PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8106000-3 1993 This BDNF and mRNA upregulation was inhibited by dizocilpine (MK-801), the noncompetitive blocker of N-methyl-D-aspartate (NMDA)-sensitive glutamate receptors, and mimicked by NMDA. Dizocilpine Maleate 49-60 brain-derived neurotrophic factor Rattus norvegicus 5-9 7950963-5 1994 Induction of different BDNF promoters after treatment with kainic acid combined with glutamate antagonists MK801 and NBQX discloses the differential participation of different glutamate receptor subtypes in regulation of the BDNF gene in the hippocampus. Dizocilpine Maleate 107-112 brain-derived neurotrophic factor Rattus norvegicus 23-27 7950963-5 1994 Induction of different BDNF promoters after treatment with kainic acid combined with glutamate antagonists MK801 and NBQX discloses the differential participation of different glutamate receptor subtypes in regulation of the BDNF gene in the hippocampus. Dizocilpine Maleate 107-112 brain-derived neurotrophic factor Rattus norvegicus 225-229 7854071-7 1994 Pretreatment with the non-competitive NMDA antagonist MK-801 (2 mg/kg, 30 min before the insult), partially blocked the increase in both BDNF and NGF mRNAs, as well as the decrease in NT3, in the contralateral hippocampus. Dizocilpine Maleate 54-60 brain-derived neurotrophic factor Rattus norvegicus 137-141 8247360-2 1993 This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. Dizocilpine Maleate 79-98 brain-derived neurotrophic factor Rattus norvegicus 5-9 8247360-2 1993 This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. Dizocilpine Maleate 100-106 brain-derived neurotrophic factor Rattus norvegicus 5-9 8106000-3 1993 This BDNF and mRNA upregulation was inhibited by dizocilpine (MK-801), the noncompetitive blocker of N-methyl-D-aspartate (NMDA)-sensitive glutamate receptors, and mimicked by NMDA. Dizocilpine Maleate 62-68 brain-derived neurotrophic factor Rattus norvegicus 5-9 8405262-0 1993 Differential effects of MK-801 on brain-derived neurotrophic factor mRNA levels in different regions of the rat brain. Dizocilpine Maleate 24-30 brain-derived neurotrophic factor Rattus norvegicus 34-67 8405262-1 1993 We have studied the effects of MK-801, a noncompetitive antagonist of N-methyl-D-aspartate-type glutamate receptors, on brain-derived neurotrophic factor (BDNF) mRNA levels in the rat brain. Dizocilpine Maleate 31-37 brain-derived neurotrophic factor Rattus norvegicus 155-159 8405262-2 1993 MK-801 decreased BDNF mRNA in the hippocampus and in the superficial layers of the cerebral cortex. Dizocilpine Maleate 0-6 brain-derived neurotrophic factor Rattus norvegicus 17-21 8405262-3 1993 However, in single cells of the middle layer of the cerebral cortex and the midline thalamic nuclei BDNF mRNA levels were markedly increased by MK-801. Dizocilpine Maleate 144-150 brain-derived neurotrophic factor Rattus norvegicus 100-104 8405262-5 1993 Pentobarbital (an enhancer of gabaergic functions) and scopolamine (a muscarinic receptor antagonist) blocked the effects of MK-801 on BDNF mRNA levels in the retrosplenial cortex, but the nicotinic and dopaminergic receptor antagonists mecamylamine and haloperidol, respectively, were ineffective. Dizocilpine Maleate 125-131 brain-derived neurotrophic factor Rattus norvegicus 135-139 8405262-6 1993 Pilocarpine, a muscarinic cholinergic agonist increased BDNF mRNA in some, but not all, cortical areas, where MK-801 had elicited an increase in BDNF mRNA. Dizocilpine Maleate 110-116 brain-derived neurotrophic factor Rattus norvegicus 145-149 8405262-7 1993 Thus, the observations made with MK-801 demonstrate that depending on the neuronal connections and the transmitter systems involved, a given compound can elicit either a decrease or an increase in BDNF mRNA levels. Dizocilpine Maleate 33-39 brain-derived neurotrophic factor Rattus norvegicus 197-201 8405262-1 1993 We have studied the effects of MK-801, a noncompetitive antagonist of N-methyl-D-aspartate-type glutamate receptors, on brain-derived neurotrophic factor (BDNF) mRNA levels in the rat brain. Dizocilpine Maleate 31-37 brain-derived neurotrophic factor Rattus norvegicus 120-153 1731336-4 1992 The increase of BDNF mRNA could be partially blocked by the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist NBQX but was not influenced by the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801. Dizocilpine Maleate 227-233 brain-derived neurotrophic factor Rattus norvegicus 16-20 8453057-0 1993 MK801 induces immediate-early gene proteins and BDNF mRNA in rat cerebrocortical neurones. Dizocilpine Maleate 0-5 brain-derived neurotrophic factor Rattus norvegicus 48-52 8453057-2 1993 Here we report that doses of MK801 (1 and 5 mg kg-1) which have been shown to produce pathomorphological changes, induce the expression of immediate-early gene proteins (IEGPs) and brain-derived neurotrophic factor (BDNF) mRNA in rat cerebrocortical neurones. Dizocilpine Maleate 29-34 brain-derived neurotrophic factor Rattus norvegicus 181-214 8453057-2 1993 Here we report that doses of MK801 (1 and 5 mg kg-1) which have been shown to produce pathomorphological changes, induce the expression of immediate-early gene proteins (IEGPs) and brain-derived neurotrophic factor (BDNF) mRNA in rat cerebrocortical neurones. Dizocilpine Maleate 29-34 brain-derived neurotrophic factor Rattus norvegicus 216-220 8453057-3 1993 Blockade of central muscarinic receptors which has been shown to prevent MK801-induced pathomorphological changes in cerebrocortical neurones, also prevented MK801-induced expression of IEGPs and BDNF mRNA. Dizocilpine Maleate 158-163 brain-derived neurotrophic factor Rattus norvegicus 196-200 8453057-4 1993 The transiently increased expression of BDNF mRNA may be an acute compensatory response of these neurones to MK801-induced injury. Dizocilpine Maleate 109-114 brain-derived neurotrophic factor Rattus norvegicus 40-44 1391750-4 1992 The stroke-induced BDNF mRNA increase was prevented by the non-competitive glutamate receptor blocker dizocilpine (MK-801). Dizocilpine Maleate 102-113 brain-derived neurotrophic factor Rattus norvegicus 19-23 1391750-4 1992 The stroke-induced BDNF mRNA increase was prevented by the non-competitive glutamate receptor blocker dizocilpine (MK-801). Dizocilpine Maleate 115-121 brain-derived neurotrophic factor Rattus norvegicus 19-23 34098454-9 2021 Histopathological and immunohistochemical evaluations showed that treatment with MK-801 significantly ameliorated the trauma-induced hippocampal neuron loss and increased BDNF, NGF, NMDA-R, GFAP expressions in CA1, CA3, and DG hippocampal regions. Dizocilpine Maleate 81-87 brain-derived neurotrophic factor Rattus norvegicus 171-175 34054433-3 2021 We previously found that BDNF signaling was upregulated by MK-801 in cultured hippocampal astrocytes, but the underlying mechanism is not clear. Dizocilpine Maleate 59-65 brain-derived neurotrophic factor Rattus norvegicus 25-29 34054433-0 2021 Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling. Dizocilpine Maleate 41-47 brain-derived neurotrophic factor Rattus norvegicus 22-26 34054433-4 2021 To address this issue, the levels of BDNF expression and secretion were evaluated in hippocampal astrocytes incubated with MK-801 by ELISA and qPCR, with and without NMDA co-incubation or pretreatment of either the ERK1/2 inhibitor, PD98059 or the PI3K inhibitor, LY294002. Dizocilpine Maleate 123-129 brain-derived neurotrophic factor Rattus norvegicus 37-41 34054433-7 2021 Expression of BDNF mRNA was enhanced after 24 h in MK-801, but returned to near baseline over the next 24 h in the continued presence of MK-801. Dizocilpine Maleate 51-57 brain-derived neurotrophic factor Rattus norvegicus 14-18 34054433-7 2021 Expression of BDNF mRNA was enhanced after 24 h in MK-801, but returned to near baseline over the next 24 h in the continued presence of MK-801. Dizocilpine Maleate 137-143 brain-derived neurotrophic factor Rattus norvegicus 14-18 34054433-10 2021 Co-addition of NMDA significantly inhibited MK-801-induced upregulation of BDNF. Dizocilpine Maleate 44-50 brain-derived neurotrophic factor Rattus norvegicus 75-79 34054433-11 2021 Similarly, MK-801-induced BDNF upregulation was blocked by pretreatment with inhibitors of PI3K and ERK1/2, but not by inhibitors of p38 and JNK. Dizocilpine Maleate 11-17 brain-derived neurotrophic factor Rattus norvegicus 26-30 34054433-12 2021 These findings suggested that astrocytes may contribute to the acute neurological and behavioral response to MK-801 treatment via a transient increase in BDNF expression involving NMDA-R-PI3K-ERK signaling. Dizocilpine Maleate 109-115 brain-derived neurotrophic factor Rattus norvegicus 154-158 32793005-8 2020 Results: In the hippocampus of MK-801-induced schizophrenia rat model, RSV enhanced silent information regulator 1 (SIRT1) and brain derived neurotrophic factor (BDNF) expression and alleviated oxidative stress. Dizocilpine Maleate 31-37 brain-derived neurotrophic factor Rattus norvegicus 127-160 32793005-8 2020 Results: In the hippocampus of MK-801-induced schizophrenia rat model, RSV enhanced silent information regulator 1 (SIRT1) and brain derived neurotrophic factor (BDNF) expression and alleviated oxidative stress. Dizocilpine Maleate 31-37 brain-derived neurotrophic factor Rattus norvegicus 162-166 32793005-10 2020 Conclusion: In conclusion, RSV showed neuroprotective effect on MK-801-induced schizophrenia rat model through regulating SIRT1 and downstream BDNF expression in the hippocampus. Dizocilpine Maleate 64-70 brain-derived neurotrophic factor Rattus norvegicus 143-147 31412259-0 2019 5-HT6 receptor agonist and antagonist improve memory impairments and hippocampal BDNF signaling alterations induced by MK-801. Dizocilpine Maleate 119-125 brain-derived neurotrophic factor Rattus norvegicus 81-85 32367475-4 2020 However, overexpression of AAV9/CREB S133A (CREB inactivated mutation) downregulated BDNF/TrkB signaling pathway and remarkably abolished the preventive effect of omega-3PUFAs in MK801-induced schizophrenia. Dizocilpine Maleate 179-184 brain-derived neurotrophic factor Rattus norvegicus 85-89 32367475-6 2020 In conclusion, these findings indicate that MK801-induced SZ lesions dephosphorylate CREB at Ser133 site, leading to neuron damage, and omega-3PUFAs improve SZ cognitive impairments by upregulating the CREB/BDNF/TrkB pathway, which provides new clues for the mechanism of SZ cognitive impairments, and a basis for therapeutic intervention. Dizocilpine Maleate 44-49 brain-derived neurotrophic factor Rattus norvegicus 207-211 31412259-4 2019 Both 5-HT6R ligands increased hippocampal BDNF protein expression, but WAY-181187 was much more potent than SB-742457 and alleviated the MK-801-induced inhibition of BDNF signaling pathways better, which seems to translate into a stronger WAY-181187 effect in behavioral tests. Dizocilpine Maleate 137-143 brain-derived neurotrophic factor Rattus norvegicus 166-170 31412259-5 2019 Collectively, both the 5-HT6R agonist and the antagonist, administered acutely and chronically, prevent memory impairments and alterations in BDNF signaling induced by MK-801 in rats. Dizocilpine Maleate 168-174 brain-derived neurotrophic factor Rattus norvegicus 142-146 31396062-2 2019 Our previous study showed that brain-derived neurotrophic factor (BDNF) signaling was upregulated in cultured hippocampal astrocytes in response to MK-801. Dizocilpine Maleate 148-154 brain-derived neurotrophic factor Rattus norvegicus 31-64 31396062-2 2019 Our previous study showed that brain-derived neurotrophic factor (BDNF) signaling was upregulated in cultured hippocampal astrocytes in response to MK-801. Dizocilpine Maleate 148-154 brain-derived neurotrophic factor Rattus norvegicus 66-70 31396062-6 2019 MK-801 treatment decreased BDNF expression in the rat hippocampus as well as the expression and secretion of BDNF in hippocampal neurons in vitro. Dizocilpine Maleate 0-6 brain-derived neurotrophic factor Rattus norvegicus 27-31 31396062-6 2019 MK-801 treatment decreased BDNF expression in the rat hippocampus as well as the expression and secretion of BDNF in hippocampal neurons in vitro. Dizocilpine Maleate 0-6 brain-derived neurotrophic factor Rattus norvegicus 109-113 31396062-7 2019 However, risperidone reversed the effects of MK801 on BDNF level and improved cognitive function in rats treated with MK801. Dizocilpine Maleate 45-50 brain-derived neurotrophic factor Rattus norvegicus 54-58 28786073-0 2017 omega-3PUFAs prevent MK-801-induced cognitive impairment in schizophrenic rats via the CREB/BDNF/TrkB pathway. Dizocilpine Maleate 21-27 brain-derived neurotrophic factor Rattus norvegicus 92-96 28786073-6 2017 The results showed that omega-3PUFAs attenuated MK-801-induced cognitive impairment and hippocampal neurons loss, reversed the injury of the CREB/BDNF/TrkB pathway induced by MK-801, and antagonized MK-801-induced down-regulation of p-AKT and p-ERK in the hippocampus of rats. Dizocilpine Maleate 175-181 brain-derived neurotrophic factor Rattus norvegicus 146-150 30677409-8 2019 MK-801 resulted in decreased levels of BDNF in the hippocampus, and EE exposure restored the decreased level. Dizocilpine Maleate 0-6 brain-derived neurotrophic factor Rattus norvegicus 39-43 28786073-6 2017 The results showed that omega-3PUFAs attenuated MK-801-induced cognitive impairment and hippocampal neurons loss, reversed the injury of the CREB/BDNF/TrkB pathway induced by MK-801, and antagonized MK-801-induced down-regulation of p-AKT and p-ERK in the hippocampus of rats. Dizocilpine Maleate 48-54 brain-derived neurotrophic factor Rattus norvegicus 146-150 28786073-6 2017 The results showed that omega-3PUFAs attenuated MK-801-induced cognitive impairment and hippocampal neurons loss, reversed the injury of the CREB/BDNF/TrkB pathway induced by MK-801, and antagonized MK-801-induced down-regulation of p-AKT and p-ERK in the hippocampus of rats. Dizocilpine Maleate 175-181 brain-derived neurotrophic factor Rattus norvegicus 146-150 25992477-0 2015 Measure of anxiety-related behaviors and hippocampal BDNF levels associated to the amnesic effect induced by MK-801 evaluated in the modified elevated plus-maze in rats. Dizocilpine Maleate 109-115 brain-derived neurotrophic factor Rattus norvegicus 53-57 28451387-0 2017 Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment. Dizocilpine Maleate 136-142 brain-derived neurotrophic factor Rattus norvegicus 79-83 28451387-1 2017 The aim of the present study was to investigate the effects of a commonly-used atypical antipsychotic, risperidone, on alterations in spatial learning and in the hippocampal brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signalling system caused by acute dizocilpine maleate (MK-801) treatment. Dizocilpine Maleate 283-302 brain-derived neurotrophic factor Rattus norvegicus 174-207 28451387-1 2017 The aim of the present study was to investigate the effects of a commonly-used atypical antipsychotic, risperidone, on alterations in spatial learning and in the hippocampal brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signalling system caused by acute dizocilpine maleate (MK-801) treatment. Dizocilpine Maleate 283-302 brain-derived neurotrophic factor Rattus norvegicus 209-213 28451387-1 2017 The aim of the present study was to investigate the effects of a commonly-used atypical antipsychotic, risperidone, on alterations in spatial learning and in the hippocampal brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signalling system caused by acute dizocilpine maleate (MK-801) treatment. Dizocilpine Maleate 304-310 brain-derived neurotrophic factor Rattus norvegicus 174-207 28451387-1 2017 The aim of the present study was to investigate the effects of a commonly-used atypical antipsychotic, risperidone, on alterations in spatial learning and in the hippocampal brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signalling system caused by acute dizocilpine maleate (MK-801) treatment. Dizocilpine Maleate 304-310 brain-derived neurotrophic factor Rattus norvegicus 209-213 28451387-2 2017 In experiment 1, adult male Sprague-Dawley rats subjected to acute treatment of either low-dose MK801 (0.1 mg/kg) or normal saline (vehicle) were tested for spatial object recognition and hippocampal expression levels of BDNF, TrkB and the phophorylation of TrkB (p-TrkB). Dizocilpine Maleate 96-101 brain-derived neurotrophic factor Rattus norvegicus 221-225 26700309-0 2015 Reactive Transformation and Increased BDNF Signaling by Hippocampal Astrocytes in Response to MK-801. Dizocilpine Maleate 94-100 brain-derived neurotrophic factor Rattus norvegicus 38-42 26700309-4 2015 Moreover, the expression levels of BDNF and its receptors TrkB and p75 were examined in MK-801-treated astrocyte cultures. Dizocilpine Maleate 88-94 brain-derived neurotrophic factor Rattus norvegicus 35-39 26700309-6 2015 Treatment of cultured hippocampal astrocytes with MK-801 enhanced protein and mRNA levels of BDNF, TrkB, and p75. Dizocilpine Maleate 50-56 brain-derived neurotrophic factor Rattus norvegicus 93-97 25992477-5 2015 Therefore, we investigated if changes in anxiety-related behaviors and hippocampal BDNF levels are related with the amnesic effect induced by MK-801 in the mEPM.Transfer latency (TL) as an index of spatial memory in the mEPM was used. Dizocilpine Maleate 142-148 brain-derived neurotrophic factor Rattus norvegicus 83-87 24978397-6 2014 Antagonism of the N-methyl-D-aspartate-type glutamate receptor by MK801 attenuates the increase in BDNF and Bax, which underscores a therapeutic role for N-methyl-D-aspartate-type glutamate receptor antagonism in the acute post-traumatic time period and suggests a value to a hippocampal IEG readout as an outcome after injury or acute therapeutic intervention. Dizocilpine Maleate 66-71 brain-derived neurotrophic factor Rattus norvegicus 99-103 25943283-3 2015 The aims of the present study were to determine: (i) the short term effects of MK-801 on hippocampal BDNF, NGF and NMDA receptor immunoreactivity and neuron density in hippocampus (ii) long term effects of MK-801 on cognitive dysfunction following TBI in the immature rats. Dizocilpine Maleate 79-85 brain-derived neurotrophic factor Rattus norvegicus 101-105 21075106-8 2011 Chronic systemic MK-801 or APO injections decreased the neuropathic manifestations in both models, increased the BDNF level and modulated the other cytokines and neurotrophins. Dizocilpine Maleate 17-23 brain-derived neurotrophic factor Rattus norvegicus 113-117 24662915-6 2014 We found that MK-801-treated rats showed significant deficits in working learning ability and hippocampal synaptic plasticity, as well as reduction of BDNF, TrkB, and phosphorylated TrkB in the hippocampus. Dizocilpine Maleate 14-20 brain-derived neurotrophic factor Rattus norvegicus 151-155 24595240-5 2014 The AChE inhibitor physostigmine ameliorated the MK801-induced reduction of BDNF mRNA and protein levels, reduced MK801-triggered MMP-2 activity and prevented decreased TIMP-2 mRNA expression. Dizocilpine Maleate 49-54 brain-derived neurotrophic factor Rattus norvegicus 76-80 21145362-10 2011 Increase in intracellular Ca(2+) concentration, phosphorylation of ERK1/2 and CREB, and BDNF expression by oroxylin A was blocked by NMDA receptor inhibitor MK-801 (10muM) as well as tetrodotoxin (TTX, 0.5 and 1muM). Dizocilpine Maleate 157-163 brain-derived neurotrophic factor Rattus norvegicus 88-92 16884712-0 2006 Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain. Dizocilpine Maleate 19-24 brain-derived neurotrophic factor Rattus norvegicus 44-77 21134422-4 2011 The aims of this study were to investigate the change in short and long term memory as assessed by the novel object recognition (NOR) test and BDNF expression in hippocampus produced by an acute hypoglutamatergic model of memory impairment in schizophrenia induced by administration of the NMDA receptor non-competitive antagonist, MK-801 and the ability of clozapine and NDMC to prevent the deleterious effects of MK-801. Dizocilpine Maleate 332-338 brain-derived neurotrophic factor Rattus norvegicus 143-147 21134422-4 2011 The aims of this study were to investigate the change in short and long term memory as assessed by the novel object recognition (NOR) test and BDNF expression in hippocampus produced by an acute hypoglutamatergic model of memory impairment in schizophrenia induced by administration of the NMDA receptor non-competitive antagonist, MK-801 and the ability of clozapine and NDMC to prevent the deleterious effects of MK-801. Dizocilpine Maleate 415-421 brain-derived neurotrophic factor Rattus norvegicus 143-147 20625416-0 2010 Postnatal BDNF expression profiles in prefrontal cortex and hippocampus of a rat schizophrenia model induced by MK-801 administration. Dizocilpine Maleate 112-118 brain-derived neurotrophic factor Rattus norvegicus 10-14 20625416-6 2010 Results showed that neonatal challenge with MK-801 persistently elevated locomotor activity as well as BDNF expression; the alterations in BDNF expression varied at different developing stages and among brain regions. Dizocilpine Maleate 44-50 brain-derived neurotrophic factor Rattus norvegicus 103-107 20625416-6 2010 Results showed that neonatal challenge with MK-801 persistently elevated locomotor activity as well as BDNF expression; the alterations in BDNF expression varied at different developing stages and among brain regions. Dizocilpine Maleate 44-50 brain-derived neurotrophic factor Rattus norvegicus 139-143 19326433-7 2009 The pan-BDNF and exon II-BDNF transcript increases were completely abolished by the prior systemic administration of MK-801, a selective antagonist of NMDA receptors. Dizocilpine Maleate 117-123 brain-derived neurotrophic factor Rattus norvegicus 8-12 19326433-7 2009 The pan-BDNF and exon II-BDNF transcript increases were completely abolished by the prior systemic administration of MK-801, a selective antagonist of NMDA receptors. Dizocilpine Maleate 117-123 brain-derived neurotrophic factor Rattus norvegicus 25-29 19326433-8 2009 MK-801 also blocked the increase in BDNF-IR cells in SN observed 7 days after unilateral 6-OHDA intrastriatal injections. Dizocilpine Maleate 0-6 brain-derived neurotrophic factor Rattus norvegicus 36-40 16884712-3 2006 Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. Dizocilpine Maleate 49-54 brain-derived neurotrophic factor Rattus norvegicus 75-79 16884712-3 2006 Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. Dizocilpine Maleate 49-54 brain-derived neurotrophic factor Rattus norvegicus 242-246 16884712-4 2006 However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. Dizocilpine Maleate 9-14 brain-derived neurotrophic factor Rattus norvegicus 39-43 16884712-4 2006 However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. Dizocilpine Maleate 9-14 brain-derived neurotrophic factor Rattus norvegicus 179-183 16884712-5 2006 These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner. Dizocilpine Maleate 78-83 brain-derived neurotrophic factor Rattus norvegicus 103-107 16884712-1 2006 To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. Dizocilpine Maleate 146-151 brain-derived neurotrophic factor Rattus norvegicus 78-111 16884712-1 2006 To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. Dizocilpine Maleate 146-151 brain-derived neurotrophic factor Rattus norvegicus 113-117 16884712-2 2006 MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Dizocilpine Maleate 0-5 brain-derived neurotrophic factor Rattus norvegicus 30-34 11425509-0 2001 Effects of age and gender on the expression of brain-derived neurotrophic factor mRNA in rat retrosplenial cortex following administration of dizocilpine. Dizocilpine Maleate 142-153 brain-derived neurotrophic factor Rattus norvegicus 47-80 15846781-1 2005 In rat hippocampal neurons cultured with the antagonist for N-methyl-D-aspartate (NMDA) receptors dizocilpine (MK-801) for 8 days in vitro (DIV), a significant decrease was seen in the expression of microtubule-associated protein-2 (MAP-2) as well as mRNA for both brain-derived neurotrophic factor (BDNF) and growth-associated protein-43 (GAP-43), in addition to decreased viability. Dizocilpine Maleate 98-109 brain-derived neurotrophic factor Rattus norvegicus 265-298 15846781-1 2005 In rat hippocampal neurons cultured with the antagonist for N-methyl-D-aspartate (NMDA) receptors dizocilpine (MK-801) for 8 days in vitro (DIV), a significant decrease was seen in the expression of microtubule-associated protein-2 (MAP-2) as well as mRNA for both brain-derived neurotrophic factor (BDNF) and growth-associated protein-43 (GAP-43), in addition to decreased viability. Dizocilpine Maleate 98-109 brain-derived neurotrophic factor Rattus norvegicus 300-304 15846781-1 2005 In rat hippocampal neurons cultured with the antagonist for N-methyl-D-aspartate (NMDA) receptors dizocilpine (MK-801) for 8 days in vitro (DIV), a significant decrease was seen in the expression of microtubule-associated protein-2 (MAP-2) as well as mRNA for both brain-derived neurotrophic factor (BDNF) and growth-associated protein-43 (GAP-43), in addition to decreased viability. Dizocilpine Maleate 111-117 brain-derived neurotrophic factor Rattus norvegicus 265-298 15846781-1 2005 In rat hippocampal neurons cultured with the antagonist for N-methyl-D-aspartate (NMDA) receptors dizocilpine (MK-801) for 8 days in vitro (DIV), a significant decrease was seen in the expression of microtubule-associated protein-2 (MAP-2) as well as mRNA for both brain-derived neurotrophic factor (BDNF) and growth-associated protein-43 (GAP-43), in addition to decreased viability. Dizocilpine Maleate 111-117 brain-derived neurotrophic factor Rattus norvegicus 300-304 15486491-0 2004 Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801. Dizocilpine Maleate 90-96 brain-derived neurotrophic factor Rattus norvegicus 31-35 15193300-4 2004 BDNF supplementation fully prevented MK801-induced neurotoxicity in immature neuronal cultures and transgenic constitutive activation of Ras was associated with marked protection against MK801-induced apoptotic neuronal death. Dizocilpine Maleate 37-42 brain-derived neurotrophic factor Rattus norvegicus 0-4 15193300-4 2004 BDNF supplementation fully prevented MK801-induced neurotoxicity in immature neuronal cultures and transgenic constitutive activation of Ras was associated with marked protection against MK801-induced apoptotic neuronal death. Dizocilpine Maleate 187-192 brain-derived neurotrophic factor Rattus norvegicus 0-4 15006687-6 2004 Coadministration of recombinant EPO (rEPO) conferred 50% neuroprotection, partially restored MK801-induced reduction of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) mRNA, and prevented decreased phosphorylation levels of extracellular signal-regulated protein kinase-1/2 (ERK1/2) and Akt. Dizocilpine Maleate 93-98 brain-derived neurotrophic factor Rattus norvegicus 120-153 15006687-6 2004 Coadministration of recombinant EPO (rEPO) conferred 50% neuroprotection, partially restored MK801-induced reduction of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) mRNA, and prevented decreased phosphorylation levels of extracellular signal-regulated protein kinase-1/2 (ERK1/2) and Akt. Dizocilpine Maleate 93-98 brain-derived neurotrophic factor Rattus norvegicus 155-159 16220190-6 2005 Furthermore, we intraperitoneally injected NMDA receptor antagonist MK801 (0.1 mg/kg) 30 min before corticosterone administration to investigate whether and how MK801 affected the regulation of BDNF gene expression by corticosterone. Dizocilpine Maleate 161-166 brain-derived neurotrophic factor Rattus norvegicus 194-198 16220190-8 2005 MK801 promoted the downregulation of BDNF gene expression in the rat hippocampus by corticosterone. Dizocilpine Maleate 0-5 brain-derived neurotrophic factor Rattus norvegicus 37-41 14664909-0 2003 Spatial learning is delayed and brain-derived neurotrophic factor mRNA expression inhibited by administration of MK-801 in rats. Dizocilpine Maleate 113-119 brain-derived neurotrophic factor Rattus norvegicus 32-65 14664909-10 2003 However, MK-801 attenuated the BDNF mRNA increase in the learning and activity-yoked conditions (P < 0.05). Dizocilpine Maleate 9-15 brain-derived neurotrophic factor Rattus norvegicus 31-35 12462419-3 2002 We applied expression profiling methods to find genes coregulated with BDNF following treatment with the prototypical NMDA/glutamate receptor antagonist MK-801. Dizocilpine Maleate 153-159 brain-derived neurotrophic factor Rattus norvegicus 71-75 11860475-6 2001 Bath applied NMDA antagonists APV and MK-801 abolished both facilitatory and inhibitory actions of BDNF on the AMPA/kainate responses indicating the requirement for functional NMDA receptors. Dizocilpine Maleate 38-44 brain-derived neurotrophic factor Rattus norvegicus 99-103 11860475-8 2001 When introduced into the motoneuron through the recording microelectrode, MK-801 selectively blocked the facilitatory action of BDNF. Dizocilpine Maleate 74-80 brain-derived neurotrophic factor Rattus norvegicus 128-132 11425509-4 2001 Administration of dizocilpine (0.3, 1.0, or 3.0 mg/kg, IP) caused a marked induction of BDNF mRNA and hsp-70 mRNA in the retrosplenial cortex of male and female rats, in a dose-dependent manner. Dizocilpine Maleate 18-29 brain-derived neurotrophic factor Rattus norvegicus 88-92 11425509-5 2001 Female rats were more sensitive to the induction of BDNF mRNA and hsp-70 mRNA in the retrosplenial cortex by dizocilpine as compared to male rats. Dizocilpine Maleate 109-120 brain-derived neurotrophic factor Rattus norvegicus 52-56 11425509-6 2001 It was also found that adult (12 weeks old) and aged (10 months old) rats were more sensitive to the induction of hsp-70 mRNA and BDNF mRNA in the retrosplenial cortex by dizocilpine as compared to young (5 weeks old) rats. Dizocilpine Maleate 171-182 brain-derived neurotrophic factor Rattus norvegicus 130-134 11425509-7 2001 These results suggest that the age and gender differences observed in the expression of BDNF mRNA and hsp-70 mRNA in the retrosplenial cortex by dizocilpine may be associated with the differences in dizocilpine-induced neurotoxicity observed with gender and age within the same region. Dizocilpine Maleate 145-156 brain-derived neurotrophic factor Rattus norvegicus 88-92 11425509-7 2001 These results suggest that the age and gender differences observed in the expression of BDNF mRNA and hsp-70 mRNA in the retrosplenial cortex by dizocilpine may be associated with the differences in dizocilpine-induced neurotoxicity observed with gender and age within the same region. Dizocilpine Maleate 199-210 brain-derived neurotrophic factor Rattus norvegicus 88-92 11461961-2 2001 A candidate sequence from the 5" flanking region of exon 3 of the rat brain-derived neurotrophic factor (BDNF) gene was used to show that exposure of rat cerebellar granule cells to 100 microM NMDA activated a specific DNA binding activity that was blocked by the NMDA receptor antagonist MK-801. Dizocilpine Maleate 289-295 brain-derived neurotrophic factor Rattus norvegicus 70-103 11461961-2 2001 A candidate sequence from the 5" flanking region of exon 3 of the rat brain-derived neurotrophic factor (BDNF) gene was used to show that exposure of rat cerebellar granule cells to 100 microM NMDA activated a specific DNA binding activity that was blocked by the NMDA receptor antagonist MK-801. Dizocilpine Maleate 289-295 brain-derived neurotrophic factor Rattus norvegicus 105-109 10616798-7 2000 Pretreatment with the N-methyl-D-aspartate receptor blocker MK-801 (2 mg/kg) 1 hour before CCAT reduced the expression of BDNF mRNA expression at 2 hours. Dizocilpine Maleate 60-66 brain-derived neurotrophic factor Rattus norvegicus 122-126 10854034-4 2000 MK-801 (5 mg/kg; 4 h) significantly increased BDNF mRNA in the entorhinal cortex, but did not influence NT-3, trkB, or trkC expression in any brain area except for the olfactory bulb. Dizocilpine Maleate 0-6 brain-derived neurotrophic factor Rattus norvegicus 46-50 10854034-5 2000 The induction of BDNF mRNA by MK-801 was attenuated by pre-treatment (1 h prior to MK-801 administration) with the antipsychotics, clozapine (25 mg/kg) and haloperidol (2 mg/kg), but not with the antidepressant desipramine (15 mg/kg). Dizocilpine Maleate 30-36 brain-derived neurotrophic factor Rattus norvegicus 17-21 10854034-5 2000 The induction of BDNF mRNA by MK-801 was attenuated by pre-treatment (1 h prior to MK-801 administration) with the antipsychotics, clozapine (25 mg/kg) and haloperidol (2 mg/kg), but not with the antidepressant desipramine (15 mg/kg). Dizocilpine Maleate 83-89 brain-derived neurotrophic factor Rattus norvegicus 17-21 10854034-6 2000 Finally, we confirmed that the effects of MK-801 on BDNF mRNA were reflected in the respective changes in BDNF protein levels: MK-801 significantly increased anti-BDNF reactivity in the entorhinal cortex (126 +/- 7% of control) while concomitantly decreasing in the hippocampus (71 +/- 2% of control). Dizocilpine Maleate 42-48 brain-derived neurotrophic factor Rattus norvegicus 52-56 10854034-6 2000 Finally, we confirmed that the effects of MK-801 on BDNF mRNA were reflected in the respective changes in BDNF protein levels: MK-801 significantly increased anti-BDNF reactivity in the entorhinal cortex (126 +/- 7% of control) while concomitantly decreasing in the hippocampus (71 +/- 2% of control). Dizocilpine Maleate 42-48 brain-derived neurotrophic factor Rattus norvegicus 106-110 10854034-6 2000 Finally, we confirmed that the effects of MK-801 on BDNF mRNA were reflected in the respective changes in BDNF protein levels: MK-801 significantly increased anti-BDNF reactivity in the entorhinal cortex (126 +/- 7% of control) while concomitantly decreasing in the hippocampus (71 +/- 2% of control). Dizocilpine Maleate 42-48 brain-derived neurotrophic factor Rattus norvegicus 106-110 10854034-6 2000 Finally, we confirmed that the effects of MK-801 on BDNF mRNA were reflected in the respective changes in BDNF protein levels: MK-801 significantly increased anti-BDNF reactivity in the entorhinal cortex (126 +/- 7% of control) while concomitantly decreasing in the hippocampus (71 +/- 2% of control). Dizocilpine Maleate 127-133 brain-derived neurotrophic factor Rattus norvegicus 52-56 10854034-6 2000 Finally, we confirmed that the effects of MK-801 on BDNF mRNA were reflected in the respective changes in BDNF protein levels: MK-801 significantly increased anti-BDNF reactivity in the entorhinal cortex (126 +/- 7% of control) while concomitantly decreasing in the hippocampus (71 +/- 2% of control). Dizocilpine Maleate 127-133 brain-derived neurotrophic factor Rattus norvegicus 106-110 10854034-6 2000 Finally, we confirmed that the effects of MK-801 on BDNF mRNA were reflected in the respective changes in BDNF protein levels: MK-801 significantly increased anti-BDNF reactivity in the entorhinal cortex (126 +/- 7% of control) while concomitantly decreasing in the hippocampus (71 +/- 2% of control). Dizocilpine Maleate 127-133 brain-derived neurotrophic factor Rattus norvegicus 106-110 10854034-7 2000 These data do not support the hypothesis that neurotrophins play an important role in antipsychotic drug action, but rather suggest that induction of BDNF in the entorhinal cortex may play a significant role in the psychotropic action of MK-801. Dizocilpine Maleate 238-244 brain-derived neurotrophic factor Rattus norvegicus 150-154 10513602-5 1999 MK801, at a dose having no significant effect alone (0.08 microg), significantly antagonized the effect of CRF on BDNF mRNA expression. Dizocilpine Maleate 0-5 brain-derived neurotrophic factor Rattus norvegicus 114-118 9473635-8 1998 MK801 abolished the increase in BDNF protein and trk B, but not trk C mRNA in granule cells at 4 h. These results demonstrate that MK801 differentially regulates the AD-increased expression of a group of genes previously identified as being likely candidates for an involvement in kindling. Dizocilpine Maleate 0-5 brain-derived neurotrophic factor Rattus norvegicus 32-36 9473635-8 1998 MK801 abolished the increase in BDNF protein and trk B, but not trk C mRNA in granule cells at 4 h. These results demonstrate that MK801 differentially regulates the AD-increased expression of a group of genes previously identified as being likely candidates for an involvement in kindling. Dizocilpine Maleate 131-136 brain-derived neurotrophic factor Rattus norvegicus 32-36 9473635-10 1998 Conversely, the role in kindling of those genes whose expression was significantly attenuated by MK801 (Fos, Jun-D, Krox-20, trkB and BDNF) requires further examination. Dizocilpine Maleate 97-102 brain-derived neurotrophic factor Rattus norvegicus 134-138