PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7858064-5 1994 Treatment of FS-4 cells with sodium arsenite led to a very strong increase in the phosphorylation of Hsp28 demonstrable after 5 min and persisting for at least 4 h. Tyrosine phosphorylation of pp42 and pp44 MAP kinases was increased by TNF treatment, whereas arsenite produced a modest increase in tyrosine phosphorylation of pp44 while decreasing that of pp42 MAP kinase. arsenite 36-44 tumor necrosis factor Homo sapiens 236-239 10775461-6 2000 Exposing the cells to 500 microM arsenite, prior to adding TNF-alpha, completely inhibited IkappaBalpha degradation, NF-kappaB translocation, NF-kappaB-dependent gene transcription, and transcription of the endogenous gene for IL-8. arsenite 33-41 tumor necrosis factor Homo sapiens 59-68 10428782-7 1999 Sorbitol, H(2)O(2), and arsenite each blocked IkappaBalpha phosphorylation induced by TNF, and SB203580 reversed the inhibitory effects of sorbitol and H(2)O(2), but not arsenite. arsenite 24-32 tumor necrosis factor Homo sapiens 86-89 9545260-5 1998 Cell stresses such as arsenite and anisomycin and the cytokines tumor necrosis factor-alpha and interleukin-1beta also cause increased phosphorylation of eIF4E, which is abolished by the specific p38 MAP kinase inhibitor, SB203580. arsenite 22-30 tumor necrosis factor Homo sapiens 64-91 9448725-2 1998 Gel mobility shift assays using total nuclear extracts isolated from tumor necrosis factor alpha-treated A549 cells demonstrated dose-dependent inhibition of NF-kappa B binding by chromium, cadmium, mercury, zinc, and arsenite. arsenite 218-226 tumor necrosis factor Homo sapiens 69-96 35378400-0 2022 TNF-alpha derived from arsenite-induced microglia activation mediated neuronal necroptosis. arsenite 23-31 tumor necrosis factor Homo sapiens 0-9 35378400-7 2022 In this study, we found that arsenite induced microglial activation through p38 MAPK signaling pathway, leading to the production of TNF-alpha. arsenite 29-37 tumor necrosis factor Homo sapiens 133-142 35378400-9 2022 Our findings suggested that necroptosis induced by microglia-derived TNF-alpha upon arsenite exposure partially played a role in arsenic-induced cell death which underlie the fundamental event of arsenic-related neurotoxicity. arsenite 84-92 tumor necrosis factor Homo sapiens 69-78 16271621-0 2005 Arsenite enhances tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1. arsenite 0-8 tumor necrosis factor Homo sapiens 18-45 19371606-3 2009 In this study, we investigated the mechanistic role of arsenite-induced HO-1 in modulating tumor necrosis factor alpha (TNF-alpha) induced monocyte adhesion to human umbilical vein endothelial cells (HUVEC). arsenite 55-63 tumor necrosis factor Homo sapiens 91-118 19371606-3 2009 In this study, we investigated the mechanistic role of arsenite-induced HO-1 in modulating tumor necrosis factor alpha (TNF-alpha) induced monocyte adhesion to human umbilical vein endothelial cells (HUVEC). arsenite 55-63 tumor necrosis factor Homo sapiens 120-129 19371606-4 2009 Arsenite pretreatment, which upregulated HO-1 in a time- and concentration-dependent manner, inhibited TNF-alpha-induced monocyte adhesion to HUVEC and intercellular adhesion molecule 1 protein expression by 50% and 40%, respectively. arsenite 0-8 tumor necrosis factor Homo sapiens 103-112 29479036-0 2018 Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species. arsenite 0-8 tumor necrosis factor Homo sapiens 60-87 22310326-13 2012 Surprisingly, we show that in hepatocytes arsenite decreases expression of two inflammatory mediators, TNF and VEGF, an effect that is not predicted from suppression of RXRalpha activity. arsenite 42-50 tumor necrosis factor Homo sapiens 103-106 16271621-6 2005 Our investigation revealed that, by depleting GSH, arsenite attenuated the TNF-alpha-induced VCAM-1 expression as well as a potentiation of AP-1 and an attenuation of NF-kappaB activations by TNF-alpha. arsenite 51-59 tumor necrosis factor Homo sapiens 75-84 16271621-6 2005 Our investigation revealed that, by depleting GSH, arsenite attenuated the TNF-alpha-induced VCAM-1 expression as well as a potentiation of AP-1 and an attenuation of NF-kappaB activations by TNF-alpha. arsenite 51-59 tumor necrosis factor Homo sapiens 192-201 16271621-9 2005 In summary, we demonstrate that arsenite enhances the TNF-alpha-induced VCAM-1 expression in HUVECs via regulation of AP-1 and NF-kappaB activities in a GSH-sensitive manner. arsenite 32-40 tumor necrosis factor Homo sapiens 54-63 16271621-4 2005 Our study demonstrated that arsenite pretreatment potentiated the TNF-alpha-induced VCAM-1 expression with up-regulations of both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB). arsenite 28-36 tumor necrosis factor Homo sapiens 66-75 15028728-0 2004 Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathway. arsenite 0-8 tumor necrosis factor Homo sapiens 53-80 15028728-4 2004 The two prerequisites that dictate apoptotic response of melanomas upon arsenite treatment are low nuclear NF-kappaB activity and an endogenous expression of tumor necrosis factor alpha. arsenite 72-80 tumor necrosis factor Homo sapiens 158-185