PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22173129-8 2012 In addition, the expression levels of phosphorylated ERK and CREB in the hippocampus were significantly increased by stigmasterol, which was blocked by tamoxifen or MK-801 with scopolamine. Scopolamine 177-188 cAMP responsive element binding protein 1 Mus musculus 61-65 26780350-9 2016 These results suggest that erucic acid has an ameliorative effect in mice with scopolamine-induced memory deficits and that the effect of erucic acid is partially due to the activation of PI3K-PKCzeta-ERK-CREB signaling as well as an increase in phosphorylated Akt in the hippocampus. Scopolamine 79-90 cAMP responsive element binding protein 1 Mus musculus 205-209 24404337-8 2013 EUE also markedly increased brain-derived neurotrophic factor (BDNF) and phosphorylation of cAMP element binding protein (CREB) in the hippocampus of scopolamine-induced mice. Scopolamine 150-161 cAMP responsive element binding protein 1 Mus musculus 122-126 23313392-11 2013 These ginsenosides also reversed hippocampal brain-derived neurotrophic factor (BDNF) expression and cAMP response element-binding protein (CREB) phosphorylation reduced by scopolamine. Scopolamine 173-184 cAMP responsive element binding protein 1 Mus musculus 101-138 23313392-11 2013 These ginsenosides also reversed hippocampal brain-derived neurotrophic factor (BDNF) expression and cAMP response element-binding protein (CREB) phosphorylation reduced by scopolamine. Scopolamine 173-184 cAMP responsive element binding protein 1 Mus musculus 140-144 23079232-2 2012 The present study aimed to determine the effect of the standardized extract of B. platyphylla bark and its major diarylheptanoids in scopolamine-induced amnesic mice through cyclic AMP response element-binding protein (CREB) activation. Scopolamine 133-144 cAMP responsive element binding protein 1 Mus musculus 174-217 23079232-2 2012 The present study aimed to determine the effect of the standardized extract of B. platyphylla bark and its major diarylheptanoids in scopolamine-induced amnesic mice through cyclic AMP response element-binding protein (CREB) activation. Scopolamine 133-144 cAMP responsive element binding protein 1 Mus musculus 219-223 23079232-4 2012 CREB phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the cortex and hippocampus of the scopolamine-treated mice were markedly increased by the treatment of the standardized extract of B. platyphylla bark and platyphylloside. Scopolamine 114-125 cAMP responsive element binding protein 1 Mus musculus 0-4 25031604-7 2014 Interestingly, the level of CREB phosphorylation and BDNF expression in hippocampal tissue of scopolamine-treated mice was significantly increased by the administration of fermented C. lanceolata. Scopolamine 94-105 cAMP responsive element binding protein 1 Mus musculus 28-32 32754961-0 2021 Protective effect of ginsenoside Rh2 on scopolamine-induced memory deficits through regulation of cholinergic transmission, oxidative stress and the ERK-CREB-BDNF signaling pathway. Scopolamine 40-51 cAMP responsive element binding protein 1 Mus musculus 153-157 21333723-8 2011 TN-2 also markedly increased BNDF expression and activated the transcription factor CREB in the hippocampi of scopolamine-treated mice. Scopolamine 110-121 cAMP responsive element binding protein 1 Mus musculus 84-88 33815562-9 2021 In addition, ChAT, mAchR, and CREB mRNA levels were increased in the hippocampus compared with the scopolamine group. Scopolamine 99-110 cAMP responsive element binding protein 1 Mus musculus 30-34 31141948-0 2019 Elaeagnus glabra f. oxyphylla Attenuates Scopolamine-Induced Learning and Memory Impairments in Mice by Improving Cholinergic Transmission via Activation of CREB/NGF Signaling. Scopolamine 41-52 cAMP responsive element binding protein 1 Mus musculus 157-161 31278934-3 2019 FRP pretreatment suppressed scopolamine-induced cognitive impairment in passive-avoidance test and significantly upregulated levels of brain-derived neurotrophic factor (BDNF) and induced the phosphorylation of cAMP response element binding (CREB) protein and extracellular signal-regulated kinase (ERK) in the hippocampus of scopolamine-treated mice. Scopolamine 326-337 cAMP responsive element binding protein 1 Mus musculus 211-240 32035879-0 2020 Dracocephalum moldavica attenuates scopolamine-induced cognitive impairment through activation of hippocampal ERK-CREB signaling in mice. Scopolamine 35-46 cAMP responsive element binding protein 1 Mus musculus 114-118 31278934-3 2019 FRP pretreatment suppressed scopolamine-induced cognitive impairment in passive-avoidance test and significantly upregulated levels of brain-derived neurotrophic factor (BDNF) and induced the phosphorylation of cAMP response element binding (CREB) protein and extracellular signal-regulated kinase (ERK) in the hippocampus of scopolamine-treated mice. Scopolamine 28-39 cAMP responsive element binding protein 1 Mus musculus 211-240 31350730-0 2019 Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex. Scopolamine 21-32 cAMP responsive element binding protein 1 Mus musculus 127-131 31350730-8 2019 Moreover, Western blot results indicated that ISO reversed the decreases in expression of phosphorylated cAMP response element binding (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex of scopolamine-treated mice. Scopolamine 228-239 cAMP responsive element binding protein 1 Mus musculus 105-134 31350730-8 2019 Moreover, Western blot results indicated that ISO reversed the decreases in expression of phosphorylated cAMP response element binding (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex of scopolamine-treated mice. Scopolamine 228-239 cAMP responsive element binding protein 1 Mus musculus 136-140 31350730-9 2019 Thus, our results provide initial evidence that ISO ameliorates scopolamine-induced memory and cognitive impairments partly by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling pathway, thereby exhibiting memory-enhancing activities. Scopolamine 64-75 cAMP responsive element binding protein 1 Mus musculus 188-192 30598686-7 2018 Therefore, it can be concluded that the fermented extract exerts memory-improving effects in the hippocampus of scopolamine-treated mice through an initial increase in ERK signaling and a sequential induction of the expression of p-CREB and BDNF, and these effects are related to the antioxidant activities of beta-carotene and other components. Scopolamine 112-123 cAMP responsive element binding protein 1 Mus musculus 232-236 29847860-8 2018 Moreover, KJH-1002 increased cGMP levels in the cortex and the scopolamine-reduced expression of phosphorylated CREB, Levels of ERK 1/2, Akt and brain-derived neurotrophic factor in the cortex and hippocampus were restored by KJH-1002 treatment. Scopolamine 63-74 cAMP responsive element binding protein 1 Mus musculus 112-116 30369882-0 2018 Genistein Ameliorates Scopolamine-Induced Amnesia in Mice Through the Regulation of the Cholinergic Neurotransmission, Antioxidant System and the ERK/CREB/BDNF Signaling. Scopolamine 22-33 cAMP responsive element binding protein 1 Mus musculus 150-154 30111074-3 2018 Furthermore, LJ treatment increased scopolamine-suppressed BDNF expression and CREB phosphorylation in the hippocampi of the brain, as well as suppressed TNF-alpha expression and NF-kappaB activation. Scopolamine 36-47 cAMP responsive element binding protein 1 Mus musculus 79-83 27677871-7 2016 Mechanistic studies revealed that Z-guggulsterone pretreatment reversed the scopolamine-induced increase in acetylcholinesterase (AchE) activity, as well as decreases in brain-derived neurotrophic factor (BDNF) protein expression and cAMP response element-binding protein (CREB), extracellular regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) phosphorylation levels in the hippocampus and cortex. Scopolamine 76-87 cAMP responsive element binding protein 1 Mus musculus 234-271 29670659-9 2018 Gagam-Palmultang has beneficial effects against scopolamine-induced memory impairments, which are exerted via modulation of the cholinergic system as well as the PI3K and ERK/CREB/BDNF signaling pathway. Scopolamine 48-59 cAMP responsive element binding protein 1 Mus musculus 175-179 29370115-0 2018 Ethanol Extract of Oldenlandia diffusa Herba Attenuates Scopolamine-Induced Cognitive Impairments in Mice via Activation of BDNF, P-CREB and Inhibition of Acetylcholinesterase. Scopolamine 56-67 cAMP responsive element binding protein 1 Mus musculus 132-136 27470063-7 2017 Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits. Scopolamine 62-73 cAMP responsive element binding protein 1 Mus musculus 130-134 29740317-6 2018 Additionally, the protein expressions of phosphorylated Akt, ERK1/2, and CREB in the hippocampus were significantly decreased by scopolamine, but these decreases were reversed by MSE treatment. Scopolamine 129-140 cAMP responsive element binding protein 1 Mus musculus 73-77 29157831-0 2017 Vitis labruscana leaf extract ameliorates scopolamine-induced impairments with activation of Akt, ERK and CREB in mice. Scopolamine 42-53 cAMP responsive element binding protein 1 Mus musculus 106-110 29157831-11 2017 Consistent with the cell experiment results, LEVL restored scopolamine-decreased phosphorylation of Akt, ERK, and CREB and scopolamine-reduced expression of brain-derived neuroprotective factor expression in mouse hippocampi. Scopolamine 59-70 cAMP responsive element binding protein 1 Mus musculus 114-118 28940173-6 2017 Furthermore, LQ markedly increased the protein level of brain-derived neurotrophic factor (BDNF) and phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response element binding (CREB) in the hippocampus of scopolamine-induced mice. Scopolamine 227-238 cAMP responsive element binding protein 1 Mus musculus 168-197 28940173-6 2017 Furthermore, LQ markedly increased the protein level of brain-derived neurotrophic factor (BDNF) and phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response element binding (CREB) in the hippocampus of scopolamine-induced mice. Scopolamine 227-238 cAMP responsive element binding protein 1 Mus musculus 199-203 28792471-8 2017 Among the sub-strains, scopolamine-treated C57BL/6N strains exhibited declined step-through latency, elevated acetylcholinesterase (AChE) activity and inflammatory protein expression, associated with reduced endogenous antioxidant levels and p-CREB/BDNF expression, compared to the control and tacrine-treated groups. Scopolamine 23-34 cAMP responsive element binding protein 1 Mus musculus 244-248 28275781-6 2017 It also reversed scopolamine-induced reduction in the hippocampal brain-derived neurotrophic factor (BDNF) and the cAMP response element-binding protein (CREB) mRNA expression. Scopolamine 17-28 cAMP responsive element binding protein 1 Mus musculus 115-152 28275781-6 2017 It also reversed scopolamine-induced reduction in the hippocampal brain-derived neurotrophic factor (BDNF) and the cAMP response element-binding protein (CREB) mRNA expression. Scopolamine 17-28 cAMP responsive element binding protein 1 Mus musculus 154-158 27677871-7 2016 Mechanistic studies revealed that Z-guggulsterone pretreatment reversed the scopolamine-induced increase in acetylcholinesterase (AchE) activity, as well as decreases in brain-derived neurotrophic factor (BDNF) protein expression and cAMP response element-binding protein (CREB), extracellular regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) phosphorylation levels in the hippocampus and cortex. Scopolamine 76-87 cAMP responsive element binding protein 1 Mus musculus 273-277 27677871-9 2016 Therefore, these findings demonstrate that Z-guggulsterone attenuates the scopolamine-induced memory impairments mainly through activation of the CREB-BDNF signaling pathway, thereby exhibiting memory-improving effects. Scopolamine 74-85 cAMP responsive element binding protein 1 Mus musculus 146-150