PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35170357-9 2022 Thus, IRE1alpha coordinates a network of stress pathways that conspire to entrap injured cells in the DATP state. 2'-deoxyadenosine triphosphate 102-106 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 6-15 35170357-4 2022 Here we show that the bifunctional kinase/RNase-IRE1alpha-a central mediator of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress is a critical promoter of DATP abundance and function. 2'-deoxyadenosine triphosphate 179-183 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 48-57 35170357-5 2022 Administration of a nanomolar-potent, mono-selective kinase inhibitor of IRE1alpha (KIRA8)-or conditional epithelial IRE1alpha gene knockout-both reduce DATP cell number and fibrosis in the bleomycin model, indicating that IRE1alpha cell-autonomously promotes transition into the DATP state. 2'-deoxyadenosine triphosphate 280-284 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 73-82 35170357-5 2022 Administration of a nanomolar-potent, mono-selective kinase inhibitor of IRE1alpha (KIRA8)-or conditional epithelial IRE1alpha gene knockout-both reduce DATP cell number and fibrosis in the bleomycin model, indicating that IRE1alpha cell-autonomously promotes transition into the DATP state. 2'-deoxyadenosine triphosphate 280-284 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 117-126 35170357-5 2022 Administration of a nanomolar-potent, mono-selective kinase inhibitor of IRE1alpha (KIRA8)-or conditional epithelial IRE1alpha gene knockout-both reduce DATP cell number and fibrosis in the bleomycin model, indicating that IRE1alpha cell-autonomously promotes transition into the DATP state. 2'-deoxyadenosine triphosphate 280-284 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 223-232 35170357-10 2022 Pharmacologic blockade of IRE1alpha signaling helps resolve the DATP state, thereby ameliorating fibrosis and promoting salutary lung regeneration. 2'-deoxyadenosine triphosphate 64-68 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 26-35