PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28212276-2	2017	Pentoxifylline (PTX), a methylxanthine derivative, has been reported to suppress the production of tumor necrosis factor (TNF)-alpha and possess anti-inflammatory properties.	methylxanthine	24-38	tumor necrosis factor	Mus musculus	99-132	
10996031-1	2000	Pentoxifylline (PTX), a methylxanthine derivative, has been reported to be an effective drug in inhibiting TNF-alpha responses during septic shock.	methylxanthine	24-38	tumor necrosis factor	Mus musculus	107-116	
8786577-0	1996	Tumor necrosis factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines.	methylxanthine	99-114	tumor necrosis factor	Mus musculus	0-21	
8764378-0	1996	Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock.	methylxanthine	102-116	tumor necrosis factor	Mus musculus	47-68	
8764378-3	1996	The methylxanthines attenuated systemic release of endogenous tumor necrosis factor (TNF) and interferon-gamma during endotoxic shock, and potently up-regulated early production of circulating interleukin-10 and interleukin-6.	methylxanthine	4-19	tumor necrosis factor	Mus musculus	62-83	
8764378-3	1996	The methylxanthines attenuated systemic release of endogenous tumor necrosis factor (TNF) and interferon-gamma during endotoxic shock, and potently up-regulated early production of circulating interleukin-10 and interleukin-6.	methylxanthine	4-19	tumor necrosis factor	Mus musculus	85-88	
8786577-4	1996	Infusion of these methylxanthines into livers from mice pretreated with lipopolysaccharide or TNF also inhibited TNF release in an immediate and reversible way even after TNF production had been initiated.	methylxanthine	18-33	tumor necrosis factor	Mus musculus	94-97	
8786577-4	1996	Infusion of these methylxanthines into livers from mice pretreated with lipopolysaccharide or TNF also inhibited TNF release in an immediate and reversible way even after TNF production had been initiated.	methylxanthine	18-33	tumor necrosis factor	Mus musculus	113-116	
8786577-4	1996	Infusion of these methylxanthines into livers from mice pretreated with lipopolysaccharide or TNF also inhibited TNF release in an immediate and reversible way even after TNF production had been initiated.	methylxanthine	18-33	tumor necrosis factor	Mus musculus	113-116