PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21162263-8	2007	MK801 inhibited the expression of bcl-2, cytoC, Caspase-3 obviously.	Dizocilpine Maleate	0-5	caspase 3	Rattus norvegicus	48-57	
19596402-0	2009	MK801-induced activated caspase-3 exhibits selective co-localization with GAD67.	Dizocilpine Maleate	0-5	caspase 3	Rattus norvegicus	24-33	
19056468-5	2009	Significantly, ablation of caspase-3 activity completely inhibited the MK-801-induced (and developmental) programmed cell death of external germinal layer neurons.	Dizocilpine Maleate	71-77	caspase 3	Rattus norvegicus	27-36	
23643674-3	2013	Moreover, early in the development MK-801 triggers widespread cortical apoptosis, inducing extensive caspase-3 expression.	Dizocilpine Maleate	35-41	caspase 3	Rattus norvegicus	101-110	
16781062-7	2006	MK-801 treatment did not modify the activity of caspase-8 at any age, but decreased caspase-9 activity at P8 and increased the activity of caspase-1 (76%) at P8, caspase-3 (160%) at P16 and caspase-9 (50%) at P12.	Dizocilpine Maleate	0-6	caspase 3	Rattus norvegicus	162-171	
17449067-5	2007	Our findings indicate that treatment of adult rats with MK801 in doses previously found to cause alterations in pyramidal neurons of the retrosplenial cortex (5mg/kg) results in an active caspase 3 (+), ultrastructurally apoptotic type of cell death involving the same projection neurons of layer IIalpha that are also vulnerable to bulbotomy lesions.	Dizocilpine Maleate	56-61	caspase 3	Rattus norvegicus	188-197	
16782280-0	2006	MK801-induced caspase-3 in the postnatal brain: inverse relationship with calcium binding proteins.	Dizocilpine Maleate	0-5	caspase 3	Rattus norvegicus	14-23	
16782280-3	2006	At postnatal day 7, MK801-induced activated caspase-3 expression was most frequently found in mutually exclusive cell populations to those expressing any of the three calcium binding proteins.	Dizocilpine Maleate	20-25	caspase 3	Rattus norvegicus	44-53	
16782280-6	2006	Suggesting expression patterns of these proteins were inversely related, these same brain regions no longer displayed MK801-induced activated caspase-3 at postnatal day 21, but instead robustly expressed calcium binding proteins.	Dizocilpine Maleate	118-123	caspase 3	Rattus norvegicus	142-151	
16708014-3	2006	Within the somatosensory cortex, MK801 triggered robust, caspase-3-dependent apoptotic injury, reduced expression of cytoskeletal proteins MAP2 and tau, and increased synapse associated protein SNAP25.	Dizocilpine Maleate	33-38	caspase 3	Rattus norvegicus	57-66	
12074912-7	2002	MK-801, an antagonist of N-methyl-D-aspartate (NMDA) glutamate receptors, prevented 3-nitropropionic acid-induced [Ca(2+)](m) elevation, caspase-3 activation, mitochondrial depolarization, and neuronal death.	Dizocilpine Maleate	0-6	caspase 3	Rattus norvegicus	137-146	
12675929-5	2003	Activation of caspase-3 was observed within 6-12 h and sustained over 36 h after exposure to MK-801/CNQX, which cleaved PHF-1 tau, the substrate for caspase-3.	Dizocilpine Maleate	93-99	caspase 3	Rattus norvegicus	14-23	
12675929-5	2003	Activation of caspase-3 was observed within 6-12 h and sustained over 36 h after exposure to MK-801/CNQX, which cleaved PHF-1 tau, the substrate for caspase-3.	Dizocilpine Maleate	93-99	caspase 3	Rattus norvegicus	149-158	
12675929-7	2003	Reducing extracellular Ca2+, but not Na+, activated caspase-3, suggesting an essential role of Ca2+ deficiency in MK-801/CNQX-induced activation of caspases.	Dizocilpine Maleate	114-120	caspase 3	Rattus norvegicus	52-61	
15562059-8	2004	However, cells protected by dizocilpine against necrosis showed evidence of caspase-3-mediated apoptosis.	Dizocilpine Maleate	28-39	caspase 3	Rattus norvegicus	76-85	
11006950-4	2000	Furthermore, MK-801 significantly decreased caspase-3 activity, and Western blots revealed a tendency towards decreased proteolytic cleavage of the caspase-3 proform.	Dizocilpine Maleate	13-19	caspase 3	Rattus norvegicus	44-53	
10428050-6	1999	Activation of caspase-3 was accompanied by MK-801-induced cell death in a dose-dependent manner, and an inhibitor of caspase-3 reduced the cell death.	Dizocilpine Maleate	43-49	caspase 3	Rattus norvegicus	14-23	
29325386-16	2017	MK-801 or PD98059 intervention further promote the Nissl body volume reduced, neurons karyopyknosis, the apoptosis of visual cortical neurons and Caspase-3 expression, and restrain the expression of NGF and c-FOS.	Dizocilpine Maleate	0-6	caspase 3	Rattus norvegicus	146-155	
27382356-10	2016	The activation of caspase-3 by PFHxS was also inhibited by MK801, diltiazem and nifedipine.	Dizocilpine Maleate	59-64	caspase 3	Rattus norvegicus	18-27	
25937004-8	2015	24h following washout of the specific drug, a significant elevation of the pro-apoptotic marker BAX, as well as activated Caspase-3 positive neurons, could be detected in cultures exposed to 100muM MK801 and 25muM S(+)-ketamine.	Dizocilpine Maleate	198-203	caspase 3	Rattus norvegicus	122-131