49-53 15632291-4 2005 In the present report, we show that Nef can interact with calmodulin, the major intracellular receptor for calcium. Calcium 107-114 S100 calcium binding protein B Homo sapiens 36-39 16248785-1 2005 S100B interacts with the p53 protein in a calcium-dependent manner and down-regulates its function as a tumor suppressor. Calcium 42-49 S100 calcium binding protein B Homo sapiens 0-5 15590070-1 2004 S100 is a family of small, acidic, calcium binding proteins involved in the control of a multitude of intra- and extracellular processes, including many pathologies. Calcium 35-42 S100 calcium binding protein B Homo sapiens 0-4 15593230-6 2004 Among the proteins that were elevated in the SF of patients with erosive RA were C-reactive protein (CRP) and 6 members of the S100 protein family of calcium-binding proteins. Calcium 150-157 S100 calcium binding protein B Homo sapiens 127-131 15191538-1 2004 The S100 proteins comprise a family of 21 low molecular weight (9-13 kDa) proteins that are characterized by the presence of two calcium-binding EF-hand motifs. Calcium 129-136 S100 calcium binding protein B Homo sapiens 4-8 15191538-3 2004 S100 proteins exist in cells as anti-parallel hetero- and homodimers and upon calcium binding interact with target proteins to regulate cell function. Calcium 78-85 S100 calcium binding protein B Homo sapiens 0-4 15191538-4 2004 S100 proteins are of interest as mediators of calcium-associated signal transduction and undergo changes in subcellular distribution in response to extracellular stimuli. Calcium 46-53 S100 calcium binding protein B Homo sapiens 0-4 15098935-1 2004 S100B belongs to a family of calcium-binding proteins involved in cell cycle and cytoskeleton regulation. Calcium 29-36 S100 calcium binding protein B Homo sapiens 0-5 14967825-0 2004 Human S100B protein interacts with the Escherichia coli division protein FtsZ in a calcium-sensitive manner. Calcium 83-90 S100 calcium binding protein B Homo sapiens 6-11 14967825-2 2004 Upon calcium binding, S100B undergoes a conformational change allowing it to interact with a variety of target proteins, including the cytoskeletal proteins tubulin and glial fibrillary acidic protein. Calcium 5-12 S100 calcium binding protein B Homo sapiens 22-27 14967825-3 2004 In both cases, S100B promotes the in vitro disassembly of these proteins in a calcium-sensitive manner. Calcium 78-85 S100 calcium binding protein B Homo sapiens 15-20 14967825-8 2004 Calcium-dependent physical interaction between S100B and FtsZ was demonstrated in vitro by affinity chromatography, and this interaction was severely inhibited by the competitor peptide TRTK-12. Calcium 0-7 S100 calcium binding protein B Homo sapiens 47-52 15033494-2 2004 S100 proteins are a group of calcium-binding proteins which exhibit cell- and tissue-specific expression, and different expression levels of members from this family have been observed in various pathological conditions. Calcium 29-36 S100 calcium binding protein B Homo sapiens 0-4 12927678-6 2003 The S100B protein, a calcium-binding protein highly concentrated in the nervous system, appears to meet the criteria required of such a marker in prenatal and perinatal medicine for its reproducible, simple and sensible measurements. Calcium 21-28 S100 calcium binding protein B Homo sapiens 4-9 15076760-1 2004 S100B is a calcium binding protein from astrocytes that regulates protein phosphorylation by binding to substrates and protein kinases. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 14757389-2 2004 Recently, it has also been shown to contain the calcium-binding S100B protein, regarded as a neurotrophic factor. Calcium 48-55 S100 calcium binding protein B Homo sapiens 64-69 14661952-10 2003 These structural studies, in combination with available biochemical data, have been used to develop a model for calcium-induced activation of NDR kinase by S100B. Calcium 112-119 S100 calcium binding protein B Homo sapiens 156-161 14672411-1 2003 S100 proteins are a calcium-binding protein family containing two EF-hand domains exclusively expressed in vertebrates and play roles in many cellular activities. Calcium 20-27 S100 calcium binding protein B Homo sapiens 0-4 12645008-1 2003 S100 calcium binding proteins have long been known to express in the adult nervous system, but their distribution in the developing brain, especially the human fetal brain, is largely unknown. Calcium 5-12 S100 calcium binding protein B Homo sapiens 0-4 12645009-1 2003 S100B is a calcium-binding peptide produced mainly by astrocytes that exert paracrine and autocrine effects on neurons and glia. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 12527118-1 2003 The present study constitutes the first finding of the calcium-binding protein S100B and of its mRNA in human milk, as revealed by a quantitative immunoluminometric assay, by Western blot analysis and by reverse transcription-polymerase chain reaction (RT-PCR) assay followed by restriction enzyme digestion. Calcium 55-62 S100 calcium binding protein B Homo sapiens 79-84 12377780-0 2002 The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes. Calcium 14-21 S100 calcium binding protein B Homo sapiens 30-35 12509947-2 2003 S-100B protein is a low molecular weight, acidic, calcium binding, cytoplasmic protein. Calcium 50-57 S100 calcium binding protein B Homo sapiens 0-6 11956293-0 2002 HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. Calcium 69-76 S100 calcium binding protein B Homo sapiens 6-9 12007679-1 2002 S100B protein is a calcium-binding protein mostly derived from glial cells, which exerts trophic or toxic effects on neural cells depending on its concentration. Calcium 19-26 S100 calcium binding protein B Homo sapiens 0-5 11956293-2 2002 Here we show that calcium/calcineurin-dependent activation of nuclear factor of activated T cells (NFAT) by Nef in Jurkat T cells requires the endoplasmic reticulum-resident inositol trisphosphate receptor (IP(3)R), but yet does not involve increase in phospholipase-C gamma 1 (PLC gamma 1)-catalyzed production of IP(3) or depletion of IP(3)-regulated intracellular calcium stores. Calcium 367-374 S100 calcium binding protein B Homo sapiens 108-111 11956293-1 2002 HIV-1 pathogenicity factor Nef has been shown to modulate calcium signaling in host cells, but the underlying molecular mechanisms have remained unclear. Calcium 58-65 S100 calcium binding protein B Homo sapiens 27-30 11956293-4 2002 Thus, the Nef/IP(3)R1-interaction defines a novel T cell receptor-independent mechanism by which Nef can promote T cell activation, and appears to involve atypical IP(3)R-triggered activation of plasma membrane calcium influx channels in a manner that is uncoupled from depletion of intracellular calcium stores. Calcium 211-218 S100 calcium binding protein B Homo sapiens 10-13 11956293-4 2002 Thus, the Nef/IP(3)R1-interaction defines a novel T cell receptor-independent mechanism by which Nef can promote T cell activation, and appears to involve atypical IP(3)R-triggered activation of plasma membrane calcium influx channels in a manner that is uncoupled from depletion of intracellular calcium stores. Calcium 211-218 S100 calcium binding protein B Homo sapiens 97-100 11956293-2 2002 Here we show that calcium/calcineurin-dependent activation of nuclear factor of activated T cells (NFAT) by Nef in Jurkat T cells requires the endoplasmic reticulum-resident inositol trisphosphate receptor (IP(3)R), but yet does not involve increase in phospholipase-C gamma 1 (PLC gamma 1)-catalyzed production of IP(3) or depletion of IP(3)-regulated intracellular calcium stores. Calcium 18-25 S100 calcium binding protein B Homo sapiens 108-111 12515998-2 2002 S-100B protein is a low molecular weight, acidic, calcium binding, cytoplasmatic protein. Calcium 50-57 S100 calcium binding protein B Homo sapiens 0-6 11809917-1 2002 To determine whether S100beta, an acidic calcium-binding protein previously demonstrated as a reliable indicator of a brain lesion, could be helpful in the detection of brain distress in intrauterine growth-retarded (IUGR) fetuses, we studied, by a case-control study, the correlation between S100B protein and the degree of fetoplacental blood flow impairment. Calcium 41-48 S100 calcium binding protein B Homo sapiens 21-29 11826241-4 2002 S100B is a calcium-binding protein localized to astroglial cells. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 11888280-4 2002 The free energy of unfolding (Delta G(u)) of wild-type apo-S100B was determined to be 72.4 +/- 4.0 kJ mol(-1), consistent with it being the most stable calcium-binding protein to date. Calcium 152-159 S100 calcium binding protein B Homo sapiens 59-64 11888280-8 2002 The calcium-bound L3S substitution proved to be significantly more stable than calcium-saturated S100B, whereas the L3A, I11A, and L3A/I11A mutants are only slightly more stable than the wild-type protein. Calcium 79-86 S100 calcium binding protein B Homo sapiens 97-102 11134923-1 2001 The crystal structure of human EF-hand calcium-binding protein S100A12 in its calcium-bound form has been determined to 1.95 A resolution by molecular replacement using the structure of the S100B protein. Calcium 39-46 S100 calcium binding protein B Homo sapiens 190-195 11390274-0 2001 S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Calcium 29-36 S100 calcium binding protein B Homo sapiens 0-4 11263412-0 2001 Arachidonic acid specifically regulates binding of S100A8/9, a heterodimer complex of the S100 class of calcium binding proteins, to human microvascular endothelial cells. Calcium 104-111 S100 calcium binding protein B Homo sapiens 51-55 11134923-1 2001 The crystal structure of human EF-hand calcium-binding protein S100A12 in its calcium-bound form has been determined to 1.95 A resolution by molecular replacement using the structure of the S100B protein. Calcium 78-85 S100 calcium binding protein B Homo sapiens 190-195 10510252-0 1999 The calcium-modulated proteins, S100A1 and S100B, as potential regulators of the dynamics of type III intermediate filaments. Calcium 4-11 S100 calcium binding protein B Homo sapiens 43-48 10858627-2 2000 S100beta, the most abundant member of this family in the CNS, mediates calcium signal transduction, and shows neurotrophic, gliotrophic and mitogenic actions that influence the development and maintenance of the nervous system. Calcium 71-78 S100 calcium binding protein B Homo sapiens 0-8 10748182-6 2000 Experiments with different dominant negative mutant signaling proteins, inhibitory chemicals, and Lck-deficient Jurkat cells revealed that this effect was mediated via activation of calcineurin by Nef-induced changes in calcium metabolism, but was independent of TCR-associated signaling events. Calcium 220-227 S100 calcium binding protein B Homo sapiens 197-200 10748182-7 2000 This ability of Nef to substitute for triggering of the calcium pathway in induction of NFAT could promote activation of human immunodeficiency virus (HIV)-infected T cells in response to stimuli mediated via TCR or other cell surface receptors under conditions when activation of Ras rather than calcium signaling would otherwise predominate. Calcium 56-63 S100 calcium binding protein B Homo sapiens 16-19 10748182-7 2000 This ability of Nef to substitute for triggering of the calcium pathway in induction of NFAT could promote activation of human immunodeficiency virus (HIV)-infected T cells in response to stimuli mediated via TCR or other cell surface receptors under conditions when activation of Ras rather than calcium signaling would otherwise predominate. Calcium 297-304 S100 calcium binding protein B Homo sapiens 16-19 10673436-1 2000 BACKGROUND: S100C (S100A11) is a member of the S100 calcium-binding protein family, the function of which is not yet entirely clear, but may include cytoskeleton assembly and dynamics. Calcium 52-59 S100 calcium binding protein B Homo sapiens 12-16 10673436-2 2000 S100 proteins consist of two EF-hand calcium-binding motifs, connected by a flexible loop. Calcium 37-44 S100 calcium binding protein B Homo sapiens 0-4 10673436-4 2000 A number of S100 proteins form complexes with annexins, another family of calcium-binding proteins that also bind to phospholipids. Calcium 74-81 S100 calcium binding protein B Homo sapiens 12-16 10913138-0 2000 S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. Calcium 47-54 S100 calcium binding protein B Homo sapiens 73-78 10913138-2 2000 Upon calcium binding, the conformation of S100B changes dramatically, leading to the exposure of hydrophobic residues at the surface of S100B. Calcium 5-12 S100 calcium binding protein B Homo sapiens 42-47 10913138-2 2000 Upon calcium binding, the conformation of S100B changes dramatically, leading to the exposure of hydrophobic residues at the surface of S100B. Calcium 5-12 S100 calcium binding protein B Homo sapiens 136-141 11106180-1 2000 The EF-hand calcium-binding protein S100B has been shown to interact in vitro in a calcium-sensitive manner with many substrates. Calcium 12-19 S100 calcium binding protein B Homo sapiens 36-41 11106180-1 2000 The EF-hand calcium-binding protein S100B has been shown to interact in vitro in a calcium-sensitive manner with many substrates. Calcium 83-90 S100 calcium binding protein B Homo sapiens 36-41 10757524-1 2000 S100B is a calcium binding protein expressed and secreted by astrocytes. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 11200185-1 2000 Many of the small, acidic, calcium binding S100 proteins present in the brain specifically map different anatomical regions and cell types and their overexpression is implicated in pathological changes. Calcium 27-34 S100 calcium binding protein B Homo sapiens 43-47 10850551-3 1999 The calcium-binding astroglial key protein S100beta is released in response to glial activation, and its measurement in serum only recently became possible. Calcium 4-11 S100 calcium binding protein B Homo sapiens 43-51 10529237-4 1999 However, at micromolar concentrations of Ca(2+), ROS-GC1 is stimulated by S100beta [also named calcium-dependent (CD) GCAP]. Calcium 95-102 S100 calcium binding protein B Homo sapiens 74-82 10501221-0 1999 Calcium-dependent interaction between the large myelin-associated glycoprotein and S100beta. Calcium 0-7 S100 calcium binding protein B Homo sapiens 83-91 10501221-6 1999 A synthetic peptide corresponding to this region bound to S100beta in a calcium-dependent manner with a stoichiometric ratio of 1:1 (K(D) approximately 7 microM). Calcium 72-79 S100 calcium binding protein B Homo sapiens 58-66 10395934-9 1999 S100 proteins probably are an example of calcium-modulated, regulatory proteins that intervene in the fine tuning of a relatively large number of specific intracellular and (in the case of some members) extracellular activities. Calcium 41-48 S100 calcium binding protein B Homo sapiens 0-4 10486246-1 1999 The S100 proteins comprise a large sub-family of the EF-hand calcium-binding proteins. Calcium 61-68 S100 calcium binding protein B Homo sapiens 4-8 10354916-1 1999 S100 is an acidic-calcium-binding protein, composed as a heterodimer of two isomeric subunits alpha and beta and was first described in cells of neuroendocrine origin. Calcium 18-25 S100 calcium binding protein B Homo sapiens 0-4 10360980-0 1999 Molecular modeling of single polypeptide chain of calcium-binding protein p26olf from dimeric S100B(betabeta). Calcium 50-57 S100 calcium binding protein B Homo sapiens 94-109 10187847-4 1999 We have confirmed a calcium-dependent interaction of the S100B with a synthetic peptide corresponding to the C-terminal region of p53 (residues 319-393 in human p53) using plasmon resonance experiments on a BIAcore system. Calcium 20-27 S100 calcium binding protein B Homo sapiens 57-62 9886297-1 1999 The aggregation and membrane fusion properties of annexin II are modulated by the association with a regulatory light chain called p11.p11 is a member of the S100 EF-hand protein family, which is unique in having lost its calcium-binding properties. Calcium 222-229 S100 calcium binding protein B Homo sapiens 158-162 10326676-0 1999 Replicating myoblasts and fused myotubes express the calcium-regulated proteins S100A1 and S100B. Calcium 53-60 S100 calcium binding protein B Homo sapiens 91-96 10377476-1 1999 S-100 protein is an acidic calcium-binding protein with a molecular weight of 21 kDa consisting of two submits alpha and beta, which are combined to give alphaalpha (S-100a), alphabeta (S-100a) and betabeta (S-100b) dimeric forms. Calcium 27-34 S100 calcium binding protein B Homo sapiens 0-5 10355284-1 1999 The S100 protein family is a group of homologous, small, calcium-binding proteins expressed in a cell specific manner. Calcium 57-64 S100 calcium binding protein B Homo sapiens 4-8 9870670-3 1998 S100 proteins constitute a family of acidic calcium-binding proteins that are important in intracellular calcium metabolism. Calcium 44-51 S100 calcium binding protein B Homo sapiens 0-4 9757414-1 1998 S100B is a multifunctional member of the S100-calmodulin-troponin superfamily of proteins and can modulate the activity of other intracellular proteins following binding of calcium. Calcium 173-180 S100 calcium binding protein B Homo sapiens 0-5 9519411-0 1998 A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form. Calcium 8-15 S100 calcium binding protein B Homo sapiens 68-73 9692960-1 1998 S100 beta is a calcium-binding protein, which regulates the activities of several enzymes and inhibits the phosphorylation of a variety of protein kinase C substrates in a calcium-dependent manner. Calcium 15-22 S100 calcium binding protein B Homo sapiens 0-9 9692960-1 1998 S100 beta is a calcium-binding protein, which regulates the activities of several enzymes and inhibits the phosphorylation of a variety of protein kinase C substrates in a calcium-dependent manner. Calcium 172-179 S100 calcium binding protein B Homo sapiens 0-9 9518690-1 1998 Transiently increased immunoreactivity of the calcium binding protein S-100beta was demonstrated in spinal ganglion nerve cells after sciatic nerve transection. Calcium 46-53 S100 calcium binding protein B Homo sapiens 70-79 9518690-3 1998 The transiently elevated co-expression of S-100beta and NPY is proposed to reflect an increased demand of neurotrophic and neuroprotective compounds in reactive neurons, tentatively regulating calcium ions. Calcium 193-200 S100 calcium binding protein B Homo sapiens 42-51 9461574-11 1998 Here we show that oxidation of the S100B cysteine residues, Cys-68 and Cys-84, induces a conformational change in the protein structure, unmasking a canonical CKII phosphorylation site located within the typical EF-hand calcium-binding site IIbeta. Calcium 220-227 S100 calcium binding protein B Homo sapiens 35-40 9693957-1 1998 Psoriasin (S100A7) is a relatively new member of the S100 gene family that is located within the S100 gene cluster on chromosome 1q21 and shares the typical calcium binding domains that define this family of proteins. Calcium 157-164 S100 calcium binding protein B Homo sapiens 11-15 9693957-1 1998 Psoriasin (S100A7) is a relatively new member of the S100 gene family that is located within the S100 gene cluster on chromosome 1q21 and shares the typical calcium binding domains that define this family of proteins. Calcium 157-164 S100 calcium binding protein B Homo sapiens 53-57 9519411-0 1998 A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form. Calcium 81-88 S100 calcium binding protein B Homo sapiens 68-73 9519411-4 1998 While several studies have suggested that this interaction is propagated through a calcium-induced conformational change, leading to the exposure of a hydrophobic region of S100B, the molecular details behind this structural alteration remain unclear. Calcium 83-90 S100 calcium binding protein B Homo sapiens 173-178 9519411-5 1998 RESULTS: The solution structure of calcium-saturated human S100B (Ca(2+)-S100B) has been determined by heteronuclear NMR spectroscopy. Calcium 35-42 S100 calcium binding protein B Homo sapiens 59-64 9519411-5 1998 RESULTS: The solution structure of calcium-saturated human S100B (Ca(2+)-S100B) has been determined by heteronuclear NMR spectroscopy. Calcium 35-42 S100 calcium binding protein B Homo sapiens 66-78 9519411-6 1998 Ca(2+)-S100B forms a well defined globular structure comprising four EF-hand calcium-binding sites and an extensive hydrophobic dimer interface. Calcium 77-84 S100 calcium binding protein B Homo sapiens 0-12 9519411-7 1998 A comparison of Ca(2+)-S100B with apo S100B and Ca(2+)-calbindin D9k indicates that while calcium-binding to S100B results in little change in the site I EF-hand, it induces a backbone reorientation of the N terminus of the site II EF-hand. Calcium 90-97 S100 calcium binding protein B Homo sapiens 16-28 9519411-10 1998 While following the general mechanism of calcium modulatory proteins, whereby a hydrophobic target site is exposed, the "calcium switch" observed in S100B appears to be unique from that of other EF-hand proteins and may provide insights into target specificity among calcium modulatory proteins. Calcium 41-48 S100 calcium binding protein B Homo sapiens 149-154 9519411-10 1998 While following the general mechanism of calcium modulatory proteins, whereby a hydrophobic target site is exposed, the "calcium switch" observed in S100B appears to be unique from that of other EF-hand proteins and may provide insights into target specificity among calcium modulatory proteins. Calcium 121-128 S100 calcium binding protein B Homo sapiens 149-154 9519411-10 1998 While following the general mechanism of calcium modulatory proteins, whereby a hydrophobic target site is exposed, the "calcium switch" observed in S100B appears to be unique from that of other EF-hand proteins and may provide insights into target specificity among calcium modulatory proteins. Calcium 121-128 S100 calcium binding protein B Homo sapiens 149-154 9349333-1 1997 S-100, an acidic calcium-binding protein, is present within cells of neuroendocrine origin. Calcium 17-24 S100 calcium binding protein B Homo sapiens 0-5 9570563-1 1998 The 14-kDa myeloid-related protein (MRP-14) and its heterodimeric partner, MRP-8, are members of the S100 family of calcium-binding proteins (S100A9 and S100A8, respectively). Calcium 116-123 S100 calcium binding protein B Homo sapiens 101-105 9416599-5 1997 They make up a patch across the S100B dimer interface and include some residues that are quite buried in the structure of calcium-free S100B. Calcium 122-129 S100 calcium binding protein B Homo sapiens 135-140 9428666-6 1997 All of the mutants exhibited heat stability and calcium dependent conformational changes which were identical to recombinant S100B. Calcium 48-55 S100 calcium binding protein B Homo sapiens 125-130 9428666-7 1997 In addition, S100B proteins containing two, one or no cysteine residues behaved as dimers in size exclusion chromatography experiments in the presence or absence of calcium as well as in the presence or absence of reducing agent. Calcium 165-172 S100 calcium binding protein B Homo sapiens 13-18 9356152-0 1997 Calcium-modulated proteins change their immunoreactivity in the presence of Ca2+: a study of antibody recognition in a dot immunoassay for calmodulin, calcineurin (beta-subunit), and S100B. Calcium 0-7 S100 calcium binding protein B Homo sapiens 183-188 9923701-1 1998 S100 proteins are a group of small dimeric calcium-binding proteins making up a large subclass of the EF-hand family of calcium-binding proteins. Calcium 43-50 S100 calcium binding protein B Homo sapiens 0-4 9923701-1 1998 S100 proteins are a group of small dimeric calcium-binding proteins making up a large subclass of the EF-hand family of calcium-binding proteins. Calcium 120-127 S100 calcium binding protein B Homo sapiens 0-4 9923701-3 1998 Recently, NMR spectroscopy has provided the three-dimensional structures of the S100 family members S100A6 and S100B in both the apo- and calcium-bound forms. Calcium 138-145 S100 calcium binding protein B Homo sapiens 80-84 9923701-3 1998 Recently, NMR spectroscopy has provided the three-dimensional structures of the S100 family members S100A6 and S100B in both the apo- and calcium-bound forms. Calcium 138-145 S100 calcium binding protein B Homo sapiens 111-116 9416599-2 1997 We have made backbone assignments of the calcium-bound form of S100B and used chemical-shift changes in spectra of 15N-labeled protein to locate the site that binds a peptide corresponding to residues 265-276 from CapZ alpha, the actin capping protein. Calcium 41-48 S100 calcium binding protein B Homo sapiens 63-68 9369488-0 1997 Structural and functional characterization of retinal calcium-dependent guanylate cyclase activator protein (CD-GCAP): identity with S100beta protein. Calcium 54-61 S100 calcium binding protein B Homo sapiens 133-141 9369488-5 1997 S100b also required about 15 times more calcium (3.2 x 10(-)5 vs 1.5 x 10(-)6 M) for half-maximal stimulation of cyclase. Calcium 40-47 S100 calcium binding protein B Homo sapiens 0-5 9245399-1 1997 S100 beta is a member of a group of low-molecular weight acidic calcium binding proteins widely distributed in the vertebrate nervous system containing two helix-loop-helix calcium binding motifs (sites I and II). Calcium 64-71 S100 calcium binding protein B Homo sapiens 0-9 9278633-11 1997 The low frequency and proliferative index of S100 beta-specific, as opposed to MBP-specific T-cell responses suggests that the T-cell response to this widely expressed calcium-binding protein is under more efficient regulatory control. Calcium 168-175 S100 calcium binding protein B Homo sapiens 45-54 9245399-1 1997 S100 beta is a member of a group of low-molecular weight acidic calcium binding proteins widely distributed in the vertebrate nervous system containing two helix-loop-helix calcium binding motifs (sites I and II). Calcium 173-180 S100 calcium binding protein B Homo sapiens 0-9 9191095-1 1997 S100 beta is a calcium-binding protein produced and secreted by glial cells in the central and peripheral nervous systems. Calcium 15-22 S100 calcium binding protein B Homo sapiens 0-9 9335118-0 1997 Assignment and secondary structure of calcium-bound human S100B. Calcium 38-45 S100 calcium binding protein B Homo sapiens 58-63 9335118-1 1997 The NMR assignments of backbone 1H, 13C, and 15N resonances for calcium-bound human S100B were completed via heteronuclear multidimensional NMR spectroscopic techniques. Calcium 64-71 S100 calcium binding protein B Homo sapiens 84-89 9335118-7 1997 In addition, several residues outside the calcium-binding loops in S100B undergo significant backbone chemical shift changes upon binding calcium which are not observed in the related protein calbindin D9k. Calcium 42-49 S100 calcium binding protein B Homo sapiens 67-72 9335118-7 1997 In addition, several residues outside the calcium-binding loops in S100B undergo significant backbone chemical shift changes upon binding calcium which are not observed in the related protein calbindin D9k. Calcium 138-145 S100 calcium binding protein B Homo sapiens 67-72 9202034-1 1997 Using a two hybrid system screen of a human cDNA library, we have found that p11, a unique member of the S100 family of calcium-binding proteins, interacts with the carboxyl region of the 85-kDa cytosolic phospholipase A2 (cPLA2). Calcium 120-127 S100 calcium binding protein B Homo sapiens 105-109 9096366-6 1997 The calcium chelating agent EGTA also inhibits the IL-10 production induced by Nef, and this inhibition is reversed by the addition of calcium along with Nef. Calcium 4-11 S100 calcium binding protein B Homo sapiens 79-82 9096366-6 1997 The calcium chelating agent EGTA also inhibits the IL-10 production induced by Nef, and this inhibition is reversed by the addition of calcium along with Nef. Calcium 4-11 S100 calcium binding protein B Homo sapiens 154-157 9266413-1 1997 S100 beta protein is a calcium binding protein that is not only expressed by astrocytes in the CNS, but also in many other tissues including the eye, thymus, spleen and lymph nodes. Calcium 23-30 S100 calcium binding protein B Homo sapiens 0-9 9059708-1 1997 Protein S-100 is a calcium binding protein, synthetized in astroglial cells in all parts of the central nervous system (CNS). Calcium 19-26 S100 calcium binding protein B Homo sapiens 8-13 21590010-0 1997 Histochemical characteristics of calcium binding S100 proteins and bone morphogenetic proteins in chondro-osseous tumors. Calcium 33-40 S100 calcium binding protein B Homo sapiens 49-53 21590010-5 1997 Biological roles of S100B in chondroid cells may involve Ca2+-signaling in precalcified tissue, cytoskeletal protein organization and matrix formation since glycosaminoglycan synthesis is mediated by calcium ions. Calcium 200-207 S100 calcium binding protein B Homo sapiens 20-25 8898860-1 1996 S100 beta is a calcium binding protein expressed primarily by astrocytes in the brain. Calcium 15-22 S100 calcium binding protein B Homo sapiens 0-9 8977631-6 1996 This gene is a previously identified member of the S100 gene family of calcium-binding proteins, namely S100P. Calcium 71-78 S100 calcium binding protein B Homo sapiens 51-55 8965656-1 1996 S100 protein is a 20 kDA calcium-binding protein that accumulates during CNS maturation in mammals. Calcium 25-32 S100 calcium binding protein B Homo sapiens 0-4 8894274-1 1996 Phosphoglucomutase was identified as a potential intracellular S100 target protein because it interacted with two members of the S100 family of calcium-modulated proteins, S100A1 and S100B, in gel overlay experiments. Calcium 144-151 S100 calcium binding protein B Homo sapiens 183-188 8894274-2 1996 These results were confirmed by affinity chromatography experiments demonstrating that S100A1 and S100B bound to phosphoglucomutase-Sepharose in a calcium-dependent manner. Calcium 147-154 S100 calcium binding protein B Homo sapiens 98-103 8894274-3 1996 In the reverse experiment, phosphoglucomutase bound to S100A1 and S100B-Sepharose in a calcium-dependent manner. Calcium 87-94 S100 calcium binding protein B Homo sapiens 66-71 8894274-5 1996 In contrast, S100B stimulated phosphoglucomutase activity in a calcium-dependent manner. Calcium 63-70 S100 calcium binding protein B Homo sapiens 13-18 8894274-8 1996 This is the first report of an S100 target protein whose activity is antagonistically regulated by S100A1 and S100B, suggesting that cellular diversity in intracellular calcium signaling pathways may be due, at least in part, to the complement of S100 proteins expressed in different cell types. Calcium 169-176 S100 calcium binding protein B Homo sapiens 110-115 8688416-0 1996 Structural influence of cation binding to recombinant human brain S100b: evidence for calcium-induced exposure of a hydrophobic surface. Calcium 86-93 S100 calcium binding protein B Homo sapiens 66-71 8688416-1 1996 The dimeric calcium-binding protein S100b is proposed to undergo a calcium-induced structural change allowing it to interact, via a hydrophobic surface, with other proteins. Calcium 12-19 S100 calcium binding protein B Homo sapiens 36-41 8688416-1 1996 The dimeric calcium-binding protein S100b is proposed to undergo a calcium-induced structural change allowing it to interact, via a hydrophobic surface, with other proteins. Calcium 67-74 S100 calcium binding protein B Homo sapiens 36-41 8688416-2 1996 Previously it has been suggested that calcium binding to S100b leads to the exposure of at least one phenylalanine residue (Mani et al., 1982, 1983). Calcium 38-45 S100 calcium binding protein B Homo sapiens 57-62 8688416-4 1996 To study these effects, we monitored calcium binding to recombinant human S100b by NMR spectroscopy under different salt (KCI) conditions. Calcium 37-44 S100 calcium binding protein B Homo sapiens 74-79 8688416-5 1996 15N-Labeled glycine residues in S100b showed calcium-induced chemical shift changes similar to those reported for the related monomeric protein calbindin D9k, suggesting similar conformational changes are occurring in the calcium-binding loops of these two proteins. Calcium 45-52 S100 calcium binding protein B Homo sapiens 32-37 8688416-5 1996 15N-Labeled glycine residues in S100b showed calcium-induced chemical shift changes similar to those reported for the related monomeric protein calbindin D9k, suggesting similar conformational changes are occurring in the calcium-binding loops of these two proteins. Calcium 222-229 S100 calcium binding protein B Homo sapiens 32-37 8688416-6 1996 Calcium binding to S100b also resulted in a shifting and broadening of several 1H resonances from the Ca-S100b form only including those from the side chains of residues F14, F70, and F73 but not those of residue Y17. Calcium 0-7 S100 calcium binding protein B Homo sapiens 19-24 8688416-6 1996 Calcium binding to S100b also resulted in a shifting and broadening of several 1H resonances from the Ca-S100b form only including those from the side chains of residues F14, F70, and F73 but not those of residue Y17. Calcium 0-7 S100 calcium binding protein B Homo sapiens 105-110 8688416-9 1996 These observations are consistent with the calcium-induced exposure of at least one of these hydrophobic residues, resulting in self-association of the S100b dimer. Calcium 43-50 S100 calcium binding protein B Homo sapiens 152-157 8663223-5 1996 The interaction of Nef and thetaPKC is independent of calcium, enhanced by phospholipid activators of PKC and not affected by a PKC pseudosubstrate peptide. Calcium 54-61 S100 calcium binding protein B Homo sapiens 19-22 8805196-0 1996 [Calcyclin--calcium binding protein of the S-100 protein]. Calcium 12-19 S100 calcium binding protein B Homo sapiens 43-48 8609051-7 1996 The evidence suggests that measurements of the calcium-binding proteins calbindin-D and S-100b would be useful for evaluating the prognosis of patients with neuroblastoma. Calcium 47-54 S100 calcium binding protein B Homo sapiens 72-94 7613474-0 1995 Human S100b protein: formation of a tetramer from synthetic calcium-binding site peptides. Calcium 60-67 S100 calcium binding protein B Homo sapiens 6-11 7552751-1 1995 The S100 calcium-binding proteins are implicated as effectors in calcium-mediated signal transduction pathways. Calcium 9-16 S100 calcium binding protein B Homo sapiens 4-8 7552751-4 1995 Dimerization is mediated by hydrophobic contacts from several highly conserved residues, which suggests that the dimer fold identified for calcyclin will serve as a structural paradigm for the S100 subfamily of calcium-binding proteins. Calcium 211-218 S100 calcium binding protein B Homo sapiens 193-197 7568910-1 1995 The S-100 is a group of low molecular weight (10-12 kD) calcium-binding proteins highly conserved among vertebrates. Calcium 56-63 S100 calcium binding protein B Homo sapiens 4-9 7606463-1 1995 S100 beta is a calcium-binding protein elevated in Down"s syndrome and Alzheimer"s disease. Calcium 15-22 S100 calcium binding protein B Homo sapiens 0-9 7609624-1 1995 S-100 beta, a calcium binding protein produced by astrocytes, has been proposed to be a neuronotropic agent. Calcium 14-21 S100 calcium binding protein B Homo sapiens 0-10 7790864-2 1995 S100 beta is an astrocyte-derived cytokine that promotes neurite growth and induces increases in levels of intracellular calcium in neurons. Calcium 121-128 S100 calcium binding protein B Homo sapiens 0-9 7613474-1 1995 Human brain S100b protein is a unique calcium-binding protein comprised of two identical 91-amino acid polypeptide chains that each contain two proposed helix-loop-helix (EF-hand) calcium-binding sites. Calcium 38-45 S100 calcium binding protein B Homo sapiens 12-17 7613474-1 1995 Human brain S100b protein is a unique calcium-binding protein comprised of two identical 91-amino acid polypeptide chains that each contain two proposed helix-loop-helix (EF-hand) calcium-binding sites. Calcium 180-187 S100 calcium binding protein B Homo sapiens 12-17 7613474-2 1995 In order to probe the assembly of the four calcium-binding sites in S100b, a peptide comprised of the N-terminal 46 residues of S100b protein was synthesized and studied by CD and 1H NMR spectroscopies as a function of concentration and temperature. Calcium 43-50 S100 calcium binding protein B Homo sapiens 68-73 7613474-7 1995 It is proposed that this tetrameric fold also occurs in S100b and is a result of the interaction of portions of all four calcium-binding sites. Calcium 121-128 S100 calcium binding protein B Homo sapiens 56-61 7759097-0 1995 Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Calcium 134-141 S100 calcium binding protein B Homo sapiens 52-56 7759097-0 1995 Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Calcium 134-141 S100 calcium binding protein B Homo sapiens 129-133 7759097-1 1995 S100 proteins are low-molecular-weight calcium-binding proteins of the EF-hand superfamily and appear to be involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Calcium 39-46 S100 calcium binding protein B Homo sapiens 0-4 7759097-3 1995 We have now isolated a YAC clone from human chromosome 1q21, on which 9 different genes coding for S100 calcium-binding proteins could be localized. Calcium 104-111 S100 calcium binding protein B Homo sapiens 99-103 1664955-1 1991 S100 protein is a calcium-binding protein composed of two subunits S100 alpha and S100 beta, which are expressed selectively by specific cell types. Calcium 18-25 S100 calcium binding protein B Homo sapiens 82-91 7808229-5 1994 The marked inhibitory effect of S100 beta required the presence of calcium in the phosphorylation reactions. Calcium 67-74 S100 calcium binding protein B Homo sapiens 32-41 1315768-0 1992 S100 beta stimulates calcium fluxes in glial and neuronal cells. Calcium 21-28 S100 calcium binding protein B Homo sapiens 0-9 1315768-2 1992 We report here that dimeric S100 beta evokes increases in intracellular free calcium concentrations ([Ca2+]i) in both glial cells and neuronal cells. Calcium 77-84 S100 calcium binding protein B Homo sapiens 28-37 1315768-4 1992 S100 beta also stimulated hydrolysis of phosphoinositides, suggesting a mobilization of calcium from intracellular stores. Calcium 88-95 S100 calcium binding protein B Homo sapiens 0-9 7620916-1 1995 The S100 family of calcium binding proteins contains approximately 16 members each of which exhibits a unique pattern of tissue/cell type specific expression. Calcium 19-26 S100 calcium binding protein B Homo sapiens 4-8 7798169-0 1994 Calcium-dependent regulation of smooth muscle calponin by S100. Calcium 0-7 S100 calcium binding protein B Homo sapiens 58-62 8341667-0 1993 Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. Calcium 124-131 S100 calcium binding protein B Homo sapiens 4-8 8341667-3 1993 Here we describe a previously unrecognized gene cluster composed of genes coding for calcium-binding proteins of the S100 family. Calcium 85-92 S100 calcium binding protein B Homo sapiens 117-121 8493503-2 1993 S-100 protein is an acidic calcium binding protein widely distributed in different tissues and cells of different origin. Calcium 27-34 S100 calcium binding protein B Homo sapiens 0-5 1420327-1 1992 S100 beta is a calcium-binding protein with neurotrophic and mitogenic activities, both of which may be mediated by the protein"s ability to stimulate an increase in intracellular free calcium ([Ca2+]i). Calcium 15-22 S100 calcium binding protein B Homo sapiens 0-9 1420327-1 1992 S100 beta is a calcium-binding protein with neurotrophic and mitogenic activities, both of which may be mediated by the protein"s ability to stimulate an increase in intracellular free calcium ([Ca2+]i). Calcium 185-192 S100 calcium binding protein B Homo sapiens 0-9 1420327-4 1992 We also report a simplified procedure for preparation of pharmacological amounts of biologically active S100 beta dimers, based on the finding that formation of disulfide-linked S100 beta dimers can be stimulated by the presence of calcium or lipid. Calcium 232-239 S100 calcium binding protein B Homo sapiens 104-113 1420327-4 1992 We also report a simplified procedure for preparation of pharmacological amounts of biologically active S100 beta dimers, based on the finding that formation of disulfide-linked S100 beta dimers can be stimulated by the presence of calcium or lipid. Calcium 232-239 S100 calcium binding protein B Homo sapiens 178-187 2146955-1 1990 S100 protein is a low molecular weight calcium-binding protein widely distributed in the central nervous system of vertebrates. Calcium 39-46 S100 calcium binding protein B Homo sapiens 0-4 2052609-3 1991 Although cells expressing Nef-1 also induce calcium mobilization and the production of IL-2 receptor alpha chain, the formation of IL-2 mRNA is blocked in response to these stimuli. Calcium 44-51 S100 calcium binding protein B Homo sapiens 26-29 34411141-0 2021 The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling. Calcium 4-11 S100 calcium binding protein B Homo sapiens 28-33 33971224-1 2021 S100B is a calcium-binding protein mainly expressed by astrocytes, but also localized in other definite neural and extra-neural cell types. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 34411141-4 2021 S100B was shown to form a calcium-dependent protein complex with the p90 ribosomal S6 kinase (RSK), which in turn sequesters RSK into the cytoplasm. Calcium 26-33 S100 calcium binding protein B Homo sapiens 0-5 2964086-1 1988 S100 protein is a calcium-binding protein found predominantly in the vertebrate nervous system. Calcium 18-25 S100 calcium binding protein B Homo sapiens 0-4 34105746-3 2021 The findings of increased an acidic calcium-binding protein (S100B) concentration in biological fluids of infants after brain injury have supported the use of S100B as a biochemical marker of CNS damage. Calcium 36-43 S100 calcium binding protein B Homo sapiens 61-66 34105746-3 2021 The findings of increased an acidic calcium-binding protein (S100B) concentration in biological fluids of infants after brain injury have supported the use of S100B as a biochemical marker of CNS damage. Calcium 36-43 S100 calcium binding protein B Homo sapiens 159-164 35577153-2 2022 Ischemic conditions may be worsened by stress-induced release of glial-derived S100-calcium-binding-protein beta (S100B), which is pro-apoptotic for cardiomyocytes Whether estradiol as coping regulator and cardio-protective factor will protect against pro-apoptotic effects, remains unclear. Calcium 84-91 S100 calcium binding protein B Homo sapiens 114-119 34099858-2 2021 S100B is a calcium-binding protein, and a marker of glial dysfunctions. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 35236877-0 2022 Salivary S100 calcium-binding protein beta (S100B) and neurofilament light (NfL) after acute exposure to repeated head impacts in collegiate water polo players. Calcium 14-21 S100 calcium binding protein B Homo sapiens 44-49 35236877-2 2022 Two putative biomarkers of sport-related concussion, neurofilament light (NfL), an axonal structural protein, and S100 calcium-binding protein beta (S100B), an astrocyte-derived protein, were measured in saliva, a biofluid which can be sampled in an athletic setting without the risks and burdens associated with blood sampled by venipuncture. Calcium 119-126 S100 calcium binding protein B Homo sapiens 149-154 35216109-7 2022 Calcium depletion blocks the S100B-IFN-beta interaction. Calcium 0-7 S100 calcium binding protein B Homo sapiens 29-34 2736040-1 1989 S100b is a calcium-binding protein that will bind to many calmodulin target molecules in a Ca2+-dependent manner. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 2510778-9 1989 S-100 protein, another brain-derived calcium-binding protein, is contained in sustentacular cells of paraneuronal organs as well as glial elements of nervous systems. Calcium 37-44 S100 calcium binding protein B Homo sapiens 0-5 3170862-0 1988 Approaches to study the role of S100 proteins in calcium-dependent cellular responses. Calcium 49-56 S100 calcium binding protein B Homo sapiens 32-36 3405210-7 1988 They belong to a novel subfamily of highly homologous calcium-binding proteins which includes S100 alpha, S100 beta, intestinal calcium-binding protein, P11, and calcyclin (2A9). Calcium 54-61 S100 calcium binding protein B Homo sapiens 106-115 2833519-5 1988 It is suggested that the homologous calcium-binding domain that characterizes the carboxyl terminus of S100 and the tubulin subunit may be responsible for the common interaction of both proteins with tau proteins. Calcium 36-43 S100 calcium binding protein B Homo sapiens 103-107 3755724-5 1986 It has an open reading frame of 270 nucleotides, which has a 55% homology with the coding sequence of the beta-subunit of the S-100 protein, a calcium-binding protein that belongs (like calmodulin and the vitamin D-dependent intestinal calcium-binding protein) to the family of calcium-modulated proteins and is found in abundance in several human tumors, including melanoma. Calcium 143-150 S100 calcium binding protein B Homo sapiens 126-131 2896046-6 1988 All purified enteric glia continue to express the calcium binding protein S100, the basement membrane glycoprotein laminin and the antigens recognized by the A2B5 antibody, and subpopulations of glia are labelled by the monoclonal antibodies LB1 which binds to GD3 gangliosides, and Leu 7. Calcium 50-57 S100 calcium binding protein B Homo sapiens 74-78 3288791-4 1988 Moreover, a similar molecular mechanism of calcium signal transduction was also observed with other calcium-modulated proteins such as troponin C and S100 protein. Calcium 43-50 S100 calcium binding protein B Homo sapiens 150-154 3288791-4 1988 Moreover, a similar molecular mechanism of calcium signal transduction was also observed with other calcium-modulated proteins such as troponin C and S100 protein. Calcium 100-107 S100 calcium binding protein B Homo sapiens 150-154 3276520-2 1988 S100 protein, an acidic and calcium-binding protein, was believed to be localized in the nervous tissue, but recently it has been reported to be mainly present in the cardiac and the skeletal muscles of various mammals in the alpha alpha form (S100a0) at much higher levels than the nervous tissues. Calcium 28-35 S100 calcium binding protein B Homo sapiens 0-4 3111527-2 1987 Whether calcium was present or not in the solution, melittin and S100b form a complex of molar ratios up to 2:1. Calcium 8-15 S100 calcium binding protein B Homo sapiens 65-70 3111527-6 1987 The conformational changes induced in S100b by interaction with melittin increased its affinity for calcium and offset the inhibition of calcium binding otherwise observed in the presence of potassium ions. Calcium 100-107 S100 calcium binding protein B Homo sapiens 38-43 3111527-6 1987 The conformational changes induced in S100b by interaction with melittin increased its affinity for calcium and offset the inhibition of calcium binding otherwise observed in the presence of potassium ions. Calcium 137-144 S100 calcium binding protein B Homo sapiens 38-43 3111527-7 1987 This corroborated the previous finding that S100b affinity for calcium greatly depends on the protein conformation. Calcium 63-70 S100 calcium binding protein B Homo sapiens 44-49 3021276-1 1986 S-100 is a calcium-binding, glial protein which has been shown to be involved in behavioral learning and memory tasks. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 3755724-5 1986 It has an open reading frame of 270 nucleotides, which has a 55% homology with the coding sequence of the beta-subunit of the S-100 protein, a calcium-binding protein that belongs (like calmodulin and the vitamin D-dependent intestinal calcium-binding protein) to the family of calcium-modulated proteins and is found in abundance in several human tumors, including melanoma. Calcium 236-243 S100 calcium binding protein B Homo sapiens 126-131 3755724-5 1986 It has an open reading frame of 270 nucleotides, which has a 55% homology with the coding sequence of the beta-subunit of the S-100 protein, a calcium-binding protein that belongs (like calmodulin and the vitamin D-dependent intestinal calcium-binding protein) to the family of calcium-modulated proteins and is found in abundance in several human tumors, including melanoma. Calcium 236-243 S100 calcium binding protein B Homo sapiens 126-131 3734419-1 1986 The immunohistochemical localization of the calcium-binding protein, S100 beta, in human nervous system tumors has been examined by using a monoclonal antibody with specificity for the S100 beta polypeptide. Calcium 44-51 S100 calcium binding protein B Homo sapiens 69-78 3734419-1 1986 The immunohistochemical localization of the calcium-binding protein, S100 beta, in human nervous system tumors has been examined by using a monoclonal antibody with specificity for the S100 beta polypeptide. Calcium 44-51 S100 calcium binding protein B Homo sapiens 185-194 6733116-0 1984 Calcium-dependent hydrophobic chromatography of calmodulin, S-100 protein and troponin-C. We have demonstrated calcium-dependent hydrophobic interactions among calmodulin, S-100 protein and troponin-C and a homologous series of omega-aminoalkyl-agaroses. Calcium 111-118 S100 calcium binding protein B Homo sapiens 60-65 3911999-16 1985 From these results we assume that S-100 protein plays an important role of intracellular transport of cations as one of the calcium binding proteins. Calcium 124-131 S100 calcium binding protein B Homo sapiens 34-39 6487634-9 1984 These results indicated that the Ca2+- and Zn2+-binding sites on S100b protein are different and suggest that Zn2+ may regulate Ca2+ binding by increasing the affinity of the protein for calcium. Calcium 187-194 S100 calcium binding protein B Homo sapiens 65-70 6733116-0 1984 Calcium-dependent hydrophobic chromatography of calmodulin, S-100 protein and troponin-C. We have demonstrated calcium-dependent hydrophobic interactions among calmodulin, S-100 protein and troponin-C and a homologous series of omega-aminoalkyl-agaroses. Calcium 0-7 S100 calcium binding protein B Homo sapiens 60-65 6733116-0 1984 Calcium-dependent hydrophobic chromatography of calmodulin, S-100 protein and troponin-C. We have demonstrated calcium-dependent hydrophobic interactions among calmodulin, S-100 protein and troponin-C and a homologous series of omega-aminoalkyl-agaroses. Calcium 0-7 S100 calcium binding protein B Homo sapiens 172-177 6733116-0 1984 Calcium-dependent hydrophobic chromatography of calmodulin, S-100 protein and troponin-C. We have demonstrated calcium-dependent hydrophobic interactions among calmodulin, S-100 protein and troponin-C and a homologous series of omega-aminoalkyl-agaroses. Calcium 111-118 S100 calcium binding protein B Homo sapiens 172-177 710399-0 1978 The amino-acid sequence of S-100 protein (PAP I-b protein) and its relation to the calcium-binding proteins. Calcium 83-90 S100 calcium binding protein B Homo sapiens 27-32 6615778-0 1983 Ions binding to S100 proteins: structural changes induced by calcium and zinc on S100a and S100b proteins. Calcium 61-68 S100 calcium binding protein B Homo sapiens 91-96 7133987-3 1982 Calcium effects within the cell are mostly mediated through binding of the ion to low molecular weight proteins that form an evolutionary family including parvalbumin, calmodulin, troponin C, the alkali and regulatory light chains of myosin, the S-100 protein and the vitamin D-dependent intestinal calcium-binding protein. Calcium 0-7 S100 calcium binding protein B Homo sapiens 246-251 6615509-3 1983 KD = 10(-7) - 10(-6)M. We suggest that S100b protein should no longer be considered only as a "calcium binding protein" but also as a "zinc binding protein", and that Zn2+ ions are involved in the functions of the S100 proteins. Calcium 95-102 S100 calcium binding protein B Homo sapiens 39-44 33122776-2 2020 We focused on S100B, a calcium-binding protein present in biological fluids, being a reliable biomarker in disorders having inflammatory processes as common basis and RAGE as main receptor. Calcium 23-30 S100 calcium binding protein B Homo sapiens 14-19 34045267-7 2021 Significance Statement S100B is a small calcium-binding protein that modulates signaling by the dopamine D2 receptor. Calcium 40-47 S100 calcium binding protein B Homo sapiens 23-28 32727332-2 2021 S100B is a helix-loop-helix protein with calcium-binding domain associated to various neurological disorders through activation of MAPK pathway, increased NFkB expression results in cell survival, proliferation and gene up-regulation. Calcium 41-48 S100 calcium binding protein B Homo sapiens 0-5 33052436-2 2021 In search of novel molecular factors that may contribute to PD pathogenesis, emerging evidence highlights the multifunctional role of the calcium-binding protein S100B that is widely expressed in the brain and predominantly in astrocytes. Calcium 138-145 S100 calcium binding protein B Homo sapiens 162-167 33294444-1 2020 Background: S100 family genes exclusively encode at least 20 calcium-binding proteins, which possess a wide spectrum of intracellular and extracellular functions in vertebrates. Calcium 61-68 S100 calcium binding protein B Homo sapiens 12-16 32722137-1 2020 S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of vertebrates, which are involved in numerous cellular processes, such as Ca2+ homeostasis, proliferation, apoptosis, differentiation, and inflammation. Calcium 59-66 S100 calcium binding protein B Homo sapiens 0-4 32664008-1 2020 BACKGROUND: The calcium binding protein S100B and brain derived neurotrophic factor (BDNF) are both biomarkers implicated in neuronal processes in the central nervous system and seem to be associated with affective disorders. Calcium 16-23 S100 calcium binding protein B Homo sapiens 40-45 32772615-1 2022 Background: Calcium-binding proteins are heterogeneous proteins that act binding this ion in specific domains, performing numerous functions.Objective: In the present review, we aim to gather principal information about S100B protein in the Central Nervous System (CNS), highlighting its particularities, mapping, functionalities, and consequences on CNS dysfunction.Methods: The research was carried out by searching Pubmed, Medline, Science Direct, Lilacs, the Cochrane Library, and Web of Science databases using the following descriptors: S100 protein; Central Nervous System; Nervous Lesions, as well as their corresponding terms in Portuguese and Spanish. Calcium 12-19 S100 calcium binding protein B Homo sapiens 220-225 32772615-1 2022 Background: Calcium-binding proteins are heterogeneous proteins that act binding this ion in specific domains, performing numerous functions.Objective: In the present review, we aim to gather principal information about S100B protein in the Central Nervous System (CNS), highlighting its particularities, mapping, functionalities, and consequences on CNS dysfunction.Methods: The research was carried out by searching Pubmed, Medline, Science Direct, Lilacs, the Cochrane Library, and Web of Science databases using the following descriptors: S100 protein; Central Nervous System; Nervous Lesions, as well as their corresponding terms in Portuguese and Spanish. Calcium 12-19 S100 calcium binding protein B Homo sapiens 220-224 32772615-2 2022 The terms were first searched separately, then together.Results: Due to its ability to bind with calcium, S100B is involved in the regulation of several intra- and extracellular physiological processes. Calcium 97-104 S100 calcium binding protein B Homo sapiens 106-111 33006697-1 2021 The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. Calcium 9-16 S100 calcium binding protein B Homo sapiens 47-52 32804418-3 2020 S100B protein is a calcium-binding protein, found in the cytoplasm of glial cells in the central nervous system, which is released in response to inflammatory stimuli. Calcium 19-26 S100 calcium binding protein B Homo sapiens 0-5 31916532-1 2020 BACKGROUND: S100B is a calcium-binding protein found primarily in glial cells. Calcium 23-30 S100 calcium binding protein B Homo sapiens 12-17 32486507-4 2020 The calcium- and zinc-binding S100B is a downstream effector in the CLSTN3beta pathways. Calcium 4-11 S100 calcium binding protein B Homo sapiens 30-35 32027773-0 2020 The Zn2+ and Ca2+ -binding S100B and S100A1 proteins: beyond the myths. Calcium 13-17 S100 calcium binding protein B Homo sapiens 27-32 32027773-1 2020 The S100 genes encode a conserved group of 21 vertebrate-specific EF-hand calcium-binding proteins. Calcium 74-81 S100 calcium binding protein B Homo sapiens 4-8 32027773-3 2020 In this review, we summarize the calcium- and zinc-binding properties of the dimeric S100B and S100A1 proteins and highlight data that shed new light on the extracellular and intracellular regulation and functions of S100B. Calcium 33-40 S100 calcium binding protein B Homo sapiens 85-90 32027773-5 2020 The Ca2+ and Zn2+ -dependent interactions of S100B with a wide array of proteins form the basis of its activities and have led to the derivation of some initial rules for S100B recognition of protein targets. Calcium 4-8 S100 calcium binding protein B Homo sapiens 45-50 32027773-5 2020 The Ca2+ and Zn2+ -dependent interactions of S100B with a wide array of proteins form the basis of its activities and have led to the derivation of some initial rules for S100B recognition of protein targets. Calcium 4-8 S100 calcium binding protein B Homo sapiens 171-176 31786729-1 2020 The calcium-binding protein S100b is secreted by glial cells in the brain and is also expressed by melanocytes. Calcium 4-11 S100 calcium binding protein B Homo sapiens 28-33 31928049-3 2019 S100B is a calcium binding protein, mainly found in astrocytes and therefore used as a marker of their activity. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 31156365-1 2019 S100 proteins are calcium-binding proteins that regulate several processes associated with Alzheimer"s disease (AD) but whose contribution and direct involvement in disease pathophysiology remains to be fully established. Calcium 18-25 S100 calcium binding protein B Homo sapiens 0-4 31103949-1 2019 S100 proteins constitute a large subfamily of the EF-hand superfamily of calcium binding proteins. Calcium 73-80 S100 calcium binding protein B Homo sapiens 0-4 30719832-0 2019 A subset of calcium-binding S100 proteins show preferential heterodimerization. Calcium 12-19 S100 calcium binding protein B Homo sapiens 28-32 30719832-5 2019 In this work, we have established co-expression methods in order to identify and quantify the distribution of homo- and heterodimers for four specific pairs of S100 proteins in their calcium-free states. Calcium 183-190 S100 calcium binding protein B Homo sapiens 160-164 31050191-1 2019 S100 proteins are a sub-family of EF-hand calcium binding proteins that form very similar, unique dimer structures. Calcium 42-49 S100 calcium binding protein B Homo sapiens 0-4 30710281-1 2019 S100B is a small, dimeric, calcium-binding protein that is implicated in various diseases, most significantly cancer; therefore, there is interest in identifying S100B inhibitors that may have therapeutic value (Bresnick et al. Calcium 27-34 S100 calcium binding protein B Homo sapiens 0-5 30902545-3 2019 Here, we identified Calcium (Ca2+)/Calmodulin dependent protein kinase II subunit delta (CAMKIIdelta) as novel Nef interacting host protein. Calcium 20-27 S100 calcium binding protein B Homo sapiens 111-114 31044150-2 2019 S100B protein is a cytosolic calcium-binding protein with a molecular weight of 21 kDa, which is present in various cells and concentrated mainly in the glial cells, which play a vital role in the maintenance of cellular homeostasis in the central nervous system. Calcium 29-36 S100 calcium binding protein B Homo sapiens 0-5 31683478-1 2019 BACKGROUND: Increased expression of the astroglial Ca2+-binding protein S100B has been observed in various neurodegenerative diseases and also seems to play a role in the unfolding of pathophysiological events at early stages of Alzheimer"s disease (AD). Calcium 51-54 S100 calcium binding protein B Homo sapiens 72-77 30710304-0 2019 Clinical Use of the Calcium-Binding S100B Protein, a Biomarker for Head Injury. Calcium 20-27 S100 calcium binding protein B Homo sapiens 36-41 30710282-1 2019 S100B is a dimeric EF-hand protein that undergoes a calcium-induced conformational change and interacts with a wide range of proteins to modulate their functions. Calcium 52-59 S100 calcium binding protein B Homo sapiens 0-5 30710304-1 2019 S100B is a calcium-binding protein most abundant in neuronal tissue. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 30710306-4 2019 Recently, the calcium-binding S100B protein has been proposed as being an ideal neurobiomarker, thanks to its simple availability and easy reproducibility, to the possibility of detecting it noninvasively in biological fluids with good reproducibility, and to the possibility of a longitudinal evaluation in relation to reference curves. Calcium 14-21 S100 calcium binding protein B Homo sapiens 30-35 30710282-3 2019 In this chapter, we describe the use of NMR spectroscopy to examine the interaction between calcium-bound S100B and the third intracellular loop (IC3) from the dopamine D2 receptor. Calcium 92-99 S100 calcium binding protein B Homo sapiens 106-111 29679260-0 2019 Slow Release of HIV-1 Protein Nef from Vesicle-like Structures Is Inhibited by Cytosolic Calcium Elevation in Single Human Microglia. Calcium 89-96 S100 calcium binding protein B Homo sapiens 30-33 29764272-2 2018 BACKGROUND: S100B is a calcium-binding protein located in glial cells; it is regarded as a potential biomarker in affective disorders. Calcium 23-30 S100 calcium binding protein B Homo sapiens 12-17 30087119-3 2018 Here, we present evidence that the equilibrium between these filaments and single NM2A and NM2B molecules can be controlled via S100 calcium-binding protein interactions and phosphorylation at the C-terminal end of the heavy chains. Calcium 133-140 S100 calcium binding protein B Homo sapiens 128-132 30018736-1 2018 The S100 gene family is the largest subfamily of calcium binding proteins of EF-hand type, expressed in tissue and cell-specific manner, acting both as intracellular regulators and extracellular mediators. Calcium 49-56 S100 calcium binding protein B Homo sapiens 4-8 29963623-0 2018 The neuronal S100B protein is a calcium-tuned suppressor of amyloid-beta aggregation. Calcium 32-39 S100 calcium binding protein B Homo sapiens 13-18 29963623-5 2018 We determined the structural details of the interaction between monomeric Abeta42 and S100B, which is favored by calcium binding to S100B, possibly involving conformational switching of disordered Abeta42 into an alpha-helical conformer, which locks aggregation. Calcium 113-120 S100 calcium binding protein B Homo sapiens 86-91 29963623-5 2018 We determined the structural details of the interaction between monomeric Abeta42 and S100B, which is favored by calcium binding to S100B, possibly involving conformational switching of disordered Abeta42 into an alpha-helical conformer, which locks aggregation. Calcium 113-120 S100 calcium binding protein B Homo sapiens 132-137 29963623-7 2018 This physical interaction is coupled to a functional role in the inhibition of Abeta42 aggregation and toxicity and is tuned by calcium binding to S100B. Calcium 128-135 S100 calcium binding protein B Homo sapiens 147-152 29963623-8 2018 S100B delays the onset of Abeta42 aggregation by interacting with Abeta42 monomers inhibiting primary nucleation, and the calcium-bound state substantially affects secondary nucleation by inhibiting fibril surface-catalyzed reactions through S100B binding to growing Abeta42 oligomers and fibrils. Calcium 122-129 S100 calcium binding protein B Homo sapiens 242-247 29529989-3 2018 S100B is widely expressed in the central nervous system and has many functions such as regulating calcium homeostasis, inflammatory processes, cytoskeleton assembly/disassembly, protein phosphorylation and degradation, and cell proliferation and differentiation. Calcium 98-105 S100 calcium binding protein B Homo sapiens 0-5 28656478-2 2017 Autoantibodies against central nervous system (CNS) proteins and S100 calcium-binding beta (S100beta) were found increased in diseases characterized by cognitive impairment like Alzheimer disease and Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). Calcium 70-77 S100 calcium binding protein B Homo sapiens 92-100 28876468-1 2018 BACKGROUND: S100 is a superfamily of calcium-binding proteins that regulate multiple biological processes and are involved in many diseases. Calcium 37-44 S100 calcium binding protein B Homo sapiens 12-16 29386995-3 2017 One such protein is neuronal S100B, a calcium and zinc binding damage-associated molecular pattern (DAMP), whose chronic upregulation is associated with aging, Alzheimer"s disease (AD), motor neuron disease and traumatic brain injury (TBI). Calcium 38-45 S100 calcium binding protein B Homo sapiens 29-34 29386995-8 2017 Our results indicate that scavenging of zinc by increased levels of S100B affects calcium levels in vitro. Calcium 82-89 S100 calcium binding protein B Homo sapiens 68-73 29386995-9 2017 Thereby S100B is able to mediate the cross talk between calcium and zinc homeostasis. Calcium 56-63 S100 calcium binding protein B Homo sapiens 8-13 29386995-10 2017 Further, we investigated a possible new neuro-protective role of S100B in excitotoxicity via its effects on calcium and zinc homeostasis. Calcium 108-115 S100 calcium binding protein B Homo sapiens 65-70 29379499-1 2017 The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, proliferation, differentiation, energy metabolism, and inflammation. Calcium 31-38 S100 calcium binding protein B Homo sapiens 4-8 29379499-1 2017 The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, proliferation, differentiation, energy metabolism, and inflammation. Calcium 150-157 S100 calcium binding protein B Homo sapiens 4-8 29146477-1 2018 S100 protein family, representing 25 relatively small calcium binding proteins, has been reported to be involved in multiple stages of tumorigenesis and progression. Calcium 54-61 S100 calcium binding protein B Homo sapiens 0-4 28435992-1 2018 S100B is a calcium binding protein mainly produced by glial cells. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 30854023-2 2018 S100B recognizes and binds effector proteins in a calcium-dependent manner. Calcium 50-57 S100 calcium binding protein B Homo sapiens 0-5 27475892-2 2016 S100B is a calcium-binding protein, mostly produced and secreted by astrocytes in the CNS that participate in several cellular responses. Calcium 11-18 S100 calcium binding protein B Homo sapiens 0-5 28251322-1 2017 Calprotectin is an S100 protein and marker of inflammation found in neutrophils and monocytes; S100 proteins are a family of calcium-modulated proteins. Calcium 125-132 S100 calcium binding protein B Homo sapiens 95-99 26726132-6 2017 A specific subset of the calcium sensor proteins (calmodulin, S100B, NCS-1, GCAP-1/2) exhibits metal-dependent binding of IL-11 with dissociation constants of 1-19 muM. Calcium 25-32 S100 calcium binding protein B Homo sapiens 62-67 27925190-0 2017 S100A1 and S100B: Calcium Sensors at the Cross-Roads of Multiple Chondrogenic Pathways. Calcium 18-25 S100 calcium binding protein B Homo sapiens 11-16 28418321-12 2017 CONCLUSION: The S100A10 and S100B genes, which are located on different chromosomes, encode specialized calcium-binding proteins. Calcium 104-111 S100 calcium binding protein B Homo sapiens 28-33 27251136-1 2016 BACKGROUND: S100 proteins are a large family of calcium binding proteins present only in vertebrates. Calcium 48-55 S100 calcium binding protein B Homo sapiens 12-16 27798165-0 2016 HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse. Calcium 35-42 S100 calcium binding protein B Homo sapiens 6-9 26833319-1 2016 S100 proteins are a family of highly acidic calcium-binding proteins involved in calcium handling in many tissues and organs. Calcium 44-51 S100 calcium binding protein B Homo sapiens 0-4 26833319-1 2016 S100 proteins are a family of highly acidic calcium-binding proteins involved in calcium handling in many tissues and organs. Calcium 81-88 S100 calcium binding protein B Homo sapiens 0-4 27870504-3 2016 We examined whether lithium pretreatment attenuates thrombin-stimulated TRPC3 expression and function in astrocytes, and levels of the calcium-binding peptide, S100B, which is expressed mainly in these cells. Calcium 135-142 S100 calcium binding protein B Homo sapiens 160-165 27600583-3 2016 Previously, we reported that S100 proteins activate PP5 in a calcium-dependent manner. Calcium 61-68 S100 calcium binding protein B Homo sapiens 29-33 27995066-1 2016 The S100B protein is an intra-cellular calcium-binding protein that mainly resides in astrocytes in the central nervous system. Calcium 39-46 S100 calcium binding protein B Homo sapiens 4-9