PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33965804-9 2021 After MRC-5 cells were co-cultured with arsenite-treated HBE cells, the levels of miR-21, AKT activation, glycolysis, and myofibroblast differentiation were enhanced, effects that were blocked by reducing miR-21 and by inhibiting the EVs in HBE cells. arsenite 40-48 AKT serine/threonine kinase 1 Homo sapiens 90-93 33743404-0 2021 MicroRNA-191 blocking the translocation of GLUT4 is involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway. arsenite 64-72 AKT serine/threonine kinase 1 Homo sapiens 136-139 33743404-9 2021 For insulin-treated L-02 cells, arsenite decreased glucose consumption and glycogen levels, increased miR-191 levels, and inhibited the IRS1/AKT pathway and the translocation of GLUT4 from the cytoplasm to the plasma membrane. arsenite 32-40 AKT serine/threonine kinase 1 Homo sapiens 141-144 33743404-10 2021 For insulin-treated L-02 cells, the decreases of glucose consumption, glycogen levels, GLUT4 on the plasma membrane, and p-AKT levels induced by arsenite were reversed by SC79 (agonist of AKT) and an miR-191 inhibitor; these effects caused by miR-191 inhibitor were restored by IRS1 siRNA. arsenite 145-153 AKT serine/threonine kinase 1 Homo sapiens 123-126 33743404-10 2021 For insulin-treated L-02 cells, the decreases of glucose consumption, glycogen levels, GLUT4 on the plasma membrane, and p-AKT levels induced by arsenite were reversed by SC79 (agonist of AKT) and an miR-191 inhibitor; these effects caused by miR-191 inhibitor were restored by IRS1 siRNA. arsenite 145-153 AKT serine/threonine kinase 1 Homo sapiens 188-191 33743404-12 2021 Thus, miR-191 blocking the translocation of GLUT4 was involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway. arsenite 66-74 AKT serine/threonine kinase 1 Homo sapiens 138-141 33965804-11 2021 Thus, miR-21 down-regulates PTEN and promotes glycolysis via activating AKT, which is associated with arsenite-induced myofibroblast differentiation and pulmonary fibrosis. arsenite 102-110 AKT serine/threonine kinase 1 Homo sapiens 72-75 32450402-8 2020 In conclusion, our data suggest that long-term exposure to arsenite promotes Nrf2 upregulation via the PI3K/Akt pathway and, along with upregulation of downstream mTOR and Bcl2, contributes to autophagy dysfunction in transformed HaCaT cells. arsenite 59-67 AKT serine/threonine kinase 1 Homo sapiens 108-111 31468445-8 2019 The decrease in p-Akt levels induced by arsenite exposure was prevented by taurine treatment. arsenite 40-48 AKT serine/threonine kinase 1 Homo sapiens 18-21 32373892-7 2020 Moreover, linc-ROR siRNA also down-regulated the PI3K/AKT pathway in arsenite-transformed HaCaT cells, and treatment with AKT inhibitor wortmannin restored P53 activity, implying that linc-ROR inhibits P53 activity by activating the PI3K/AKT pathway. arsenite 69-77 AKT serine/threonine kinase 1 Homo sapiens 54-57 32373892-8 2020 Taken together, the present study shows that linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity through activating PI3K/AKT, providing a novel carcinogenic mechanism of arsenite-induced skin cancer. arsenite 63-71 AKT serine/threonine kinase 1 Homo sapiens 162-165 32373892-8 2020 Taken together, the present study shows that linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity through activating PI3K/AKT, providing a novel carcinogenic mechanism of arsenite-induced skin cancer. arsenite 211-219 AKT serine/threonine kinase 1 Homo sapiens 162-165 31468445-9 2019 Thus, taurine attenuated the effect of arsenite on primary cortical neurons, an effect that may involve the Akt pathway. arsenite 39-47 AKT serine/threonine kinase 1 Homo sapiens 108-111 30066004-6 2018 Furthermore, Ras/Raf/MAPK, PI3K/AKT, and JAK2/STAT3 signaling pathways were activated by arsenite treatment. arsenite 89-97 AKT serine/threonine kinase 1 Homo sapiens 32-35 27347121-9 2016 Pretreatment with arsenite significantly suppressed PDGF-BB-induced phosphorylation of Akt, but not of p44/p42 MAPK in AsPC-1 cells. arsenite 18-26 AKT serine/threonine kinase 1 Homo sapiens 87-90 27347121-11 2016 Since the inhibition of the Akt signaling pathway markedly reduced PDGF-BB-induced migration in AsPC-1 cells, the present results strongly suggest that arsenite inhibits PDGF-BB-induced migration by suppressing the Akt signaling pathway in AsPC-1 cells. arsenite 152-160 AKT serine/threonine kinase 1 Homo sapiens 28-31 27347121-11 2016 Since the inhibition of the Akt signaling pathway markedly reduced PDGF-BB-induced migration in AsPC-1 cells, the present results strongly suggest that arsenite inhibits PDGF-BB-induced migration by suppressing the Akt signaling pathway in AsPC-1 cells. arsenite 152-160 AKT serine/threonine kinase 1 Homo sapiens 215-218 21971544-0 2011 Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1. arsenite 0-8 AKT serine/threonine kinase 1 Homo sapiens 65-68 22859221-10 2014 These results suggested that beta-catenin plays a role in arsenite-induced VEGF in SH-SY5Y cells, and the induction of beta-catenin by arsenite is mediated by inhibition of GSK3 without activating its upstream kinase Akt. arsenite 135-143 AKT serine/threonine kinase 1 Homo sapiens 217-220 23968725-8 2013 In conclusion, arsenite-induced COX-2, VEGF and HIF-1alpha expressions, mediated partially by reactive oxygen species (ROS), were regulated by MAPK and PI3K/AKT signaling pathways in human uroepithelial cells. arsenite 15-23 AKT serine/threonine kinase 1 Homo sapiens 157-160 30090420-0 2016 MicroRNA-21 activation of Akt via PTEN is involved in the epithelial-mesenchymal transition and malignant transformation of human keratinocytes induced by arsenite. arsenite 155-163 AKT serine/threonine kinase 1 Homo sapiens 26-29 30090420-5 2016 In HaCaT cells, arsenite caused an increase of miR-21 levels and a decrease of PTEN, which activated Akt signaling and induced the EMT. arsenite 16-24 AKT serine/threonine kinase 1 Homo sapiens 101-104 22859221-9 2014 Inhibition of PI3K/Akt which negatively regulates GSK3 activity by LY294002 resulted in a decrease in arsenite-mediated beta-catenin nuclear accumulation, and VEGF expression. arsenite 102-110 AKT serine/threonine kinase 1 Homo sapiens 19-22 24535192-5 2014 Exposure of cells to arsenite for 24 h rendered cells less responsive toward stimulation of Akt by insulin. arsenite 21-29 AKT serine/threonine kinase 1 Homo sapiens 92-95 24535192-6 2014 At the same time, short-term exposure to arsenite induced a concentration-dependent increase in phosphorylation of Akt at Ser-473, followed by phosphorylation of FoxO proteins at sites known to be phosphorylated by Akt. arsenite 41-49 AKT serine/threonine kinase 1 Homo sapiens 115-118 24535192-6 2014 At the same time, short-term exposure to arsenite induced a concentration-dependent increase in phosphorylation of Akt at Ser-473, followed by phosphorylation of FoxO proteins at sites known to be phosphorylated by Akt. arsenite 41-49 AKT serine/threonine kinase 1 Homo sapiens 215-218 24024143-0 2013 Arsenite-induced stress signaling: modulation of the phosphoinositide 3"-kinase/Akt/FoxO signaling cascade. arsenite 0-8 AKT serine/threonine kinase 1 Homo sapiens 80-83 24024143-5 2013 In contrast, a strong phosphorylation of FoxO1a/FoxO3a and Akt was observed at subcytotoxic concentrations of arsenite in HaCaT human keratinocytes. arsenite 110-118 AKT serine/threonine kinase 1 Homo sapiens 59-62 20862710-0 2010 Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. arsenite 130-138 AKT serine/threonine kinase 1 Homo sapiens 27-30 21396911-0 2011 Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response. arsenite 20-28 AKT serine/threonine kinase 1 Homo sapiens 68-71 21268130-4 2011 The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway. arsenite 166-174 AKT serine/threonine kinase 1 Homo sapiens 23-26 21268130-4 2011 The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway. arsenite 166-174 AKT serine/threonine kinase 1 Homo sapiens 245-248 21268130-4 2011 The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway. arsenite 216-224 AKT serine/threonine kinase 1 Homo sapiens 23-26 22040890-2 2011 Arsenite decreases catalase activity; it activates phosphatidylinositol 3-kinase (PI3K) and its key downstream effector Akt in a variety of cells. arsenite 0-8 AKT serine/threonine kinase 1 Homo sapiens 120-123 22040890-6 2011 Arsenite treatment markedly activated Akt and decreased the levels of both catalase mRNA and protein. arsenite 0-8 AKT serine/threonine kinase 1 Homo sapiens 38-41 22040890-7 2011 Both PHA and LY attenuated arsenite-induced activation of Akt. arsenite 27-35 AKT serine/threonine kinase 1 Homo sapiens 58-61 18197291-0 2008 PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation. arsenite 68-76 AKT serine/threonine kinase 1 Homo sapiens 6-9 19519318-0 2009 PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells. arsenite 55-63 AKT serine/threonine kinase 1 Homo sapiens 5-8 19519318-7 2009 Overall, our data suggest a pathway of PI-3K/Akt/JNK/c-Jun/cylin D1 signaling in response to arsenite in human bronchial epithelial cells. arsenite 93-101 AKT serine/threonine kinase 1 Homo sapiens 45-48 18197291-3 2008 OBJECTIVES: In this study, we investigated the potential role of PI-3K/Akt/cyclin D1in the transformation of human keratinocytic cells upon arsenite exposure. arsenite 140-148 AKT serine/threonine kinase 1 Homo sapiens 71-74 18197291-8 2008 Treatment of cells with arsenite also induced significant activation of PI-3K and Akt, which was responsible for the anchorage-independent cell growth induced by arsenite exposure. arsenite 24-32 AKT serine/threonine kinase 1 Homo sapiens 82-85 18197291-8 2008 Treatment of cells with arsenite also induced significant activation of PI-3K and Akt, which was responsible for the anchorage-independent cell growth induced by arsenite exposure. arsenite 162-170 AKT serine/threonine kinase 1 Homo sapiens 82-85 18197291-9 2008 Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite. arsenite 144-152 AKT serine/threonine kinase 1 Homo sapiens 106-109 18197291-9 2008 Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite. arsenite 144-152 AKT serine/threonine kinase 1 Homo sapiens 264-267 18197291-9 2008 Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite. arsenite 435-443 AKT serine/threonine kinase 1 Homo sapiens 106-109 18197291-10 2008 CONCLUSION: Our results demonstrate that PI-3K/Akt-mediated cyclin D1 expression is at least one key event implicated in the arsenite human skin carcinogenic effect. arsenite 125-133 AKT serine/threonine kinase 1 Homo sapiens 47-50 17520061-3 2007 We have previously shown that trivalent metabolites of iAs, arsenite (iAs(III)) and methylarsonous acid (MAs(III)) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt). arsenite 60-68 AKT serine/threonine kinase 1 Homo sapiens 259-262 17370311-0 2007 PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1. arsenite 49-57 AKT serine/threonine kinase 1 Homo sapiens 6-9 17370311-4 2007 Taken together, we provide the direct evidence that PI-3K/Akt pathway plays a role in the regulation of cell proliferation through the induction of cyclin D1 in human keratinocytes upon arsenite treatment. arsenite 186-194 AKT serine/threonine kinase 1 Homo sapiens 58-61 17370311-5 2007 Given the importance of aberrant cell proliferation in cell transformation, we propose that the activation of PI-3K/Akt pathway and cyclin D1 induction may be the important mediators of human skin carcinogenic effect of arsenite. arsenite 220-228 AKT serine/threonine kinase 1 Homo sapiens 116-119 17520061-3 2007 We have previously shown that trivalent metabolites of iAs, arsenite (iAs(III)) and methylarsonous acid (MAs(III)) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt). arsenite 60-68 AKT serine/threonine kinase 1 Homo sapiens 263-266 16239170-4 2005 In our present study, we investigated the effect of arsenite on Akt1 and eNOS and its involvement in cytotoxicity of vascular endothelial cells. arsenite 52-60 AKT serine/threonine kinase 1 Homo sapiens 64-68 16239170-5 2005 Our study demonstrated that arsenite decreased the protein levels of both Akt1 and eNOS accompanied with increased levels of ubiquitination of total cell lysates. arsenite 28-36 AKT serine/threonine kinase 1 Homo sapiens 74-78 16239170-6 2005 We found that inhibition of the ubiquitin-proteasome pathway by MG-132 could partially protect Akt1 and eNOS from degradation by arsenite together with a proportional protection from the arsenite-induced cytoxicity. arsenite 129-137 AKT serine/threonine kinase 1 Homo sapiens 95-99 16239170-8 2005 Our study indicated that endothelial eNOS activity could be attenuated by arsenite via the ubiquitin-proteasome-mediated degradation of Akt1/eNOS as well as via direct inhibition of eNOS activity. arsenite 74-82 AKT serine/threonine kinase 1 Homo sapiens 136-140 15028728-6 2004 On the other hand, signaling pathways including those of phosphatidylinositol 3-kinase-AKT, MEK-ERK, and JNK play a protective role against arsenite-induced oxidative stress and apoptosis in melanoma cells. arsenite 140-148 AKT serine/threonine kinase 1 Homo sapiens 87-90 14971644-0 2004 Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells. arsenite 0-8 AKT serine/threonine kinase 1 Homo sapiens 51-54 14971644-7 2004 We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF. arsenite 19-27 AKT serine/threonine kinase 1 Homo sapiens 47-50 14971644-7 2004 We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF. arsenite 73-81 AKT serine/threonine kinase 1 Homo sapiens 47-50 14971644-11 2004 These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis. arsenite 29-37 AKT serine/threonine kinase 1 Homo sapiens 65-68 14971644-11 2004 These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis. arsenite 185-193 AKT serine/threonine kinase 1 Homo sapiens 65-68 12614848-0 2003 Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation. arsenite 55-63 AKT serine/threonine kinase 1 Homo sapiens 98-101 12640124-6 2003 In contrast to its extensively documented antiapoptotic influence, the elevated activity of Akt appears to be important in sensitizing caveolin-expressing cells to arsenite-induced toxicity, as both pretreatment of cells with the PI3K inhibitor wortmannin and overexpression of a dominant-negative Akt mutant markedly improved the survival of arsenite-treated cells. arsenite 343-351 AKT serine/threonine kinase 1 Homo sapiens 92-95 12640124-8 2003 In summary, our results indicate that caveolin-induced upregulation of the PI3K/Akt signaling pathway, which appears to be a death signal in the presence of arsenite and H(2)O(2), sensitizes cells to environmental stress. arsenite 157-165 AKT serine/threonine kinase 1 Homo sapiens 80-83 12640124-0 2003 Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. arsenite 87-95 AKT serine/threonine kinase 1 Homo sapiens 65-68 12640124-6 2003 In contrast to its extensively documented antiapoptotic influence, the elevated activity of Akt appears to be important in sensitizing caveolin-expressing cells to arsenite-induced toxicity, as both pretreatment of cells with the PI3K inhibitor wortmannin and overexpression of a dominant-negative Akt mutant markedly improved the survival of arsenite-treated cells. arsenite 164-172 AKT serine/threonine kinase 1 Homo sapiens 92-95 12614848-7 2003 These results suggested that selective blockade of the arsenite-provoked PI-3 kinase/Akt pathway can promote the arsenite-triggered pathway for caspase activation, and this may open a new study area for wider applications of arsenic as a drug for treating various kinds of leukemia. arsenite 55-63 AKT serine/threonine kinase 1 Homo sapiens 85-88 12614848-7 2003 These results suggested that selective blockade of the arsenite-provoked PI-3 kinase/Akt pathway can promote the arsenite-triggered pathway for caspase activation, and this may open a new study area for wider applications of arsenic as a drug for treating various kinds of leukemia. arsenite 113-121 AKT serine/threonine kinase 1 Homo sapiens 85-88 12614848-4 2003 Arsenite-induced Akt phosphorylation also was inhibited by sequestrating membrane cholesterol with beta cyclodextrin. arsenite 0-8 AKT serine/threonine kinase 1 Homo sapiens 17-20 12614848-5 2003 Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked. arsenite 67-75 AKT serine/threonine kinase 1 Homo sapiens 84-87 12614848-5 2003 Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked. arsenite 67-75 AKT serine/threonine kinase 1 Homo sapiens 211-214 11788791-0 2001 Arsenite activation of P13K/AKT cell survival pathway is mediated by p38 in cultured human keratinocytes. arsenite 0-8 AKT serine/threonine kinase 1 Homo sapiens 28-31 11788791-12 2001 PI-3-kinase inhibitors, Wortmannin and LY294002 inhibited arsenite-induced phosphorylation of AKT and eNOS but had no effect on phosphorylation of p38. arsenite 58-66 AKT serine/threonine kinase 1 Homo sapiens 94-97 11788791-10 2001 RESULTS: Arsenite induced the activation of AKT at both Ser473 and Thr308, and its downstream effector eNOS in cultured human keratinocytes. arsenite 9-17 AKT serine/threonine kinase 1 Homo sapiens 44-47 11788791-13 2001 Interestingly, however, SB203580, a known p38 inhibitor, completely inhibited arsenite-induced phosphorylation of AKT and eNOS. arsenite 78-86 AKT serine/threonine kinase 1 Homo sapiens 114-117 11259586-4 2001 In contrast, activation of stress-activated c-Jun N-terminal kinase and p38 pathways by expression of constitutively active mutants of Rac, transforming growth factor beta-activated kinase 1 (TAK1), MAPK kinase 3 (MKK3), or MKK6 or by treatment with arsenite or anisomycin did not alone markedly enhance MMP-1 promoter activity. arsenite 250-258 AKT serine/threonine kinase 1 Homo sapiens 135-138 11788791-15 2001 CONCLUSIONS: Collectively, our data indicate that arsenite induces activation of AKT and eNOS, via PI-3-kinase and p38 pathway, likely bypassing the activation of EGF receptor in cultured human keratinocytes. arsenite 50-58 AKT serine/threonine kinase 1 Homo sapiens 81-84 32890875-7 2021 Furthermore, inhibition of HER2, as well as that of the MAPK, AKT and STAT3 pathways, attenuated arsenite-induced proliferation, migration and angiogenesis of human uroepithelial cells, and increased apoptosis rates in vitro. arsenite 97-105 AKT serine/threonine kinase 1 Homo sapiens 62-65