PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16411658-2	2006	We compared the respective roles of aldo-keto reductase 1A1 (AKR1A1, aldehyde reductase) and P4501B1 in the formation of BP-7,8-dione and BP-tetrols, respectively, in intact bronchoalveolar cells manipulated to express either enzyme.	benzo(a)pyrene-7,8-dione	121-133	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	93-100	
16411658-5	2006	In H358 AKR1A1 transfectants, formation of BP-7,8-dione was elevated for 3-12 h but significantly decreased after 24 h. Interestingly, BP-tetrols were also detected in AKR1A1 transfectants even though they do not constitutively express P4501A1/P4501B1 enzymes.	benzo(a)pyrene-7,8-dione	43-55	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	244-251	
16411658-6	2006	Northern and Western blotting confirmed the induction of P4501B1 by BP-7,8-dione in parental cells and the induction of P4501B1 by BP-7,8-diol in AKR1A1-transfected cells.	benzo(a)pyrene-7,8-dione	68-80	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	57-64	
16411658-9	2006	Our studies show that the formation of BP-7,8-dione by AKR1A1 in human bronchoalveolar cells leads to an induction of P4501B1 and that a functional consequence of this induction is elevated anti-BPDE production as detected by increased BP-tetrol formation.	benzo(a)pyrene-7,8-dione	39-51	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	118-125	
16411658-10	2006	Therefore, the role of AKR1A1 in the activation of BP-7,8-diol is bifunctional; that is, it directly activates BP-7,8-diol to the reactive and redox-active PAH o-quinone (BP-7,8-dione) and it indirectly trans-activates the P4501B1 gene by generating the aryl hydrocarbon receptor (AhR) ligand BP-7,8-dione.	benzo(a)pyrene-7,8-dione	171-183	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	223-230