PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28716944-2	2017	Nucleoside analogs such as gemcitabine diphosphate and clofarabine nucleotides target the large subunit (hRRM1) of hRR.	Nucleosides	0-10	ribonucleotide reductase catalytic subunit M1	Homo sapiens	105-110	
23570983-7	2013	Moreover, we also showed that the RRM1-overexpressing tumor cells were also cross-resistant to cytarabine, another nucleoside analog commonly used in cancer therapy, and 4-(N)-stearoyl cytarabine carried by solid lipid nanoparticles can also overcome the resistance.	Nucleosides	115-125	ribonucleotide reductase catalytic subunit M1	Homo sapiens	34-38	
19771229-2	2009	Previous studies have shown that RNAi-mediated knockdown of either the RRM1 or RRM2 subunit sensitizes cells to the cytotoxic effects of the nucleoside analogs and more recently it has been shown that RRM2 knockdown itself has a growth inhibitory effect.	Nucleosides	141-151	ribonucleotide reductase catalytic subunit M1	Homo sapiens	71-75