PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22492015-1 2012 SLC28 genes encode three plasma membrane transporter proteins, human concentrative nucleoside transporter (CNT)1, CNT2, and CNT3, all of which are implicated in the uptake of natural nucleosides and a variety of nucleoside analogs used in the chemotherapy of cancer and viral and inflammatory diseases. Nucleosides 183-194 solute carrier family 28 member 2 Homo sapiens 114-118 22492015-1 2012 SLC28 genes encode three plasma membrane transporter proteins, human concentrative nucleoside transporter (CNT)1, CNT2, and CNT3, all of which are implicated in the uptake of natural nucleosides and a variety of nucleoside analogs used in the chemotherapy of cancer and viral and inflammatory diseases. Nucleosides 83-93 solute carrier family 28 member 2 Homo sapiens 114-118 20506327-1 2010 Concentrative nucleoside transporter 2 (CNT2) is a high-affinity adenosine transporter that may play physiological roles beyond nucleoside salvage. Nucleosides 14-24 solute carrier family 28 member 2 Homo sapiens 40-44 19380585-2 2009 Na(+)-coupled hCNT1 and hCNT2 transport pyrimidine and purine nucleosides, respectively, whereas hCNT3 mediates transport of both pyrimidine and purine nucleosides utilizing Na(+) and/or H(+) electrochemical gradients. Nucleosides 62-73 solute carrier family 28 member 2 Homo sapiens 24-29 19098160-1 2009 The human concentrative nucleoside transporter 2 (CNT2) plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs. Nucleosides 149-160 solute carrier family 28 member 2 Homo sapiens 10-48 19098160-1 2009 The human concentrative nucleoside transporter 2 (CNT2) plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs. Nucleosides 149-160 solute carrier family 28 member 2 Homo sapiens 50-54 19098160-1 2009 The human concentrative nucleoside transporter 2 (CNT2) plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs. Nucleosides 24-34 solute carrier family 28 member 2 Homo sapiens 50-54 19430172-1 2009 The human concentrative nucleoside transporter 2 (hCNT2) plays a major role in the intestinal absorption of naturally occurring nucleosides as well as some nucleoside analog drugs. Nucleosides 128-139 solute carrier family 28 member 2 Homo sapiens 10-48 19430172-1 2009 The human concentrative nucleoside transporter 2 (hCNT2) plays a major role in the intestinal absorption of naturally occurring nucleosides as well as some nucleoside analog drugs. Nucleosides 128-139 solute carrier family 28 member 2 Homo sapiens 50-55 19430172-1 2009 The human concentrative nucleoside transporter 2 (hCNT2) plays a major role in the intestinal absorption of naturally occurring nucleosides as well as some nucleoside analog drugs. Nucleosides 24-34 solute carrier family 28 member 2 Homo sapiens 50-55 18621735-1 2008 In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs. Nucleosides 35-45 solute carrier family 28 member 2 Homo sapiens 147-152 18621735-1 2008 In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs. Nucleosides 179-189 solute carrier family 28 member 2 Homo sapiens 147-152 18668436-2 2008 hCNT1 and hCNT2 translocate pyrimidine- and purine-nucleosides, respectively, by a sodium-dependent mechanism, whereas hCNT3 shows broad substrate selectivity and the unique ability of translocating nucleosides both in a sodium- and a proton-coupled manner. Nucleosides 51-62 solute carrier family 28 member 2 Homo sapiens 10-15 18668436-2 2008 hCNT1 and hCNT2 translocate pyrimidine- and purine-nucleosides, respectively, by a sodium-dependent mechanism, whereas hCNT3 shows broad substrate selectivity and the unique ability of translocating nucleosides both in a sodium- and a proton-coupled manner. Nucleosides 199-210 solute carrier family 28 member 2 Homo sapiens 10-15 17700367-1 2007 The human concentrative nucleoside transporter (hCNT2), also known as SLC28A2, plays an important role in the cellular uptake across intestinal membrane of some naturally occurring nucleosides and nucleoside analogs. Nucleosides 181-192 solute carrier family 28 member 2 Homo sapiens 48-53 17700367-1 2007 The human concentrative nucleoside transporter (hCNT2), also known as SLC28A2, plays an important role in the cellular uptake across intestinal membrane of some naturally occurring nucleosides and nucleoside analogs. Nucleosides 181-192 solute carrier family 28 member 2 Homo sapiens 70-77 17700367-1 2007 The human concentrative nucleoside transporter (hCNT2), also known as SLC28A2, plays an important role in the cellular uptake across intestinal membrane of some naturally occurring nucleosides and nucleoside analogs. Nucleosides 24-34 solute carrier family 28 member 2 Homo sapiens 48-53 17700367-1 2007 The human concentrative nucleoside transporter (hCNT2), also known as SLC28A2, plays an important role in the cellular uptake across intestinal membrane of some naturally occurring nucleosides and nucleoside analogs. Nucleosides 24-34 solute carrier family 28 member 2 Homo sapiens 70-77 17453413-8 2007 The Na(+)/nucleoside stoichiometry of hCNT2, as determined from both Hill coefficients and direct charge/flux measurements, was 1:1. Nucleosides 10-20 solute carrier family 28 member 2 Homo sapiens 38-43 17215872-7 2006 In renal epithelial cells, hCNT1, hCNT2, and hCNT3 at apical membranes, and hENT1 and hENT2 at basolateral membranes, apparently work in concert to mediate reabsorption of nucleosides from lumen to blood, driven by Na+ gradients. Nucleosides 172-183 solute carrier family 28 member 2 Homo sapiens 34-39 16840788-0 2006 Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. Nucleosides 52-62 solute carrier family 28 member 2 Homo sapiens 116-120 16840788-4 2006 In this study, we take advantage of the large species difference that exists between human and rat CNT2 (hCNT2 and rCNT2) in their ability to transport the nucleoside analog drug cladribine, 2CdA, (rCNT2 > > > hCNT2) to identify the critical domains and amino acid residues that contribute to the observed difference in specificity between CNT2 orthologs. Nucleosides 156-166 solute carrier family 28 member 2 Homo sapiens 105-110 15955867-1 2005 Human concentrative nucleoside transporters 1, 2, and 3 (hCNT1, hCNT2, and hCNT3) exhibit different functional characteristics, and a better understanding of their permeant selectivities is critical for development of nucleoside analog drugs with optimal pharmacokinetic properties. Nucleosides 20-30 solute carrier family 28 member 2 Homo sapiens 64-69 15861032-1 2005 The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs. Nucleosides 133-144 solute carrier family 28 member 2 Homo sapiens 41-45 15861032-1 2005 The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs. Nucleosides 133-144 solute carrier family 28 member 2 Homo sapiens 47-52 15861032-1 2005 The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs. Nucleosides 133-144 solute carrier family 28 member 2 Homo sapiens 54-61 15861032-1 2005 The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs. Nucleosides 18-28 solute carrier family 28 member 2 Homo sapiens 41-45 15861032-1 2005 The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs. Nucleosides 18-28 solute carrier family 28 member 2 Homo sapiens 47-52 15861032-1 2005 The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs. Nucleosides 18-28 solute carrier family 28 member 2 Homo sapiens 54-61 15861032-2 2005 The aim of the present study was to characterize genetic variation in SLC28A2, the gene encoding CNT2, and to functionally analyse non-synonymous variants of CNT2, as a first step towards understanding whether genetic variation in this nucleoside transporter contributes to variation in response to nucleoside analogs. Nucleosides 236-246 solute carrier family 28 member 2 Homo sapiens 158-162 15861032-8 2005 The variant CNT2-F355S exhibited a change in specificity for the naturally occurring nucleosides, inosine and uridine. Nucleosides 85-96 solute carrier family 28 member 2 Homo sapiens 12-16 15861032-10 2005 However, CNT2-F355S (3% allele frequency in the African-American sample) was found to alter specificity for naturally occurring nucleosides, which may have implications for nucleoside homeostasis. Nucleosides 128-139 solute carrier family 28 member 2 Homo sapiens 9-13 15861032-10 2005 However, CNT2-F355S (3% allele frequency in the African-American sample) was found to alter specificity for naturally occurring nucleosides, which may have implications for nucleoside homeostasis. Nucleosides 128-138 solute carrier family 28 member 2 Homo sapiens 9-13 14978234-3 2004 To define the relative and unified structural requirements of nucleoside analogs for interaction with hCNT1, hCNT2, and hENT1, we applied an array of structure-activity techniques. Nucleosides 62-72 solute carrier family 28 member 2 Homo sapiens 109-114 12893280-12 2003 This suggests that hCNT2 (and rCNT2) may have a significant role in uptake of nucleoside drugs from the intestine and is a potential transporter target for the development of nucleoside and nucleoside-mimetic drugs. Nucleosides 78-88 solute carrier family 28 member 2 Homo sapiens 19-24 12110519-4 2002 Purine nucleosides and uridine induced currents in oocytes expressing rat SPNT (rSPNT) or human SPNT1 (hSPNT1). Nucleosides 7-18 solute carrier family 28 member 2 Homo sapiens 96-101 12110519-4 2002 Purine nucleosides and uridine induced currents in oocytes expressing rat SPNT (rSPNT) or human SPNT1 (hSPNT1). Nucleosides 7-18 solute carrier family 28 member 2 Homo sapiens 103-109 12110519-5 2002 The rank order of magnitude of nucleoside-induced currents was guanosine > uridine > adenosine > inosine and guanosine > uridine > inosine > adenosine for rSPNT- and hSPNT1-expressing oocytes, respectively. Nucleosides 31-41 solute carrier family 28 member 2 Homo sapiens 184-190 12110519-9 2002 These data suggest that there are notable species differences in the specificity of SPNT for synthetic nucleoside analogs. Nucleosides 103-113 solute carrier family 28 member 2 Homo sapiens 84-88 12055084-1 2002 The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1, hCNT2, and hCNT3 are pyrimidine nucleoside-selective (system cit), purine nucleoside-selective (system cif), or broadly selective for both pyrimidine and purine nucleosides (system cib), respectively. Nucleosides 240-251 solute carrier family 28 member 2 Homo sapiens 79-84 11641443-7 2001 The impact of hCNT2-mediated transport on chemosensitivity was assessed by comparing antiproliferative activity of nucleoside analogs against hCNT2-containing cells with transport-defective, drug-resistant cells. Nucleosides 115-125 solute carrier family 28 member 2 Homo sapiens 14-19 11032837-1 2001 The human concentrative (Na(+)-linked) plasma membrane transport proteins hCNT1 and hCNT2 are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively. Nucleosides 119-130 solute carrier family 28 member 2 Homo sapiens 84-89 11396613-1 2001 The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1 and hCNT2, found primarily in specialized epithelia, are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively. Nucleosides 160-171 solute carrier family 28 member 2 Homo sapiens 82-87 10455109-1 1999 hCNT1 and hCNT2 mediate concentrative (Na(+)-linked) cellular uptake of nucleosides and nucleoside drugs by human cells and tissues. Nucleosides 72-83 solute carrier family 28 member 2 Homo sapiens 10-15 10455109-1 1999 hCNT1 and hCNT2 mediate concentrative (Na(+)-linked) cellular uptake of nucleosides and nucleoside drugs by human cells and tissues. Nucleosides 72-82 solute carrier family 28 member 2 Homo sapiens 10-15 10336543-2 1999 With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney. Nucleosides 179-190 solute carrier family 28 member 2 Homo sapiens 86-92 10336543-2 1999 With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney. Nucleosides 179-190 solute carrier family 28 member 2 Homo sapiens 106-111 10336543-2 1999 With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney. Nucleosides 62-72 solute carrier family 28 member 2 Homo sapiens 86-92 10336543-2 1999 With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney. Nucleosides 62-72 solute carrier family 28 member 2 Homo sapiens 106-111 10336543-2 1999 With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney. Nucleosides 179-189 solute carrier family 28 member 2 Homo sapiens 86-92 10336543-2 1999 With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney. Nucleosides 179-189 solute carrier family 28 member 2 Homo sapiens 106-111 10336543-3 1999 In this study we examined the substrate selectivity of hSPNT1 for nucleosides and nucleoside analogs. Nucleosides 66-77 solute carrier family 28 member 2 Homo sapiens 55-61 10336543-3 1999 In this study we examined the substrate selectivity of hSPNT1 for nucleosides and nucleoside analogs. Nucleosides 66-76 solute carrier family 28 member 2 Homo sapiens 55-61 10087507-0 1998 Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Nucleosides 155-166 solute carrier family 28 member 2 Homo sapiens 127-132 10087507-7 1998 In Xenopus oocytes, recombinant hCNT2 exhibited the functional characteristics of a Na(+)-dependent nucleoside transporter with selectivity for adenosine, other purine nucleosides and uridine (adenosine and uridine K(m) app values 8 and 40 microM, respectively). Nucleosides 168-179 solute carrier family 28 member 2 Homo sapiens 32-37 10087507-10 1998 hCNT2 also mediated small, but significant, fluxes of the antiviral purine nucleoside analogue 2",3"-dideoxyinosine. Nucleosides 75-85 solute carrier family 28 member 2 Homo sapiens 0-5 9435697-3 1997 Functional expression in Xenopus laevis oocytes identified hSPNT1 as a Na(+)-dependent nucleoside transporter that selectively transports purine nucleosides but also transports uridine. Nucleosides 145-156 solute carrier family 28 member 2 Homo sapiens 59-65 32126230-1 2020 Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides. Nucleosides 152-163 solute carrier family 28 member 2 Homo sapiens 195-200 32126230-1 2020 Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides. Nucleosides 219-230 solute carrier family 28 member 2 Homo sapiens 195-200 32126230-1 2020 Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides. Nucleosides 219-230 solute carrier family 28 member 2 Homo sapiens 195-200 30076612-1 2018 BACKGROUND AND PURPOSE: The concentrative nucleoside transporter 2 (CNT2) mediates the uptake of both natural nucleosides and nucleoside-derived drugs. Nucleosides 110-121 solute carrier family 28 member 2 Homo sapiens 28-66 30076612-1 2018 BACKGROUND AND PURPOSE: The concentrative nucleoside transporter 2 (CNT2) mediates the uptake of both natural nucleosides and nucleoside-derived drugs. Nucleosides 110-121 solute carrier family 28 member 2 Homo sapiens 68-72 30076612-1 2018 BACKGROUND AND PURPOSE: The concentrative nucleoside transporter 2 (CNT2) mediates the uptake of both natural nucleosides and nucleoside-derived drugs. Nucleosides 42-52 solute carrier family 28 member 2 Homo sapiens 68-72 25713533-4 2015 They translocate nucleosides in a Na(+) coupled manner with high affinity and some substrate selectivity, being hCNT1 and hCNT2 pyrimidine- and purine-preferring, respectively, and hCNT3 a broad selectivity transporter. Nucleosides 17-28 solute carrier family 28 member 2 Homo sapiens 122-127 22709993-0 2012 Hypouricemic effects of novel concentrative nucleoside transporter 2 inhibitors through suppressing intestinal absorption of purine nucleosides. Nucleosides 132-143 solute carrier family 28 member 2 Homo sapiens 30-68 22709993-4 2012 Based on the expression profile of human CNTs in digestive tract tissues, we established a working hypothesis that mainly CNT2 contributes to the intestinal absorption of purine nucleosides. Nucleosides 178-189 solute carrier family 28 member 2 Homo sapiens 122-126