PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7896799-6 1995 Therefore, the R79K substitution seems to have a greater effect on dGuo binding than on that of dAdo, but dGK modification appears to produce a stimulatory conformational effect on the opposite subunit, resembling the known unidirectional activation of dAK by either dGuo or dGTP. deoxyguanosine triphosphate 275-279 Diacyl glycerol kinase Drosophila melanogaster 106-109 26342080-4 2015 The deoxyguanosine released by SAMHD1 from dGTP can be phosphorylated inside mitochondria by deoxyguanosine kinase (dGK) or degraded in the cytosol by purine nucleoside phosphorylase. deoxyguanosine triphosphate 43-47 Diacyl glycerol kinase Drosophila melanogaster 116-119 26342080-6 2015 We studied if SAMHD1 and dGK interact in the regulation of the dGTP pool during quiescence employing dGK-mutated skin fibroblasts derived from three unrelated patients. deoxyguanosine triphosphate 63-67 Diacyl glycerol kinase Drosophila melanogaster 25-28 26342080-11 2015 Our results prove the importance of SAMHD1 in the regulation of all dNTP pools and suggest that dGK inside mitochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by SAMHD1 in the nucleus. deoxyguanosine triphosphate 193-197 Diacyl glycerol kinase Drosophila melanogaster 96-99 12297037-4 2002 However, the mutant dGKs were no longer inhibited by dGTP, normally a potent distal endproduct inhibitor of dGK. deoxyguanosine triphosphate 53-57 Diacyl glycerol kinase Drosophila melanogaster 20-23 12297037-5 2002 Moreover, the allosteric activation of dAK activity by dGTP or dGuo was lost in the modified heterodimeric dAK/dGK enzyme. deoxyguanosine triphosphate 55-59 Diacyl glycerol kinase Drosophila melanogaster 111-114