PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9852118-4	1998	In contrast, the cAMP phosphodiesterase inhibitor, theophylline, inhibited mTOR activity not only when added to intact adipocytes but also when added to immunopurified mTOR in vitro, demonstrating that certain methylxanthines are able to inhibit mTOR independently of increasing cAMP.	methylxanthine	210-225	mechanistic target of rapamycin kinase	Homo sapiens	75-79	
30875347-1	2019	Methylxanthine derivatives, such as caffeine and theophylline, enhance cell apoptosis and autophagy and reportedly induce the activity of phosphatase and tensin homologue (PTEN) and inhibit the mammalian target of rapamycin (mTOR).	methylxanthine	0-14	mechanistic target of rapamycin kinase	Homo sapiens	194-223	
30875347-1	2019	Methylxanthine derivatives, such as caffeine and theophylline, enhance cell apoptosis and autophagy and reportedly induce the activity of phosphatase and tensin homologue (PTEN) and inhibit the mammalian target of rapamycin (mTOR).	methylxanthine	0-14	mechanistic target of rapamycin kinase	Homo sapiens	225-229	
30875347-7	2019	PTEN knockdown impaired the methylxanthine derivative-mediated inhibition of PI3K/Akt/mTOR signalling.	methylxanthine	28-42	mechanistic target of rapamycin kinase	Homo sapiens	86-90	
30875347-9	2019	These results show that the methylxanthine derivatives (caffeine and theophylline) effectively induce gastric cancer cell apoptosis and autophagy by PTEN activation and PI3K/Akt/mTOR pathway suppression and strongly support the use of methylxanthine derivatives as potential anticancer therapeutics.	methylxanthine	28-42	mechanistic target of rapamycin kinase	Homo sapiens	178-182