PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20859795-3	2011	A number of studies have indicated that methylxanthines also exert effects through alternative mechanisms, in particular via activation of sarcoplasmic reticulum or endoplasmic reticulum ryanodine receptor (RyR) channels.	methylxanthine	40-55	ryanodine receptor 1	Homo sapiens	187-205	
20859795-3	2011	A number of studies have indicated that methylxanthines also exert effects through alternative mechanisms, in particular via activation of sarcoplasmic reticulum or endoplasmic reticulum ryanodine receptor (RyR) channels.	methylxanthine	40-55	ryanodine receptor 1	Homo sapiens	207-210	
20859795-4	2011	More specifically, RyR channel activation by methylxanthines was reported (1) to stimulate the process of excitation coupling in muscle cells, (2) to augment the excitability of neurons and thus their capacity to release neurotransmitters, and also (3) to improve their survival.	methylxanthine	45-60	ryanodine receptor 1	Homo sapiens	19-22	
20859795-5	2011	Here, we address the mechanisms by which methylxanthines control RyR activation and we consider the pharmacological consequences of this activation, in muscle and neuronal cells.	methylxanthine	41-56	ryanodine receptor 1	Homo sapiens	65-68