PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31420268-7 2019 Notably, our screen yielded non-competitive UCK2 inhibitors which were able to suppress nucleoside salvage in cells both in the presence and absence of DHODH inhibitors. Nucleosides 88-98 uridine-cytidine kinase 2 Homo sapiens 44-48 232427-1 1979 The activity of uridine kinase, a key enzyme in the salvage pathway for pyrimidine bases and nucleosides and for the activation of the corresponding chemotherapeutic analogs, varied 10-fold in a series of human colon adenosarcomas; similar variations were observed with other tumor types. Nucleosides 93-104 uridine-cytidine kinase 2 Homo sapiens 16-30 195585-3 1977 Further, comparisons of the Km values of isolated uridine kinases with those for cellular uptake of pyrimidine nucleosides and their rate of intracellular phosphorylation suggest that nucleoside-transport systems play a rate-limiting role in nucleoside analogue activation and consequently that it is impossible to estimate the Km of uridine kinase in the intact cell. Nucleosides 111-121 uridine-cytidine kinase 2 Homo sapiens 50-64