PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19726680-0 2009 Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2"-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione. benzo(a)pyrene-7,8-dione 129-153 aryl hydrocarbon receptor Homo sapiens 0-25 16411658-10 2006 Therefore, the role of AKR1A1 in the activation of BP-7,8-diol is bifunctional; that is, it directly activates BP-7,8-diol to the reactive and redox-active PAH o-quinone (BP-7,8-dione) and it indirectly trans-activates the P4501B1 gene by generating the aryl hydrocarbon receptor (AhR) ligand BP-7,8-dione. benzo(a)pyrene-7,8-dione 171-183 aryl hydrocarbon receptor Homo sapiens 254-279 16411658-10 2006 Therefore, the role of AKR1A1 in the activation of BP-7,8-diol is bifunctional; that is, it directly activates BP-7,8-diol to the reactive and redox-active PAH o-quinone (BP-7,8-dione) and it indirectly trans-activates the P4501B1 gene by generating the aryl hydrocarbon receptor (AhR) ligand BP-7,8-dione. benzo(a)pyrene-7,8-dione 171-183 aryl hydrocarbon receptor Homo sapiens 281-284