PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15592331-0	2004	Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism.	Ciprofloxacin	0-13	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	102-121	
16211753-2	2005	We have studied the effect of a cytochrome P-450 1A2 inhibitor, ciprofloxacin, on the pharmacokinetics of lidocaine.	Ciprofloxacin	64-77	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	32-52	
15592331-2	2004	The fluoroquinolone antibiotic ciprofloxacin is only a moderately potent inhibitor of CYP1A2.	Ciprofloxacin	31-44	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	86-92	
15592331-11	2004	CONCLUSIONS: Ciprofloxacin greatly elevates plasma concentrations of tizanidine and dangerously potentiates its hypotensive and sedative effects, mainly by inhibiting its CYP1A2-mediated metabolism, at least when administered 1 hour before tizanidine.	Ciprofloxacin	13-26	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	171-177	
15385831-3	2004	Therefore, the objective of the study was to determine whether potential inhibition of CYP1A2 by the quinolone antibiotic agent ciprofloxacin would alter the stereoselective disposition of mexiletine.	Ciprofloxacin	128-141	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	87-93	
15385831-9	2004	In conclusion, the increase in mexiletine nonrenal clearance in smokers and its decrease during the combined administration of ciprofloxacin confirm the role of CYP1A2 in the overall clearance of the drug.	Ciprofloxacin	127-140	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	161-167	
15058617-5	2004	Likewise, quinolone antibiotics such as ciprofloxacin inhibit the metabolism of CYP1A2 substrates.	Ciprofloxacin	40-53	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86	
11145498-2	2000	We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone.	Ciprofloxacin	35-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	63-69	
12610740-9	2003	CONCLUSION: Ciprofloxacin modestly decreased the mean ropivacaine CL by inhibiting the CYP1A2-mediated formation of 3-OH-ropivacaine.	Ciprofloxacin	12-25	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	87-93	
11151749-11	2000	A probable mechanism of interaction is an inhibition of CYP1A2 enzyme by ciprofloxacin.	Ciprofloxacin	73-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	56-62	
11069211-10	2000	The CYP1A2 inhibitor ciprofloxacin produced increases in the plasma concentrations of ropinirole when these 2 drugs were coadministered, but no interaction was seen with theophylline which, like ropinirole, is also a substrate for CYP1A2.	Ciprofloxacin	21-34	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	4-10	
11069211-10	2000	The CYP1A2 inhibitor ciprofloxacin produced increases in the plasma concentrations of ropinirole when these 2 drugs were coadministered, but no interaction was seen with theophylline which, like ropinirole, is also a substrate for CYP1A2.	Ciprofloxacin	21-34	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	231-237	
33404754-2	2021	Therefore, coadministration with potent CYP1A2 inhibitors, such as ciprofloxacin, is contraindicated.	Ciprofloxacin	67-80	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	40-46	
7619673-12	1995	The results suggest that inter-individual variability in the inhibition of theophylline metabolism by ciprofloxacin can be attributed to inter-individual differences in the level of CYP1A2 expression and/or in the degree of inhibition of hepatic CYP1A2 and CYP3A4.	Ciprofloxacin	102-115	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	182-188	
7619673-12	1995	The results suggest that inter-individual variability in the inhibition of theophylline metabolism by ciprofloxacin can be attributed to inter-individual differences in the level of CYP1A2 expression and/or in the degree of inhibition of hepatic CYP1A2 and CYP3A4.	Ciprofloxacin	102-115	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	246-252	
7888295-4	1994	The results suggest an inhibition of 3-N-demethylation of caffeine (CYP1A2 enzyme activity) by ciprofloxacin.	Ciprofloxacin	95-108	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	68-74	
19026171-6	2008	Ciprofloxacin showed weak inhibition on both the activity of CYP1A2 (IC50 135 micromol/L) and CYP2C9 (IC50 180 micromol/L), whereas levofloxacin inhibited only CYP2C9 (IC50 210 micromol/L).	Ciprofloxacin	0-13	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	61-67	
24366834-2	2013	Four days after surgery he showed symptoms of clozapine intoxication, probably because the ciprofloxacin had inhibited CYP1A2.	Ciprofloxacin	91-104	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	119-125	
21190921-3	2011	To cure them, physicians commonly prescribe fluoroquinolones like Ciprofloxacin (CYP1A2 inhibitor) along with Carbamazepine (CBZ).	Ciprofloxacin	66-79	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	81-87