PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2553211-9 1989 Pretreatment with the non-competitive NMDA antagonist MK-801 at doses sufficient to completely prevent massive degeneration of the hippocampal CA1 failed to prevent the degeneration of RT neurons, suggesting that if RT degeneration involves an excitotoxic process it acts through non-NMDA receptors. Dizocilpine Maleate 54-60 carbonic anhydrase 1 Rattus norvegicus 143-146 2552968-6 1989 Hippocampal neuronal damage in the CA1 and CA3 regions was prevented in animals pretreated with MK-801 vs saline-treated controls. Dizocilpine Maleate 96-102 carbonic anhydrase 1 Rattus norvegicus 35-38 31539160-9 2019 Administration of MK-801, GSNO, and 7-NI significantly decreased the neuronal damage in rat hippocampal CA1 caused by cerebral ischemia-reperfusion (p<0.05). Dizocilpine Maleate 18-24 carbonic anhydrase 1 Rattus norvegicus 104-107 2563246-0 1989 The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice. Dizocilpine Maleate 68-74 carbonic anhydrase 1 Rattus norvegicus 119-122 2563246-5 1989 Untreated CA1 pyramidal cells recovered to 8 +/- 3% of their preanoxic amplitude after 5 min of anoxia; they recovered to 59 +/- 6% when treated with MK-801 and 31 +/- 13% when treated with APV. Dizocilpine Maleate 150-156 carbonic anhydrase 1 Rattus norvegicus 10-13 2563246-10 1989 These differences between drug-treated and untreated tissue were significant with APV and MK-801 in dentate tissue after 10 min of anoxia and with MK-801 in CA1 tissue after 5 min of anoxia. Dizocilpine Maleate 147-153 carbonic anhydrase 1 Rattus norvegicus 157-160 30322800-4 2018 Treatment with ouabain, a Na+, K+-ATPase inhibitor, increased the ratio of propidium iodide-positive cells among NeuN-positive cells in the hippocampal CA1 region, which was prevented by MK-801 and d-AP5, specific blockers of the N-methyl-d-aspartate (NMDA) receptor. Dizocilpine Maleate 187-193 carbonic anhydrase 1 Rattus norvegicus 152-155 27806441-0 2017 Acute systemic MK-801 induced functional uncoupling between hippocampal areas CA3 and CA1 with distant effect in the retrosplenial cortex. Dizocilpine Maleate 15-21 carbonic anhydrase 1 Rattus norvegicus 86-89 27806441-12 2017 The data provide support for MK-801-induced functional uncoupling between CA3 and CA1 and suggest that ensemble coding deficit may extend downstream of CA1. Dizocilpine Maleate 29-35 carbonic anhydrase 1 Rattus norvegicus 82-85 27806441-12 2017 The data provide support for MK-801-induced functional uncoupling between CA3 and CA1 and suggest that ensemble coding deficit may extend downstream of CA1. Dizocilpine Maleate 29-35 carbonic anhydrase 1 Rattus norvegicus 152-155 27806441-7 2017 Acute systemic MK-801 (0.15 mg/kg) impaired cognitive control in rats and ensemble code for spatial context in CA1. Dizocilpine Maleate 15-21 carbonic anhydrase 1 Rattus norvegicus 111-114 26519264-7 2015 Thus, MK-801 can prevent the inhibitory action of NMDA on synaptic transmission in Schaffer collaterals-hippocampal CA1 pyramidal neurons axis via blocking the channel of NMDA-receptor complex, while NMDA exerts its effect only via activation of NMDA receptors. Dizocilpine Maleate 6-12 carbonic anhydrase 1 Rattus norvegicus 116-119 25377775-3 2016 Both Meth and Glu induced a rapid increase in Ca(++) i, which was blocked by MK801, suggesting that Meth enhanced Ca(++) i through Glu receptor in neurons. Dizocilpine Maleate 77-82 carbonic anhydrase 1 Rattus norvegicus 46-54 25377775-3 2016 Both Meth and Glu induced a rapid increase in Ca(++) i, which was blocked by MK801, suggesting that Meth enhanced Ca(++) i through Glu receptor in neurons. Dizocilpine Maleate 77-82 carbonic anhydrase 1 Rattus norvegicus 114-122 24659959-11 2014 We show that the same dose of MK-801 that impairs spatial coordination of rats on the Carousel also eliminates contextual specificity of IEG expression in hippocampal CA1 ensembles. Dizocilpine Maleate 30-36 carbonic anhydrase 1 Rattus norvegicus 167-170 24710315-0 2014 Involvement of the CA1 GABAA receptors in MK-801-induced anxiolytic-like effects: an isobologram analysis. Dizocilpine Maleate 42-48 carbonic anhydrase 1 Rattus norvegicus 19-22 24710315-2 2014 This study investigated the possible involvement of the CA1 GABAA receptors in anxiolytic-like effects induced by (+)-MK-801 (a noncompetitive antagonist of the NMDA subtype of the glutamate receptor). Dizocilpine Maleate 114-124 carbonic anhydrase 1 Rattus norvegicus 56-59 24710315-4 2014 An intra-CA1 injection of (+)-MK-801 (2 mug/rat) and muscimol (0.5 mug/rat; a GABAA receptor agonist) increased %OAT and %OAE by themselves while not altering the closed arm entries, indicating an anxiolytic-like effect of these drugs. Dizocilpine Maleate 26-36 carbonic anhydrase 1 Rattus norvegicus 9-12 24710315-8 2014 In conclusion, the CA1 GABAA receptors appear to be involved in anxiolytic-like behaviors induced by (+)-MK-801. Dizocilpine Maleate 101-111 carbonic anhydrase 1 Rattus norvegicus 19-22 23396086-5 2013 Recordings from the mPFC and CA1 in rats revealed regular delta and theta oscillations, respectively, which were disrupted by MK-801. Dizocilpine Maleate 126-132 carbonic anhydrase 1 Rattus norvegicus 29-32 21979451-4 2012 In freely moving rats, acute injection of MK801 or ketamine increased gamma power in both CA1 and dentate gyrus of the hippocampus. Dizocilpine Maleate 42-47 carbonic anhydrase 1 Rattus norvegicus 90-93 22885281-0 2012 Dopaminergic system in CA1 modulates MK-801 induced anxiolytic-like responses. Dizocilpine Maleate 37-43 carbonic anhydrase 1 Rattus norvegicus 23-26 22885281-3 2012 Thus, on the basis of the involvement of dopaminergic system in anxiety-related behaviors, the present study aimed to investigate the involvement of the dorsal hippocampal (CA1) dopaminergic system in anxiolytic-like responses induced by MK801 (NMDA receptor antagonist) in male Wistar rats. Dizocilpine Maleate 238-243 carbonic anhydrase 1 Rattus norvegicus 173-176 22885281-6 2012 RESULTS: The data showed that, intra-CA1 injection of MK801 (2 mug/rat) increases %OAT and %OAE but not other exploratory behaviors, indicating an anxiolytic-like effect. Dizocilpine Maleate 54-59 carbonic anhydrase 1 Rattus norvegicus 37-40 22885281-9 2012 Furthermore, intra-CA1 administration of different doses of sulpiride (0.12, 0.5 and 0.75 mug/rat), 5 min before the injection of an effective dose of MK801 (2 mug/rat), decreased %OAT and %OAE, however did not alter other exploratory behaviors induced by MK801. Dizocilpine Maleate 151-156 carbonic anhydrase 1 Rattus norvegicus 19-22 22885281-10 2012 CONCLUSION: Our results suggested a modulatory effect of the CA1 dopaminergic system on the anxiolytic-like effects induced by MK801. Dizocilpine Maleate 127-132 carbonic anhydrase 1 Rattus norvegicus 61-64 15464742-6 2004 Treatment with 30 microM MK-801 for 2 h at the time of crush injury prevented the increase in PI fluorescence at days 4-7 at the site of injury, in CA1, and in CA3. Dizocilpine Maleate 25-31 carbonic anhydrase 1 Rattus norvegicus 148-151 16183195-0 2006 Enhancement of long-term potentiation at CA1-subiculum synapses in MK-801-treated rats. Dizocilpine Maleate 67-73 carbonic anhydrase 1 Rattus norvegicus 41-44 16183195-5 2006 We report here that systemic application of MK-801 causes a facilitation of LTP at CA1-subiculum synapses 24 h after treatment as compared with control LTP. Dizocilpine Maleate 44-50 carbonic anhydrase 1 Rattus norvegicus 83-86 15266351-6 2004 Systemic injection of the NMDAR antagonist MK-801 (0.25 mg/kg) on day 1 of withdrawal prevented reduced NMDAR-mediated currents in CA1 neurons from 2-day FZP-withdrawn rats, whereas AMPAR-mediated currents remained upregulated. Dizocilpine Maleate 43-49 carbonic anhydrase 1 Rattus norvegicus 131-134 23093008-5 2012 Bilateral administration of MK801 to the mPFC produced changes in the behavior (increased stereotypy and decreased sleep-like behavior) and complex changes in c-Fos protein expression with significant increases observed in the nucleus accumbens (core and shell), amygdala (basolateral and central nuclei), the CA1 field of the hippocampus, and mediodorsal and paraventricular thalamic nuclei, as compared to the saline group. Dizocilpine Maleate 28-33 carbonic anhydrase 1 Rattus norvegicus 310-313 21871530-4 2011 RESULTS: The data indicated that intra-CA1 administration of MK-801 increased %OAT (2mug/rat) and %OAE (1 and 2mug/rat) while decreased %CAT and %CAE and did not alter other exploratory behaviors, indicating an anxiolytic-like effect. Dizocilpine Maleate 61-67 carbonic anhydrase 1 Rattus norvegicus 39-42 21871530-7 2011 The data may indicate the possible involvement of the cholinergic system of the CA1 in the anxiolytic-like response induced by MK-801. Dizocilpine Maleate 127-133 carbonic anhydrase 1 Rattus norvegicus 80-83 20382186-7 2010 Subsequent electrophysiological experiments (under urethane anesthesia) assessing changes in plasticity of hippocampal synapses showed that subchronic MK-801 treatment resulted in an increase in long-term potentiation in area CA1 in response to high frequency stimulation of the contralateral CA3 area, while housing condition had no effect. Dizocilpine Maleate 151-157 carbonic anhydrase 1 Rattus norvegicus 226-229 19428648-5 2009 Furthermore, immunoblotting results indicated KCC2 expression in hippocampal CA1 of MK-801-treated rats was lower than that of normal rats before LTP induction. Dizocilpine Maleate 84-90 carbonic anhydrase 1 Rattus norvegicus 77-80 19428648-7 2009 Our results suggested that KCC2 expression in hippocampal CA1 of MK-801-treated rats was not further decreased by LTP induction because of its low expression caused by MK-801 treatment. Dizocilpine Maleate 65-71 carbonic anhydrase 1 Rattus norvegicus 58-61 16859717-10 2006 Moreover, both MK801 (10 microM), an antagonist of NMDA receptor, and EGTA (100 mM, but neither 50 nor 150 mM), an extracellular Ca2+ chelator, not only effectively inhibited the ERK5 activation but also markedly abolished CIP-induced survival of the CA1 neurons. Dizocilpine Maleate 15-20 carbonic anhydrase 1 Rattus norvegicus 251-254 16429444-8 2006 We found decreases in [3H]MK801 binding in the hippocampus CA1 region by LPS-treatment for 5 days. Dizocilpine Maleate 26-31 carbonic anhydrase 1 Rattus norvegicus 59-62 16340465-10 2005 However, exposure to Abeta during EWD from 100 mM produced marked increases in CA1 pyramidal cell region cytotoxicity, effects reversed by cotreatment with a nontoxic concentration of the NMDA receptor channel blocker MK-801 (20 microM). Dizocilpine Maleate 218-224 carbonic anhydrase 1 Rattus norvegicus 79-82 14700727-3 2004 We studied the effects of systemic administration of MK-801 on the signal transfer from the EC layer III to the hippocampal area CA1. Dizocilpine Maleate 53-59 carbonic anhydrase 1 Rattus norvegicus 129-132 14972661-5 2004 Acute ischemic paradigm resulted in selective death of pyramidal neurons in the CA1 region, which was prevented by treatment with an NMDA-antagonist, MK-801. Dizocilpine Maleate 150-156 carbonic anhydrase 1 Rattus norvegicus 80-83 14700727-7 2004 We suggest, that MK-801 causes disinhibition of layer III projection cells and, therefore, may cause strong, pathological activation of direct layer III-CA1 pathway. Dizocilpine Maleate 17-23 carbonic anhydrase 1 Rattus norvegicus 153-156 11513485-5 2001 The levels of NR1 mRNA were significantly increased (9-20%) in the cerebral cortex, striatum, septum, and CA1 of hippocampus in MK-801-infused rats. Dizocilpine Maleate 128-134 carbonic anhydrase 1 Rattus norvegicus 106-109 12373516-7 2002 MK801 significantly increased the combined neuroprotective effect of NBQX and NS102 against 10 microM domoic acid in both CA1 and FD, but not in CA3. Dizocilpine Maleate 0-5 carbonic anhydrase 1 Rattus norvegicus 122-125 11711057-4 2001 Dehydroepiandrosterone sulfate treatment significantly increased the [3H]MK801 binding sites in hippocampal areas (field CA1, CA3, dentate gyrus lateral blade and medial blade) and in cortex layer IV as compared to the control group. Dizocilpine Maleate 73-78 carbonic anhydrase 1 Rattus norvegicus 121-124 11687723-7 2001 RESULTS: NMDA exposure produced significant neurotoxicity, particularly in pyramidal cell layers of CA3 and CA1, that was prevented by co-exposure to MK-801 (10 microM). Dizocilpine Maleate 150-156 carbonic anhydrase 1 Rattus norvegicus 108-111 11292582-7 2001 However, an increase in [3H]MK801 binding was only observed in CA1 of the hippocampus in the continuously Pb-exposed rats. Dizocilpine Maleate 28-33 carbonic anhydrase 1 Rattus norvegicus 63-66 11306194-3 2001 When applied during ischemia, the NMDA receptor antagonist MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine maleate) inhibited the ischemic Ca(2+) accumulation only in the CA1, but the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) inhibited it in all the three regions. Dizocilpine Maleate 59-65 carbonic anhydrase 1 Rattus norvegicus 197-200 11145473-4 2001 Ten microM MK-801, alone or in combination with the other compounds, prevented loss of CA1 neurons and preserved their histologic appearance. Dizocilpine Maleate 11-17 carbonic anhydrase 1 Rattus norvegicus 87-90 10362302-4 1999 In rats killed 30 min after odour discrimination learning, dizocilpine maleate binding was significantly reduced in hippocampal sub-regions CA3, CA1 and fascia dentata and in frontal cortex. Dizocilpine Maleate 59-78 carbonic anhydrase 1 Rattus norvegicus 145-148 11069578-7 2000 OGD produced neuronal damage predominantly in the CA1 region, which was prevented by MK-801 and memantine, but not by APV or CPP. Dizocilpine Maleate 85-91 carbonic anhydrase 1 Rattus norvegicus 50-53 10780984-4 2000 The involvement of NMDA receptors was confirmed by the ability of dizocilpine (1 mg kg(-1)) to reduce cell loss in the CA1 region from 92 to 42%. Dizocilpine Maleate 66-77 carbonic anhydrase 1 Rattus norvegicus 119-122 9784284-7 1998 The expression of the heat shock protein was partially prevented in the injected hippocampus and completely blocked in the contralateral CA1 region, by the systemic previous administration of the NMDA receptor antagonist MK-801. Dizocilpine Maleate 221-227 carbonic anhydrase 1 Rattus norvegicus 137-140 9764974-8 1998 Significant septotemporal gradients of [3H]MK-801 binding were observed in selected layers of CA1 and the dentate gyrus, a septal to temporal decrease of binding in the oriens and radiatum layers of CA1 being most prominent. Dizocilpine Maleate 43-49 carbonic anhydrase 1 Rattus norvegicus 94-97 9804290-3 1998 caused significant decreases in [3H]MK801 binding in several hippocampus subareas and layers, mainly in CA1 and CA3 at seizure (11-27%) and postseizure (8-16%) and in cerebral occipital cortex at seizure (18-22%). Dizocilpine Maleate 36-41 carbonic anhydrase 1 Rattus norvegicus 104-107 9804290-7 1998 When CPA was administered 30 minutes before MP (which delayed seizure onset) and rats were sacrificed at seizure, decreases in [3H]MK801 binding in several layers of CA1 and CA3 of hippocampus (11-27%) and in CA1, CA2, CA3 (24-35%) after CPA+MP postseizure, and an increase in CA2 after CPA and CPA+MP postseizure (20-34%), were observed. Dizocilpine Maleate 131-136 carbonic anhydrase 1 Rattus norvegicus 166-169 9768547-6 1998 Infusions of the non-competitive NMDA antagonist MK 801 in the AcbC or CA1 resulted in dose-dependent full substitution for i.p. Dizocilpine Maleate 49-55 carbonic anhydrase 1 Rattus norvegicus 71-74 9764974-8 1998 Significant septotemporal gradients of [3H]MK-801 binding were observed in selected layers of CA1 and the dentate gyrus, a septal to temporal decrease of binding in the oriens and radiatum layers of CA1 being most prominent. Dizocilpine Maleate 43-49 carbonic anhydrase 1 Rattus norvegicus 199-202 9744424-14 1998 Immunocytochemical localization of parvalbumin showed that chronic administration of MK-801 in the combined insult cases attenuated the injury-induced dendritic atrophy of inhibitory neurons in the dentate gyrus and area CA1. Dizocilpine Maleate 85-91 carbonic anhydrase 1 Rattus norvegicus 221-224 9760459-11 1998 However, lead caused a significant increase in [3H]MK-801 binding in the hippocampus including CA1 and CA2, and in the occipital and temporal cortical areas at PN 56 and at PN 112. Dizocilpine Maleate 51-57 carbonic anhydrase 1 Rattus norvegicus 95-98 9674584-3 1998 Analysis by in vitro autoradiography showed a significant decrease in [3H]MK-801 binding in the dentate gyrus, CA1 and CA4 areas, as well as the temporal cortex. Dizocilpine Maleate 74-80 carbonic anhydrase 1 Rattus norvegicus 111-114 9329034-3 1997 On the other hand, the control and MK-801 (NMDA-antagonist) treated rats did not depress the Schaffer collaterals and showed persistent hypermetabolism of glucose in the CA1 pyramidal cell layer, where neurons were not preserved seven days later. Dizocilpine Maleate 35-41 carbonic anhydrase 1 Rattus norvegicus 170-173 9394125-14 1997 (Hepatology 5:224-232, 1985), small, but significant, increases in the binding of [3H]MK-801 were seen in the CA1 and dentate gyrus regions of the hippocampus. Dizocilpine Maleate 86-92 carbonic anhydrase 1 Rattus norvegicus 110-113 9380438-6 1997 Both doses of MK-801 and 4 mmol/kg MgSO4 induced a temporary decrease in glucose use in the posterior cingulate and retrosplenial cortex, the CA1 and CA3 subfields of the hippocampus, the caudoputamen, and the parietal cortex. Dizocilpine Maleate 14-20 carbonic anhydrase 1 Rattus norvegicus 142-145 9242358-5 1997 However, lead caused a significant increase in [3H]MK-801 binding in the hippocampus including CA1 and CA2, and in the occipital and temporal cortical areas at PN 56 and at PN 112. Dizocilpine Maleate 51-57 carbonic anhydrase 1 Rattus norvegicus 95-98 9437768-2 1997 An in situ hybridization study showed that a single injection of MK-801 increased the NMDAR1 mRNA level in the CA1 region after 3 and 24 h, and in the CA3 one after 3 h, whereas chronic administration of the drug increased the mRNA level in the dentate gyrus and CA1 at the latter time. Dizocilpine Maleate 65-71 carbonic anhydrase 1 Rattus norvegicus 111-114 9437768-2 1997 An in situ hybridization study showed that a single injection of MK-801 increased the NMDAR1 mRNA level in the CA1 region after 3 and 24 h, and in the CA3 one after 3 h, whereas chronic administration of the drug increased the mRNA level in the dentate gyrus and CA1 at the latter time. Dizocilpine Maleate 65-71 carbonic anhydrase 1 Rattus norvegicus 263-266 9437768-4 1997 Chronic MK-801 administration decreased GluR2 flip mRNA level in the dentate gyrus at 3 and 24 h, and in the CA1 region at 3 h only. Dizocilpine Maleate 8-14 carbonic anhydrase 1 Rattus norvegicus 109-112 7552365-2 1995 In castrated male rats, [125I]MK801 binding was significantly increased in both the stratum oriens and radiatum and the pyramidal cell layer of CA1. Dizocilpine Maleate 30-35 carbonic anhydrase 1 Rattus norvegicus 144-147 8758950-12 1996 When the animals were treated with MK-801 4 h after kainic acid treatment followed by additional daily administration for 3 days, a negligible number of pyramidal neurons expressed HSP70, and the survival of pyramidal cells was significantly increased in the CA1 field. Dizocilpine Maleate 35-41 carbonic anhydrase 1 Rattus norvegicus 259-262 7593357-8 1995 However, immediate postischemic hypothermia combined with delayed MK-801 treatment led to significant increases in normal CA1 neuron counts per microscopic field compared with normothermic ischemia. Dizocilpine Maleate 66-72 carbonic anhydrase 1 Rattus norvegicus 122-125 7593357-9 1995 For example, neuronal counts within the hippocampal CA1 areas were 58 +/- 39 (mean +/- SD) in normothermic ischemic rats compared with 395 +/- 198 in rats treated with postischemic hypothermia and MK-801. Dizocilpine Maleate 197-203 carbonic anhydrase 1 Rattus norvegicus 52-55 9174068-8 1997 However, at the latest time measured, kainate had the stronger effect in decreasing both messenger RNA N-methyl-D-aspartate receptor subunit-1 and [3H]dizocilpine maleate binding in CA1 and CA3 hippocampal pyramidal cells. Dizocilpine Maleate 151-170 carbonic anhydrase 1 Rattus norvegicus 182-185 9084094-3 1997 On the other hand, the control and MK-801 (NMDA-antagonist) treated rats did not depress the Schaffer collaterals and showed persistent hypermetabolism of glucose in the CA1 pyramidal cell layer, where neurons were not preserved seven days later. Dizocilpine Maleate 35-41 carbonic anhydrase 1 Rattus norvegicus 170-173 9114938-2 1997 In slices superfused by a Mg(2+)-free medium, both drugs, dizocilpine (2 to 100 microM) and CPP (0.2 to 10 microM), applied by perfusion, depressed the NMDA receptor mediated secondary population spikes (PSs) in the CA1 pyramidal cell layer. Dizocilpine Maleate 58-69 carbonic anhydrase 1 Rattus norvegicus 216-219 9017237-7 1996 Under the hypoxic condition, MK-801, L-NNA, and anti-PAF IgG significantly protected the CA1 neurons from hypoxic injury compared with cortical neurons, while cycloheximide protected both cultures equally. Dizocilpine Maleate 29-35 carbonic anhydrase 1 Rattus norvegicus 89-92 8758950-10 1996 When a single dose of MK-801 was given 4 h after kainic acid treatment, HSP70 expression was partially blocked; 18% of neurons expressed HSP70 on day 1 and 37% on day 4 in CA1 pyramidal neurons in comparison to the kainic acid controls. Dizocilpine Maleate 22-28 carbonic anhydrase 1 Rattus norvegicus 172-175 7552365-5 1995 The observed increase in [125I]MK801 binding in pyramidal cell neurons within CA1 suggests that androgens may potentially affect hippocampal function by modulating pyramidal cell NMDA receptors. Dizocilpine Maleate 31-36 carbonic anhydrase 1 Rattus norvegicus 78-81 7882020-0 1994 NMDA receptor responses in adult hippocampal CA1 region after neonatal treatment with MK-801: comparison with NMDA receptor responses in the immature rat. Dizocilpine Maleate 86-92 carbonic anhydrase 1 Rattus norvegicus 45-48 7757264-7 1995 In addition, MK-801 inhibited the kainic acid-induced expression of HSP-70 mRNA and protein in certain brain regions, notably the cortex, the pyramidal cell layer of CA1, and discrete thalamic nuclei. Dizocilpine Maleate 13-19 carbonic anhydrase 1 Rattus norvegicus 166-169 8224752-6 1993 The incidence of reappearance of the CA1 population spike after hypoxia was significantly increased (P < 0.05) by carbentapentane (50-100 microM), caramiphen (50-100 microM), 5,5-diphenylhydantoin (25-50 microM), and MK 801 (25-50 microM). Dizocilpine Maleate 220-226 carbonic anhydrase 1 Rattus norvegicus 37-40 8408318-7 1993 In area CA1 of the hippocampus, numbers of normal neurons were increased 11- to 14-fold by MK-801 treatment (p < 0.01). Dizocilpine Maleate 91-97 carbonic anhydrase 1 Rattus norvegicus 8-11 1535800-3 1992 Using lectin histochemistry to detect microglia, we show that the systemic administration of MK-801 prior to ischemia prevents microglial activation, as well as delayed death of CA1 pyramidal neurons. Dizocilpine Maleate 93-99 carbonic anhydrase 1 Rattus norvegicus 178-181 8467875-3 1993 Perfusion of slices with 50 microM of MK-801 or with 50-100 microM of U-78517F, but not with 100-200 microM of U-74500A, significantly (P < 0.01) increased the incidence of reappearance of the CA1 population spikes after reoxygenation in rat hippocampal slices subjected to a 45-min hypoxic period followed by a 45-min reoxygenation period. Dizocilpine Maleate 38-44 carbonic anhydrase 1 Rattus norvegicus 196-199 8467875-4 1993 Perfusion of slices with 12.5 microM of MK-801 plus 12.5 microM of U-78517F significantly (P < 0.05) increased the incidence of reappearance of the CA1 population spikes after reoxygenation with respect to perfusion of slices with 12.5 microM of U-78517F alone or with 12.5 microM of MK-801 alone. Dizocilpine Maleate 40-46 carbonic anhydrase 1 Rattus norvegicus 151-154 8467875-4 1993 Perfusion of slices with 12.5 microM of MK-801 plus 12.5 microM of U-78517F significantly (P < 0.05) increased the incidence of reappearance of the CA1 population spikes after reoxygenation with respect to perfusion of slices with 12.5 microM of U-78517F alone or with 12.5 microM of MK-801 alone. Dizocilpine Maleate 287-293 carbonic anhydrase 1 Rattus norvegicus 151-154 1357602-7 1992 4-Aminopyridine (100 nmol), given into the CA1 area elicited a similar motor and ECoG pattern to that of Dtx except no brain damage could be seen at 24 h. Systemic pretreatment with antagonists of N-methyl-D-aspartate receptors (MK-801 or CGP 37849) did not protect against the effects typically evoked by injecting Dtx into the CA1 area. Dizocilpine Maleate 229-235 carbonic anhydrase 1 Rattus norvegicus 43-46 1313997-8 1992 Pretreatment with 5 mg/kg MK-801 prevented field potential and pathological changes completely in the dentate gyrus and partially in the CA1 region. Dizocilpine Maleate 26-32 carbonic anhydrase 1 Rattus norvegicus 137-140 2200595-16 1990 In the hippocampus, MK-801 treated animals showed hippocampal damage limited to the vulnerable portion of the pyramidal cell band comprising 48.8% of the CA1 pyramidal cells, as opposed to 72.4% in untreated controls. Dizocilpine Maleate 20-26 carbonic anhydrase 1 Rattus norvegicus 154-157 1522756-6 1992 The incidence of reappearance of the CA1 PS during reoxygenation after long- (45 min) lasting hypoxia was significantly increased (P less than 0.05) by slice perfusion with MK 801 (50 microM), while it was not significantly affected by slice perfusion with caffeine (50 microM) or DPCPX (0.2 microM) or L-PIA (0.2 microM) or CPA (0.05 microM) or CGS 21680 (5 microM). Dizocilpine Maleate 173-179 carbonic anhydrase 1 Rattus norvegicus 37-40 1980849-1 1990 We studied the effects of iontophoretically administered MK-801 (50-150 nA) on ischemic changes on the CA1 hippocampal field potential. Dizocilpine Maleate 57-63 carbonic anhydrase 1 Rattus norvegicus 103-106 1705675-3 1990 The neuronal perikaryal death produced in the subicular, CA1 and CA2 regions was only partially decreased by intraperitoneal injections of the anticonvulsants diazepam and MK-801; these drugs were without effect in the CA3 or hilar interneuronal regions. Dizocilpine Maleate 172-178 carbonic anhydrase 1 Rattus norvegicus 57-60 2255390-8 1990 A 2 h MK-801 pretreatment produced a 30-50% increase in [3H]glutamate binding at N-methyl-D-aspartate preferring recognition sites in all four brain regions examined (areas CA1 and CA3 of the hippocampus, corpus striatum, cingulate cortex) in comparison with saline-treated controls (P less than 0.05, ANOVA). Dizocilpine Maleate 6-12 carbonic anhydrase 1 Rattus norvegicus 173-176 2158640-4 1990 However, higher doses (1.0 and 10.0 mg/kg) of MK-801 reduced the amount of kainate-induced granule cell and to some extent CA1 pyramidal cell damage in the hippocampus. Dizocilpine Maleate 46-52 carbonic anhydrase 1 Rattus norvegicus 123-126 7944826-5 1994 Slice superfusion with 50 microM of the NMDA antagonist dizocilpine (MK801) plus 50-100 microM NMDA prevented in all experiments the irreversible disappearance of the CA1 population spike with respect to a slice superfusion with 50-100 microM alone. Dizocilpine Maleate 56-67 carbonic anhydrase 1 Rattus norvegicus 167-170 7944826-5 1994 Slice superfusion with 50 microM of the NMDA antagonist dizocilpine (MK801) plus 50-100 microM NMDA prevented in all experiments the irreversible disappearance of the CA1 population spike with respect to a slice superfusion with 50-100 microM alone. Dizocilpine Maleate 69-74 carbonic anhydrase 1 Rattus norvegicus 167-170 34098454-9 2021 Histopathological and immunohistochemical evaluations showed that treatment with MK-801 significantly ameliorated the trauma-induced hippocampal neuron loss and increased BDNF, NGF, NMDA-R, GFAP expressions in CA1, CA3, and DG hippocampal regions. Dizocilpine Maleate 81-87 carbonic anhydrase 1 Rattus norvegicus 210-213