PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11916243-7	2002	This activation directly correlates with cytotoxicity, because inhibition of the MAP kinase extracellular regulated kinase (Erk) by PD98059, reversed GCV-mediated cytotoxicity.	Ganciclovir	150-153	mitogen-activated protein kinase 1	Homo sapiens	92-122	
29845211-0	2018	HSV-TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK.	Ganciclovir	7-10	mitogen-activated protein kinase 1	Homo sapiens	102-106	
29845211-0	2018	HSV-TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK.	Ganciclovir	7-10	mitogen-activated protein kinase 1	Homo sapiens	107-110	
29845211-11	2018	The above results demonstrate that the mechanism undertaken by HSV-TK/GCV to exhibit therapeutic effects mechanism may inhibit autophagy by activating MAPK/ERK.	Ganciclovir	70-73	mitogen-activated protein kinase 1	Homo sapiens	151-155	
29845211-11	2018	The above results demonstrate that the mechanism undertaken by HSV-TK/GCV to exhibit therapeutic effects mechanism may inhibit autophagy by activating MAPK/ERK.	Ganciclovir	70-73	mitogen-activated protein kinase 1	Homo sapiens	156-159	
11916243-7	2002	This activation directly correlates with cytotoxicity, because inhibition of the MAP kinase extracellular regulated kinase (Erk) by PD98059, reversed GCV-mediated cytotoxicity.	Ganciclovir	150-153	mitogen-activated protein kinase 1	Homo sapiens	124-127	
11916243-10	2002	These effects appear to be downstream of the earlier activation of Erk in this system, which may be a novel mechanism of action for GCV cytotoxicity in HSV-TK gene-modified tumor cells, and thus, needs to be further evaluated as the mechanism of tumor cell killing by other antitumor NAs.	Ganciclovir	132-135	mitogen-activated protein kinase 1	Homo sapiens	67-70