PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23570983-7 2013 Moreover, we also showed that the RRM1-overexpressing tumor cells were also cross-resistant to cytarabine, another nucleoside analog commonly used in cancer therapy, and 4-(N)-stearoyl cytarabine carried by solid lipid nanoparticles can also overcome the resistance. Nucleosides 115-125 ribonucleotide reductase catalytic subunit M1 Homo sapiens 34-38 19771229-2 2009 Previous studies have shown that RNAi-mediated knockdown of either the RRM1 or RRM2 subunit sensitizes cells to the cytotoxic effects of the nucleoside analogs and more recently it has been shown that RRM2 knockdown itself has a growth inhibitory effect. Nucleosides 141-151 ribonucleotide reductase catalytic subunit M1 Homo sapiens 71-75 28716944-2 2017 Nucleoside analogs such as gemcitabine diphosphate and clofarabine nucleotides target the large subunit (hRRM1) of hRR. Nucleosides 0-10 ribonucleotide reductase catalytic subunit M1 Homo sapiens 105-110