PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20118535-0	2010	The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells.	hypothemycin	28-40	Eph receptor B1	Rattus norvegicus	106-143	
20118535-1	2010	The resorcylic acid lactone hypothemycin has been shown to inactivate protein kinases by binding to a cysteine conserved in 46 protein kinases, including mitogen-activated protein kinase kinase (MEK), extracellular signal-regulated kinase (ERK) and platelet-derived growth factor receptor (PDGFR).	hypothemycin	28-40	Eph receptor B1	Rattus norvegicus	201-238	
20118535-1	2010	The resorcylic acid lactone hypothemycin has been shown to inactivate protein kinases by binding to a cysteine conserved in 46 protein kinases, including mitogen-activated protein kinase kinase (MEK), extracellular signal-regulated kinase (ERK) and platelet-derived growth factor receptor (PDGFR).	hypothemycin	28-40	Eph receptor B1	Rattus norvegicus	240-243	
20118535-4	2010	In Ki-ras-transformed and phorbol 12-myristate 13-acetate (PMA)-treated NRK cells, hypothemycin blocked ERK activation but showed a minimal effect on autophosphorylation of protein kinase D1 (PKD1), another kinase containing the conserved cysteine.	hypothemycin	83-95	Eph receptor B1	Rattus norvegicus	104-107	
20118535-5	2010	Hypothemycin potently inhibited PDGFR autophosphorylation and activation of the MEK-ERK pathway in platelet-derived growth factor (PDGF)-treated NRK cells.	hypothemycin	0-12	Eph receptor B1	Rattus norvegicus	84-87	
20118535-7	2010	Hypothemycin also inhibited growth factor- and anchorage-independent growth of human cancer cell lines with a constitutively active MEK-ERK pathway.	hypothemycin	0-12	Eph receptor B1	Rattus norvegicus	136-139	
20118535-8	2010	Although hypothemycin has the potential to inactivate various protein kinases, the results indicate that in intracellular environments, hypothemycin can inhibit the MEK-ERK axis with sufficient selectivity to normalize transformed phenotypes of cells dependent on this pathway.	hypothemycin	136-148	Eph receptor B1	Rattus norvegicus	169-172