PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1933433-2 1991 A previous study from this laboratory showed that treatment with the NMDA receptor antagonist, MK-801, induced an apparent increase in the density of calcitonin gene-related peptide (CGRP)-immunoreactive primary afferent fibers in the dorsal spinal cord of the rat. Dizocilpine Maleate 95-101 calcitonin-related polypeptide alpha Rattus norvegicus 150-181 24184018-5 2013 Consistently we found that CGRP-triggered CREB activation can be blocked by both PI3K inhibitor LY294002 and NMDAR antagonists MK801 and D-AP5. Dizocilpine Maleate 127-132 calcitonin-related polypeptide alpha Rattus norvegicus 27-31 7683239-4 1993 Changes in immunostaining densities of substance P (SP) and calcitonin gene-related peptide (CGRP) within the spinal cord of untreated (reference population) neuropathic rats and that of neuropathic rats treated for 7 days with MK-801 were quantified and compared. Dizocilpine Maleate 228-234 calcitonin-related polypeptide alpha Rattus norvegicus 60-91 7683239-4 1993 Changes in immunostaining densities of substance P (SP) and calcitonin gene-related peptide (CGRP) within the spinal cord of untreated (reference population) neuropathic rats and that of neuropathic rats treated for 7 days with MK-801 were quantified and compared. Dizocilpine Maleate 228-234 calcitonin-related polypeptide alpha Rattus norvegicus 93-97 7683239-8 1993 MK-801 treatment in naive rats caused a global increase in both SP and CGRP staining in the dorsal horn. Dizocilpine Maleate 0-6 calcitonin-related polypeptide alpha Rattus norvegicus 71-75 9131643-4 1997 MK-801 increased CGRP in a dose-response manner in frontal cortex, and NKA-LI in occipital cortex. Dizocilpine Maleate 0-6 calcitonin-related polypeptide alpha Rattus norvegicus 17-21 1306489-3 1992 We are attempting to determine the level of the primary afferent neuron at which MK-801 might have a restorative effect on CGRP immunostaining. Dizocilpine Maleate 81-87 calcitonin-related polypeptide alpha Rattus norvegicus 123-127 1306489-4 1992 Thus, the purpose of this study was to determine if MK-801 had a similar restorative effect on immunostaining for CGRP in bladder nerves after a direct lesion of the sacral afferent system, i.e., rhizotomy of the L6 and S1 dorsal roots. Dizocilpine Maleate 52-58 calcitonin-related polypeptide alpha Rattus norvegicus 114-118 1306489-9 1992 These data suggest that MK-801-induced restoration of bladder CGRP-I primary afferent nerve fibers may rely on an intact central process. Dizocilpine Maleate 24-30 calcitonin-related polypeptide alpha Rattus norvegicus 62-68 1587334-0 1992 Effects of spinal cord transection and MK-801 on CGRP immunostaining in the rat urinary bladder. Dizocilpine Maleate 39-45 calcitonin-related polypeptide alpha Rattus norvegicus 49-53 1587334-6 1992 In bladders from rats receiving a spinal cord transection and MK-801 treatment, CGRP-immunoreactive fibers were abundantly distributed throughout the detrusor muscle; these fibers exhibited numerous varicosities as well as some enlarged terminal varicosities. Dizocilpine Maleate 62-68 calcitonin-related polypeptide alpha Rattus norvegicus 80-84 1587334-7 1992 These data demonstrate that (i) an upper motor neuron-type lesion markedly decreases the density of CGRP-immunoreactive peripheral afferent nerve processes and (ii) following a spinal cord transection, MK-801 appears to enhance the density of CGRP immunostaining in the bladder. Dizocilpine Maleate 202-208 calcitonin-related polypeptide alpha Rattus norvegicus 100-104 1587334-7 1992 These data demonstrate that (i) an upper motor neuron-type lesion markedly decreases the density of CGRP-immunoreactive peripheral afferent nerve processes and (ii) following a spinal cord transection, MK-801 appears to enhance the density of CGRP immunostaining in the bladder. Dizocilpine Maleate 202-208 calcitonin-related polypeptide alpha Rattus norvegicus 243-247 1933433-2 1991 A previous study from this laboratory showed that treatment with the NMDA receptor antagonist, MK-801, induced an apparent increase in the density of calcitonin gene-related peptide (CGRP)-immunoreactive primary afferent fibers in the dorsal spinal cord of the rat. Dizocilpine Maleate 95-101 calcitonin-related polypeptide alpha Rattus norvegicus 183-187 1933433-3 1991 The present study was undertaken to extend this work by: 1) quantifying the MK-801-induced increase in CGRP immunostaining in the dorsal grey commissure/medial dorsal horn region and 2) examining the effect of MK-801 on the number of CGRP-immunoreactive primary afferent cell bodies in lumbar dorsal root ganglia. Dizocilpine Maleate 76-82 calcitonin-related polypeptide alpha Rattus norvegicus 103-107 1933433-3 1991 The present study was undertaken to extend this work by: 1) quantifying the MK-801-induced increase in CGRP immunostaining in the dorsal grey commissure/medial dorsal horn region and 2) examining the effect of MK-801 on the number of CGRP-immunoreactive primary afferent cell bodies in lumbar dorsal root ganglia. Dizocilpine Maleate 76-82 calcitonin-related polypeptide alpha Rattus norvegicus 234-238 1933433-4 1991 Following 7 days of MK-801 treatment, a significant increase (p less than 0.001) in CGRP immunostaining was observed in the dorsal grey commissure/medial dorsal horn. Dizocilpine Maleate 20-26 calcitonin-related polypeptide alpha Rattus norvegicus 84-88 1933433-6 1991 These data suggest that MK-801 produces significant alterations in the intraspinal projection of CGRP-immunoreactive fibers without inducing immunocytochemically detectable CGRP within a new population of primary afferent neurons. Dizocilpine Maleate 24-30 calcitonin-related polypeptide alpha Rattus norvegicus 97-101 2216055-0 1990 MK-801-induced sprouting by CGRP immunoreactive primary afferent fibers in the dorsal spinal cord of the rat. Dizocilpine Maleate 0-6 calcitonin-related polypeptide alpha Rattus norvegicus 28-32 2216055-2 1990 The effects of MK-801 on the distribution of calcitonin gene-related peptide (CGRP)-immunoreactive fibers in the dorsal spinal cord of the rat were subsequently examined. Dizocilpine Maleate 15-21 calcitonin-related polypeptide alpha Rattus norvegicus 45-76 2216055-2 1990 The effects of MK-801 on the distribution of calcitonin gene-related peptide (CGRP)-immunoreactive fibers in the dorsal spinal cord of the rat were subsequently examined. Dizocilpine Maleate 15-21 calcitonin-related polypeptide alpha Rattus norvegicus 78-82 2216055-5 1990 These observations suggest that MK-801 induces intraspinal sprouting by CGRP immunoreactive primary afferent fibers in vivo. Dizocilpine Maleate 32-38 calcitonin-related polypeptide alpha Rattus norvegicus 72-76