PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30875347-0	2019	Methylxanthine derivatives promote autophagy in gastric cancer cells targeting PTEN.	methylxanthine	0-14	phosphatase and tensin homolog	Homo sapiens	79-83	
30875347-1	2019	Methylxanthine derivatives, such as caffeine and theophylline, enhance cell apoptosis and autophagy and reportedly induce the activity of phosphatase and tensin homologue (PTEN) and inhibit the mammalian target of rapamycin (mTOR).	methylxanthine	0-14	phosphatase and tensin homolog	Homo sapiens	138-170	
20103602-11	2010	Our data suggest that the methylxanthine caffeine or its derivative pentoxifylline are promising candidate drugs for the radiosensitization of glioma cells particularly with PTEN mutations.	methylxanthine	26-40	phosphatase and tensin homolog	Homo sapiens	174-178	
30875347-1	2019	Methylxanthine derivatives, such as caffeine and theophylline, enhance cell apoptosis and autophagy and reportedly induce the activity of phosphatase and tensin homologue (PTEN) and inhibit the mammalian target of rapamycin (mTOR).	methylxanthine	0-14	phosphatase and tensin homolog	Homo sapiens	172-176	
30875347-7	2019	PTEN knockdown impaired the methylxanthine derivative-mediated inhibition of PI3K/Akt/mTOR signalling.	methylxanthine	28-42	phosphatase and tensin homolog	Homo sapiens	0-4	
30875347-9	2019	These results show that the methylxanthine derivatives (caffeine and theophylline) effectively induce gastric cancer cell apoptosis and autophagy by PTEN activation and PI3K/Akt/mTOR pathway suppression and strongly support the use of methylxanthine derivatives as potential anticancer therapeutics.	methylxanthine	28-42	phosphatase and tensin homolog	Homo sapiens	149-153