PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19409920-4	2009	Dizocilpine treatment on P7 increased cleaved caspase-3 immunoreactivity (IR) in the PFC on P8.	Dizocilpine Maleate	0-11	caspase 3	Mus musculus	46-55	
20577261-4	2011	Sustained calcium (Ca(2+)) signals and caspase-3 activation in thymocytes were induced by interaction with antigen-pulsed dendritic cells (DCs) and were inhibited by NMDAR antagonists MK801 and memantine.	Dizocilpine Maleate	184-189	caspase 3	Mus musculus	39-48	
19759125-6	2010	The NMDA antagonist MK801 acted as a potent caspase-3 activator in immature layers II-IV and affected gamma aminobutyric acid (GABA)ergic interneurons.	Dizocilpine Maleate	20-25	caspase 3	Mus musculus	44-53	
25045830-10	2014	Finally, VX-induced caspase-3 or -9 activities were reduced with the addition of pralidoxime (2-PAM), one of the current therapeutics used against NA toxicity, and dizocilpine (MK-801).	Dizocilpine Maleate	164-175	caspase 3	Mus musculus	20-29	
25045830-10	2014	Finally, VX-induced caspase-3 or -9 activities were reduced with the addition of pralidoxime (2-PAM), one of the current therapeutics used against NA toxicity, and dizocilpine (MK-801).	Dizocilpine Maleate	177-183	caspase 3	Mus musculus	20-29	
32920884-8	2020	In contrast, the expression of apoptotic markers including caspase 3, caspase 9 and Bax was increased in the presence of MK801.	Dizocilpine Maleate	121-126	caspase 3	Mus musculus	59-68	
11738131-5	2001	In a low Ca(2+)/low Na(+) medium, a 5-h exposure to 50-500 microM AMPA in the presence of the NMDA receptor antagonist MK801 induced dose-dependent neuronal death 24 h after the onset of the insult, accompanied by intracellular K(+) reduction and caspase-3 activation.	Dizocilpine Maleate	119-124	caspase 3	Mus musculus	247-256	
15446579-7	2004	However, inhibition of NMDA receptors with MK-801 completely suppressed caspase 3 activation, pointing to glutamate neurotoxicity as the upstream inducer of the observed cell death.	Dizocilpine Maleate	43-49	caspase 3	Mus musculus	72-81	
29272008-14	2017	Both of MK801 and KN93 inhibit CaMK II phosphorylation, decreases caspase 3 activation, and suppresses neurons apoptosis CONCLUSIONS: APOE triggers Ca2+ overload through NMDAR and CaMK II signaling pathway, both of which cause Ca2+ concentration increasing, CaMK II phosphorylation abnormity, and finally aggravate oxidative stress damaged neurons apoptosis.	Dizocilpine Maleate	8-13	caspase 3	Mus musculus	66-75	
31756355-3	2020	Herein, we studied the phosphorylated Akt (pAkt) and caspase-3, the key regulators of neuronal cell survival/death, as the probable downstream targets of MK-801 often used to engender ADHD-like condition.	Dizocilpine Maleate	154-160	caspase 3	Mus musculus	53-62	
31756355-9	2020	A significant increase in caspase-3 expression was noted in the prefrontal cortex (PFC) and hippocampus, whereas increased pAkt was noticed only in the hippocampus, following a single injection of MK-801 at PND 7.	Dizocilpine Maleate	197-203	caspase 3	Mus musculus	26-35