PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31141459-3 2019 Treatment of yeast with the toxic trivalent metalloid arsenite (As(III)) also activates Hog1 as part of a protective response in which Hog1 closes Fps1, the main entry port for As(III). arsenite 54-62 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 88-92 33425986-4 2020 Distinct from stressors such as arsenite that activates Hog1 via inhibiting its phosphatases, activation of Hog1 by MMS is phosphatase-independent. arsenite 32-40 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 56-60 31141459-3 2019 Treatment of yeast with the toxic trivalent metalloid arsenite (As(III)) also activates Hog1 as part of a protective response in which Hog1 closes Fps1, the main entry port for As(III). arsenite 54-62 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 135-139 29846136-0 2018 Intracellular mechanism by which arsenite activates the yeast stress MAPK Hog1. arsenite 33-41 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 74-78 30377756-6 2019 Our work has uncovered the mechanisms by which two stresses, arsenite treatment and DNA damage, stimulate the yeast SAPKs Hog1 and Mpk1, respectively. arsenite 61-69 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 122-126 29846136-3 2018 In this study, we delineate the intracellular signaling pathway by which the trivalent toxic metalloid arsenite [As(III)] activates the yeast SAPK Hog1. arsenite 103-111 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 147-151 16885417-0 2006 The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast. arsenite 41-49 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 9-14 21655328-6 2011 Next, we use these novel inhibitors to pinpoint the time of Hog1 action during recovery from G(1) checkpoint arrest, providing further evidence for a specific role of Hog1 in regulating cell cycle resumption during arsenite stress. arsenite 215-223 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 60-64 21655328-6 2011 Next, we use these novel inhibitors to pinpoint the time of Hog1 action during recovery from G(1) checkpoint arrest, providing further evidence for a specific role of Hog1 in regulating cell cycle resumption during arsenite stress. arsenite 215-223 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 167-171 20026328-1 2010 The stress-activated kinase Hog1p mediates arsenic tolerance by decreasing arsenite influx through the aquaglyceroporin Fps1p in Saccharomyces cerevisiae. arsenite 75-83 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 28-33 18552285-0 2008 Mitogen-activated protein kinase Hog1 mediates adaptation to G1 checkpoint arrest during arsenite and hyperosmotic stress. arsenite 89-97 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 33-37 18552285-8 2008 Moreover, the Sic1 protein was stabilized in arsenite-treated hog1Delta cells. arsenite 45-53 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 62-66 16920868-0 2006 Mitogen-activated protein kinase Hog1 is essential for the response to arsenite in Saccharomyces cerevisiae. arsenite 71-79 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 33-37 16920868-1 2006 Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite. arsenite 171-179 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 90-94 16920868-2 2006 Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification. arsenite 46-54 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 0-4 16920868-2 2006 Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification. arsenite 149-157 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 0-4 27607883-3 2016 The mitogen-activated protein kinase (MAPK) Hog1 has previously been shown to restrict arsenite influx through Fps1. arsenite 87-95 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 44-48 27607883-6 2016 While Hog1 prevents arsenite influx via phosphorylation of T231 at the N-terminal domain of Fps1, Slt2 promotes arsenite efflux through phosphorylation of S537 at the C terminus. arsenite 20-28 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 6-10 20632810-9 2010 Activation of the Hog1 MAP kinase in response to osmotic stress or arsenite leads to the transient arrest of the cell cycle in G1 phase, which is mediated by direct phosphorylation of the CDK inhibitor, Sic1, and by downregulation of cyclin expression. arsenite 67-75 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 18-22 16885417-3 2006 Here, we describe a novel role of the S. cerevisiae mitogen-activated protein kinase Hog1p in protecting cells during exposure to arsenite and the related metalloid antimonite. arsenite 130-138 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 85-90 16885417-5 2006 Hog1p is phosphorylated in response to arsenite and this phosphorylation requires Ssk1p and Pbs2p. arsenite 39-47 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 0-5 10519165-6 1999 Using deletion-reporter gene constructs, we have mapped sites that mediate the arsenite-dependent induction of HO-1, and we have shown that components of the extracellular signal-regulated kinase (ERK) and p38 (a homologue of the yeast HOG1 kinase), but not c-jun N-terminal kinase (JNK), mitogen-activated protein (MAP) kinase pathways are involved in arsenite-dependent upregulation. arsenite 79-87 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 236-240