PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17849503-6	2008	Apoptotic signaling following exposure to arsenite involved cytochrome C release from mitochondria, and this was reduced by inhibition of GSK3 indicating that GSK3 promotes arsenite-induced apoptotic signaling upstream of mitochondrial disruption.	arsenite	42-50	cytochrome c, somatic	Homo sapiens	60-72	
30713663-4	2019	The decline of cell viability is due to apoptotic death since arsenite treatment reduces Akt activity and the Bcl2 level but increases caspase 3 activity and the cytochrome c level.	arsenite	62-70	cytochrome c, somatic	Homo sapiens	162-174	
26306706-3	2016	In this study, using human bronchial epithelial cell as a culture system, we demonstrated that arsenite-induced nuclear translocation of nuclear factor kappa B (NF-kappaB) resulted in the release of cytochrome c, the modulation of Fas and FasL, caspase activation, and ultimately leading to cell apoptosis.	arsenite	95-103	cytochrome c, somatic	Homo sapiens	199-211	
18715270-8	2009	In the mitochondrial pathway, arsenite-induced increases in Bcl-2 levels and cytosolic cytochrome c were reduced by melatonin.	arsenite	30-38	cytochrome c, somatic	Homo sapiens	87-99	
9766529-7	1998	Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32.	arsenite	147-155	cytochrome c, somatic	Homo sapiens	85-97	
9766529-8	1998	These results lead to a working hypothesis that arsenite-induced apoptosis is triggered by the generation of hydrogen peroxide through activation of flavoprotein-dependent superoxide-producing enzymes (such as NADPH oxidase), and hydrogen peroxide might play a role as a mediator to induce apoptosis through release of cytochrome c to cytosol, activation of CPP32 protease, and PARP degradation.	arsenite	48-56	cytochrome c, somatic	Homo sapiens	319-331	
25809564-1	2015	Arsenite directly triggers cytochrome c and Smac/DIABLO release in mitochondria isolated from U937 cells.	arsenite	0-8	cytochrome c, somatic	Homo sapiens	27-39	
21439358-6	2011	Arsenite leads to an increase in intracellular Ca levels and generation of reactive oxygen species, which may cause a decrease in mitochondrial transmembrane potential, release of cytochrome c, and consequent activation of caspases.	arsenite	0-8	cytochrome c, somatic	Homo sapiens	180-192	
18077580-7	2007	In the mitochondrial pathway, NAC attenuated arsenite-induced elevation in Bcl-2 level and cytosolic cytochrome c, as well as arsenite-induced reduction in procaspase-3 levels.	arsenite	45-53	cytochrome c, somatic	Homo sapiens	101-113	
11147836-5	2000	The effect of Hsp90 can be blocked by sulfhydryl reagents including arsenite and cadmium, which indicates the involvement of the vicinal cysteines Cys589/590 in the reduction of cytochrome c.	arsenite	68-76	cytochrome c, somatic	Homo sapiens	178-190